Diagrams as a visual technique played a key role in early modern natural history.Robert Morison,a Scottish botanist and the first Professor of Botany at Oxford University,made a noteworthy early attempt in the 17th ce...Diagrams as a visual technique played a key role in early modern natural history.Robert Morison,a Scottish botanist and the first Professor of Botany at Oxford University,made a noteworthy early attempt in the 17th century to promote the use of diagrams in plant taxonomy.By pioneering the use of diagrams as the core of his botanical monographs,Morison inverted the order in which text and diagrams are read in natural history books and made diagrams more than a mere adjunct to the main text.Morison also consciously aligned the structure of the diagrams with the spatial arrangement of his seed collection and the Oxford Botanic Garden,so that the diagrams functioned productively as a means of bridging difierent botanical practices and retrieving information from multiple aspects.Morison’s appropriation and mobilisation of the diagrammatic mode of representation that originated in the Middle Ages helped pave the way for the diagram,as a visual language between textuality and pictoriality,to become prevalent amongst early modern naturalists.展开更多
“Journal of Jilin University(Science Edition)”is a comprehensive academic journal in the fields of science sponsored by Jilin University and administrated by the Ministry of Education of the Peoples Republic of Chin...“Journal of Jilin University(Science Edition)”is a comprehensive academic journal in the fields of science sponsored by Jilin University and administrated by the Ministry of Education of the Peoples Republic of China.The journal started publication in 1955.The original name at starting publication was “Journal of Natural Science of Northeast People University”,which was changed into “Acta Scientiarum Naturalium Universitatis Jilinensis”in 1958owing to the name change of the university.The present journal name has been begun since the beginning of 2002after a new Jilin University was set up,which comes from the amalgamation of the original Jilin University,Jilin University of Technology,Bethune Medicine University,Changchun University of Science and Technology and Changchun Post and Telecommunication Institute on June 12,2000.The domestic journal number is CN 22-1340/O,and the international journal number is ISSN 1671-5489.展开更多
Natural Gas Industry B创刊于2014年,是天然气工业杂志社与KeAi公司合作出版的国际OA期刊,在爱思唯尔旗下的ScienceDirect平台上双月出版。论文聚焦天然气、氢气、氦气、地热等地质能源,涵盖地质勘探、气藏开发、工程技术、储运利用、...Natural Gas Industry B创刊于2014年,是天然气工业杂志社与KeAi公司合作出版的国际OA期刊,在爱思唯尔旗下的ScienceDirect平台上双月出版。论文聚焦天然气、氢气、氦气、地热等地质能源,涵盖地质勘探、气藏开发、工程技术、储运利用、净化化工、产业趋势等专业方向。期刊服务全球天然气产业,并积极推动能源行业碳减排和低碳转型的发展。展开更多
Natural Gas Industry B创刊于2014年,是天然气工业杂志社与KeAi公司合作出版的国际OA期刊,在爱思唯尔旗下的Science Direct平台上双月出版。论文聚焦天然气、氢气、氦气、地热等地质能源,涵盖地质勘探、气藏开发、工程技术、储运利用...Natural Gas Industry B创刊于2014年,是天然气工业杂志社与KeAi公司合作出版的国际OA期刊,在爱思唯尔旗下的Science Direct平台上双月出版。论文聚焦天然气、氢气、氦气、地热等地质能源,涵盖地质勘探、气藏开发、工程技术、储运利用、净化化工、产业趋势等专业方向。期刊服务全球天然气产业,并积极推动能源行业碳减排和低碳转型的发展。展开更多
1.Introduction In recent years,intensifying climate extremes have triggered a sharp increase in global natural disasters,over 90%attributable to water-related hazards,particularly floods(Hirabayashi et al.,2013).Over ...1.Introduction In recent years,intensifying climate extremes have triggered a sharp increase in global natural disasters,over 90%attributable to water-related hazards,particularly floods(Hirabayashi et al.,2013).Over the past two decades,floods have inundated approximately 2.23 million km2 of land worldwide(Tellman et al.,2021),affecting over 250 million people and causing economic losses exceeding USD 651 billion(Devitt et al.,2023).Recent catastrophic floods in Pakistan,landslides in Indonesia,and dike breaches in China have intensified concerns over the effectiveness of current flood management strategies.展开更多
The modern world remains vulnerable to natural disasters,including floods,earthquakes,wildfires,and others.These events remain unpredictable and inevitable,and recovering quickly and effectively requires significant e...The modern world remains vulnerable to natural disasters,including floods,earthquakes,wildfires,and others.These events remain unpredictable and inevitable,and recovering quickly and effectively requires significant effort and expense.Monitoring is becoming more efficient thanks to technologies such as Unmanned Aerial Vehicles(UAVs),which can access hard-to-reach areas and provide real-time data.However,in disaster-affected areas,these monitoring systems may encounter many obstacles when communicating with servers or transmitting monitored data.This paper proposes an adaptive communication model to overcome the challenges faced in disaster-affected areas.A base station is responsible for collecting data(such as images and videos)captured by UAVs performing surveillance within its communication range.This station is typically a tower providing fixed cellular network service.However,in the absence of such a tower,a selected UAV may serve as the station,depending on the situation.If surveillance needs to be performed outside the coverage area,it can continue to communicate via nearby UAVs through cooperative communication.UAVs with internet support,known as the Internet of Flying Things(IoFT),will also be utilized to enhance communication capacity and efficiency.The proposed communication model is validated through experiments,showing superior data transmission performance and higher throughput.Analysis indicates it outperforms traditional systems,even in rural areas,with or without internet access.展开更多
Knee osteoarthritis(KOA)is a prevalent chronic degenerative joint disorder characterized by an imbalance between articular cartilage degradation and synthesis,a central mechanism in KOA pathogenesis.Given the absence ...Knee osteoarthritis(KOA)is a prevalent chronic degenerative joint disorder characterized by an imbalance between articular cartilage degradation and synthesis,a central mechanism in KOA pathogenesis.Given the absence of disease-modifying therapies,there is a critical need to elucidate the underlying pathological processes,establish reliable biomarkers for early detection and prognosis,and identify safer,more effective therapeutic agents.In recent years,natural products have attracted considerable interest due to their low toxicity,cost-effectiveness,and distinct biological activities,demonstrating significant potential in KOA management.These compounds can impede KOA progression through multiple mechanisms,including promoting cartilage matrix synthesis,mitigating inflammation,reducing oxidative stress,suppressing chondrocyte apoptosis,and modulating autophagy,thereby supporting their translational application.This review summarizes biomarkers relevant to early diagnosis and phenotypic stratification in KOA,with a focus on elucidating the pharmacological actions and molecular mechanisms of natural products,such as flavonoids,alkaloids,saponins,terpenes,and traditional Chinese medicine(TCM)formulas,in KOA intervention,aiming to provide evidence-based strategies for improved disease management.展开更多
Thermal power plants are the main contributors to greenhouse gas emissions.The prediction of the emission supports the decision makers and environmental sustainability.The objective of this study is to enhance the acc...Thermal power plants are the main contributors to greenhouse gas emissions.The prediction of the emission supports the decision makers and environmental sustainability.The objective of this study is to enhance the accuracy of emission prediction models,supporting more effective real-time monitoring and enabling informed operational decisions that align with environmental compliance efforts.This paper presents a data-driven approach for the accurate prediction of gas emissions,specifically nitrogen oxides(NOx)and carbon monoxide(CO),in natural gas power plants using an optimized hybrid machine learning framework.The proposed model integrates a Feedforward Neural Network(FFNN)trained using Particle Swarm Optimization to capture the nonlinear emission dynamics under varying gas turbine operating conditions.To further enhance predictive performance,the K-Nearest Neighbor(K-NN)algorithm serves as a post-processing method to enhance IPSO-FFNN predictions through adjustment and refinement,improving overall prediction accuracy,while Neighbor Component Analysis is used to identify and rank the most influential operational variables.The study makes a significant contribution through the combination of NCA feature selection with PSO global optimization,FFNN nonlinear modelling,and K-NN error correction into one unified system,which delivers precise emission predictions.The model was developed and tested using a real-world dataset collected from gas-fired turbine operations,with validated results demonstrating robust accuracy,achieving Root Mean Square Error values of 0.355 for CO and 0.368 for NOx.When benchmarked against conventional models such as standard FFNN,Support Vector Regression,and Long Short-Term Memory networks,the hybrid model achieved substantial improvements,up to 97.8%in Mean Squared Error,95%in Mean Absolute Error(MAE),and 85.19%in RMSE for CO;and 97.16%in MSE,93.4%in MAE,and 83.15%in RMSE for NOx.These results underscore the model’s potential for improving emission prediction,thereby supporting enhanced operational efficiency and adherence to environmental standards.展开更多
This paper studies the structural response of high-speed train wipers under the combined action of complex flow fields and scraping actions.The stress concentration areas are determined through simulation analysis,and...This paper studies the structural response of high-speed train wipers under the combined action of complex flow fields and scraping actions.The stress concentration areas are determined through simulation analysis,and the stress and aerodynamic load measurement points are reasonably arranged accordingly.The actual measurement is carried out in combination with the operating conditions of the existing lines.The stress variations and spectral characteristics of the train under different speed levels(80,160,180,200 km/h),tunnel entry and exit,and scraper action conditions were compared and analyzed.The stress amplification factors under tunnel intersection and scraper action were obtained,providing boundary conditions for the design of wipers for highspeed s.The research results show that the maximum stress of the wiper structure obtained through simulation calculation is concentrated at the connection of the wiper arm.Structural stress increases with the rise of speed grade.The stress increases by 1.11 times when the tunnel meets.When the scraper operates,the stress on the scraper arm increases by 4.1–7.6 times.Due to the broadband excitation effect of the aerodynamic load,the spectral energy of the structure is relatively high at the natural frequency,which excites the natural mode of the wiper.展开更多
Gazetteer of Garze’s Natural Scenery This book is divided into five chapters,provides a comprehensive exploration of the geographical features and cultural context surrounding the thirteen renowned mountains,five maj...Gazetteer of Garze’s Natural Scenery This book is divided into five chapters,provides a comprehensive exploration of the geographical features and cultural context surrounding the thirteen renowned mountains,five major rivers,as well as numerous lakes,glaciers,and ancient trails within Garze Tibetan Autonomous Prefecture,Sichuan Province.By combining academic rigor with accessibility and substantial documentary value,it allows readers to survey all of Garze with a single volume in hand.Published by the Local Records Publishing House.展开更多
Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass,compromised bone microstructure,and an increased risk of fractures,primarily due to excessive osteoclast-mediated bone resorption relativ...Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass,compromised bone microstructure,and an increased risk of fractures,primarily due to excessive osteoclast-mediated bone resorption relative to osteoblast-mediated bone formation.While current anti-osteoporosis drugs,such as bisphosphonates and denosumab,predominantly focus on reducing bone resorption,osteoanabolic approaches are essential for restoring bone microarchitecture and ultimately reducing fracture risk.Traditional Chinese medicines(TCMs)and their active ingredients have long been used in China for osteoporosis prevention and treatment.This review provides a comprehensive evaluation of the effects and molecular mechanisms of 65 natural products across 24 categories on osteoblast-mediated bone formation.These compounds promote bone formation by regulating key transcription factors(RUNX2 and Osterix)and signaling pathways,including WNT/β-catenin,bone morphogenic protein(BMP),mitogen-activated protein kinase(MAPK),phosphoinositide 3-kinase/protein kinase B(PI3K/AKT),oxidative stress,autophagy,and epigenetic regulation.Notably,certain natural products[e.g.,icariin(ICA)]exert their effects through multiple targets and pathways.Many of these natural products have demonstrated significant therapeutic efficacy in animal models,such as ovariectomized(OVX)mice.Our findings suggest that natural products with kidney-tonifying,anti-inflammatory,and antioxidant properties,as well as those inhibiting adipocyte differentiation,may hold promise for osteoporosis treatment.Additionally,we highlight current research gaps and propose future directions,including high-throughput screening and validation in diverse animal models,development of novel bone-targeting delivery systems,and identification of natural compounds targeting osteocytes.展开更多
Mesenchymal stem cells(MSCs)are pluripotent stem cells isolated from human tissues.Due to their strong self-renewal capacity,pluripotency,and immunomodulatory properties,MSCs have garnered significant attention in cel...Mesenchymal stem cells(MSCs)are pluripotent stem cells isolated from human tissues.Due to their strong self-renewal capacity,pluripotency,and immunomodulatory properties,MSCs have garnered significant attention in cell therapy and tissue regeneration.However,cellular senescence induced by replication or external stimuli can impair MSC proliferation and differentiation,making it crucial to develop interventions that delay or reverse the senescence process.From a traditional Chinese medicine perspective,senescence stems from spleen and stomach deficiency,kidney deficiency,and related factors;thus,medicines that tonify the kidney and promote Qi and blood circulation play vital roles in anti-senescence therapy.Chinese medicine,characterized by low toxicity and multi-target,multi-functional properties,has become prominent in anti-senescence research.This paper examines the MSC senescence process by discussing its causes,characteristics,and mechanisms,then summarizes how active ingredients in herbal medicines and natural compounds reverse MSC senescence,facilitating the discovery of additional anti-senescence Chinese medicines and their effective components.展开更多
Pulmonary fibrosis(PF)is a progressive,fatal fibrotic disease caused by respiratory conditions.The condition can ultimately lead to severe organ failure and mortality,and is associated with multiple risk factors.Growi...Pulmonary fibrosis(PF)is a progressive,fatal fibrotic disease caused by respiratory conditions.The condition can ultimately lead to severe organ failure and mortality,and is associated with multiple risk factors.Growing evidence highlights the immune system’s role in PF,with various immune components participating in inflammatory and fibrotic processes.Different immune cells,including neutrophils,lymphocytes,and macrophages,demonstrate distinct effects on PF progression and development.Furthermore,key immune system cytokines,including the interleukin(IL)family,tumor necrosis factor(TNF)-α,interferon(IFN)-γ,transforming growth factor(TGF)-β,and connective tissue growth factor(CTGF),contribute to PF initiation and progression through independent mechanisms and mutual regulation.Currently,limited effective treatments exist for PF,with several treatments causing severe adverse reactions.Natural products,characterized by multi-target effects,holistic regulation,and low toxicity,have emerged as a research focus.This review compiles the mechanisms,therapeutic potential,and active components of various natural products.These compounds can ameliorate pulmonary inflammation,epithelial-mesenchymal transition,and collagen deposition through diverse immune mechanisms,acting at specific stages or throughout the fibrotic process,thereby supporting PF management.This review examines current scientific understanding of natural products’immunological effects in PF,which is crucial for developing future anti-PF therapeutics.展开更多
Natural product(NPT)derived from traditional Chinese medicine has a rich history as an integral part of Chinese healthcare for thousands of years.Recently,the application of NPT in sonodynamic antibacterial therapy(SD...Natural product(NPT)derived from traditional Chinese medicine has a rich history as an integral part of Chinese healthcare for thousands of years.Recently,the application of NPT in sonodynamic antibacterial therapy(SDAT)has emerged as a promising area of research.This perspective summarizes the recent NPT-based sonosensitizers in SDAT.Currently,common NPT-based sonosensitizers include curcumin,chlorophyll derivatives,hypericin,and berberine.Compared with other sonosensitizers,natural sources of NPT-based sonosensitizers with reactive oxide species production performance under ultrasound conditions,low biotoxicity,and other additional biological activity make them have application prospects in bacterial removal.Finally,the potential benefits and challenges of NPT-based nanosonosensitizers were also discussed.展开更多
Thiswork explores aMagnetohydrodynamic(MHD)flowin a triangular cavitywith a thermally insulated baffle.Enclosure’s inclined wall is hotter,whereas the vertical border is adiabatic and the bottom is cooler.The study a...Thiswork explores aMagnetohydrodynamic(MHD)flowin a triangular cavitywith a thermally insulated baffle.Enclosure’s inclined wall is hotter,whereas the vertical border is adiabatic and the bottom is cooler.The study aims to clarify how geometric changes affect thermal performance and offers new perspectives on how to improve heat dissipation mechanisms.A COMSOL Multiphysics version 6.2 has been used to solve numerical solutions.Streamlines and thermal distributions are examined systematically in order to understand how the unique geometry and baffle size of triangular cavities can influence the fluid flow.This influence can result in optimized flow patterns,promoting efficient heat transfer by directing the fluid to specific areas that require more cooling.In comparison with conventional designs,this optimization results in more efficient convective heat transfer,which raises cooling efficiency and lowers thermal resistance.Furthermore,by strengthening heat transfer characteristics in heat transfer systems,these geometries increase thermal efficiency,which helps several sectors,including the production of electricity,HVAC,and the automobile industry.展开更多
China-Zimbabwe collaboration is creating new opportunities for innovation and development of youth Zimbabwe’s development has long faced obstacles linked to Western economic sanctions,measures that many view as unjus...China-Zimbabwe collaboration is creating new opportunities for innovation and development of youth Zimbabwe’s development has long faced obstacles linked to Western economic sanctions,measures that many view as unjust or unlawful.Yet,despite these constraints,Zimbabwe remains a nation rich in natural resources and endowed with a highly educated population,with its youth standing out as a particularly dynamic force.展开更多
Mesenchymal stem cells(MSCs) are widely utilized in disease treatment and regenerative medicine due to their potent immunomodulatory properties and capacity for tissue repair.However, limitations—including insufficie...Mesenchymal stem cells(MSCs) are widely utilized in disease treatment and regenerative medicine due to their potent immunomodulatory properties and capacity for tissue repair.However, limitations—including insufficient migratory capacity, suboptimal survival, proliferation, differentiation potential, and variable immunomodulatory responses—significantly hinder their clinical translation and therapeutic impact. Natural products have been shown to enhance MSC homing, stress resilience, immune regulation, and lineage-specific differentiation through multi-target mechanisms, thereby emerging as promising, safe, and practical strategies to improve the in vivo performance of MSC-based therapies. This review examines the key translational challenges associated with MSCs, elucidates the mechanistic basis by which natural products regulate the in vivo fate of MSCs, and explores the potential of integrating natural product adjuvants with MSC therapy for enhanced clinical outcomes.展开更多
Optimizing pyrolysis processes is critical for improving the efficiency of pyrolysis furnaces.This study presents a strategy to enhance heat transfer through agitation,employing Fluent for detailed numerical simulatio...Optimizing pyrolysis processes is critical for improving the efficiency of pyrolysis furnaces.This study presents a strategy to enhance heat transfer through agitation,employing Fluent for detailed numerical simulation of the thermal behavior.The simulation results show strong agreement with experimental measurements of localized fluid temperature rise.Forced convection induced by impeller rotation significantly improves heat transfer between the fluid and the furnace walls,effectively reducing thermal stratification.At an impeller speed of 240 RPM,the axial temperature difference decreases from 200 K to 50 K compared with stationary conditions,while the average heat transfer coefficient increases by approximately 50%throughout the heating process.The swirl flow generated by impeller motion disrupts the thermal boundary layer,achieving a more uniform temperature distribution and faster thermal response.展开更多
Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continu...Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continue to increase.While multiple clinical treatments exist,conventional therapies frequently present limitations and adverse effects.Natural polysaccharides(PSs)have emerged as a significant focus of research interest due to their therapeutic potential and applications in functional foods and health products.This review synthesizes current understanding of IBD pathophysiology and the mechanisms by which natural PSs counter IBD,including their capacity to restore immune homeostasis and intestinal barrier function,modulate gut microbiota and metabolites,reduce oxidative stress,and address irregularities in autophagy and endoplasmic reticulum stress(ERS).The review examines the structure-activity relationships of PSs demonstrating anti-IBD effects and identifies promising therapeutic products.The discussion encompasses pharmacokinetics,safety evaluations,and clinical applications of these compounds.This comprehensive review establishes a theoretical foundation for developing natural PS-based therapeutic approaches for IBD management.展开更多
文摘Diagrams as a visual technique played a key role in early modern natural history.Robert Morison,a Scottish botanist and the first Professor of Botany at Oxford University,made a noteworthy early attempt in the 17th century to promote the use of diagrams in plant taxonomy.By pioneering the use of diagrams as the core of his botanical monographs,Morison inverted the order in which text and diagrams are read in natural history books and made diagrams more than a mere adjunct to the main text.Morison also consciously aligned the structure of the diagrams with the spatial arrangement of his seed collection and the Oxford Botanic Garden,so that the diagrams functioned productively as a means of bridging difierent botanical practices and retrieving information from multiple aspects.Morison’s appropriation and mobilisation of the diagrammatic mode of representation that originated in the Middle Ages helped pave the way for the diagram,as a visual language between textuality and pictoriality,to become prevalent amongst early modern naturalists.
文摘“Journal of Jilin University(Science Edition)”is a comprehensive academic journal in the fields of science sponsored by Jilin University and administrated by the Ministry of Education of the Peoples Republic of China.The journal started publication in 1955.The original name at starting publication was “Journal of Natural Science of Northeast People University”,which was changed into “Acta Scientiarum Naturalium Universitatis Jilinensis”in 1958owing to the name change of the university.The present journal name has been begun since the beginning of 2002after a new Jilin University was set up,which comes from the amalgamation of the original Jilin University,Jilin University of Technology,Bethune Medicine University,Changchun University of Science and Technology and Changchun Post and Telecommunication Institute on June 12,2000.The domestic journal number is CN 22-1340/O,and the international journal number is ISSN 1671-5489.
文摘Natural Gas Industry B创刊于2014年,是天然气工业杂志社与KeAi公司合作出版的国际OA期刊,在爱思唯尔旗下的ScienceDirect平台上双月出版。论文聚焦天然气、氢气、氦气、地热等地质能源,涵盖地质勘探、气藏开发、工程技术、储运利用、净化化工、产业趋势等专业方向。期刊服务全球天然气产业,并积极推动能源行业碳减排和低碳转型的发展。
文摘Natural Gas Industry B创刊于2014年,是天然气工业杂志社与KeAi公司合作出版的国际OA期刊,在爱思唯尔旗下的Science Direct平台上双月出版。论文聚焦天然气、氢气、氦气、地热等地质能源,涵盖地质勘探、气藏开发、工程技术、储运利用、净化化工、产业趋势等专业方向。期刊服务全球天然气产业,并积极推动能源行业碳减排和低碳转型的发展。
基金supported by National Key Research and Development Program of China(Grants No.2022YFF0802401 and 2023YFF0806900)China Postdoctoral Science Foundation(Grants No.2023M743456,GZB20230740,and 2024T170908).
文摘1.Introduction In recent years,intensifying climate extremes have triggered a sharp increase in global natural disasters,over 90%attributable to water-related hazards,particularly floods(Hirabayashi et al.,2013).Over the past two decades,floods have inundated approximately 2.23 million km2 of land worldwide(Tellman et al.,2021),affecting over 250 million people and causing economic losses exceeding USD 651 billion(Devitt et al.,2023).Recent catastrophic floods in Pakistan,landslides in Indonesia,and dike breaches in China have intensified concerns over the effectiveness of current flood management strategies.
文摘The modern world remains vulnerable to natural disasters,including floods,earthquakes,wildfires,and others.These events remain unpredictable and inevitable,and recovering quickly and effectively requires significant effort and expense.Monitoring is becoming more efficient thanks to technologies such as Unmanned Aerial Vehicles(UAVs),which can access hard-to-reach areas and provide real-time data.However,in disaster-affected areas,these monitoring systems may encounter many obstacles when communicating with servers or transmitting monitored data.This paper proposes an adaptive communication model to overcome the challenges faced in disaster-affected areas.A base station is responsible for collecting data(such as images and videos)captured by UAVs performing surveillance within its communication range.This station is typically a tower providing fixed cellular network service.However,in the absence of such a tower,a selected UAV may serve as the station,depending on the situation.If surveillance needs to be performed outside the coverage area,it can continue to communicate via nearby UAVs through cooperative communication.UAVs with internet support,known as the Internet of Flying Things(IoFT),will also be utilized to enhance communication capacity and efficiency.The proposed communication model is validated through experiments,showing superior data transmission performance and higher throughput.Analysis indicates it outperforms traditional systems,even in rural areas,with or without internet access.
基金supported by the National Science Foundation of China(No.82474144)the Zhejiang Province Technological Leading Talents Fund Project(No.2022R52031)。
文摘Knee osteoarthritis(KOA)is a prevalent chronic degenerative joint disorder characterized by an imbalance between articular cartilage degradation and synthesis,a central mechanism in KOA pathogenesis.Given the absence of disease-modifying therapies,there is a critical need to elucidate the underlying pathological processes,establish reliable biomarkers for early detection and prognosis,and identify safer,more effective therapeutic agents.In recent years,natural products have attracted considerable interest due to their low toxicity,cost-effectiveness,and distinct biological activities,demonstrating significant potential in KOA management.These compounds can impede KOA progression through multiple mechanisms,including promoting cartilage matrix synthesis,mitigating inflammation,reducing oxidative stress,suppressing chondrocyte apoptosis,and modulating autophagy,thereby supporting their translational application.This review summarizes biomarkers relevant to early diagnosis and phenotypic stratification in KOA,with a focus on elucidating the pharmacological actions and molecular mechanisms of natural products,such as flavonoids,alkaloids,saponins,terpenes,and traditional Chinese medicine(TCM)formulas,in KOA intervention,aiming to provide evidence-based strategies for improved disease management.
文摘Thermal power plants are the main contributors to greenhouse gas emissions.The prediction of the emission supports the decision makers and environmental sustainability.The objective of this study is to enhance the accuracy of emission prediction models,supporting more effective real-time monitoring and enabling informed operational decisions that align with environmental compliance efforts.This paper presents a data-driven approach for the accurate prediction of gas emissions,specifically nitrogen oxides(NOx)and carbon monoxide(CO),in natural gas power plants using an optimized hybrid machine learning framework.The proposed model integrates a Feedforward Neural Network(FFNN)trained using Particle Swarm Optimization to capture the nonlinear emission dynamics under varying gas turbine operating conditions.To further enhance predictive performance,the K-Nearest Neighbor(K-NN)algorithm serves as a post-processing method to enhance IPSO-FFNN predictions through adjustment and refinement,improving overall prediction accuracy,while Neighbor Component Analysis is used to identify and rank the most influential operational variables.The study makes a significant contribution through the combination of NCA feature selection with PSO global optimization,FFNN nonlinear modelling,and K-NN error correction into one unified system,which delivers precise emission predictions.The model was developed and tested using a real-world dataset collected from gas-fired turbine operations,with validated results demonstrating robust accuracy,achieving Root Mean Square Error values of 0.355 for CO and 0.368 for NOx.When benchmarked against conventional models such as standard FFNN,Support Vector Regression,and Long Short-Term Memory networks,the hybrid model achieved substantial improvements,up to 97.8%in Mean Squared Error,95%in Mean Absolute Error(MAE),and 85.19%in RMSE for CO;and 97.16%in MSE,93.4%in MAE,and 83.15%in RMSE for NOx.These results underscore the model’s potential for improving emission prediction,thereby supporting enhanced operational efficiency and adherence to environmental standards.
文摘This paper studies the structural response of high-speed train wipers under the combined action of complex flow fields and scraping actions.The stress concentration areas are determined through simulation analysis,and the stress and aerodynamic load measurement points are reasonably arranged accordingly.The actual measurement is carried out in combination with the operating conditions of the existing lines.The stress variations and spectral characteristics of the train under different speed levels(80,160,180,200 km/h),tunnel entry and exit,and scraper action conditions were compared and analyzed.The stress amplification factors under tunnel intersection and scraper action were obtained,providing boundary conditions for the design of wipers for highspeed s.The research results show that the maximum stress of the wiper structure obtained through simulation calculation is concentrated at the connection of the wiper arm.Structural stress increases with the rise of speed grade.The stress increases by 1.11 times when the tunnel meets.When the scraper operates,the stress on the scraper arm increases by 4.1–7.6 times.Due to the broadband excitation effect of the aerodynamic load,the spectral energy of the structure is relatively high at the natural frequency,which excites the natural mode of the wiper.
文摘Gazetteer of Garze’s Natural Scenery This book is divided into five chapters,provides a comprehensive exploration of the geographical features and cultural context surrounding the thirteen renowned mountains,five major rivers,as well as numerous lakes,glaciers,and ancient trails within Garze Tibetan Autonomous Prefecture,Sichuan Province.By combining academic rigor with accessibility and substantial documentary value,it allows readers to survey all of Garze with a single volume in hand.Published by the Local Records Publishing House.
基金supported by the National Natural Science Foundation of China(No.31800059)。
文摘Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass,compromised bone microstructure,and an increased risk of fractures,primarily due to excessive osteoclast-mediated bone resorption relative to osteoblast-mediated bone formation.While current anti-osteoporosis drugs,such as bisphosphonates and denosumab,predominantly focus on reducing bone resorption,osteoanabolic approaches are essential for restoring bone microarchitecture and ultimately reducing fracture risk.Traditional Chinese medicines(TCMs)and their active ingredients have long been used in China for osteoporosis prevention and treatment.This review provides a comprehensive evaluation of the effects and molecular mechanisms of 65 natural products across 24 categories on osteoblast-mediated bone formation.These compounds promote bone formation by regulating key transcription factors(RUNX2 and Osterix)and signaling pathways,including WNT/β-catenin,bone morphogenic protein(BMP),mitogen-activated protein kinase(MAPK),phosphoinositide 3-kinase/protein kinase B(PI3K/AKT),oxidative stress,autophagy,and epigenetic regulation.Notably,certain natural products[e.g.,icariin(ICA)]exert their effects through multiple targets and pathways.Many of these natural products have demonstrated significant therapeutic efficacy in animal models,such as ovariectomized(OVX)mice.Our findings suggest that natural products with kidney-tonifying,anti-inflammatory,and antioxidant properties,as well as those inhibiting adipocyte differentiation,may hold promise for osteoporosis treatment.Additionally,we highlight current research gaps and propose future directions,including high-throughput screening and validation in diverse animal models,development of novel bone-targeting delivery systems,and identification of natural compounds targeting osteocytes.
基金supported by Zhejiang Provincial Natural Science Foundation of China(No.LQ23H290006)the National Natural Science Foundation of China(No.82204781)+2 种基金the Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province(No.2020E10021)Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents(No.ZWB-2020-18)Zhejiang Provincial Traditional Chinese Medicine Science and Technology Project(No.2023ZR119).
文摘Mesenchymal stem cells(MSCs)are pluripotent stem cells isolated from human tissues.Due to their strong self-renewal capacity,pluripotency,and immunomodulatory properties,MSCs have garnered significant attention in cell therapy and tissue regeneration.However,cellular senescence induced by replication or external stimuli can impair MSC proliferation and differentiation,making it crucial to develop interventions that delay or reverse the senescence process.From a traditional Chinese medicine perspective,senescence stems from spleen and stomach deficiency,kidney deficiency,and related factors;thus,medicines that tonify the kidney and promote Qi and blood circulation play vital roles in anti-senescence therapy.Chinese medicine,characterized by low toxicity and multi-target,multi-functional properties,has become prominent in anti-senescence research.This paper examines the MSC senescence process by discussing its causes,characteristics,and mechanisms,then summarizes how active ingredients in herbal medicines and natural compounds reverse MSC senescence,facilitating the discovery of additional anti-senescence Chinese medicines and their effective components.
基金supported by the National Natural Science Foundation of China(No.82260820)the Natural Science Foundation of Jilin Province,Jilin,China(No.YDZJ202201ZYTS155).
文摘Pulmonary fibrosis(PF)is a progressive,fatal fibrotic disease caused by respiratory conditions.The condition can ultimately lead to severe organ failure and mortality,and is associated with multiple risk factors.Growing evidence highlights the immune system’s role in PF,with various immune components participating in inflammatory and fibrotic processes.Different immune cells,including neutrophils,lymphocytes,and macrophages,demonstrate distinct effects on PF progression and development.Furthermore,key immune system cytokines,including the interleukin(IL)family,tumor necrosis factor(TNF)-α,interferon(IFN)-γ,transforming growth factor(TGF)-β,and connective tissue growth factor(CTGF),contribute to PF initiation and progression through independent mechanisms and mutual regulation.Currently,limited effective treatments exist for PF,with several treatments causing severe adverse reactions.Natural products,characterized by multi-target effects,holistic regulation,and low toxicity,have emerged as a research focus.This review compiles the mechanisms,therapeutic potential,and active components of various natural products.These compounds can ameliorate pulmonary inflammation,epithelial-mesenchymal transition,and collagen deposition through diverse immune mechanisms,acting at specific stages or throughout the fibrotic process,thereby supporting PF management.This review examines current scientific understanding of natural products’immunological effects in PF,which is crucial for developing future anti-PF therapeutics.
基金supported by the Innovation and Entrepreneurship Training Program for College Students(X2025102911746,X2025102910483).
文摘Natural product(NPT)derived from traditional Chinese medicine has a rich history as an integral part of Chinese healthcare for thousands of years.Recently,the application of NPT in sonodynamic antibacterial therapy(SDAT)has emerged as a promising area of research.This perspective summarizes the recent NPT-based sonosensitizers in SDAT.Currently,common NPT-based sonosensitizers include curcumin,chlorophyll derivatives,hypericin,and berberine.Compared with other sonosensitizers,natural sources of NPT-based sonosensitizers with reactive oxide species production performance under ultrasound conditions,low biotoxicity,and other additional biological activity make them have application prospects in bacterial removal.Finally,the potential benefits and challenges of NPT-based nanosonosensitizers were also discussed.
文摘Thiswork explores aMagnetohydrodynamic(MHD)flowin a triangular cavitywith a thermally insulated baffle.Enclosure’s inclined wall is hotter,whereas the vertical border is adiabatic and the bottom is cooler.The study aims to clarify how geometric changes affect thermal performance and offers new perspectives on how to improve heat dissipation mechanisms.A COMSOL Multiphysics version 6.2 has been used to solve numerical solutions.Streamlines and thermal distributions are examined systematically in order to understand how the unique geometry and baffle size of triangular cavities can influence the fluid flow.This influence can result in optimized flow patterns,promoting efficient heat transfer by directing the fluid to specific areas that require more cooling.In comparison with conventional designs,this optimization results in more efficient convective heat transfer,which raises cooling efficiency and lowers thermal resistance.Furthermore,by strengthening heat transfer characteristics in heat transfer systems,these geometries increase thermal efficiency,which helps several sectors,including the production of electricity,HVAC,and the automobile industry.
文摘China-Zimbabwe collaboration is creating new opportunities for innovation and development of youth Zimbabwe’s development has long faced obstacles linked to Western economic sanctions,measures that many view as unjust or unlawful.Yet,despite these constraints,Zimbabwe remains a nation rich in natural resources and endowed with a highly educated population,with its youth standing out as a particularly dynamic force.
基金supported by the Leading Technology Foundation Research Project of Jiangsu Province (No. BK20232035)the Key Project of Basic Research Program of Jiangsu Province(No. BK20243061)+1 种基金the Project of State Key Laboratory of Natural Medicines,China Pharmaceutical University (No.SKLNMZZ202302)the Haihe Laboratory of Cell Ecosystem Innovation Fund (No. 22HHXBSS00005)。
文摘Mesenchymal stem cells(MSCs) are widely utilized in disease treatment and regenerative medicine due to their potent immunomodulatory properties and capacity for tissue repair.However, limitations—including insufficient migratory capacity, suboptimal survival, proliferation, differentiation potential, and variable immunomodulatory responses—significantly hinder their clinical translation and therapeutic impact. Natural products have been shown to enhance MSC homing, stress resilience, immune regulation, and lineage-specific differentiation through multi-target mechanisms, thereby emerging as promising, safe, and practical strategies to improve the in vivo performance of MSC-based therapies. This review examines the key translational challenges associated with MSCs, elucidates the mechanistic basis by which natural products regulate the in vivo fate of MSCs, and explores the potential of integrating natural product adjuvants with MSC therapy for enhanced clinical outcomes.
基金supported by the National Natural Science Foundation of China(Grant No.52166004)the Yunnan Fundamental Research Projects(Grant No.202501AS070131).
文摘Optimizing pyrolysis processes is critical for improving the efficiency of pyrolysis furnaces.This study presents a strategy to enhance heat transfer through agitation,employing Fluent for detailed numerical simulation of the thermal behavior.The simulation results show strong agreement with experimental measurements of localized fluid temperature rise.Forced convection induced by impeller rotation significantly improves heat transfer between the fluid and the furnace walls,effectively reducing thermal stratification.At an impeller speed of 240 RPM,the axial temperature difference decreases from 200 K to 50 K compared with stationary conditions,while the average heat transfer coefficient increases by approximately 50%throughout the heating process.The swirl flow generated by impeller motion disrupts the thermal boundary layer,achieving a more uniform temperature distribution and faster thermal response.
基金supported by the National Natural Science Foundation of China(Nos.82003977,82274134 and 82274139)the National Key Research and Development Plan(No.2017YFC1702200)+1 种基金the Key Research and Development Program of Zhejiang Province(No.2020C04020)the Science and Technology Program of Zhejiang Province(No.2025C02183).
文摘Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continue to increase.While multiple clinical treatments exist,conventional therapies frequently present limitations and adverse effects.Natural polysaccharides(PSs)have emerged as a significant focus of research interest due to their therapeutic potential and applications in functional foods and health products.This review synthesizes current understanding of IBD pathophysiology and the mechanisms by which natural PSs counter IBD,including their capacity to restore immune homeostasis and intestinal barrier function,modulate gut microbiota and metabolites,reduce oxidative stress,and address irregularities in autophagy and endoplasmic reticulum stress(ERS).The review examines the structure-activity relationships of PSs demonstrating anti-IBD effects and identifies promising therapeutic products.The discussion encompasses pharmacokinetics,safety evaluations,and clinical applications of these compounds.This comprehensive review establishes a theoretical foundation for developing natural PS-based therapeutic approaches for IBD management.
