背景:本研究探讨了内脏肥胖指数与美国高血压患病率之间的关系。研究方法:这项横断面研究使用了美国国家健康与营养调查(national health and nutrition examination survey, NHANES)的数据,该调查在2007年至2018年期间连续进行了六次,...背景:本研究探讨了内脏肥胖指数与美国高血压患病率之间的关系。研究方法:这项横断面研究使用了美国国家健康与营养调查(national health and nutrition examination survey, NHANES)的数据,该调查在2007年至2018年期间连续进行了六次,每次为期两年。研究采用多变量逻辑回归和平滑曲线拟合技术,分别研究了高血压患病率与内脏脂肪指数(visceral adiposity index, VAI)之间的关系。利用亚组分析和交互检验对二者之间关系的稳定性进行了检验。结果:在28,743名参与者中,有12,405人患有高血压,16,338人不患有高血压。在对所有协变量进行调整后,VAI与高血压患病率呈显著正相关[OR = 1.07, 95% CI = 1.06~1.08;P Background: This research examined the connection between the visceral obesity index and the prevalence of hypertension in the United States. Methods: This cross-sectional research used data from the National Health and Nutrition Examination Survey (NHANES), conducted in six consecutive two-year cycles between 2007 and 2018. The study employed multivariable logistic regression and smoothing curve fitting techniques to investigate the relationship between the prevalence of hypertension and the visceral adiposity index (VAI), respectively. The stability of the association between them was tested utilizing subgroup analysis and interaction tests. Results: Of the 28,743 participants, 12,405 had hypertension and 16,338 did not. After adjusting for all covariates, VAI was significantly and positively associated with the prevalence of hypertension [odd ratio (OR) = 1.07, 95% confidence interval (CI) 1.06~1.08;P-value < 0.0001] and remained stable after converting VAI to a categorical variable. Subgroup analyses revealed a greater correlation between VAI and the prevalence of hypertension among participants who were female, aged 20~39, without diabetes, or smoked a small number of cigarettes. Conclusions: Higher VAI scores and a greater prevalence of hypertension seem to be correlated. Reducing visceral fat may help reduce the prevalence of hypertension.展开更多
Objective The relationship between non-high-density lipoprotein(NHDL)cholesterol to high-density lipoprotein cholesterol(HDL-C)ratio(NHHR)and stoke remains unknown.This study aimed to evaluate the association between ...Objective The relationship between non-high-density lipoprotein(NHDL)cholesterol to high-density lipoprotein cholesterol(HDL-C)ratio(NHHR)and stoke remains unknown.This study aimed to evaluate the association between the adult NHHR and stroke occurrence in the United States of America(USA).Methods To clarify the relationship between the NHHR and stroke risk,this study used a multivariable logistic regression model and a restricted cubic spline(RCS)model to investigate the association between the NHHR and stroke,and data from the National Health and Nutrition Examination Survey(NHANES)from 2005 to 2018.Subgroup and sensitivity analyses were conducted to test the robustness of the results.Results This study included 29,928 adult participants,of which 1,165 participants had a history of stroke.Logistic regression analysis of variables demonstrated a positive association between NHHR and stroke(OR 1.24,95%CI:1.03-1.50,P=0.026).Compared with the lowest reference group of NHHR,participants in the second,third,and fourth quartile had a significantly increased risk of stroke after full adjustments(OR:1.35,95%CI:1.08-1.69)(OR:1.83,95%CI:1.42-2.36)(OR:2.04,95%CI:1.50-2.79).In the total population,a nonlinear dose-response relationship was observed between the NHHR and stroke risk(P non-linearity=0.002).This association remained significant in several subgroup analyses.Further investigation of the NHHR may enhance our understanding of stroke prevention and treatment.Conclusion Our findings suggest a positive correlation between the NHHR and an increased prevalence of stroke,potentially serving as a novel predictive factor for stroke.Timely intervention and management of the NHHR may effectively mitigate stroke occurrence.Prospective studies are required to validate this association and further explore the underlying biological mechanisms.展开更多
目的基于NHANES 2011~2012的数据评估成人血压与肺功能之间的相关性。方法根据国家健康和营养检查调查数据进行横断面研究。暴露因素为血压,结局指标为肺功能。采用加权多元线性回归模型和平滑曲线拟合来评估血压与肺功能之间的相关性...目的基于NHANES 2011~2012的数据评估成人血压与肺功能之间的相关性。方法根据国家健康和营养检查调查数据进行横断面研究。暴露因素为血压,结局指标为肺功能。采用加权多元线性回归模型和平滑曲线拟合来评估血压与肺功能之间的相关性。结果最终纳入了6750例受试者的数据进行数据分析,结果表明:收缩压(SBP)与用力肺活量(FVC)呈负相关(β=-2.11,95%CI:-3.00~-1.22,P<0.001);且成年人SBP和FVC之间的相关性呈倒U型曲线(转折点:SBP 112 mm Hg),当SBP<112 mm Hg时,SBP和FVC呈正相关(P<0.05),当SBP>112 mm Hg时,SBP和FVC呈负相关(P<0.05)。SBP与第1秒用力呼气(FEV1)呈负相关(β=-0.79,95%CI:-1.57~-0.00,P=0.050);且成年人SBP与FEV1之间的相关性呈倒U型曲线(转折点:SBP 118 mm Hg);当SBP<118 mm Hg时,SBP与FEV1呈正相关(P<0.05);当SBP>118 mm Hg时,SBP与FEV1呈负相关(P<0.05)。舒张压(DBP)与FVC均呈正相关(β=3.63,95%CI:2.48~4.77,P<0.001);成年人DBP和FVC之间的相关性呈倒U型曲线(转折点:DBP 90 mm Hg);当DBP<90 mm Hg时,DBP和FVC呈正相关(P<0.05);当DBP>90 mm Hg时,DBP和FVC呈负相关(P<0.05)。DBP与FEV1呈正相关(β=3.74,95%CI:2.71~4.77,P<0.001);成年人DBP和FEV1之间的相关性呈倒U型曲线(转折点:DBP 88 mm Hg);当DBP<88 mm Hg时,DBP和FEV1呈正相关(P<0.05);当DBP>88 mm Hg时,DBP和FEV1呈负相关(P<0.05)。结论成年人血压和肺功能之间的相关性呈倒U型曲线,较低的收缩压和舒张压与肺功能呈正相关,而较高的收缩压和舒张压与肺功能呈负相关,根据本研究的结果,建议将血压控制在一定范围(SBP<112 mm Hg,DBP<88 mm Hg),未来的高血压防治战略应将肺器官保护问题作为一个重要的指导原则。展开更多
目的探讨身体形态指数(a body shape index,ABSI)与骨密度、骨质疏松及骨折风险之间的关系,分析其作为中老年人骨骼健康风险预测指标的潜在价值,为骨质疏松和骨折的早期筛查及干预提供科学依据。方法基于国家健康与营养调查(National He...目的探讨身体形态指数(a body shape index,ABSI)与骨密度、骨质疏松及骨折风险之间的关系,分析其作为中老年人骨骼健康风险预测指标的潜在价值,为骨质疏松和骨折的早期筛查及干预提供科学依据。方法基于国家健康与营养调查(National Health and Nutrition Examination Survey,NHANES)2017~2020年的数据,选取年龄≥50岁的中老年人作为研究对象。计算ABSI值并按四分位数分类。通过逻辑回归模型分析ABSI与骨折风险的关系,并调整人口学特征、生活方式和临床相关因素的影响。同时,采用限制性立方样条(restricted cubic spline,RCS)模型探索ABSI与骨折风险的剂量-反应关系,并进行亚组分析以识别潜在的影响修饰因素。结果随着ABSI四分位数的升高,骨密度逐渐降低,骨质疏松及骨折风险显著增加(趋势P<0.05)。与ABSI最低四分位数比较,最高四分位数的骨折风险显著增加(调整后OR为1.33,95%CI:1.04~1.70)。RCS分析显示,ABSI与骨折风险呈线性正相关(整体P<0.001),骨折风险随着ABSI水平的升高而逐渐增加。亚组分析结果显示,这一关联在不同年龄、性别和体重指数(body mass index,BMI)类别中具有一致性。结论ABSI与较低的骨密度、较高的骨质疏松及骨折风险独立相关。这表明,ABSI是一种简便有效的工具,可用于筛查骨骼健康风险较高的人群,为骨质疏松及骨折的早期预防和干预策略提供科学依据。展开更多
目的:预后营养指数(PNI)是一种新颖的营养免疫指标,与心血管事件相关。本研究旨在探讨PNI与高血压之间可能存在的联系。方法:本项横断面研究纳入了2007~2018年国家健康与营养调查(NHANES)中PNI和高血压数据完整的参与者。将PNI进行对数...目的:预后营养指数(PNI)是一种新颖的营养免疫指标,与心血管事件相关。本研究旨在探讨PNI与高血压之间可能存在的联系。方法:本项横断面研究纳入了2007~2018年国家健康与营养调查(NHANES)中PNI和高血压数据完整的参与者。将PNI进行对数转换后作为连续的自变量进行评估,并按三分位数分组评估其稳健性。采用logistic回归分析和交互作用检验,并通过2个分段logistic回归模型进一步探究二者之间的关系。结果:研究共纳入30,017名参与者,结果显示高血压组的PNI略低于非高血压组(52.53 vs. 53.56, P 0.05)。在两段式Logistic回归模型分析中发现,当LogPNI值 ≥ 1.66时,其升高与较高的高血压患病风险显著相关(OR: 19.23, 95% CI: 8.18~45.16, P < 0.0001)。结论:较高的PNI与美国成年人高血压风险增加相关。这提示PNI可以作为高血压风险的有用生物标志物。展开更多
文摘背景:本研究探讨了内脏肥胖指数与美国高血压患病率之间的关系。研究方法:这项横断面研究使用了美国国家健康与营养调查(national health and nutrition examination survey, NHANES)的数据,该调查在2007年至2018年期间连续进行了六次,每次为期两年。研究采用多变量逻辑回归和平滑曲线拟合技术,分别研究了高血压患病率与内脏脂肪指数(visceral adiposity index, VAI)之间的关系。利用亚组分析和交互检验对二者之间关系的稳定性进行了检验。结果:在28,743名参与者中,有12,405人患有高血压,16,338人不患有高血压。在对所有协变量进行调整后,VAI与高血压患病率呈显著正相关[OR = 1.07, 95% CI = 1.06~1.08;P Background: This research examined the connection between the visceral obesity index and the prevalence of hypertension in the United States. Methods: This cross-sectional research used data from the National Health and Nutrition Examination Survey (NHANES), conducted in six consecutive two-year cycles between 2007 and 2018. The study employed multivariable logistic regression and smoothing curve fitting techniques to investigate the relationship between the prevalence of hypertension and the visceral adiposity index (VAI), respectively. The stability of the association between them was tested utilizing subgroup analysis and interaction tests. Results: Of the 28,743 participants, 12,405 had hypertension and 16,338 did not. After adjusting for all covariates, VAI was significantly and positively associated with the prevalence of hypertension [odd ratio (OR) = 1.07, 95% confidence interval (CI) 1.06~1.08;P-value < 0.0001] and remained stable after converting VAI to a categorical variable. Subgroup analyses revealed a greater correlation between VAI and the prevalence of hypertension among participants who were female, aged 20~39, without diabetes, or smoked a small number of cigarettes. Conclusions: Higher VAI scores and a greater prevalence of hypertension seem to be correlated. Reducing visceral fat may help reduce the prevalence of hypertension.
文摘Objective The relationship between non-high-density lipoprotein(NHDL)cholesterol to high-density lipoprotein cholesterol(HDL-C)ratio(NHHR)and stoke remains unknown.This study aimed to evaluate the association between the adult NHHR and stroke occurrence in the United States of America(USA).Methods To clarify the relationship between the NHHR and stroke risk,this study used a multivariable logistic regression model and a restricted cubic spline(RCS)model to investigate the association between the NHHR and stroke,and data from the National Health and Nutrition Examination Survey(NHANES)from 2005 to 2018.Subgroup and sensitivity analyses were conducted to test the robustness of the results.Results This study included 29,928 adult participants,of which 1,165 participants had a history of stroke.Logistic regression analysis of variables demonstrated a positive association between NHHR and stroke(OR 1.24,95%CI:1.03-1.50,P=0.026).Compared with the lowest reference group of NHHR,participants in the second,third,and fourth quartile had a significantly increased risk of stroke after full adjustments(OR:1.35,95%CI:1.08-1.69)(OR:1.83,95%CI:1.42-2.36)(OR:2.04,95%CI:1.50-2.79).In the total population,a nonlinear dose-response relationship was observed between the NHHR and stroke risk(P non-linearity=0.002).This association remained significant in several subgroup analyses.Further investigation of the NHHR may enhance our understanding of stroke prevention and treatment.Conclusion Our findings suggest a positive correlation between the NHHR and an increased prevalence of stroke,potentially serving as a novel predictive factor for stroke.Timely intervention and management of the NHHR may effectively mitigate stroke occurrence.Prospective studies are required to validate this association and further explore the underlying biological mechanisms.
文摘目的基于NHANES 2011~2012的数据评估成人血压与肺功能之间的相关性。方法根据国家健康和营养检查调查数据进行横断面研究。暴露因素为血压,结局指标为肺功能。采用加权多元线性回归模型和平滑曲线拟合来评估血压与肺功能之间的相关性。结果最终纳入了6750例受试者的数据进行数据分析,结果表明:收缩压(SBP)与用力肺活量(FVC)呈负相关(β=-2.11,95%CI:-3.00~-1.22,P<0.001);且成年人SBP和FVC之间的相关性呈倒U型曲线(转折点:SBP 112 mm Hg),当SBP<112 mm Hg时,SBP和FVC呈正相关(P<0.05),当SBP>112 mm Hg时,SBP和FVC呈负相关(P<0.05)。SBP与第1秒用力呼气(FEV1)呈负相关(β=-0.79,95%CI:-1.57~-0.00,P=0.050);且成年人SBP与FEV1之间的相关性呈倒U型曲线(转折点:SBP 118 mm Hg);当SBP<118 mm Hg时,SBP与FEV1呈正相关(P<0.05);当SBP>118 mm Hg时,SBP与FEV1呈负相关(P<0.05)。舒张压(DBP)与FVC均呈正相关(β=3.63,95%CI:2.48~4.77,P<0.001);成年人DBP和FVC之间的相关性呈倒U型曲线(转折点:DBP 90 mm Hg);当DBP<90 mm Hg时,DBP和FVC呈正相关(P<0.05);当DBP>90 mm Hg时,DBP和FVC呈负相关(P<0.05)。DBP与FEV1呈正相关(β=3.74,95%CI:2.71~4.77,P<0.001);成年人DBP和FEV1之间的相关性呈倒U型曲线(转折点:DBP 88 mm Hg);当DBP<88 mm Hg时,DBP和FEV1呈正相关(P<0.05);当DBP>88 mm Hg时,DBP和FEV1呈负相关(P<0.05)。结论成年人血压和肺功能之间的相关性呈倒U型曲线,较低的收缩压和舒张压与肺功能呈正相关,而较高的收缩压和舒张压与肺功能呈负相关,根据本研究的结果,建议将血压控制在一定范围(SBP<112 mm Hg,DBP<88 mm Hg),未来的高血压防治战略应将肺器官保护问题作为一个重要的指导原则。
文摘目的探讨身体形态指数(a body shape index,ABSI)与骨密度、骨质疏松及骨折风险之间的关系,分析其作为中老年人骨骼健康风险预测指标的潜在价值,为骨质疏松和骨折的早期筛查及干预提供科学依据。方法基于国家健康与营养调查(National Health and Nutrition Examination Survey,NHANES)2017~2020年的数据,选取年龄≥50岁的中老年人作为研究对象。计算ABSI值并按四分位数分类。通过逻辑回归模型分析ABSI与骨折风险的关系,并调整人口学特征、生活方式和临床相关因素的影响。同时,采用限制性立方样条(restricted cubic spline,RCS)模型探索ABSI与骨折风险的剂量-反应关系,并进行亚组分析以识别潜在的影响修饰因素。结果随着ABSI四分位数的升高,骨密度逐渐降低,骨质疏松及骨折风险显著增加(趋势P<0.05)。与ABSI最低四分位数比较,最高四分位数的骨折风险显著增加(调整后OR为1.33,95%CI:1.04~1.70)。RCS分析显示,ABSI与骨折风险呈线性正相关(整体P<0.001),骨折风险随着ABSI水平的升高而逐渐增加。亚组分析结果显示,这一关联在不同年龄、性别和体重指数(body mass index,BMI)类别中具有一致性。结论ABSI与较低的骨密度、较高的骨质疏松及骨折风险独立相关。这表明,ABSI是一种简便有效的工具,可用于筛查骨骼健康风险较高的人群,为骨质疏松及骨折的早期预防和干预策略提供科学依据。
文摘目的:预后营养指数(PNI)是一种新颖的营养免疫指标,与心血管事件相关。本研究旨在探讨PNI与高血压之间可能存在的联系。方法:本项横断面研究纳入了2007~2018年国家健康与营养调查(NHANES)中PNI和高血压数据完整的参与者。将PNI进行对数转换后作为连续的自变量进行评估,并按三分位数分组评估其稳健性。采用logistic回归分析和交互作用检验,并通过2个分段logistic回归模型进一步探究二者之间的关系。结果:研究共纳入30,017名参与者,结果显示高血压组的PNI略低于非高血压组(52.53 vs. 53.56, P 0.05)。在两段式Logistic回归模型分析中发现,当LogPNI值 ≥ 1.66时,其升高与较高的高血压患病风险显著相关(OR: 19.23, 95% CI: 8.18~45.16, P < 0.0001)。结论:较高的PNI与美国成年人高血压风险增加相关。这提示PNI可以作为高血压风险的有用生物标志物。
