Based on the diversified technology and the cross-validation mechanism,the N-variant system provides a secure service architecture for cloud providers to protect the cloud applications from attacks by executing multip...Based on the diversified technology and the cross-validation mechanism,the N-variant system provides a secure service architecture for cloud providers to protect the cloud applications from attacks by executing multiple variants of a single software in parallel and then checking their behaviors’consistency.However,it is complex to upgrade current Software as a Service(SaaS)applications to adapt N-variant system architecture.Challenges arise from the inability of tenants to adjust the application architecture in the cloud environment,and the difficulty for cloud service providers to implement N-variant systems using existing API gateways.This paper proposes SecIngress,an API gateway framework,to overcome the challenge that it is hard in the cloud environment to upgrade the applications based on N-variants system.We design a two-stage timeout processing method to lessen the service latency and an Analytic Hierarchy Process Voting under the Metadata mechanism(AHPVM)to enhance voting accuracy.We implement a prototype in a testbed environment and analyze the security and performance metrics before and after deploying the prototype to show the effectiveness of SecIngress.The results reveal that SecIngress enhances the reliability of cloud applications with acceptable performance degradation.展开更多
Throughout history, humanity has referred to reactions occurring with food, plants and, recently, medicines or drugs. The increase in pulmonary tuberculosis cases and the availability of treatment showed that genetic ...Throughout history, humanity has referred to reactions occurring with food, plants and, recently, medicines or drugs. The increase in pulmonary tuberculosis cases and the availability of treatment showed that genetic human differences can interfere in the capacity to metabolize drugs. There are remarkable genetic polymorphisms of N-acetyltransferase 2 (NAT2) activity that have been associated with different levels of susceptibility to developing many kinds of cancers. This review considers the field as an open window for the application of molecular epidemiology tools that led to the development of pharmacogenomics. We cover historical data and the most recent knowledge about NAT2 genetic polymorphisms and its distribution in different populations, which is an important concept being incorporated in epidemiological studies of cancer risk. We present up to date information about these studies, including meta-analysis based on the NAT2 distribution in different types of cancer. A critical broad at advances in NAT2 research, high-lighting recent studies related to NAT2 alleles in cancer susceptibility. Although there are multifactorial aspects involved in cancer risk, the variability in NAT2 allelic frequency can be related to carcinogenesis through alterations in the metabolic rate after exposure to carcinogens.展开更多
基金the Foundation of the National Natural Science Foundation of China(62072467)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(61521003)the Foundation of the National Natural Science Foundation of China(62002383).
文摘Based on the diversified technology and the cross-validation mechanism,the N-variant system provides a secure service architecture for cloud providers to protect the cloud applications from attacks by executing multiple variants of a single software in parallel and then checking their behaviors’consistency.However,it is complex to upgrade current Software as a Service(SaaS)applications to adapt N-variant system architecture.Challenges arise from the inability of tenants to adjust the application architecture in the cloud environment,and the difficulty for cloud service providers to implement N-variant systems using existing API gateways.This paper proposes SecIngress,an API gateway framework,to overcome the challenge that it is hard in the cloud environment to upgrade the applications based on N-variants system.We design a two-stage timeout processing method to lessen the service latency and an Analytic Hierarchy Process Voting under the Metadata mechanism(AHPVM)to enhance voting accuracy.We implement a prototype in a testbed environment and analyze the security and performance metrics before and after deploying the prototype to show the effectiveness of SecIngress.The results reveal that SecIngress enhances the reliability of cloud applications with acceptable performance degradation.
文摘Throughout history, humanity has referred to reactions occurring with food, plants and, recently, medicines or drugs. The increase in pulmonary tuberculosis cases and the availability of treatment showed that genetic human differences can interfere in the capacity to metabolize drugs. There are remarkable genetic polymorphisms of N-acetyltransferase 2 (NAT2) activity that have been associated with different levels of susceptibility to developing many kinds of cancers. This review considers the field as an open window for the application of molecular epidemiology tools that led to the development of pharmacogenomics. We cover historical data and the most recent knowledge about NAT2 genetic polymorphisms and its distribution in different populations, which is an important concept being incorporated in epidemiological studies of cancer risk. We present up to date information about these studies, including meta-analysis based on the NAT2 distribution in different types of cancer. A critical broad at advances in NAT2 research, high-lighting recent studies related to NAT2 alleles in cancer susceptibility. Although there are multifactorial aspects involved in cancer risk, the variability in NAT2 allelic frequency can be related to carcinogenesis through alterations in the metabolic rate after exposure to carcinogens.
