New monazite U\|Pb geochronological data from the Everest region suggest that 20～25Ma elapsed between the initial India—Asia collision and kyanite\|sillimanite grade metamorphism. Our results indicate a two\|phase m...New monazite U\|Pb geochronological data from the Everest region suggest that 20～25Ma elapsed between the initial India—Asia collision and kyanite\|sillimanite grade metamorphism. Our results indicate a two\|phase metamorphic history, with peak Barrovian metamorphism at (32 2±0 4)Ma and a later high\|temperature, low\|pressure event (620℃, 400MPa) at (22 7±0 2)Ma.. Emplacement and crystallization of the Everest granite subsequently occurred at 20 5～21 3Ma. The monazite crystallization ages that differ by 10Ma are recorded in two structurally adjacent rocks of different lithology, which have the same post collisional p—T history.. Scanning electron microscopy reveals that the younger monazite is elaborately shaped and grew in close association with apatite at grain boundaries and triple junctions, suggesting that growth was stimulated by a change in the fluid regime. The older monazite is euhedral, is not associated with apatite, and is commonly armoured within silicate minerals. During the low\|pressure metamorphic event, the armouring protected the older monazites, and a lack of excess apatite in this sample prevented new growth. Textural relationships suggest that apatite is one of the necessary monazite\|producing reactants, and spots within monazite that are rich in Ca, Fe, Al and Si suggest that allanite acted as a preexisting rare earth element host. We propose a simplified reaction for monazite crystallization based on this evidence.展开更多
The Nepalese Himalaya is well known for ongoing collisional tectonics,witnessed by major historical and recent earthquakes.The Siwalik Hills in Midwestern Nepalese Himalaya are bounded by eastwest trending Main Fronta...The Nepalese Himalaya is well known for ongoing collisional tectonics,witnessed by major historical and recent earthquakes.The Siwalik Hills in Midwestern Nepalese Himalaya are bounded by eastwest trending Main Frontal Thrust(MFT)to the south and the Main Boundary Thrust(MBT)to the north.The area is dissected by numerous southwest to south-flowing bedrock rivers.This study investigates geomorphic metrics of these rivers to unravel landscape evolution and active tectonics of the Siwalik Hills.Digital Elevation Model(DEM)analysis was conducted to extract structural lineaments and longitudinal river profile and their metrics(knickpoints,Normalized Steepness Index(ksn),concavity index,and chi integral)using steam powerlaw approaches.Most of the lineaments trend eastwest like MFT.River profiles exhibit convex to double-concave shapes with upstream-propagating tectonic knickpoints that separate upstream and downstream reaches,indicating different phases of river incision.The spatial distribution of ksn shows high values along with low concavity values at the eastern part of the study area,reflecting disequilibrium conditions that are likely responding to a high uplift rate.Chi integral distribution shows a variation in drainage divide migration between the eastern and western parts of the study area.This study suggests that the rivers in the Siwalik Hills are undergoing active incision likely related to the ongoing uplift and active deformation associated with the Himalayan tectonics.The above findings can bring fresh perspectives to comprehend the neotectonic deformation and lateral variability along the Siwalik Hills landscapes within the Himalaya.展开更多
Background: Nepal is one of the fastest urbanizing countries in South Asia and is facing the consequences of urban lifestyle leading to obesity and metabolic syndrome. Type 2 diabetes mellitus (T2DM) is currently a hi...Background: Nepal is one of the fastest urbanizing countries in South Asia and is facing the consequences of urban lifestyle leading to obesity and metabolic syndrome. Type 2 diabetes mellitus (T2DM) is currently a high-burden disease in Nepal with a prevalence of 8.4%. Of these 8% - 18% patients are on insulin and 42% patients were reported to have uncontrolled diabetes in the past year. This suggests a need for better therapy options in terms of efficacy and safety. The current study was designed to investigate the effects of Insulin glargine-based therapy in Nepalese with T2DM who could not achieve adequate glycemic control with oral and non-glargine-insulin therapy. Methods: This is a prospective, multi-centric, single arm and post marketing observational study to assess the safety and effectiveness of Glaritus®(Wockhardt’s Insulin Glargine) in 52 T2DM patients from 3 (three) different study sites in Nepal (Bharatpur, Kathmandu and Pokhra) from September 2015 to December 2016. The primary objective of the study was to evaluate the safety of Glaritus®, mainly in terms of hypoglycemia, renal function tests and liver function tests. The secondary objectives were to evaluate the effectiveness of Glaritus®in terms of percentage of patients achieving HbA1c goal of less than 7%, mean changes in HbA1c & fasting plasma glucose (FPG) levels from baseline till the end of study. Results: 3.85% of subjects experienced hypoglycemia during first 3 months of therapy whereas 1.92% had similar experience in next 3 months of therapy. The mean HbA1c values reduced from 9.16% to 7.15% at the end of study. 21.05% of the enrolled subjects achieved the goal of HbA1c ®was well tolerated by the study patients. Conclusion: In patients with type 2 diabetes mellitus inadequately controlled on oral hypoglycemic agents and/or insulin, initiation with Glaritus®significantly improved glycemic control with good tolerability and acceptability. This analysis in T2DM Nepalese patients shows that by significantly improving glycemic control while not increasing risk of hypoglycemia, Glaritus®provides safer basal insulin and may be suited to aggressive treatment regimens. From a societal perspective, it will help more patients reach the glycemic control target as recommended by the current treatment guidelines.展开更多
With the continued progress of the Belt and Road Initiative,the educational cooperation between China and countries along the Belt and Road has been elevated to a new level.The number of foreign students choosing to s...With the continued progress of the Belt and Road Initiative,the educational cooperation between China and countries along the Belt and Road has been elevated to a new level.The number of foreign students choosing to study in China has grown by a large margin.Foreign students,as the main force of cultural exchanges,have taken the mission of cultural dissemination along the Belt and Road and are proactively making contribution to peopleto-people connectivity of the Belt and Road Initiative.As follows are some articles written by foreign students in China,about China’s social development and cultural traits as well as political landscape,from their own perspectives.展开更多
NEPAL and China are good neighbors. In the 1980s many Chinese technicians went to Nepal to help build roads and other projects. As an interpreter with a Chinese construction cooperative, I worked there from 1993 to 19...NEPAL and China are good neighbors. In the 1980s many Chinese technicians went to Nepal to help build roads and other projects. As an interpreter with a Chinese construction cooperative, I worked there from 1993 to 1994. During my stay in Nepal, I met many different Nepalese women who impressed me deeply. My landlady Sumiyala, was the first Nepalese woman to come into my life. She was over 40 years old, a healthy and good-humored housewife. Whenever Ⅰ had time, I liked to chat with her and gradually we became friends. I remember my landlady was busy in and out of her house all day long— cleaning, cooking and taking care of her grandchildren and her parents-in-laws.展开更多
Objective:To study the differences between the lipid profiles of the subjects whose parents are having known non-modifiable risk factors such as obesity,hypertension(HTN),myocardial infarction and diabetes,and compare...Objective:To study the differences between the lipid profiles of the subjects whose parents are having known non-modifiable risk factors such as obesity,hypertension(HTN),myocardial infarction and diabetes,and compare them with the lipid profiles of the subjects whose parents are not having those risk factors.Methods:A total of 402 subjects were recruited to this study.A detailed questionnaire which included information on the past medical history,height,weight,blood pressure,physical activity,smoke,alcohol,family history of coronary heart disease,HTN.diabetics and obesity.Basic demographic data and dietary habits were completed by all participants.Blood samples were obtained from all subjects after 14 h.Lipid profiles were analyzed using automated analyzer.The results were analyzed using SPSS software packages.Results:The mean body mass index of the population was well below the cut-off value of obesity(>24.5 kg/m") and high risk of future cardiovascular disorder(CVD) events in this age group.The mean levels of total cholesterol(TC),triglycerides(TG) and TC/high density lipoprotein(HDL) were less than the risk levels indicative of future CVD events according to the ATP Ⅲ cut-off values.However the mean HDL level in our population was slightly greater than the cut-off value while the mean low density lipoprotein level was almost similar to the risk level.Differences were observed when the subjects without history of maternal obesity were compared with subjects with history of maternal obesity.The greater percentage of subjects who are having risk levels of body mass index.TC.low density lipoprotein.TG.and TC/HDI.indicated that maternal obesity contributed to the greater susceptibility of developing CVD risk in their offspring.Conclusions:Advancing age may result in changes that could be atherogenic in the future.Such atherogenic changes have already initialed when the subjects are about 21 years old.The incidence of atherogenic changes is far greater when mothers who are having any of the risk factors such as obesity,diabetes,HTN and myocardial infarction than that fathers who are havine similar risk factors.展开更多
This study examines the relationship between domestic savings,investment,and economic growth in Nepal by using time series data covering from the period 1975 to 2019.The vector error correction model(VECM)has been use...This study examines the relationship between domestic savings,investment,and economic growth in Nepal by using time series data covering from the period 1975 to 2019.The vector error correction model(VECM)has been used to investigate the long-run and short-run causal relationship between the variables.The Johansen cointegration test results confirmed that there is a long-run relationship between savings,investment,and economic growth.Therefore,further analysis has to be set for the VEC model to analyze both long-run and short-run causality.The VECM equation result is-0.1363 which is the adjustment speed of disequilibrium towards the equilibrium in long run.The coeffi cient of savings and investments are positive with economic growth which also indicates that both variables have a positive impact on economic growth in the short run.The results of the Jarque-Bera test show the residual distribution is normally distributed.For the model stability test,the study performed recursive estimation applying CUSUM and CUSUM of square,and both tests move within the 5 percent level of upper and lesser bound significance indicating that the model is stable over the observation period.Overall,the study suggests that in Nepal,domestic savings and investment growth have a positive contribution to economic growth.The central bank,planning commission,and ministry of finance should focus on stimulating the capital formation and productive sector investment for sustainable economic growth in Nepal.展开更多
文摘New monazite U\|Pb geochronological data from the Everest region suggest that 20～25Ma elapsed between the initial India—Asia collision and kyanite\|sillimanite grade metamorphism. Our results indicate a two\|phase metamorphic history, with peak Barrovian metamorphism at (32 2±0 4)Ma and a later high\|temperature, low\|pressure event (620℃, 400MPa) at (22 7±0 2)Ma.. Emplacement and crystallization of the Everest granite subsequently occurred at 20 5～21 3Ma. The monazite crystallization ages that differ by 10Ma are recorded in two structurally adjacent rocks of different lithology, which have the same post collisional p—T history.. Scanning electron microscopy reveals that the younger monazite is elaborately shaped and grew in close association with apatite at grain boundaries and triple junctions, suggesting that growth was stimulated by a change in the fluid regime. The older monazite is euhedral, is not associated with apatite, and is commonly armoured within silicate minerals. During the low\|pressure metamorphic event, the armouring protected the older monazites, and a lack of excess apatite in this sample prevented new growth. Textural relationships suggest that apatite is one of the necessary monazite\|producing reactants, and spots within monazite that are rich in Ca, Fe, Al and Si suggest that allanite acted as a preexisting rare earth element host. We propose a simplified reaction for monazite crystallization based on this evidence.
基金supported by the Western Kentucky University(WKU)RCAP-I(#148055)grant to Ganithe donors of the American Chemical Society Petroleum Research Fund(#PRF 54500-UNI8)to Gani for partial support of this research。
文摘The Nepalese Himalaya is well known for ongoing collisional tectonics,witnessed by major historical and recent earthquakes.The Siwalik Hills in Midwestern Nepalese Himalaya are bounded by eastwest trending Main Frontal Thrust(MFT)to the south and the Main Boundary Thrust(MBT)to the north.The area is dissected by numerous southwest to south-flowing bedrock rivers.This study investigates geomorphic metrics of these rivers to unravel landscape evolution and active tectonics of the Siwalik Hills.Digital Elevation Model(DEM)analysis was conducted to extract structural lineaments and longitudinal river profile and their metrics(knickpoints,Normalized Steepness Index(ksn),concavity index,and chi integral)using steam powerlaw approaches.Most of the lineaments trend eastwest like MFT.River profiles exhibit convex to double-concave shapes with upstream-propagating tectonic knickpoints that separate upstream and downstream reaches,indicating different phases of river incision.The spatial distribution of ksn shows high values along with low concavity values at the eastern part of the study area,reflecting disequilibrium conditions that are likely responding to a high uplift rate.Chi integral distribution shows a variation in drainage divide migration between the eastern and western parts of the study area.This study suggests that the rivers in the Siwalik Hills are undergoing active incision likely related to the ongoing uplift and active deformation associated with the Himalayan tectonics.The above findings can bring fresh perspectives to comprehend the neotectonic deformation and lateral variability along the Siwalik Hills landscapes within the Himalaya.
文摘Background: Nepal is one of the fastest urbanizing countries in South Asia and is facing the consequences of urban lifestyle leading to obesity and metabolic syndrome. Type 2 diabetes mellitus (T2DM) is currently a high-burden disease in Nepal with a prevalence of 8.4%. Of these 8% - 18% patients are on insulin and 42% patients were reported to have uncontrolled diabetes in the past year. This suggests a need for better therapy options in terms of efficacy and safety. The current study was designed to investigate the effects of Insulin glargine-based therapy in Nepalese with T2DM who could not achieve adequate glycemic control with oral and non-glargine-insulin therapy. Methods: This is a prospective, multi-centric, single arm and post marketing observational study to assess the safety and effectiveness of Glaritus®(Wockhardt’s Insulin Glargine) in 52 T2DM patients from 3 (three) different study sites in Nepal (Bharatpur, Kathmandu and Pokhra) from September 2015 to December 2016. The primary objective of the study was to evaluate the safety of Glaritus®, mainly in terms of hypoglycemia, renal function tests and liver function tests. The secondary objectives were to evaluate the effectiveness of Glaritus®in terms of percentage of patients achieving HbA1c goal of less than 7%, mean changes in HbA1c & fasting plasma glucose (FPG) levels from baseline till the end of study. Results: 3.85% of subjects experienced hypoglycemia during first 3 months of therapy whereas 1.92% had similar experience in next 3 months of therapy. The mean HbA1c values reduced from 9.16% to 7.15% at the end of study. 21.05% of the enrolled subjects achieved the goal of HbA1c ®was well tolerated by the study patients. Conclusion: In patients with type 2 diabetes mellitus inadequately controlled on oral hypoglycemic agents and/or insulin, initiation with Glaritus®significantly improved glycemic control with good tolerability and acceptability. This analysis in T2DM Nepalese patients shows that by significantly improving glycemic control while not increasing risk of hypoglycemia, Glaritus®provides safer basal insulin and may be suited to aggressive treatment regimens. From a societal perspective, it will help more patients reach the glycemic control target as recommended by the current treatment guidelines.
文摘With the continued progress of the Belt and Road Initiative,the educational cooperation between China and countries along the Belt and Road has been elevated to a new level.The number of foreign students choosing to study in China has grown by a large margin.Foreign students,as the main force of cultural exchanges,have taken the mission of cultural dissemination along the Belt and Road and are proactively making contribution to peopleto-people connectivity of the Belt and Road Initiative.As follows are some articles written by foreign students in China,about China’s social development and cultural traits as well as political landscape,from their own perspectives.
文摘NEPAL and China are good neighbors. In the 1980s many Chinese technicians went to Nepal to help build roads and other projects. As an interpreter with a Chinese construction cooperative, I worked there from 1993 to 1994. During my stay in Nepal, I met many different Nepalese women who impressed me deeply. My landlady Sumiyala, was the first Nepalese woman to come into my life. She was over 40 years old, a healthy and good-humored housewife. Whenever Ⅰ had time, I liked to chat with her and gradually we became friends. I remember my landlady was busy in and out of her house all day long— cleaning, cooking and taking care of her grandchildren and her parents-in-laws.
基金Supported by Confederation of Epidemiological Associations registered under Govt of Kerala(Grant No.30-955/2012 CEA)
文摘Objective:To study the differences between the lipid profiles of the subjects whose parents are having known non-modifiable risk factors such as obesity,hypertension(HTN),myocardial infarction and diabetes,and compare them with the lipid profiles of the subjects whose parents are not having those risk factors.Methods:A total of 402 subjects were recruited to this study.A detailed questionnaire which included information on the past medical history,height,weight,blood pressure,physical activity,smoke,alcohol,family history of coronary heart disease,HTN.diabetics and obesity.Basic demographic data and dietary habits were completed by all participants.Blood samples were obtained from all subjects after 14 h.Lipid profiles were analyzed using automated analyzer.The results were analyzed using SPSS software packages.Results:The mean body mass index of the population was well below the cut-off value of obesity(>24.5 kg/m") and high risk of future cardiovascular disorder(CVD) events in this age group.The mean levels of total cholesterol(TC),triglycerides(TG) and TC/high density lipoprotein(HDL) were less than the risk levels indicative of future CVD events according to the ATP Ⅲ cut-off values.However the mean HDL level in our population was slightly greater than the cut-off value while the mean low density lipoprotein level was almost similar to the risk level.Differences were observed when the subjects without history of maternal obesity were compared with subjects with history of maternal obesity.The greater percentage of subjects who are having risk levels of body mass index.TC.low density lipoprotein.TG.and TC/HDI.indicated that maternal obesity contributed to the greater susceptibility of developing CVD risk in their offspring.Conclusions:Advancing age may result in changes that could be atherogenic in the future.Such atherogenic changes have already initialed when the subjects are about 21 years old.The incidence of atherogenic changes is far greater when mothers who are having any of the risk factors such as obesity,diabetes,HTN and myocardial infarction than that fathers who are havine similar risk factors.
文摘This study examines the relationship between domestic savings,investment,and economic growth in Nepal by using time series data covering from the period 1975 to 2019.The vector error correction model(VECM)has been used to investigate the long-run and short-run causal relationship between the variables.The Johansen cointegration test results confirmed that there is a long-run relationship between savings,investment,and economic growth.Therefore,further analysis has to be set for the VEC model to analyze both long-run and short-run causality.The VECM equation result is-0.1363 which is the adjustment speed of disequilibrium towards the equilibrium in long run.The coeffi cient of savings and investments are positive with economic growth which also indicates that both variables have a positive impact on economic growth in the short run.The results of the Jarque-Bera test show the residual distribution is normally distributed.For the model stability test,the study performed recursive estimation applying CUSUM and CUSUM of square,and both tests move within the 5 percent level of upper and lesser bound significance indicating that the model is stable over the observation period.Overall,the study suggests that in Nepal,domestic savings and investment growth have a positive contribution to economic growth.The central bank,planning commission,and ministry of finance should focus on stimulating the capital formation and productive sector investment for sustainable economic growth in Nepal.
