目的探究不同亚型重性抑郁障碍(major depressive disorder,MDD)患者事件相关电位(event-related potential,ERP)N170差异。方法纳入MDD患者和健康对照,采用30项抑郁症状量表(30-item inventory of depressive symptomatology,IDS-30)...目的探究不同亚型重性抑郁障碍(major depressive disorder,MDD)患者事件相关电位(event-related potential,ERP)N170差异。方法纳入MDD患者和健康对照,采用30项抑郁症状量表(30-item inventory of depressive symptomatology,IDS-30)、17项汉密尔顿抑郁量表(17-item Hamilton depression rating scale,HAMD-17)将患者分为焦虑型、忧郁型、混合型。对所有受试者评估重复性成套神经心理状态测验(repeatable battery for the assessment of neuropsychological status,RBANS),采集中性面孔刺激任务下N170波幅与潜伏期。结果共纳入74例焦虑型(anxious-somatizing depression,ASD)、40例忧郁型(melancholic depression,MD)、66例混合型MDD患者,以及38名对照。焦虑型、混合型HAMD-17总分、焦虑分比忧郁型高(P<0.05)。焦虑型、混合型RBANS总分低于对照组[中位数及四分位数:449(419,488)vs.481(419,500)vs.507.5(474,542),P<0.05]。事件相关电位N170经重复测量方差分析显示,分组和电极点对波幅有交互作用(P<0.05),其中在Pz电极点,混合型波幅比对照组低[(2.96±4.61)μV vs.(4.75±5.00)μV],差异有统计学意义(P<0.05)。结论焦虑型与混合型MDD患者抑郁症状及认知功能损害比忧郁型严重。在中性情绪面孔刺激下,混合型患者存在面孔认知功能障碍。展开更多
Objective The left-lateralized N170, an event-related potential component consistently shown in response to alphabetic words, is a robust electrophysiological marker for reading expertise in an alphabetic language. In...Objective The left-lateralized N170, an event-related potential component consistently shown in response to alphabetic words, is a robust electrophysiological marker for reading expertise in an alphabetic language. In contrast, such a marker is lacking for expertise in reading Chinese, because the existing results about the lateralization of N170 for Chinese characters are mixed, reflecting complicated factors such as top-down modulation that contribute to the relative magnitudes of N170 in the left and right hemispheres. The present study aimed to explore a potential electrophysiological marker for reading expertise in Chinese with minimal top-down influence. Methods We recorded N170 responses to Chinese characters and three kinds of control stimuli in a content-irrelevant task, minimizing potential top-down effects. Results Direct comparison of the N170 amplitude in response to Chinese characters between the hemispheres showed a marginally significant left-lateralization effect. However, detailed analyses of N170 in each hemisphere revealed a more robust pattern of left-lateralization - the N170 in the left but not the right hemisphere differentiated Chinese characters from control stimuli. Conclusion These results suggest that the selectivity of N170 （a greater N170 in response to Chinese characters than to control stimuli） within the left hemisphere rather than the hemispheric difference of N170 with regard to Chinese characters is an electrophysiological marker for expertise in reading Chinese.展开更多
文摘目的探究不同亚型重性抑郁障碍(major depressive disorder,MDD)患者事件相关电位(event-related potential,ERP)N170差异。方法纳入MDD患者和健康对照,采用30项抑郁症状量表(30-item inventory of depressive symptomatology,IDS-30)、17项汉密尔顿抑郁量表(17-item Hamilton depression rating scale,HAMD-17)将患者分为焦虑型、忧郁型、混合型。对所有受试者评估重复性成套神经心理状态测验(repeatable battery for the assessment of neuropsychological status,RBANS),采集中性面孔刺激任务下N170波幅与潜伏期。结果共纳入74例焦虑型(anxious-somatizing depression,ASD)、40例忧郁型(melancholic depression,MD)、66例混合型MDD患者,以及38名对照。焦虑型、混合型HAMD-17总分、焦虑分比忧郁型高(P<0.05)。焦虑型、混合型RBANS总分低于对照组[中位数及四分位数:449(419,488)vs.481(419,500)vs.507.5(474,542),P<0.05]。事件相关电位N170经重复测量方差分析显示,分组和电极点对波幅有交互作用(P<0.05),其中在Pz电极点,混合型波幅比对照组低[(2.96±4.61)μV vs.(4.75±5.00)μV],差异有统计学意义(P<0.05)。结论焦虑型与混合型MDD患者抑郁症状及认知功能损害比忧郁型严重。在中性情绪面孔刺激下,混合型患者存在面孔认知功能障碍。
基金supported by National Natural Science Foundation of China (31070905,30870779)
文摘Objective The left-lateralized N170, an event-related potential component consistently shown in response to alphabetic words, is a robust electrophysiological marker for reading expertise in an alphabetic language. In contrast, such a marker is lacking for expertise in reading Chinese, because the existing results about the lateralization of N170 for Chinese characters are mixed, reflecting complicated factors such as top-down modulation that contribute to the relative magnitudes of N170 in the left and right hemispheres. The present study aimed to explore a potential electrophysiological marker for reading expertise in Chinese with minimal top-down influence. Methods We recorded N170 responses to Chinese characters and three kinds of control stimuli in a content-irrelevant task, minimizing potential top-down effects. Results Direct comparison of the N170 amplitude in response to Chinese characters between the hemispheres showed a marginally significant left-lateralization effect. However, detailed analyses of N170 in each hemisphere revealed a more robust pattern of left-lateralization - the N170 in the left but not the right hemisphere differentiated Chinese characters from control stimuli. Conclusion These results suggest that the selectivity of N170 （a greater N170 in response to Chinese characters than to control stimuli） within the left hemisphere rather than the hemispheric difference of N170 with regard to Chinese characters is an electrophysiological marker for expertise in reading Chinese.
