Antibiotic resistance genes(ARGs) are recognized as a primary threat to the sustainability of environment and human health in the 21^(st) century.Nanomaterials(NMs) have attracted substantial attention due to their un...Antibiotic resistance genes(ARGs) are recognized as a primary threat to the sustainability of environment and human health in the 21^(st) century.Nanomaterials(NMs) have attracted substantial attention due to their unique dimensions and structures.Unfortunately,emerging evidence suggests that NMs may facilitate the transmission of ARGs.It is crucial to elucidate how NMs affect the evolution and dissemination of ARGs.The current review comprehensively examines the role of NMs in the widespread transmission of ARGs in aquatic environments and the underlying mechanisms involved in the process.It aims to clarify the effects and mechanisms of NMs on the horizontal gene transfer processes that are associated with ARGs,including the enhancement of cell membrane permeability,the formation of nanopores on membranes,promotion of mutagenesis,and the generation of reactive oxygen species(ROSs).Furthermore,the trade-off between the removal of ARGs and horizontal transfer has been elucidated.The review aspires to guide future research directions,advance knowledge on the implications of NMs in the field of ARGs' transmission,and provide a theoretical foundation for the development of safer and more effective applications of NMs.展开更多
Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within...Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the brain.Lysosomes,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular homeostasis.Some studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s disease.Restoring the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s disease.Currently,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and targeting.Recently,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical properties.This review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s disease.This review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal function.In conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s disease.The application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.展开更多
Hepatocellular carcinoma(HCC)remains one of the most common cancers worldwide.Transcatheter arterial chemoembolization has become a common treatment modality for some patients with unresectable advanced HCC.Since the ...Hepatocellular carcinoma(HCC)remains one of the most common cancers worldwide.Transcatheter arterial chemoembolization has become a common treatment modality for some patients with unresectable advanced HCC.Since the introduction of nanomaterials in 1974,their use in various fields has evolved rapidly.In medical applications,nanomaterials can serve as carriers for the delivery of chemotherapeutic drugs to tumour tissues.Additionally,nanomaterials have potential for in vivo tumour imaging.This article covers the properties and uses of several kinds of nanomaterials,focusing on their use in transcatheter arterial chemoembolization for HCC treatment.This paper also discusses the limitations currently associated with the use of nanomaterials.展开更多
Various chemical irrigants and drugs have been employed for intra-canal disinfection in root canal therapy(RCT).However,due to the complexity of root canal anatomy,many drugs still exhibit poor penetrability and antib...Various chemical irrigants and drugs have been employed for intra-canal disinfection in root canal therapy(RCT).However,due to the complexity of root canal anatomy,many drugs still exhibit poor penetrability and antibiotic resistance,leading to suboptimal treatment outcomes.Thus,it is challenging to remove the organic biofilms from root canals.In recent years,light-responsive therapy,with deeper tissue penetration than traditional treatments,has emerged as an effective RCT modality.Herein,this review summarizes the recent development of light-responsive nanomaterials for biofilm removal in RCT.The light-responsive nanomaterials and the corresponding therapeutic methods in RCT,including photodynamic therapy(PDT),photothermal therapy(PTT),and laser-activated therapy,are highlighted.Finally,the challenges that light-responsive nanomaterials and treatment modalities will encounter to conquer the biofilm in future RCT are discussed.This review is believed to significantly accelerate the future development of light-responsive nanomaterials for RCT from bench to bedside.展开更多
Lignocellulosic materials(LCMs),abundant biomass residues,pose significant environmental challenges when improperly disposed of.LCMs,such as sugarcane bagasse,rice straw,saw dust and agricultural residues,are abun-dant...Lignocellulosic materials(LCMs),abundant biomass residues,pose significant environmental challenges when improperly disposed of.LCMs,such as sugarcane bagasse,rice straw,saw dust and agricultural residues,are abun-dant but often burned,contributing to air pollution and greenhouse gas emissions.This review explores the potential of transforming these materials into high-value carbon nanomaterials(CNMs).We explore the potential of transforming these materials into high-value CNMs.By employing techniques like carbonization and activa-tion,LCMs can be converted into various CNMs,including carbon nanotubes(CNTs),graphene(G),graphene oxide(GO),carbon quantum dots(CQDs),nanodiamonds(NDs),fullerenes(F),carbon nanofibers(CNFs),and others.Hybridizing different carbon allotropes further enhances their properties.CNMs derived from cellulose,lignin,and hemicellulose exhibit promising applications in diversefields.For instance,CNTs can be used in energy storage devices like batteries and supercapacitors due to their exceptional electrical conductivity and mechanical strength.Additionally,CNTs can be incorporated into recycled paper as afire retardant additive,enhancing itsflame resistance.G,renowned for its high surface area and excellent electrical conductivity,finds applications in electronics,sensors,catalysis,and water treatment,where it can be used to adsorb heavy metal ions.CQDs,owing to their unique optical properties,are used in bioimaging,drug delivery,and optoelectronic devices.By harnessing the potential of LCMs,we can not only mitigate environmental concerns but also contri-bute to a sustainable future.Continued research is essential to optimize synthesis methods,explore novel applica-tions,and unlock the full potential of these versatile materials.展开更多
Protein glycosylation and phosphorylation,as two of the most important protein post-translational modifications(PTMs),play key roles in living organisms.However,glycopeptides and phosphopeptides have low abundance in ...Protein glycosylation and phosphorylation,as two of the most important protein post-translational modifications(PTMs),play key roles in living organisms.However,glycopeptides and phosphopeptides have low abundance in biological samples.In addition,the low ionization efficiency and the severe signal interference in the presence of other peptides present great difficulties for their direct mass spectrometry(MS)analysis.Therefore,it is important to develop feasible enrichment strategies to pretreat glycopeptides and phosphopeptides in complex samples before MS detection.This paper reviews the application of various magnetic nanomaterials(MNMs)in glycopeptides and phosphopeptides in the last decade,with emphasis on the enrichment principles,the design and synthesis process of the materials,and the effectiveness of the application in biological samples.In addition,possible future trends and potential challenges are presented.展开更多
Environmental catalysis has been considered one of the important research topics.Some technologies(e.g.,photocatalysis and electrocatalysis)have been intensively developed with the advance of synthetic technologies of...Environmental catalysis has been considered one of the important research topics.Some technologies(e.g.,photocatalysis and electrocatalysis)have been intensively developed with the advance of synthetic technologies of catalytical materials.In 2019,we discussed the development trend of this field,and wrote a roadmap on this topic in Chinese Chemical Letters(30(2019)2065-2088).Nowadays,we discuss it again from a new viewpoint along this road.In this paper,several subtopics are discussed,e.g.,photocatalysis based on titanium dioxide,violet phosphorus,graphitic carbon and covalent organic frameworks,electrocatalysts based on carbon,metal-and covalent-organic framework.Finally,we hope that this roadmap can enrich the development of two-dimensional materials in environmental catalysis with novel understanding,and give useful inspiration to explore new catalysts for practical applications.展开更多
Nanomaterials have garnered recognition for their notable surface effects and demonstration of superior mechanical properties.Previous studies on the surface effects of nanomaterials,employing the finite element metho...Nanomaterials have garnered recognition for their notable surface effects and demonstration of superior mechanical properties.Previous studies on the surface effects of nanomaterials,employing the finite element method,often relied on simplified twodimensional models due to theoretical complexities.Consequently,these simplified models inadequately represent the mechanical properties of nanomaterials and fail to capture the substantial impact of surface effects,particularly the curvature dependence of nanosurfaces.This study applies the principle of minimum energy and leverages the Steigmann-Ogden surface theory of nanomaterials to formulate a novel finite element surface element that comprehensively accounts for surface effects.We conducted an analysis of the stress distribution and deformation characteristics of four typical 2D and 3D nanomaterial models.The accuracy of the developed surface element and finite element calculation method was verified through comparison with established references.The resulting finite element model provides a robust and compelling scientific approach for accurately predicting the mechanical performance of nanomaterials.展开更多
Carbon nanotubes(CNTs),black phosphorus nanotubes(BPNTs),and graphene derivatives exhibit significant promise for applications in nano-electromechanical systems(NEMS),energy storage,and sensing technologies due to the...Carbon nanotubes(CNTs),black phosphorus nanotubes(BPNTs),and graphene derivatives exhibit significant promise for applications in nano-electromechanical systems(NEMS),energy storage,and sensing technologies due to their exceptional mechanical,electrical,and thermal properties.This review summarizes recent advances in understanding the dynamic behaviors of these nanomaterials,with a particular focus on insights gained from molecular dynamics(MD)simulations.Key areas discussed include the oscillatory and rotational dynamics of double-walled CNTs,fabrication and stability challenges associated with BPNTs,and the emerging potential of graphyne nanotubes(GNTs).The review also outlines design strategies for enhancing nanodevice performance and underscores the importance of future efforts in experimental validation,multi-scale coupling analyses,and the development of novel nanocomposites to accelerate practical deployment.展开更多
Human life quality requires both industrial/agricultural fast development and high environmental quality.However,the two aspects are conflicted as some contaminants are accidentally released into the environment,poten...Human life quality requires both industrial/agricultural fast development and high environmental quality.However,the two aspects are conflicted as some contaminants are accidentally released into the environment,potentially harmful to human health even at extra-low concentrations.展开更多
Thermoelectric(TE)materials,with the ability to convert heat into electrical energy,can generate micro-electrical fields at electronic interfaces with biological systems,making them applicable in electric-catalyzing a...Thermoelectric(TE)materials,with the ability to convert heat into electrical energy,can generate micro-electrical fields at electronic interfaces with biological systems,making them applicable in electric-catalyzing as nanozymes,and modulate the infected microenvironment of skin wounds.Thereby,by harnessing temperature differences in vitro or in vivo,TE nanomaterials can provide antimicrobial reactive oxygen species(ROS)by catalyzing redox reactions,thereby accelerating wound healing by suppressing infection.However,despite their promising potential,there is still a lack of comprehensive understanding of the antimicrobial mechanisms,biocompatibility,and practical applications of TE nanomaterials in wound healing,as this is a newly-emerged sub-area of energy-related biomedical applications.This review aims to address this gap by highlighting the emerging progress of TE materials in wound healing,clarifying their mechanism and advances,emphasizing their potential challenges for commercialization and clinical use,and proposing novel design strategies of TE nanomaterials for effective antibacterial performance.展开更多
Renal cell carcinoma(RCC)as one of the most commonly diagnosed cancers threatens human health.The treatment of RCC demands more advanced protocols for better prognosis and higher quality of life.In recent years,the bl...Renal cell carcinoma(RCC)as one of the most commonly diagnosed cancers threatens human health.The treatment of RCC demands more advanced protocols for better prognosis and higher quality of life.In recent years,the blooming of nanomaterials in various fields demonstrates its critical role as one of the most important components in constructing a smart therapeutic platform against RCC.Herein,focusing on the therapeutic inorganic nanomaterials(such as carbon nanomaterials,metal nanomaterials,oxide nanomaterials),their functions as drug carriers,external field sensitizers,and/or RCC microenvironment sensitizers are analyzed.In combination with the advantages of nanomaterial and RCC characteristics,the trends in integrating nanomaterial to construct multifunctional theranostic platforms for RCC treatment are highlighted.Also,possible solutions concerning the life trajectory and long-term toxicity of nanomaterials are put forward.These perspectives may promote the development of smarter and more effective systems for comprehensive RCC treatment.展开更多
Two-dimensional(2D) nanomaterials have always been regarded as having great development potential in the field of oil-based lubrication due to their designable structures,functional groups,and abundant active sites.Ho...Two-dimensional(2D) nanomaterials have always been regarded as having great development potential in the field of oil-based lubrication due to their designable structures,functional groups,and abundant active sites.However,understanding the structure-performance relationship between the chemical structure of 2D nanomaterials and their lubrication performance from a comprehensive perspective is crucial for guiding their future development.This review provides a timely and comprehensive overview of the applications of 2D nanomaterials in oil-based lubrication.First,the bottlenecks and mechanisms of action of 2D nanomaterials are outlined,including adsorption protective films,charge adsorption effects,tribochemical reaction films,interlayer slip,and synergistic effects.On this basis,the review summarizes recent structural regulation strategies for 2D nanomaterials,including doping engineering,surface modification,structural optimization,and interfacial mixing engineering.Then,the focus was on analyzing the structure-performance relationship between the chemical structure of 2D nanomaterials and their lubrication performance.The effects of thickness,number of layers,sheet diameter,interlayer spacing,Moiré patterns,wettability,functional groups,concentration,as well as interfacial compatibility and dispersion behavior of 2D nanomaterials were systematically investigated in oil-based lubrication,with the intrinsic correlations resolved through computational simulations.Finally,the review offers a preliminary summary of the significant challenges and future directions for 2D nanomaterials in oil-based lubrication.This review aims to provide valuable insights and development strategies for the rational design of high-performance oil-based lubrication materials.展开更多
Owing to their unique biological effects and physicochemical properties,nanomaterials have garnered substantial attention in the field of bone tissue engineering(BTE),targeting the repair and restoration of impaired b...Owing to their unique biological effects and physicochemical properties,nanomaterials have garnered substantial attention in the field of bone tissue engineering(BTE),targeting the repair and restoration of impaired bone tissue.In recent years,strategies for the design and optimization of nanomaterials through thiolation modification have been widely applied in BTE.This review concisely summarizes the categories of nanomaterials commonly used in BTE and focuses on various strategies for the modification of nanomaterials via thiolation.A multifaceted analysis of the mechanisms by which thiolated nanomaterials enhance nanomaterial-cell interactions,promote drug loading and release,and modulate osteogenic differentiation is presented.Furthermore,this review introduces biomedical applications of thiolated nanomaterials in BTE,including as scaffold components for bone regeneration,coatings for bone implants,and drug delivery systems.Finally,the future perspectives and challenges in the development of this field are discussed.Thiolation modification strategies provide a platform for developing new ideas and methods for designing nanomaterials for BTE and are expected to accelerate the development and clinical translation of novel bone repair materials.展开更多
The development of cost-effective and high-efficiency catalysts for sustainable hydrogen production through electrocatalytic hydrogen evolution reaction(HER) is crucial yet remains challenging. In this work, we synthe...The development of cost-effective and high-efficiency catalysts for sustainable hydrogen production through electrocatalytic hydrogen evolution reaction(HER) is crucial yet remains challenging. In this work, we synthesized two types of bimetallic Pt Ni nanoparticles embedded in N-doped porous carbons derived from Ni-ABDC(5-aminoisophthalate) using both in-situ and ex-situ Pt inclusion methods. The in-situ Pt doping notably disrupted the effective growth of Ni-ABDC nanostrips owing to strong interactions between Pt and ABDC, resulting in an amorphous nanostructure. The optimized PtinNi-NC exhibited remarkable HER performance with a low overpotential of 29 mV at 10 mA/cm^(2), a Tafel slope of 47.4 mV/dec, and a current retention of 91.2% after 200 h in 1.0 mol/L KOH solution, surpassing the performance of Ni-NC, PtexNi-NC, and Pt/C. This research demonstrates the rational design and preparation of transition metal-based coordination polymer-derived metal-carbon nanomaterials with low Pt loading,emphasizing their considerable potential in energy conversion and storage technologies.展开更多
Nanomaterials are extensively utilized in a multitude of sectors,but their propensity to aggregate can considerably diminish the efficacy of functional materials.A pivotal challenge in this domain is achieving a homog...Nanomaterials are extensively utilized in a multitude of sectors,but their propensity to aggregate can considerably diminish the efficacy of functional materials.A pivotal challenge in this domain is achieving a homogenous distribution of nanomaterials,which is essential for enhancing their performance while also reducing production costs.In this work,we achieve uniform and stable dispersion of various nano-materials through the confinement effect generated by the stereocomplex cross-linked network formed by the combination of poly(L-lactic)acid and poly(D-lactic)acid.The unique confinement effect of poly-lactic acid(PLA)isomers is universal and significantly enhances the dispersion of nanomaterials in both PLA solutions and films.To demonstrate the efficacy of our approach,we disperse aggregation-induced emission(AIE)molecules within PLA,which leads to the production of PLA films exhibiting improved fluorescence property.This work provides an effective solution for the preparation of nanocomposite ma-terials that are both high-performing and cost-efficient.展开更多
Ultrafast Joule heating(JH)has emerged as a powerful and scalable platform for rapid thermal processing of advanced nanomaterials.By delivering transient,high-intensity electrical pulses,JH induces ultrafast heating a...Ultrafast Joule heating(JH)has emerged as a powerful and scalable platform for rapid thermal processing of advanced nanomaterials.By delivering transient,high-intensity electrical pulses,JH induces ultrafast heating and cooling rates on the order of milliseconds,facilitating nonequilibrium phase transitions,defect modulation,and tailored nanostructural evolution.This technique offers unprecedented control over material synthesis and has been successfully applied to a broad spectrum of functional property-driven materials,including graphene,single-atom catalysts,transition metal carbides,oxides,nitrides,phosphides,and chalcogenides,as well as complex multicomponent frameworks such as high-entropy alloys.This review systematically explores the principles governing JH,highlights recent advances in its application to diverse materials systems,and critically assesses current limitations related to process uniformity,scalability,and mechanistic understanding.Particular attention is given to its intrinsic advantages,including energy efficiency,fast rate,environmental sustainability,and compatibility with sustainable manufacturing.Finally,we propose guidance for expanding the utility of JH for new materials discovery,including integration with in-situ diagnostics,theoretical compatibility and data-driven optimization of synthesis to effectively correlate structure-property relationships.展开更多
Presently,many asphalts and modified asphalts fail to satisfy long-term serviceability and durability criteria.Researchers are utilizing several asphalt modifiers to enhance the overall performance of flexible pavemen...Presently,many asphalts and modified asphalts fail to satisfy long-term serviceability and durability criteria.Researchers are utilizing several asphalt modifiers to enhance the overall performance of flexible pavements.This study consolidated findings from multiple research efforts on using nanomaterials for modifying SBS modified asphalt(SBS MA)and conducted a comprehensive literature review.Initially,it discussed the importance of SBS MA within asphalt modification systems and identified the key nanomaterials utilized in SBS modified asphalt.After this,it reviewed their preparation methods,dispersion and characterization techniques,and their impact on the key performance parameters of SBS MA binder and its mixture such as viscosity,rutting resistance,fatigue resistance,ageing and moisture damage etc.Additionally,it highlighted the advantages of nanomaterials over other modifiers.This study also addressed the challenges and limitations of incorporating nanomaterials in SBS MA.The findings indicated that when properly integrated,nanomaterials could significantly improve the performance of SBS MA,making them a promising addition to future road construction and maintenance projects.However,using nanomaterials for SBS MA modifications and mixtures has been challenged by limited practical applications,insufficient life cycle cost analyses,a lack of standardized guidelines,cost-effective nanomaterials and insufficient mixing procedures.Those areas require additional research to realise the potential application of nanomaterials in SBS modified asphalt modifications full.展开更多
In the context of diminishing energy resources and worsening greenhouse effect,thermoelectric materials have great potential for sustainable development due to their green and environmentally friendly characteristics....In the context of diminishing energy resources and worsening greenhouse effect,thermoelectric materials have great potential for sustainable development due to their green and environmentally friendly characteristics.Among inorganic thermoelectric materials,copper sulfide compounds have greater potential than others due to their abundant element reserves on Earth,lower usage costs,non-toxicity,and good biocompatibility.Compared to organic thermoelectric materials,the"phonon liquid-electron crystal"(PLEC)feature of copper sulfide compounds makes them have stronger thermoelectric performance.This review summarizes the latest research progress in the synthesis methods and thermoelectric modification strategies of copper sulfide compounds.It first explains the importance of the solid-phase method in the manufacture of thermoelectric devices,and then focuses on the great potential of nanoscale synthesis technology based on liquid-phase method in the preparation of thermoelectric materials.Finally,it systematically discusses several strategies for regulating the thermoelectric performance of copper sulfide compounds,including adjusting the chemical proportion of Cu_(2-x)S and introducing element doping to regulate the crystal structure,phase composition,chemical composition,band structure,and nanoscale microstructure of copper sulfide compounds,and directly affecting ZT value by adjusting conductivity and thermal conductivity.In addition,it discusses composite engineering based on copper sulfide compounds,including inorganic,organic,and metal compounds,and discusses tri-component compounds derived from sulfide copper.Finally,it discusses the main challenges and prospects of the development of copper sulfide-based thermoelectric materials,hoping that this review will promote the development of copper sulfide-based thermoelectric materials.展开更多
Amorphous two-dimensional transition metal oxide/(oxy)hydroxide(2D TMO/TMHO)nanomaterials(NMs)have the properties of both 2D and amorphous materials,displaying outstanding physicochemical qualities.Therefore,they demo...Amorphous two-dimensional transition metal oxide/(oxy)hydroxide(2D TMO/TMHO)nanomaterials(NMs)have the properties of both 2D and amorphous materials,displaying outstanding physicochemical qualities.Therefore,they demonstrate considerable promise for use in electrocatalytic water splitting applications.Here,the primary amorphization strategies for achieving the 2D TMO/TMHO NMs are comprehensively reviewed,including low-temperature reaction,rapid reaction,exchange/doping effect,ligand modulation,and interfacial energy confinement.By integrating these strategies with various physicochemical synthesis methods,it is feasible to control the amorphization of TMO/TMHO NMs while maintaining the distinctive benefits of their 2D structures.Furthermore,it delves into the structural advantages of amorphous 2D TMO/TMHO NMs in electrocatalytic water splitting,particularly emphasizing recent advancements in enhancing their electrocatalytic performance through interface engineering.The challenges and potential future directions for the precise synthesis and practical application of amorphous 2D TMO/TMHO NMs are also provided.This review aims to establish a theoretical foundation and offer experimental instructions for developing effective and enduring electrocatalysts for water splitting.展开更多
基金supported by the State Key Laboratory of Urban Water Resource and Environment (Harbin Institute of Technology) (No.2022TS13)the key projects of National Natural Science Foundation of China (No.2019YFC0408503)the Key Research Program of Wuhan (No.2022022202015015)。
文摘Antibiotic resistance genes(ARGs) are recognized as a primary threat to the sustainability of environment and human health in the 21^(st) century.Nanomaterials(NMs) have attracted substantial attention due to their unique dimensions and structures.Unfortunately,emerging evidence suggests that NMs may facilitate the transmission of ARGs.It is crucial to elucidate how NMs affect the evolution and dissemination of ARGs.The current review comprehensively examines the role of NMs in the widespread transmission of ARGs in aquatic environments and the underlying mechanisms involved in the process.It aims to clarify the effects and mechanisms of NMs on the horizontal gene transfer processes that are associated with ARGs,including the enhancement of cell membrane permeability,the formation of nanopores on membranes,promotion of mutagenesis,and the generation of reactive oxygen species(ROSs).Furthermore,the trade-off between the removal of ARGs and horizontal transfer has been elucidated.The review aspires to guide future research directions,advance knowledge on the implications of NMs in the field of ARGs' transmission,and provide a theoretical foundation for the development of safer and more effective applications of NMs.
基金supported by the Natural Science Foundation of Shanghai,No.22ZR147750Science and Technology Innovation Action Plan of Shanghai Science and Technology Commission,No.23Y11906600Shanghai Changzheng Hospital Innovative Clinical Research Project,No.2020YLCYJ-Y02(all to YY).
文摘Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the brain.Lysosomes,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular homeostasis.Some studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s disease.Restoring the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s disease.Currently,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and targeting.Recently,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical properties.This review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s disease.This review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal function.In conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s disease.The application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.
文摘Hepatocellular carcinoma(HCC)remains one of the most common cancers worldwide.Transcatheter arterial chemoembolization has become a common treatment modality for some patients with unresectable advanced HCC.Since the introduction of nanomaterials in 1974,their use in various fields has evolved rapidly.In medical applications,nanomaterials can serve as carriers for the delivery of chemotherapeutic drugs to tumour tissues.Additionally,nanomaterials have potential for in vivo tumour imaging.This article covers the properties and uses of several kinds of nanomaterials,focusing on their use in transcatheter arterial chemoembolization for HCC treatment.This paper also discusses the limitations currently associated with the use of nanomaterials.
基金supported by the Natural Science Foundation of Jiangsu Province(No.BK20200092)。
文摘Various chemical irrigants and drugs have been employed for intra-canal disinfection in root canal therapy(RCT).However,due to the complexity of root canal anatomy,many drugs still exhibit poor penetrability and antibiotic resistance,leading to suboptimal treatment outcomes.Thus,it is challenging to remove the organic biofilms from root canals.In recent years,light-responsive therapy,with deeper tissue penetration than traditional treatments,has emerged as an effective RCT modality.Herein,this review summarizes the recent development of light-responsive nanomaterials for biofilm removal in RCT.The light-responsive nanomaterials and the corresponding therapeutic methods in RCT,including photodynamic therapy(PDT),photothermal therapy(PTT),and laser-activated therapy,are highlighted.Finally,the challenges that light-responsive nanomaterials and treatment modalities will encounter to conquer the biofilm in future RCT are discussed.This review is believed to significantly accelerate the future development of light-responsive nanomaterials for RCT from bench to bedside.
文摘Lignocellulosic materials(LCMs),abundant biomass residues,pose significant environmental challenges when improperly disposed of.LCMs,such as sugarcane bagasse,rice straw,saw dust and agricultural residues,are abun-dant but often burned,contributing to air pollution and greenhouse gas emissions.This review explores the potential of transforming these materials into high-value carbon nanomaterials(CNMs).We explore the potential of transforming these materials into high-value CNMs.By employing techniques like carbonization and activa-tion,LCMs can be converted into various CNMs,including carbon nanotubes(CNTs),graphene(G),graphene oxide(GO),carbon quantum dots(CQDs),nanodiamonds(NDs),fullerenes(F),carbon nanofibers(CNFs),and others.Hybridizing different carbon allotropes further enhances their properties.CNMs derived from cellulose,lignin,and hemicellulose exhibit promising applications in diversefields.For instance,CNTs can be used in energy storage devices like batteries and supercapacitors due to their exceptional electrical conductivity and mechanical strength.Additionally,CNTs can be incorporated into recycled paper as afire retardant additive,enhancing itsflame resistance.G,renowned for its high surface area and excellent electrical conductivity,finds applications in electronics,sensors,catalysis,and water treatment,where it can be used to adsorb heavy metal ions.CQDs,owing to their unique optical properties,are used in bioimaging,drug delivery,and optoelectronic devices.By harnessing the potential of LCMs,we can not only mitigate environmental concerns but also contri-bute to a sustainable future.Continued research is essential to optimize synthesis methods,explore novel applica-tions,and unlock the full potential of these versatile materials.
基金supported by National Key Research and Development Program of China(No.2023YFF0613402)。
文摘Protein glycosylation and phosphorylation,as two of the most important protein post-translational modifications(PTMs),play key roles in living organisms.However,glycopeptides and phosphopeptides have low abundance in biological samples.In addition,the low ionization efficiency and the severe signal interference in the presence of other peptides present great difficulties for their direct mass spectrometry(MS)analysis.Therefore,it is important to develop feasible enrichment strategies to pretreat glycopeptides and phosphopeptides in complex samples before MS detection.This paper reviews the application of various magnetic nanomaterials(MNMs)in glycopeptides and phosphopeptides in the last decade,with emphasis on the enrichment principles,the design and synthesis process of the materials,and the effectiveness of the application in biological samples.In addition,possible future trends and potential challenges are presented.
基金supported by the National Natural Science Foundation of China(Nos.52272290,21972030,52073119,and 52373210)the Natural Science Foundation of Jilin Province(No.20230101029JC)+1 种基金the Fundamental Research Program of Shanxi Province(No.202303021212159)the Monash University Malaysia–ASEAN grant(No.ASE-000010)。
文摘Environmental catalysis has been considered one of the important research topics.Some technologies(e.g.,photocatalysis and electrocatalysis)have been intensively developed with the advance of synthetic technologies of catalytical materials.In 2019,we discussed the development trend of this field,and wrote a roadmap on this topic in Chinese Chemical Letters(30(2019)2065-2088).Nowadays,we discuss it again from a new viewpoint along this road.In this paper,several subtopics are discussed,e.g.,photocatalysis based on titanium dioxide,violet phosphorus,graphitic carbon and covalent organic frameworks,electrocatalysts based on carbon,metal-and covalent-organic framework.Finally,we hope that this roadmap can enrich the development of two-dimensional materials in environmental catalysis with novel understanding,and give useful inspiration to explore new catalysts for practical applications.
基金supported by the Jiangsu Funding Program for Excellent Postdoctoral Talent (Grant No.2023ZB397)the Project funded by China Postdoctoral Science Foundation (Grant No.2023M732986).
文摘Nanomaterials have garnered recognition for their notable surface effects and demonstration of superior mechanical properties.Previous studies on the surface effects of nanomaterials,employing the finite element method,often relied on simplified twodimensional models due to theoretical complexities.Consequently,these simplified models inadequately represent the mechanical properties of nanomaterials and fail to capture the substantial impact of surface effects,particularly the curvature dependence of nanosurfaces.This study applies the principle of minimum energy and leverages the Steigmann-Ogden surface theory of nanomaterials to formulate a novel finite element surface element that comprehensively accounts for surface effects.We conducted an analysis of the stress distribution and deformation characteristics of four typical 2D and 3D nanomaterial models.The accuracy of the developed surface element and finite element calculation method was verified through comparison with established references.The resulting finite element model provides a robust and compelling scientific approach for accurately predicting the mechanical performance of nanomaterials.
文摘Carbon nanotubes(CNTs),black phosphorus nanotubes(BPNTs),and graphene derivatives exhibit significant promise for applications in nano-electromechanical systems(NEMS),energy storage,and sensing technologies due to their exceptional mechanical,electrical,and thermal properties.This review summarizes recent advances in understanding the dynamic behaviors of these nanomaterials,with a particular focus on insights gained from molecular dynamics(MD)simulations.Key areas discussed include the oscillatory and rotational dynamics of double-walled CNTs,fabrication and stability challenges associated with BPNTs,and the emerging potential of graphyne nanotubes(GNTs).The review also outlines design strategies for enhancing nanodevice performance and underscores the importance of future efforts in experimental validation,multi-scale coupling analyses,and the development of novel nanocomposites to accelerate practical deployment.
基金supported by National Natural Science Foundation of China(No.U21A20290)。
文摘Human life quality requires both industrial/agricultural fast development and high environmental quality.However,the two aspects are conflicted as some contaminants are accidentally released into the environment,potentially harmful to human health even at extra-low concentrations.
基金financially supported by the Sichuan Science and Technology Program(Nos.2023ZYD0064 and 2023YFG0220)the Fundamental Research Funds for the Central Universities(No.YJ202242)the Research Funding from West China School/Hospital of Stomatology,Sichuan University(No.QDJF2022–2).
文摘Thermoelectric(TE)materials,with the ability to convert heat into electrical energy,can generate micro-electrical fields at electronic interfaces with biological systems,making them applicable in electric-catalyzing as nanozymes,and modulate the infected microenvironment of skin wounds.Thereby,by harnessing temperature differences in vitro or in vivo,TE nanomaterials can provide antimicrobial reactive oxygen species(ROS)by catalyzing redox reactions,thereby accelerating wound healing by suppressing infection.However,despite their promising potential,there is still a lack of comprehensive understanding of the antimicrobial mechanisms,biocompatibility,and practical applications of TE nanomaterials in wound healing,as this is a newly-emerged sub-area of energy-related biomedical applications.This review aims to address this gap by highlighting the emerging progress of TE materials in wound healing,clarifying their mechanism and advances,emphasizing their potential challenges for commercialization and clinical use,and proposing novel design strategies of TE nanomaterials for effective antibacterial performance.
基金the financial support from the National Natural Science Foundation of China(No.82270756)the Basic and Applied Basic Research Foundation of Guangdong Province,China(Nos.2414050006150,2024A1515011405)+2 种基金the Science and Technology Project of Guangzhou,China(No.202102010133)the Science and Technology Project of Heyuan,China(Nos.230510171473346,230510171473347)the Medical Joint Fund of Jinan University。
文摘Renal cell carcinoma(RCC)as one of the most commonly diagnosed cancers threatens human health.The treatment of RCC demands more advanced protocols for better prognosis and higher quality of life.In recent years,the blooming of nanomaterials in various fields demonstrates its critical role as one of the most important components in constructing a smart therapeutic platform against RCC.Herein,focusing on the therapeutic inorganic nanomaterials(such as carbon nanomaterials,metal nanomaterials,oxide nanomaterials),their functions as drug carriers,external field sensitizers,and/or RCC microenvironment sensitizers are analyzed.In combination with the advantages of nanomaterial and RCC characteristics,the trends in integrating nanomaterial to construct multifunctional theranostic platforms for RCC treatment are highlighted.Also,possible solutions concerning the life trajectory and long-term toxicity of nanomaterials are put forward.These perspectives may promote the development of smarter and more effective systems for comprehensive RCC treatment.
基金supported by the National Natural Science Foundation of China(No.51874036)the Natural Science Foundation of Ningxia(No.2024AAC02034)。
文摘Two-dimensional(2D) nanomaterials have always been regarded as having great development potential in the field of oil-based lubrication due to their designable structures,functional groups,and abundant active sites.However,understanding the structure-performance relationship between the chemical structure of 2D nanomaterials and their lubrication performance from a comprehensive perspective is crucial for guiding their future development.This review provides a timely and comprehensive overview of the applications of 2D nanomaterials in oil-based lubrication.First,the bottlenecks and mechanisms of action of 2D nanomaterials are outlined,including adsorption protective films,charge adsorption effects,tribochemical reaction films,interlayer slip,and synergistic effects.On this basis,the review summarizes recent structural regulation strategies for 2D nanomaterials,including doping engineering,surface modification,structural optimization,and interfacial mixing engineering.Then,the focus was on analyzing the structure-performance relationship between the chemical structure of 2D nanomaterials and their lubrication performance.The effects of thickness,number of layers,sheet diameter,interlayer spacing,Moiré patterns,wettability,functional groups,concentration,as well as interfacial compatibility and dispersion behavior of 2D nanomaterials were systematically investigated in oil-based lubrication,with the intrinsic correlations resolved through computational simulations.Finally,the review offers a preliminary summary of the significant challenges and future directions for 2D nanomaterials in oil-based lubrication.This review aims to provide valuable insights and development strategies for the rational design of high-performance oil-based lubrication materials.
基金financially supported by the National Natural Science Foundation of China(Nos.52103184 and 8226030956)the National Key Research and Development Program of China(No.2022YFC2407503)+3 种基金Key Project of the Natural Science Basic Research Plan of Shaanxi Province(No.2022JZ43)Natural Science Basic Research Program of Shaanxi Province(No.2024JCYBQN-0874)Medical Research Key Project of Xi'an Science and Technology Bureau(No.2024JH-YXZD-0055)Medical Research Project of Xi'an Science and Technology Bureau(No.22YXYJ0083)
文摘Owing to their unique biological effects and physicochemical properties,nanomaterials have garnered substantial attention in the field of bone tissue engineering(BTE),targeting the repair and restoration of impaired bone tissue.In recent years,strategies for the design and optimization of nanomaterials through thiolation modification have been widely applied in BTE.This review concisely summarizes the categories of nanomaterials commonly used in BTE and focuses on various strategies for the modification of nanomaterials via thiolation.A multifaceted analysis of the mechanisms by which thiolated nanomaterials enhance nanomaterial-cell interactions,promote drug loading and release,and modulate osteogenic differentiation is presented.Furthermore,this review introduces biomedical applications of thiolated nanomaterials in BTE,including as scaffold components for bone regeneration,coatings for bone implants,and drug delivery systems.Finally,the future perspectives and challenges in the development of this field are discussed.Thiolation modification strategies provide a platform for developing new ideas and methods for designing nanomaterials for BTE and are expected to accelerate the development and clinical translation of novel bone repair materials.
基金financially supported by National Natural Science Foundation of China (No. 21601137)Basic Science and Technology Research Project of Wenzhou, Zhejiang Province (No. G20240038)+2 种基金the Special Basic Cooperative Research Programs of Yunnan Provincial Undergraduate Universities Association (Nos. 202101BA070001-031, 202101BA070001-042 and 202301BA070001-093)Yunnan Province Young and Middle-aged Academic and Technical Leaders Reserve Talent Project (No. 202105AC160060)Yunnan Province High-level Talent Training Support Program “Youth Top Talent” Project (2020)。
文摘The development of cost-effective and high-efficiency catalysts for sustainable hydrogen production through electrocatalytic hydrogen evolution reaction(HER) is crucial yet remains challenging. In this work, we synthesized two types of bimetallic Pt Ni nanoparticles embedded in N-doped porous carbons derived from Ni-ABDC(5-aminoisophthalate) using both in-situ and ex-situ Pt inclusion methods. The in-situ Pt doping notably disrupted the effective growth of Ni-ABDC nanostrips owing to strong interactions between Pt and ABDC, resulting in an amorphous nanostructure. The optimized PtinNi-NC exhibited remarkable HER performance with a low overpotential of 29 mV at 10 mA/cm^(2), a Tafel slope of 47.4 mV/dec, and a current retention of 91.2% after 200 h in 1.0 mol/L KOH solution, surpassing the performance of Ni-NC, PtexNi-NC, and Pt/C. This research demonstrates the rational design and preparation of transition metal-based coordination polymer-derived metal-carbon nanomaterials with low Pt loading,emphasizing their considerable potential in energy conversion and storage technologies.
基金supported by the National Key R&D Program of China(No.2022YFB3804204)the National Natural Science Foundation of China(Nos.52127805,52102090,12172005,and 12325202)+1 种基金the Fundamental Research Funds for the Central Uni-versities(No.2232022D-04)the Innovation and Development Sup-port Plan for Key Industries in Southern Xinjiang(No.2022DB011).
文摘Nanomaterials are extensively utilized in a multitude of sectors,but their propensity to aggregate can considerably diminish the efficacy of functional materials.A pivotal challenge in this domain is achieving a homogenous distribution of nanomaterials,which is essential for enhancing their performance while also reducing production costs.In this work,we achieve uniform and stable dispersion of various nano-materials through the confinement effect generated by the stereocomplex cross-linked network formed by the combination of poly(L-lactic)acid and poly(D-lactic)acid.The unique confinement effect of poly-lactic acid(PLA)isomers is universal and significantly enhances the dispersion of nanomaterials in both PLA solutions and films.To demonstrate the efficacy of our approach,we disperse aggregation-induced emission(AIE)molecules within PLA,which leads to the production of PLA films exhibiting improved fluorescence property.This work provides an effective solution for the preparation of nanocomposite ma-terials that are both high-performing and cost-efficient.
基金supported by the National Natural Science Foundation of China(Grant No.22402030)the Fujian Province Young and Middle-Aged Teacher Education Research Project(JZ240012)+1 种基金I.S.A.acknowledges funding support from Research Ireland under the SFI-IRC Pathway Program(Grant no:22/PATH-S/10725)the SFI Industry RD&I Fellowship Program(Grant no:21/IRDIF/9876).
文摘Ultrafast Joule heating(JH)has emerged as a powerful and scalable platform for rapid thermal processing of advanced nanomaterials.By delivering transient,high-intensity electrical pulses,JH induces ultrafast heating and cooling rates on the order of milliseconds,facilitating nonequilibrium phase transitions,defect modulation,and tailored nanostructural evolution.This technique offers unprecedented control over material synthesis and has been successfully applied to a broad spectrum of functional property-driven materials,including graphene,single-atom catalysts,transition metal carbides,oxides,nitrides,phosphides,and chalcogenides,as well as complex multicomponent frameworks such as high-entropy alloys.This review systematically explores the principles governing JH,highlights recent advances in its application to diverse materials systems,and critically assesses current limitations related to process uniformity,scalability,and mechanistic understanding.Particular attention is given to its intrinsic advantages,including energy efficiency,fast rate,environmental sustainability,and compatibility with sustainable manufacturing.Finally,we propose guidance for expanding the utility of JH for new materials discovery,including integration with in-situ diagnostics,theoretical compatibility and data-driven optimization of synthesis to effectively correlate structure-property relationships.
基金supported by the Key R&D Project in Shaanxi Province(No.2024GX-YBXM-371)Shaanxi Qinchuangyuan“Scientists+Engineers”Team Construction Project(2025QCY-KXJ-141).
文摘Presently,many asphalts and modified asphalts fail to satisfy long-term serviceability and durability criteria.Researchers are utilizing several asphalt modifiers to enhance the overall performance of flexible pavements.This study consolidated findings from multiple research efforts on using nanomaterials for modifying SBS modified asphalt(SBS MA)and conducted a comprehensive literature review.Initially,it discussed the importance of SBS MA within asphalt modification systems and identified the key nanomaterials utilized in SBS modified asphalt.After this,it reviewed their preparation methods,dispersion and characterization techniques,and their impact on the key performance parameters of SBS MA binder and its mixture such as viscosity,rutting resistance,fatigue resistance,ageing and moisture damage etc.Additionally,it highlighted the advantages of nanomaterials over other modifiers.This study also addressed the challenges and limitations of incorporating nanomaterials in SBS MA.The findings indicated that when properly integrated,nanomaterials could significantly improve the performance of SBS MA,making them a promising addition to future road construction and maintenance projects.However,using nanomaterials for SBS MA modifications and mixtures has been challenged by limited practical applications,insufficient life cycle cost analyses,a lack of standardized guidelines,cost-effective nanomaterials and insufficient mixing procedures.Those areas require additional research to realise the potential application of nanomaterials in SBS modified asphalt modifications full.
文摘In the context of diminishing energy resources and worsening greenhouse effect,thermoelectric materials have great potential for sustainable development due to their green and environmentally friendly characteristics.Among inorganic thermoelectric materials,copper sulfide compounds have greater potential than others due to their abundant element reserves on Earth,lower usage costs,non-toxicity,and good biocompatibility.Compared to organic thermoelectric materials,the"phonon liquid-electron crystal"(PLEC)feature of copper sulfide compounds makes them have stronger thermoelectric performance.This review summarizes the latest research progress in the synthesis methods and thermoelectric modification strategies of copper sulfide compounds.It first explains the importance of the solid-phase method in the manufacture of thermoelectric devices,and then focuses on the great potential of nanoscale synthesis technology based on liquid-phase method in the preparation of thermoelectric materials.Finally,it systematically discusses several strategies for regulating the thermoelectric performance of copper sulfide compounds,including adjusting the chemical proportion of Cu_(2-x)S and introducing element doping to regulate the crystal structure,phase composition,chemical composition,band structure,and nanoscale microstructure of copper sulfide compounds,and directly affecting ZT value by adjusting conductivity and thermal conductivity.In addition,it discusses composite engineering based on copper sulfide compounds,including inorganic,organic,and metal compounds,and discusses tri-component compounds derived from sulfide copper.Finally,it discusses the main challenges and prospects of the development of copper sulfide-based thermoelectric materials,hoping that this review will promote the development of copper sulfide-based thermoelectric materials.
基金supported by the National Key Research and Development Program of China(No.2018YFA0703700)the National Natural Science Foundation of China(No.12034002)the Interdisciplinary Research Project for Young Teachers of USTB(Fundamental Research Funds for the Central Universities,No.FRF-IDRY-23-033)。
文摘Amorphous two-dimensional transition metal oxide/(oxy)hydroxide(2D TMO/TMHO)nanomaterials(NMs)have the properties of both 2D and amorphous materials,displaying outstanding physicochemical qualities.Therefore,they demonstrate considerable promise for use in electrocatalytic water splitting applications.Here,the primary amorphization strategies for achieving the 2D TMO/TMHO NMs are comprehensively reviewed,including low-temperature reaction,rapid reaction,exchange/doping effect,ligand modulation,and interfacial energy confinement.By integrating these strategies with various physicochemical synthesis methods,it is feasible to control the amorphization of TMO/TMHO NMs while maintaining the distinctive benefits of their 2D structures.Furthermore,it delves into the structural advantages of amorphous 2D TMO/TMHO NMs in electrocatalytic water splitting,particularly emphasizing recent advancements in enhancing their electrocatalytic performance through interface engineering.The challenges and potential future directions for the precise synthesis and practical application of amorphous 2D TMO/TMHO NMs are also provided.This review aims to establish a theoretical foundation and offer experimental instructions for developing effective and enduring electrocatalysts for water splitting.
