患者女性,66岁,初次就诊时可见甲状腺肿物大小约12 * 12 cm,颈部MRI示气管受压明显,但无明显呼吸困难等症状。本文通过报道了一例巨大NIFTP患者,回顾其诊疗过程,针对其定义、研究进展、诊断标准、治疗及预后进行文献回顾。A patient, a ...患者女性,66岁,初次就诊时可见甲状腺肿物大小约12 * 12 cm,颈部MRI示气管受压明显,但无明显呼吸困难等症状。本文通过报道了一例巨大NIFTP患者,回顾其诊疗过程,针对其定义、研究进展、诊断标准、治疗及预后进行文献回顾。A patient, a 66-year-old female, with a goiter about 12 * 12 cm in size at the first visit. Cervical MRI showed obvious trachea compression, but no obvious dyspnea and other symptoms. In this paper, we report a huge NIFTP patient, review its diagnosis and treatment process, and review the literature on its definition, research progress, diagnostic criteria, treatment and prognosis.展开更多
Objective:To evaluate the diagnostic utility of The Bethesda System for Reporting Thyroid Cytology(TBSRTC)at Peking University Cancer Hospital,the incidence of noninvasive follicular thyroid neoplasms with papillary-l...Objective:To evaluate the diagnostic utility of The Bethesda System for Reporting Thyroid Cytology(TBSRTC)at Peking University Cancer Hospital,the incidence of noninvasive follicular thyroid neoplasms with papillary-like nuclear features(NIFTP),and the impact of reclassification on cytopathological outcomes.Methods:We performed a retrospective study of thyroid fine-needle aspiration(FNA)cases between April 2014 and March 2019.The FNA results were classified according to TBSRTC.Post-surgery histological findings were followed up.Results:A total of 2,781 thyroid FNAs were performed.The incidences of the 6 diagnostic categories(DCs I-VI)were 14.8%,17.1%,15.8%,2.3%,11.6%and 38.5%,respectively.A total of 1,122 patients(40.3%)had corresponding histological results.NIFTP accounted for 0.4%of papillary thyroid carcinoma(PTC)cases,and there was no significant difference in the risk of malignancy(ROM)for each TBSRTC DC between"NIFTP=carcinoma(Ca)"and"NIFTP≠Ca".When"NIFTP=Ca",the sensitivity,specificity,positive predictive value(PPV),negative predictive value(NPV),and accuracy of TBSRTC were 98.0%,84.0%,99.4%,58.3%,and97.5%,respectively.When"NIFTP≠Ca",the sensitivity,specificity,PPV,NPV and accuracy of the TBSRTC were 98.1%,81.5%,99.3%,61.1%,and 97.5%,respectively.Conclusions:TBSRTC is effective in the preoperative diagnosis of thyroid nodules in Peking University Cancer Hospital.The impact of the reclassification of NIFTP on cytopathological outcomes is limited because of its low incidence,and the revised ROMs are not suitable for Asian patients.展开更多
文摘患者女性,66岁,初次就诊时可见甲状腺肿物大小约12 * 12 cm,颈部MRI示气管受压明显,但无明显呼吸困难等症状。本文通过报道了一例巨大NIFTP患者,回顾其诊疗过程,针对其定义、研究进展、诊断标准、治疗及预后进行文献回顾。A patient, a 66-year-old female, with a goiter about 12 * 12 cm in size at the first visit. Cervical MRI showed obvious trachea compression, but no obvious dyspnea and other symptoms. In this paper, we report a huge NIFTP patient, review its diagnosis and treatment process, and review the literature on its definition, research progress, diagnostic criteria, treatment and prognosis.
文摘Objective:To evaluate the diagnostic utility of The Bethesda System for Reporting Thyroid Cytology(TBSRTC)at Peking University Cancer Hospital,the incidence of noninvasive follicular thyroid neoplasms with papillary-like nuclear features(NIFTP),and the impact of reclassification on cytopathological outcomes.Methods:We performed a retrospective study of thyroid fine-needle aspiration(FNA)cases between April 2014 and March 2019.The FNA results were classified according to TBSRTC.Post-surgery histological findings were followed up.Results:A total of 2,781 thyroid FNAs were performed.The incidences of the 6 diagnostic categories(DCs I-VI)were 14.8%,17.1%,15.8%,2.3%,11.6%and 38.5%,respectively.A total of 1,122 patients(40.3%)had corresponding histological results.NIFTP accounted for 0.4%of papillary thyroid carcinoma(PTC)cases,and there was no significant difference in the risk of malignancy(ROM)for each TBSRTC DC between"NIFTP=carcinoma(Ca)"and"NIFTP≠Ca".When"NIFTP=Ca",the sensitivity,specificity,positive predictive value(PPV),negative predictive value(NPV),and accuracy of TBSRTC were 98.0%,84.0%,99.4%,58.3%,and97.5%,respectively.When"NIFTP≠Ca",the sensitivity,specificity,PPV,NPV and accuracy of the TBSRTC were 98.1%,81.5%,99.3%,61.1%,and 97.5%,respectively.Conclusions:TBSRTC is effective in the preoperative diagnosis of thyroid nodules in Peking University Cancer Hospital.The impact of the reclassification of NIFTP on cytopathological outcomes is limited because of its low incidence,and the revised ROMs are not suitable for Asian patients.
