研究了NGP(nearly general stewart-gough platform)并联机构动平台位置与姿态变量之间的耦合关系,将9个变量中的6个用其余的3个表达出来,从而实现了位置变量和姿态变量的解耦.运用Gr bner基算法,得到了15个只含有其余3个变量的4次相容...研究了NGP(nearly general stewart-gough platform)并联机构动平台位置与姿态变量之间的耦合关系,将9个变量中的6个用其余的3个表达出来,从而实现了位置变量和姿态变量的解耦.运用Gr bner基算法,得到了15个只含有其余3个变量的4次相容方程.在此基础上,采用变量代换的方法消去其中的高次项,最终将NGP并联机构的运动学正解问题简化为求解一个一元20次的代数方程;这个方程是通过计算一个10阶行列式得出的,并且通过一个具体的算例验证了该方法的正确性.该方法适用于所有的NGP并联机构.展开更多
The stability analysis of linear multistep methods for the numerical solutions of the systems of generalized neutral delay differential equations is discussed. The stability behaviour of linear multistep methods was a...The stability analysis of linear multistep methods for the numerical solutions of the systems of generalized neutral delay differential equations is discussed. The stability behaviour of linear multistep methods was analysed for the solution of the generalized system of linear neutral test equations, After the establishment of a sufficient condition for asymptotic stability of the solutions of the generalized system, it is shown that a linear multistep method is NGP(G)-stable if and only if it is A-stable.展开更多
下一代益生菌(NGPs)作为新型微生物疗法,因其更强的肠道定植能力和多样的健康益处,正在引领健康干预领域的变革。本文系统综述了嗜黏蛋白阿克曼氏菌、长双歧杆菌1714、克里斯滕森菌和普拉氏栖粪杆菌等主要NGPs的作用机制,并探讨了NGPs...下一代益生菌(NGPs)作为新型微生物疗法,因其更强的肠道定植能力和多样的健康益处,正在引领健康干预领域的变革。本文系统综述了嗜黏蛋白阿克曼氏菌、长双歧杆菌1714、克里斯滕森菌和普拉氏栖粪杆菌等主要NGPs的作用机制,并探讨了NGPs在代谢性疾病、肿瘤、肠道疾病和其他疾病中的临床应用进展。研究发现,NGPs通过调节肠道微生物群落结构、增强免疫功能、改善肠道屏障完整性等多种机制,展现出对多种疾病的显著治疗潜力。例如,嗜黏蛋白阿克曼氏菌通过激活脂质氧化和胆汁酸代谢改善代谢功能障碍;长双歧杆菌1714可能通过调节神经营养因子水平减轻压力;克里斯滕森菌通过调节炎症信号通路和短链脂肪酸水平发挥抗肥胖作用;普拉氏栖粪杆菌产生丁酸盐从而发挥抗炎作用。尽管NGPs的研究取得了显著进展,但仍需通过大规模临床试验进一步验证其安全性和有效性,并结合基因编辑技术开发个性化制剂,以推动精准医疗的发展。Next-generation probiotics (NGPs), as novel microbial therapeutics, are leading the change in the field of health interventions due to their enhanced intestinal colonisation and diverse health benefits. In this paper, we systematically review the mechanism of action of major NGPs, such as Akkermansia muciniphila, Bifidobacterium longum 1714, Christensenella minuta, and Faecalibacterium prausnitzii, and discuss the advances in the clinical application of NGPs in metabolic disorders, oncology, intestinal disorders, and other diseases. It was found that NGPs exhibit significant therapeutic potential for a wide range of diseases through a variety of mechanisms, such as regulating the structure of the intestinal microbial community, enhancing immune function, and improving the integrity of the intestinal barrier. For example, Akkermansia muciniphila improves metabolic dysfunction by activating lipid oxidation and bile acid metabolism;Bifidobacterium longum 1714 reduces stress by regulating the level of neurotrophic factors;Christensenella minuta exerts an anti-obesity effect by regulating inflammatory signalling pathways and the level of short-chain fatty acids;and Faecalibacterium prausnitzii exerts an anti-inflammatory effect by producing butyrate. Despite the significant progress in the research of NGPs, there is still a need to further validate their safety and efficacy through large-scale clinical trials and to develop personalised agents in combination with gene editing technologies to promote the development of precision medicine.展开更多
文中建立输气干线稳态运行优化的数学模型,并采用动态规划法进行求解。在求解的过程中,综合考虑计算速度和精度,建议离散步长选取20~40 k Pa。设计了天然气管道稳态运行优化软件—Opt NGP软件,采用TGNET软件和控制条件法分别对优化方案...文中建立输气干线稳态运行优化的数学模型,并采用动态规划法进行求解。在求解的过程中,综合考虑计算速度和精度,建议离散步长选取20~40 k Pa。设计了天然气管道稳态运行优化软件—Opt NGP软件,采用TGNET软件和控制条件法分别对优化方案的合理性和最优性进行了验证,验证结果显示,Opt NGP软件能够为输气干线提供稳态最优运行方案。展开更多
Non-alcoholic fatty liver disease(NAFLD),which has a global prevalence of 20%–33%,has become the main cause of chronic liver disease.Except for lifestyle medication,no definitive medical treatment has been establishe...Non-alcoholic fatty liver disease(NAFLD),which has a global prevalence of 20%–33%,has become the main cause of chronic liver disease.Except for lifestyle medication,no definitive medical treatment has been established so far,making it urgent to find effective strategies for the treatment of NAFLD.With the identification of the significant role played by the gut microbiota in the pathogenesis of NAFLD,studies on probiotics for the prevention and treatment of NAFLD are increasing in number.Bacteria from the Bifidobacterium and Lactobacillus genera constitute the most widely used traditional probiotics.More recently,emerging next-generation probiotics(NGPs)such as Akkermansia muciniphila and Faecalibacterium prausnitzii have also gained attention due to their potential as therapeutic options for the treatment of NAFLD.This review provides an overview of the effects of oral administration of traditional probiotics and NGPs on the development and progress of NAFLD.The mechanisms by which probiotics directly or indirectly affect the disease are illustrated,based on the most recent animal and clinical studies.Although numerous studies have been published on this topic,further research is required to comprehensively understand the specific underlying mechanisms among probiotics,gut microbiota,and NAFLD,and additional large-scale clinical trials are required to evaluate the therapeutic efficacy of probiotics for the treatment of NAFLD,as well as the safety of probiotics in the human body.展开更多
文摘研究了NGP(nearly general stewart-gough platform)并联机构动平台位置与姿态变量之间的耦合关系,将9个变量中的6个用其余的3个表达出来,从而实现了位置变量和姿态变量的解耦.运用Gr bner基算法,得到了15个只含有其余3个变量的4次相容方程.在此基础上,采用变量代换的方法消去其中的高次项,最终将NGP并联机构的运动学正解问题简化为求解一个一元20次的代数方程;这个方程是通过计算一个10阶行列式得出的,并且通过一个具体的算例验证了该方法的正确性.该方法适用于所有的NGP并联机构.
文摘The stability analysis of linear multistep methods for the numerical solutions of the systems of generalized neutral delay differential equations is discussed. The stability behaviour of linear multistep methods was analysed for the solution of the generalized system of linear neutral test equations, After the establishment of a sufficient condition for asymptotic stability of the solutions of the generalized system, it is shown that a linear multistep method is NGP(G)-stable if and only if it is A-stable.
文摘下一代益生菌(NGPs)作为新型微生物疗法,因其更强的肠道定植能力和多样的健康益处,正在引领健康干预领域的变革。本文系统综述了嗜黏蛋白阿克曼氏菌、长双歧杆菌1714、克里斯滕森菌和普拉氏栖粪杆菌等主要NGPs的作用机制,并探讨了NGPs在代谢性疾病、肿瘤、肠道疾病和其他疾病中的临床应用进展。研究发现,NGPs通过调节肠道微生物群落结构、增强免疫功能、改善肠道屏障完整性等多种机制,展现出对多种疾病的显著治疗潜力。例如,嗜黏蛋白阿克曼氏菌通过激活脂质氧化和胆汁酸代谢改善代谢功能障碍;长双歧杆菌1714可能通过调节神经营养因子水平减轻压力;克里斯滕森菌通过调节炎症信号通路和短链脂肪酸水平发挥抗肥胖作用;普拉氏栖粪杆菌产生丁酸盐从而发挥抗炎作用。尽管NGPs的研究取得了显著进展,但仍需通过大规模临床试验进一步验证其安全性和有效性,并结合基因编辑技术开发个性化制剂,以推动精准医疗的发展。Next-generation probiotics (NGPs), as novel microbial therapeutics, are leading the change in the field of health interventions due to their enhanced intestinal colonisation and diverse health benefits. In this paper, we systematically review the mechanism of action of major NGPs, such as Akkermansia muciniphila, Bifidobacterium longum 1714, Christensenella minuta, and Faecalibacterium prausnitzii, and discuss the advances in the clinical application of NGPs in metabolic disorders, oncology, intestinal disorders, and other diseases. It was found that NGPs exhibit significant therapeutic potential for a wide range of diseases through a variety of mechanisms, such as regulating the structure of the intestinal microbial community, enhancing immune function, and improving the integrity of the intestinal barrier. For example, Akkermansia muciniphila improves metabolic dysfunction by activating lipid oxidation and bile acid metabolism;Bifidobacterium longum 1714 reduces stress by regulating the level of neurotrophic factors;Christensenella minuta exerts an anti-obesity effect by regulating inflammatory signalling pathways and the level of short-chain fatty acids;and Faecalibacterium prausnitzii exerts an anti-inflammatory effect by producing butyrate. Despite the significant progress in the research of NGPs, there is still a need to further validate their safety and efficacy through large-scale clinical trials and to develop personalised agents in combination with gene editing technologies to promote the development of precision medicine.
文摘文中建立输气干线稳态运行优化的数学模型,并采用动态规划法进行求解。在求解的过程中,综合考虑计算速度和精度,建议离散步长选取20~40 k Pa。设计了天然气管道稳态运行优化软件—Opt NGP软件,采用TGNET软件和控制条件法分别对优化方案的合理性和最优性进行了验证,验证结果显示,Opt NGP软件能够为输气干线提供稳态最优运行方案。
基金This study was supported by grants from the National Key Research and Development Program of China(2018YFC2000500)the National Natural Science Foundation of China(81790631 and 81330011).
文摘Non-alcoholic fatty liver disease(NAFLD),which has a global prevalence of 20%–33%,has become the main cause of chronic liver disease.Except for lifestyle medication,no definitive medical treatment has been established so far,making it urgent to find effective strategies for the treatment of NAFLD.With the identification of the significant role played by the gut microbiota in the pathogenesis of NAFLD,studies on probiotics for the prevention and treatment of NAFLD are increasing in number.Bacteria from the Bifidobacterium and Lactobacillus genera constitute the most widely used traditional probiotics.More recently,emerging next-generation probiotics(NGPs)such as Akkermansia muciniphila and Faecalibacterium prausnitzii have also gained attention due to their potential as therapeutic options for the treatment of NAFLD.This review provides an overview of the effects of oral administration of traditional probiotics and NGPs on the development and progress of NAFLD.The mechanisms by which probiotics directly or indirectly affect the disease are illustrated,based on the most recent animal and clinical studies.Although numerous studies have been published on this topic,further research is required to comprehensively understand the specific underlying mechanisms among probiotics,gut microbiota,and NAFLD,and additional large-scale clinical trials are required to evaluate the therapeutic efficacy of probiotics for the treatment of NAFLD,as well as the safety of probiotics in the human body.
