Two new triterpenoid saponins named notoginsenoside-Ng3(1) and notoginsenoside-Ng4(2) along with three known saponins (3-5), were isolated from a water extract of the leaves of Panax notoginseng. Their structures were...Two new triterpenoid saponins named notoginsenoside-Ng3(1) and notoginsenoside-Ng4(2) along with three known saponins (3-5), were isolated from a water extract of the leaves of Panax notoginseng. Their structures were elucidated by HRESIMS, NMR, X-ray techniques and acid hydrolysis. Moreover,compound 2 was characterized with the conjugated double bonds side-chain, which was rarely found in this plant. The absolute configuration of notoginsenoside Fa (3) with five sugars was confirmed by the single-crystal X-ray diffraction for the first time. Acetylcholinesterase inhibitory activity experiments were also conducted, all the isolated saponins showed weak inhibitory activities in the final concentration of 0.16 mmol/L.展开更多
Objective To observe the clinical efficacy of acupuncture at ＂four gates＂（Hég（合谷 LI 4） and Tàichōng（太冲 LR 3） on sport insomnia. Methods Fifty three free combat athletes with insomnia were treated...Objective To observe the clinical efficacy of acupuncture at ＂four gates＂（Hég（合谷 LI 4） and Tàichōng（太冲 LR 3） on sport insomnia. Methods Fifty three free combat athletes with insomnia were treated with acupuncture at ＂four gates＂（LI 4 and LR 3）. The treatment was given once daily, 5 days were one course. Flicker fusion frequency and clinical efficacy were evaluated after two courses. Results Flicker fusion frequencies before and after treatment were（235.40±4.12） Hz and（298.56±5.35） Hz, respectively, and the difference was statistically significant（P0.05）. Total effective rate was 92.45%（49/53） with a cure rate of 52.83%（29/53）. Conclusion The clinical efficacy of acupuncture at ＂four gates＂（LI 4 and LR 3） is significant in treatment of sport insomnia.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos. 81630094and 81730093)CAMS Innovation Fund for Medical Sciences (CIFMS)(No. 2016-I2M-2-003)
文摘Two new triterpenoid saponins named notoginsenoside-Ng3(1) and notoginsenoside-Ng4(2) along with three known saponins (3-5), were isolated from a water extract of the leaves of Panax notoginseng. Their structures were elucidated by HRESIMS, NMR, X-ray techniques and acid hydrolysis. Moreover,compound 2 was characterized with the conjugated double bonds side-chain, which was rarely found in this plant. The absolute configuration of notoginsenoside Fa (3) with five sugars was confirmed by the single-crystal X-ray diffraction for the first time. Acetylcholinesterase inhibitory activity experiments were also conducted, all the isolated saponins showed weak inhibitory activities in the final concentration of 0.16 mmol/L.
文摘Objective To observe the clinical efficacy of acupuncture at ＂four gates＂（Hég（合谷 LI 4） and Tàichōng（太冲 LR 3） on sport insomnia. Methods Fifty three free combat athletes with insomnia were treated with acupuncture at ＂four gates＂（LI 4 and LR 3）. The treatment was given once daily, 5 days were one course. Flicker fusion frequency and clinical efficacy were evaluated after two courses. Results Flicker fusion frequencies before and after treatment were（235.40±4.12） Hz and（298.56±5.35） Hz, respectively, and the difference was statistically significant（P0.05）. Total effective rate was 92.45%（49/53） with a cure rate of 52.83%（29/53）. Conclusion The clinical efficacy of acupuncture at ＂four gates＂（LI 4 and LR 3） is significant in treatment of sport insomnia.
