This study analyzes fast ion losses in the EHL-2 fusion device,focusing on both beam ions and alpha particles as p-11B fusion reaction products.Using the Monte Carlo orbit-following code TGCO,we evaluate particle conf...This study analyzes fast ion losses in the EHL-2 fusion device,focusing on both beam ions and alpha particles as p-11B fusion reaction products.Using the Monte Carlo orbit-following code TGCO,we evaluate particle confinement under various operational scenarios,including co-injected tangential neutral beam injection at beam energies of 60 keV,80 keV,and 200 keV.Our simulations estimate the heat load driven by lost beam ions and find it to be within acceptable material limits for a plasma current on the order of mega-amperes.Additionally,we simulate the distribution of fusion products and observe a higher particle loss fraction for alpha particles compared to beam ions.However,due to the relatively low fusion power,these lost alpha particles are unlikely to significantly impact the plasma-facing materials.To assess the impact of the magnetic ripple,we compute the ripple field distribution by modelling the toroidal field(TF)coils as current filaments.The results indicate that the ripple field effect on particle confinement is minimal,primarily due to the large distance of over 1 m between the TF coils and the plasma on the low-field side.The analysis based on the test particle model is a foundational step in ensuring the basic safety aspects of the new device,which is essential for developing a robust design,optimizing performance,and maintaining safe operation.展开更多
The bone marrow microenvironment is critical for the maintenance and functionality of stem/progenitor cells,which are essential for bone development and regeneration.However,the composition and potential use of bone m...The bone marrow microenvironment is critical for the maintenance and functionality of stem/progenitor cells,which are essential for bone development and regeneration.However,the composition and potential use of bone marrow interstitial fluid have not been well explored.In this study,we report the role of neonatal bovine bone marrow interstitial fluid(NBIF)in enhancing the bone regeneration capacity of human bone marrow mesenchymal stem cells(hBMSCs).Unlike adult bovine bone marrow interstitial fluid(ABIF),NBIF-fed hBMSCs exhibit enhanced self-renewal and osteogenic potential and bone marrow homing ability,along with transcriptome changes as compared to hBMSCs cultured in standard fetal bovine serum(FBS)supplemented medium.Mass spectrometry analysis reveals that multiple secreted factors associated with tissue repair and bone development are enriched in NBIF compared to FBS and ABIF.The combined use of NBIF-enriched Nerve Growth Factor(NGF),Lactoferrin(LTF),and High Mobility Group Protein B1(HMGB1),together with Insulin-Like Growth Factor 1(IGF1)for culturing hBMSCs in the presence of FBS can enhance osteogenic potential and bone marrow homing ability,mimicking NBIF's effects.These findings highlight the role of interstitial fluid in the bone marrow microenvironment and its potential to optimize stem cell-based therapies.展开更多
目的探讨窄带光谱成像技术(narrow band imaging,NBI)联合放大内镜检查在咽喉部肿瘤诊断中的应用价值。方法选取2011年7月至2014年6月我科胃镜中心的105 000例患者进行胃镜检查,在胃镜检查前先常规用白光进行咽喉部的观察,然后再用NBI...目的探讨窄带光谱成像技术(narrow band imaging,NBI)联合放大内镜检查在咽喉部肿瘤诊断中的应用价值。方法选取2011年7月至2014年6月我科胃镜中心的105 000例患者进行胃镜检查,在胃镜检查前先常规用白光进行咽喉部的观察,然后再用NBI模式光对咽部进行观察,发现病变及时送病理检查。结果检出咽喉部肿瘤22例(0.021%),包括进展期鳞状细胞癌10例(0.010%)和早期癌(包括高级别上皮内瘤变及原位癌)12例(0.011%)。其中在进展期鳞状细胞癌的诊断中,NBI内镜(9例)和白光内镜(10例),两组无显著差异(P>0.05);在早期癌的诊断中,NBI内镜(12例)和白光内镜(1例),两组有显著差异(P<0.01)。咽部癌并食道癌者共占45.45%(10/22),咽部癌合并直肠癌1例。结论 NBI放大内镜检查前对咽喉部早期癌的检出率优于白光内镜,但是对于进展期咽喉癌的诊断,NBI内镜和白光内镜无差异。在检查中应特别注意咽部癌和食道癌同时存在的情况。展开更多
基金supported by ENN Group and ENN Energy Research Institute.
文摘This study analyzes fast ion losses in the EHL-2 fusion device,focusing on both beam ions and alpha particles as p-11B fusion reaction products.Using the Monte Carlo orbit-following code TGCO,we evaluate particle confinement under various operational scenarios,including co-injected tangential neutral beam injection at beam energies of 60 keV,80 keV,and 200 keV.Our simulations estimate the heat load driven by lost beam ions and find it to be within acceptable material limits for a plasma current on the order of mega-amperes.Additionally,we simulate the distribution of fusion products and observe a higher particle loss fraction for alpha particles compared to beam ions.However,due to the relatively low fusion power,these lost alpha particles are unlikely to significantly impact the plasma-facing materials.To assess the impact of the magnetic ripple,we compute the ripple field distribution by modelling the toroidal field(TF)coils as current filaments.The results indicate that the ripple field effect on particle confinement is minimal,primarily due to the large distance of over 1 m between the TF coils and the plasma on the low-field side.The analysis based on the test particle model is a foundational step in ensuring the basic safety aspects of the new device,which is essential for developing a robust design,optimizing performance,and maintaining safe operation.
基金financially supported by the Guangzhou National Laboratory(grant#GZNL2025C02022,A.M.#QNPG2317,J.Z.)partially by the National Natural Science Foundation of China(31988101)。
文摘The bone marrow microenvironment is critical for the maintenance and functionality of stem/progenitor cells,which are essential for bone development and regeneration.However,the composition and potential use of bone marrow interstitial fluid have not been well explored.In this study,we report the role of neonatal bovine bone marrow interstitial fluid(NBIF)in enhancing the bone regeneration capacity of human bone marrow mesenchymal stem cells(hBMSCs).Unlike adult bovine bone marrow interstitial fluid(ABIF),NBIF-fed hBMSCs exhibit enhanced self-renewal and osteogenic potential and bone marrow homing ability,along with transcriptome changes as compared to hBMSCs cultured in standard fetal bovine serum(FBS)supplemented medium.Mass spectrometry analysis reveals that multiple secreted factors associated with tissue repair and bone development are enriched in NBIF compared to FBS and ABIF.The combined use of NBIF-enriched Nerve Growth Factor(NGF),Lactoferrin(LTF),and High Mobility Group Protein B1(HMGB1),together with Insulin-Like Growth Factor 1(IGF1)for culturing hBMSCs in the presence of FBS can enhance osteogenic potential and bone marrow homing ability,mimicking NBIF's effects.These findings highlight the role of interstitial fluid in the bone marrow microenvironment and its potential to optimize stem cell-based therapies.
文摘目的探讨窄带光谱成像技术(narrow band imaging,NBI)联合放大内镜检查在咽喉部肿瘤诊断中的应用价值。方法选取2011年7月至2014年6月我科胃镜中心的105 000例患者进行胃镜检查,在胃镜检查前先常规用白光进行咽喉部的观察,然后再用NBI模式光对咽部进行观察,发现病变及时送病理检查。结果检出咽喉部肿瘤22例(0.021%),包括进展期鳞状细胞癌10例(0.010%)和早期癌(包括高级别上皮内瘤变及原位癌)12例(0.011%)。其中在进展期鳞状细胞癌的诊断中,NBI内镜(9例)和白光内镜(10例),两组无显著差异(P>0.05);在早期癌的诊断中,NBI内镜(12例)和白光内镜(1例),两组有显著差异(P<0.01)。咽部癌并食道癌者共占45.45%(10/22),咽部癌合并直肠癌1例。结论 NBI放大内镜检查前对咽喉部早期癌的检出率优于白光内镜,但是对于进展期咽喉癌的诊断,NBI内镜和白光内镜无差异。在检查中应特别注意咽部癌和食道癌同时存在的情况。
