Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal sur...Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic function.Increasing amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of cancers.These findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative diseases.Through a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.展开更多
目的探究大脑中动脉(MCA)经颅多普勒超声血流动力学参数及血清神经轴突导向因子1(netrin-1)水平与新生儿缺血缺氧性脑病(HIE)患儿疾病转归的预测价值。方法收集2021年12月至2023年8月于河南科技大学第一附属医院就诊的108例HIE患儿,根...目的探究大脑中动脉(MCA)经颅多普勒超声血流动力学参数及血清神经轴突导向因子1(netrin-1)水平与新生儿缺血缺氧性脑病(HIE)患儿疾病转归的预测价值。方法收集2021年12月至2023年8月于河南科技大学第一附属医院就诊的108例HIE患儿,根据治疗后是否有效可将其分为良好组(78例)、不良组(30例),比较两组一般资料及MCA经颅多普勒超声血流动力学参数[阻力指数(RI)、舒张末期流速(Vd)、收缩期峰值流速(Vs)、平均血流速度(Vm)]、血清netrin-1水平,分析HIE预后不良的影响因素,采用Spearman法、受试者工作特征(ROC)曲线分析相关性及联合预测价值。结果不良组无早期干预、病情程度为重度、10 min Apgar评分≥4分中的占比大于良好组(P<0.05);良好组Vd、Vs、Vm及血清netrin-1水平高于不良组,RI值低于不良组(P<0.05);Vd、Vs、Vm、RI、血清netrin-1水平、无早期干预、病情程度、10 min Apgar评分均为HIE患儿预后不良的影响因素(P<0.05);Vd、Vs、Vm及血清netrin-1与预后情况均呈负相关,RI值与预后情况呈正相关(P<0.05);Vd、Vs、Vm、RI、血清netrin-1水平联合预测HIE患儿预后不良的AUC为0.864,最佳预测敏感度为93.33%,特异度为79.49%。结论MCA经颅多普勒超声血流动力学参数及血清netrin-1水平可作为临床预测HIE患儿预后情况的辅助指标,两项检查联合检测可显著提高预测效能。展开更多
基金supported by the National Natural Science Foundation of China(Youth Science Fund Project),No.81901292(to GC)the National Key Research and Development Program of China,No.2021YFC2502100(to GC)the National Natural Science Foundation of China,No.82071183(to ZZ).
文摘Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic function.Increasing amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of cancers.These findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative diseases.Through a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.
文摘目的探究大脑中动脉(MCA)经颅多普勒超声血流动力学参数及血清神经轴突导向因子1(netrin-1)水平与新生儿缺血缺氧性脑病(HIE)患儿疾病转归的预测价值。方法收集2021年12月至2023年8月于河南科技大学第一附属医院就诊的108例HIE患儿,根据治疗后是否有效可将其分为良好组(78例)、不良组(30例),比较两组一般资料及MCA经颅多普勒超声血流动力学参数[阻力指数(RI)、舒张末期流速(Vd)、收缩期峰值流速(Vs)、平均血流速度(Vm)]、血清netrin-1水平,分析HIE预后不良的影响因素,采用Spearman法、受试者工作特征(ROC)曲线分析相关性及联合预测价值。结果不良组无早期干预、病情程度为重度、10 min Apgar评分≥4分中的占比大于良好组(P<0.05);良好组Vd、Vs、Vm及血清netrin-1水平高于不良组,RI值低于不良组(P<0.05);Vd、Vs、Vm、RI、血清netrin-1水平、无早期干预、病情程度、10 min Apgar评分均为HIE患儿预后不良的影响因素(P<0.05);Vd、Vs、Vm及血清netrin-1与预后情况均呈负相关,RI值与预后情况呈正相关(P<0.05);Vd、Vs、Vm、RI、血清netrin-1水平联合预测HIE患儿预后不良的AUC为0.864,最佳预测敏感度为93.33%,特异度为79.49%。结论MCA经颅多普勒超声血流动力学参数及血清netrin-1水平可作为临床预测HIE患儿预后情况的辅助指标,两项检查联合检测可显著提高预测效能。
