Background:This study focused on developing and optimizing a self-microemulsifying drug delivery system(SMEDDS)to improve Lafutidine’s solubility and bioavailability,thereby enhancing its effectiveness in treating ga...Background:This study focused on developing and optimizing a self-microemulsifying drug delivery system(SMEDDS)to improve Lafutidine’s solubility and bioavailability,thereby enhancing its effectiveness in treating gastric ulcers.Traditional formulations are less effective due to their limited water solubility and bioavailability.Methods:The study used solubility tests,pseudo-ternary phase diagrams,and central composite design(CCD)to optimize.The formulation was optimized by varying the oil concentration(10–40%)and surfactant/cosurfactant ratio(0.33–3.00),and then tested for droplet size,drug content,emulsification,phase stability,and in vitro dissolution.Results:The study found that the optimized formulation contained 14%Capmul PG 8NF oil,62%Labrasol surfactant,and 24%Tween 80 cosurfactant.This combination generated an average droplet size of 111.02 nm and improved drug release properties.Furthermore,the formulation was stable without phase separation,with a drug content of 88.2–99.8%.Conclusion:SMEDDS significantly improves lafutidine delivery by increasing solubility and absorption,thereby overcoming oral administration challenges.The system quickly formed small droplets in water and released the drug in 15 min.Enhancing lafutidine’s bioavailability may improve its efficacy in treating gastric ulcers,resulting in better patient outcomes and potentially lower dosing frequency.展开更多
传统的网络文件系统难以满足高性能计算系统的I/O需求,基于对象存储的全局并行文件系统Lustre可以有效地解决传统文件系统在可扩展性、可用性和性能上存在的问题。该文介绍了Lustre文件系统的结构及其优势,对NFS over Lustre进行了性能...传统的网络文件系统难以满足高性能计算系统的I/O需求,基于对象存储的全局并行文件系统Lustre可以有效地解决传统文件系统在可扩展性、可用性和性能上存在的问题。该文介绍了Lustre文件系统的结构及其优势,对NFS over Lustre进行了性能测试,并将测试结果与Lustre文件系统、NFS网络文件系统及本地磁盘Ext3文件系统的性能进行了比较分析,给出了性能差异的原因,提出了一种可行的解决方法。展开更多
文摘Background:This study focused on developing and optimizing a self-microemulsifying drug delivery system(SMEDDS)to improve Lafutidine’s solubility and bioavailability,thereby enhancing its effectiveness in treating gastric ulcers.Traditional formulations are less effective due to their limited water solubility and bioavailability.Methods:The study used solubility tests,pseudo-ternary phase diagrams,and central composite design(CCD)to optimize.The formulation was optimized by varying the oil concentration(10–40%)and surfactant/cosurfactant ratio(0.33–3.00),and then tested for droplet size,drug content,emulsification,phase stability,and in vitro dissolution.Results:The study found that the optimized formulation contained 14%Capmul PG 8NF oil,62%Labrasol surfactant,and 24%Tween 80 cosurfactant.This combination generated an average droplet size of 111.02 nm and improved drug release properties.Furthermore,the formulation was stable without phase separation,with a drug content of 88.2–99.8%.Conclusion:SMEDDS significantly improves lafutidine delivery by increasing solubility and absorption,thereby overcoming oral administration challenges.The system quickly formed small droplets in water and released the drug in 15 min.Enhancing lafutidine’s bioavailability may improve its efficacy in treating gastric ulcers,resulting in better patient outcomes and potentially lower dosing frequency.
文摘传统的网络文件系统难以满足高性能计算系统的I/O需求,基于对象存储的全局并行文件系统Lustre可以有效地解决传统文件系统在可扩展性、可用性和性能上存在的问题。该文介绍了Lustre文件系统的结构及其优势,对NFS over Lustre进行了性能测试,并将测试结果与Lustre文件系统、NFS网络文件系统及本地磁盘Ext3文件系统的性能进行了比较分析,给出了性能差异的原因,提出了一种可行的解决方法。
