A novel adaptive detection scheme both for point-like and distributed targets in the presence of Gaussian disturbance in the partial y homogeneous environment （PHE） is proposed. The novel detection scheme is based o...A novel adaptive detection scheme both for point-like and distributed targets in the presence of Gaussian disturbance in the partial y homogeneous environment （PHE） is proposed. The novel detection scheme is based on the orthogonal projection technique. Both the case of known covariance matrix structure and the case of unknown covariance matrix structure are con-sidered. For the former case, the closed-form statistical pro-perty of the novel detectors is derived. When the covariance matrix is unknown, the corresponding detectors have higher probabilities of detection （PDs） than their natural competitors. Moreover, they ensure constant false alarm rate （CFAR） property.展开更多
Seminal plasma is a rich source of proteins and serves as an ideal sample for proteomic analysis of male infertility.In varicoceleassociated in fertility,the contributory role of semi nal plasma proteins specific to u...Seminal plasma is a rich source of proteins and serves as an ideal sample for proteomic analysis of male infertility.In varicoceleassociated in fertility,the contributory role of semi nal plasma proteins specific to un ilateral and bilateral varicocele is not clear.Furthermore,there is a lack of specific protein biomarker to differentiate bilateral from unilateral varicocele.The main objective is to identify the differentially regulated molecular and cellular pathways in bilateral varicocele?Furthermore,we intend to identify seminal plasma biomarkers to differentiate bilateral and unilateral varicocele patients in comparison with fertile healthy men.Global proteomic an alysis of seminal plasma protei ns has identified the function ality of d iff ere ntially expressed proteins(DEPs)in varicocele patients.Bioinformatic analysis has revealed response to reactive oxygen species and oxidative stress,and tissue homeostasis as top process pathways that are affected in bilateral varicocele patients compared to fertile healthy men.In comparison with unilateral varicocele patients,inflammatory response pathways were dysregulated,especially interleukin 6(IL-6)signaling and Janus kinasesignal transducer and activator of transcription(Jak?STAT)pathways,in bilateral varicocele patients,owing to the involvement of underexpressed DEPs.Key DEPs associated with oxidative stress(peroxiredoxin 2;PRDX2),DNA fragmentation(fatty acid synthase;FASN),and inflammatory resp onse(fibr on ectin 1;FN1)validated by western blot analysis revealed differential expressi on of these proteins in unilateral and bilateral varicocele groups.Altered expression of DEPs and its association with key processes show that the seminal plasma homeostasis is compromised in bilateral varicocele patients?Furthermore,we propose PRDX2,FASN,and FN1 as potential noninvasive seminal plasma markers for the differentiation of unilateral and bilateral varicocele patients.展开更多
AIM: To investigate the frequency of seropositivity aga- inst CagA, VacA proteins and to determine their indepen- dent effects on the development of duodenal ulcer (DU) in Turkish patients. METHODS: The study was desi...AIM: To investigate the frequency of seropositivity aga- inst CagA, VacA proteins and to determine their indepen- dent effects on the development of duodenal ulcer (DU) in Turkish patients. METHODS: The study was designed as a prospective one from a tertiary referral hospital. Dyspeptic patients who were referred to our endoscopy unit for upper gas- trointestinal endoscopy between June 2003 and March 2004 and diagnosed to have DU or nonulcer dyspepsia (NUD) were included. Biopsies from the antrum and body of the stomach were taken in order to assess the current H pylori status by histology, rapid urease test and culture. Fasting sera were obtained from all patients and H pylori status of all sera was determined by IgG antibo- dies using an enzyme-linked immunosorbent assay (ELI- SA) kit. All seropositive patients were further analysed using Western blot assays detecting IgG antibodies aga- inst CagA and VacA proteins. The χ2 test was used for statistical comparison of the values and age-sex adjusted multiple regression analysis was used to determine the independent effects of CagA and VacA seropositivities on the development of DU. RESULTS: Sixty-three patients with DU and 62 patients with NUD were eligible for the final analysis. Seropositi- vity for anti-CagA was detected in 51 of 62 (82%), andin 55 of 63 (87%) patients with NUD and DU, respec- tively (p = no significance), and seropositivity for anti- VacA was found in 25 of 62 (40% ) and in 16 of 63 (25%) patients, with NUD and DU, respectively. CONCLUSION: These findings suggest that none of the- se virulence factors is associated with the development of DU in the studied Turkish patients with dyspepsia.展开更多
基金supported by the National Natural Science Foundation of China(61102169)the Outstanding Youth Fund of the National Natural Science Foundation of China(60925005)
文摘A novel adaptive detection scheme both for point-like and distributed targets in the presence of Gaussian disturbance in the partial y homogeneous environment （PHE） is proposed. The novel detection scheme is based on the orthogonal projection technique. Both the case of known covariance matrix structure and the case of unknown covariance matrix structure are con-sidered. For the former case, the closed-form statistical pro-perty of the novel detectors is derived. When the covariance matrix is unknown, the corresponding detectors have higher probabilities of detection （PDs） than their natural competitors. Moreover, they ensure constant false alarm rate （CFAR） property.
文摘Seminal plasma is a rich source of proteins and serves as an ideal sample for proteomic analysis of male infertility.In varicoceleassociated in fertility,the contributory role of semi nal plasma proteins specific to un ilateral and bilateral varicocele is not clear.Furthermore,there is a lack of specific protein biomarker to differentiate bilateral from unilateral varicocele.The main objective is to identify the differentially regulated molecular and cellular pathways in bilateral varicocele?Furthermore,we intend to identify seminal plasma biomarkers to differentiate bilateral and unilateral varicocele patients in comparison with fertile healthy men.Global proteomic an alysis of seminal plasma protei ns has identified the function ality of d iff ere ntially expressed proteins(DEPs)in varicocele patients.Bioinformatic analysis has revealed response to reactive oxygen species and oxidative stress,and tissue homeostasis as top process pathways that are affected in bilateral varicocele patients compared to fertile healthy men.In comparison with unilateral varicocele patients,inflammatory response pathways were dysregulated,especially interleukin 6(IL-6)signaling and Janus kinasesignal transducer and activator of transcription(Jak?STAT)pathways,in bilateral varicocele patients,owing to the involvement of underexpressed DEPs.Key DEPs associated with oxidative stress(peroxiredoxin 2;PRDX2),DNA fragmentation(fatty acid synthase;FASN),and inflammatory resp onse(fibr on ectin 1;FN1)validated by western blot analysis revealed differential expressi on of these proteins in unilateral and bilateral varicocele groups.Altered expression of DEPs and its association with key processes show that the seminal plasma homeostasis is compromised in bilateral varicocele patients?Furthermore,we propose PRDX2,FASN,and FN1 as potential noninvasive seminal plasma markers for the differentiation of unilateral and bilateral varicocele patients.
文摘AIM: To investigate the frequency of seropositivity aga- inst CagA, VacA proteins and to determine their indepen- dent effects on the development of duodenal ulcer (DU) in Turkish patients. METHODS: The study was designed as a prospective one from a tertiary referral hospital. Dyspeptic patients who were referred to our endoscopy unit for upper gas- trointestinal endoscopy between June 2003 and March 2004 and diagnosed to have DU or nonulcer dyspepsia (NUD) were included. Biopsies from the antrum and body of the stomach were taken in order to assess the current H pylori status by histology, rapid urease test and culture. Fasting sera were obtained from all patients and H pylori status of all sera was determined by IgG antibo- dies using an enzyme-linked immunosorbent assay (ELI- SA) kit. All seropositive patients were further analysed using Western blot assays detecting IgG antibodies aga- inst CagA and VacA proteins. The χ2 test was used for statistical comparison of the values and age-sex adjusted multiple regression analysis was used to determine the independent effects of CagA and VacA seropositivities on the development of DU. RESULTS: Sixty-three patients with DU and 62 patients with NUD were eligible for the final analysis. Seropositi- vity for anti-CagA was detected in 51 of 62 (82%), andin 55 of 63 (87%) patients with NUD and DU, respec- tively (p = no significance), and seropositivity for anti- VacA was found in 25 of 62 (40% ) and in 16 of 63 (25%) patients, with NUD and DU, respectively. CONCLUSION: These findings suggest that none of the- se virulence factors is associated with the development of DU in the studied Turkish patients with dyspepsia.
