Chemotherapy is the cornerstone of cancer treatment,and paclitaxel(PTX),as a first-line broad-spectrum chemotherapy drug,is widely used in the treatment of multiple tumors in the clinic.However,unsatisfactory efficacy...Chemotherapy is the cornerstone of cancer treatment,and paclitaxel(PTX),as a first-line broad-spectrum chemotherapy drug,is widely used in the treatment of multiple tumors in the clinic.However,unsatisfactory efficacy and drug resistance of single chemotherapy have severely hampered the clinical progress of PTX.Herein,three-in-one naringenin(NAR)-loaded PTX polymer prodrug micelles were constructed for efficient and synergistic antitumor therapy.Firstly,the polymer prodrug micelles could simultaneously act as nanoreservoirs for two hydrophobic drugs,PTX and NAR.Secondly,the polymer prodrug micelles enabled dual-responsive intelligent release of PTX and NAR triggered by reduction and acid.Finally,released PTX and NAR exerted synergistic antitumor effects for reversing tumor resistance,while NAR enhanced the immune and anti-inflammatory functions of polymer prodrug micelles.Due to the cascade-enhanced chemotherapeutic augmentation,the intelligent-responsive nanoreservoir proved to be an excellent antitumor therapeutic platform.This work was of great interest for designing superior chemotherapeutic augmentation regimens.展开更多
基金supported by the National Natural Science Foundation of China(No.U1904155)the Henan Provincial Key Research Development and Special Project for Promotion(Nos.242102310455,242102310473)+4 种基金the Key Project of Science and Technology Research funded by the Henan Provincial Department of Education(No.24A350002)Postdoctoral Fellowship Program of CPSF(No.GZC20231732)China Postdoctoral Science Foundation(Nos.2023TQ0222,2023MD744229)General Program of Department of Education of Liaoning Province(No.JYTMS20231372)Doctoral Scientific Research Staring Foundation of Liaoning Province(No.2024-BS-073)。
文摘Chemotherapy is the cornerstone of cancer treatment,and paclitaxel(PTX),as a first-line broad-spectrum chemotherapy drug,is widely used in the treatment of multiple tumors in the clinic.However,unsatisfactory efficacy and drug resistance of single chemotherapy have severely hampered the clinical progress of PTX.Herein,three-in-one naringenin(NAR)-loaded PTX polymer prodrug micelles were constructed for efficient and synergistic antitumor therapy.Firstly,the polymer prodrug micelles could simultaneously act as nanoreservoirs for two hydrophobic drugs,PTX and NAR.Secondly,the polymer prodrug micelles enabled dual-responsive intelligent release of PTX and NAR triggered by reduction and acid.Finally,released PTX and NAR exerted synergistic antitumor effects for reversing tumor resistance,while NAR enhanced the immune and anti-inflammatory functions of polymer prodrug micelles.Due to the cascade-enhanced chemotherapeutic augmentation,the intelligent-responsive nanoreservoir proved to be an excellent antitumor therapeutic platform.This work was of great interest for designing superior chemotherapeutic augmentation regimens.
