In the context of global warming,it is anticipated that both the intensity and the frequency of future global extreme high precipitation(EHP)and extreme high temperature(EHT)events will increase.To evaluate the future...In the context of global warming,it is anticipated that both the intensity and the frequency of future global extreme high precipitation(EHP)and extreme high temperature(EHT)events will increase.To evaluate the future extreme climate changes in the Asian arid region and Tibetan Plateau,this study applied the NASA Earth Exchange Global Daily Downscaled Projections(NEX-GDDP-CMIP6)to assess the changes in EHP(Rx5d and R95pTOT)and EHT(TX90p and TXx)under different emission scenarios in the 21st century.Findings suggest that both the frequency and the intensity of the extreme indices will increase,exhibiting accelerated growth under higher emission scenarios,particularly under the SSP5-8.5 emission scenario.It is suggested that the growth of EHT and EHP in the early subperiod of the 21st century(2026-2045)will be relatively moderate,with small differences between different emission scenarios.However,by the middle subperiod of the 21st century(2041-2060),the differences between different emission scenarios will become larger than the 2035s and the growth will become more intense.In western central Asia,TX90p,TXx,Rx5d,and R95pTOT increase by 9.7%-14.2%(13.3%-24.7%),1.3℃-1.7℃(1.6℃-2.7℃),6.5%-8.9%(8.2%-8.8%),and 18.1%-27.0%(25.6%-30.0%)by the early(middle)subperiod;in eastern central Asia,TX90p,TXx,Rx5d,and R95pTOT increase 8.1%-12.0%(11.3%-21.1%),1.4℃-1.8℃(1.9℃-2.9℃),7.4%-9.7%(10.4%-13.8%),and 20.2%-29.3%(32.0%-40.8%)by the early(middle)subperiod;and over the Tibetan Plateau,TX90p,TXx,Rx5d,and R95pTOT increase 12.5%-17.4%(17.0%-31.0%),1.2℃-1.5℃(1.6℃-2.5℃),7.2%-10.0%(9.9%-15.0%),and 26.6%-33.1%(36.1%-55.3%)by the early(middle)subperiod.展开更多
目的:分析二肽基肽酶样蛋白-6(dipeptidyl-peptidase-like protein 6,DPPX)抗体相关脑炎患者的临床特征。方法:对2016年1月—2025年2月南京医科大学附属脑科医院就诊的5例DPPX抗体相关脑炎患者的临床特点、脑电图、磁共振成像(magnetic ...目的:分析二肽基肽酶样蛋白-6(dipeptidyl-peptidase-like protein 6,DPPX)抗体相关脑炎患者的临床特征。方法:对2016年1月—2025年2月南京医科大学附属脑科医院就诊的5例DPPX抗体相关脑炎患者的临床特点、脑电图、磁共振成像(magnetic resonance imaging,MRI)及预后进行回顾性研究。结果:5例均为男性,年龄14~56岁。5例患者血清DPPX抗体均为阳性,滴度1∶100~1∶10,其中1例合并血清接触蛋白关联蛋白2(contactin-associated protein-like 2,CASPR2)抗体阳性,4例脑脊液DPPX抗体阴性,1例滴度1∶1。2例患者以行为异常起病,1例以癫痫发作起病,1例以记忆力减退起病,1例合并CASPR2抗体阳性患者以多部位游走性肌阵挛起病。4例患者头颅MRI正常,1例头颅MRI提示双侧颞叶异常信号。以癫痫发作起病的患者脑电图背景重度异常合并左前颞尖波、尖慢波频发。结论:DPPX抗体相关脑炎临床表现具有异质性,早期诊断与鉴别困难,免疫治疗有效,易复发。展开更多
基金supported by the Second Tibetan Plateau Scientific Expedition and Research Program[grant number 2019QZKK0101]。
文摘In the context of global warming,it is anticipated that both the intensity and the frequency of future global extreme high precipitation(EHP)and extreme high temperature(EHT)events will increase.To evaluate the future extreme climate changes in the Asian arid region and Tibetan Plateau,this study applied the NASA Earth Exchange Global Daily Downscaled Projections(NEX-GDDP-CMIP6)to assess the changes in EHP(Rx5d and R95pTOT)and EHT(TX90p and TXx)under different emission scenarios in the 21st century.Findings suggest that both the frequency and the intensity of the extreme indices will increase,exhibiting accelerated growth under higher emission scenarios,particularly under the SSP5-8.5 emission scenario.It is suggested that the growth of EHT and EHP in the early subperiod of the 21st century(2026-2045)will be relatively moderate,with small differences between different emission scenarios.However,by the middle subperiod of the 21st century(2041-2060),the differences between different emission scenarios will become larger than the 2035s and the growth will become more intense.In western central Asia,TX90p,TXx,Rx5d,and R95pTOT increase by 9.7%-14.2%(13.3%-24.7%),1.3℃-1.7℃(1.6℃-2.7℃),6.5%-8.9%(8.2%-8.8%),and 18.1%-27.0%(25.6%-30.0%)by the early(middle)subperiod;in eastern central Asia,TX90p,TXx,Rx5d,and R95pTOT increase 8.1%-12.0%(11.3%-21.1%),1.4℃-1.8℃(1.9℃-2.9℃),7.4%-9.7%(10.4%-13.8%),and 20.2%-29.3%(32.0%-40.8%)by the early(middle)subperiod;and over the Tibetan Plateau,TX90p,TXx,Rx5d,and R95pTOT increase 12.5%-17.4%(17.0%-31.0%),1.2℃-1.5℃(1.6℃-2.5℃),7.2%-10.0%(9.9%-15.0%),and 26.6%-33.1%(36.1%-55.3%)by the early(middle)subperiod.
