Patients with ovarian cancer(OC)are at high risk of developing transcoelomic metastasis in the early stages,which is strongly associated with increased mortality rates.However,the mechanism by which OC cells dissemina...Patients with ovarian cancer(OC)are at high risk of developing transcoelomic metastasis in the early stages,which is strongly associated with increased mortality rates.However,the mechanism by which OC cells disseminate from the primary site and colonize distant sites remains unknown.Here,through an in vivo genome-wide CRISPR/Cas9 screen,we identified NBL1,which increased dramatically in OC patients during peritoneal metastasis,as a key factor promoting the transcoelomic metastasis of OC.Overexpression of NBL1 in OC cells greatly promotes the transcoelomic metastasis.When OC cells disseminate into the peritoneal cavity,they induce the transition of peritoneal epithelial cells to mesothelial cells,ultimately activating the Jak/Stat3 signaling pathway.Thus,we show a NBL1-mediated crosstalk between peritoneum epithelial cells and mesothelial cells that supports a metastasis-promoting process.展开更多
2016年4月21日,2016-2019全国男子篮球联赛（The Men’s National Basketball League,以下简称NBL）商务运营签约仪式在北京梅地亚中心隆重举行,智美体育集团将作为该联赛的独家商务运营机构参与联赛相关事务。中国篮协联赛办公室主任...2016年4月21日,2016-2019全国男子篮球联赛（The Men’s National Basketball League,以下简称NBL）商务运营签约仪式在北京梅地亚中心隆重举行,智美体育集团将作为该联赛的独家商务运营机构参与联赛相关事务。中国篮协联赛办公室主任张雄先生代表中国篮协出席并见证了本次签约仪式,智美体育集团首席运营官康鑫女士发表致辞,北京恩彼欧体育管理有限公司总经理胡杨先生和智美体育集团高级副总裁宋鸿飞先生现场进行了签约仪式,展开更多
基金funded by Tianjin Science and Technology Project(No.24JCYBJC01650)the Tianjin Education Commission Planning Project(No.2023YXZD06).
文摘Patients with ovarian cancer(OC)are at high risk of developing transcoelomic metastasis in the early stages,which is strongly associated with increased mortality rates.However,the mechanism by which OC cells disseminate from the primary site and colonize distant sites remains unknown.Here,through an in vivo genome-wide CRISPR/Cas9 screen,we identified NBL1,which increased dramatically in OC patients during peritoneal metastasis,as a key factor promoting the transcoelomic metastasis of OC.Overexpression of NBL1 in OC cells greatly promotes the transcoelomic metastasis.When OC cells disseminate into the peritoneal cavity,they induce the transition of peritoneal epithelial cells to mesothelial cells,ultimately activating the Jak/Stat3 signaling pathway.Thus,we show a NBL1-mediated crosstalk between peritoneum epithelial cells and mesothelial cells that supports a metastasis-promoting process.
文摘2016年4月21日,2016-2019全国男子篮球联赛（The Men’s National Basketball League,以下简称NBL）商务运营签约仪式在北京梅地亚中心隆重举行,智美体育集团将作为该联赛的独家商务运营机构参与联赛相关事务。中国篮协联赛办公室主任张雄先生代表中国篮协出席并见证了本次签约仪式,智美体育集团首席运营官康鑫女士发表致辞,北京恩彼欧体育管理有限公司总经理胡杨先生和智美体育集团高级副总裁宋鸿飞先生现场进行了签约仪式,
