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Antipyretic and anticonvulsant activity of n-hexane fraction of viola betonicifolia
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作者 Naveed Muhammad Muhammad Saeed +2 位作者 Haroon Khan Naila Raziq Syed Muhammad Ashhad Halimi 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2013年第4期280-283,共4页
Objective:To investigate the antipyretic and anticonvulsant activities of n-hexane fraction of Viola betonicifolia(V.betonicifolia).Methods:The antipyretic effect was scrutinized using brewer's yeast induced pyrex... Objective:To investigate the antipyretic and anticonvulsant activities of n-hexane fraction of Viola betonicifolia(V.betonicifolia).Methods:The antipyretic effect was scrutinized using brewer's yeast induced pyrexia and anticonvlsion effect was tested using pentylenetetrazol and strychnine induced convulsion in mice.Results:N-hexane fraction of V.betonicifolia demonstrated highly significant antipyretic activity during various assessment times(1-5 h)when challenged in yeast induced pyrexia test.The effect was in a dose dependent manner with maximum attenuation(82.50%)observed at 300 mg/kg i.p.When tested in pentylenetetrazol induced convulsion test,the 1st stage(Ear and facial twitching)and 2nd stage(Convulsive wave through the body)was 100%protected during 24 h at all the test doses(300,400 and 500 mg/kg i.p.),while the latency time of remaining stages was significantly increased.The maximum effect was observed by n-hexane fraction of V.betonicifolia at 400 and 500 mg/kg i.p.,as the latency time for generalized clonic-tonic seizure(5th stage)was increased up to 25.34 min.However,n-hexane fraction of V.betonicifolia had no protection in strychnine induced convulsion test.Conclusions:In conclusion,phytopharmacological studies provide scientific foundation to the folk uses of the plant in the treatment of pyrexia and neurological disorders. 展开更多
关键词 VIOLA betonicifolia n-hexane fraction ANTIPYRETIC ANTICONVULSANT
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GC/MS analyses of fractionated extraction of Shenfu coal with CS2,n-hexane,benzene 被引量:2
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作者 王晓华 魏贤勇 《Journal of Coal Science & Engineering(China)》 2008年第4期672-674,共3页
Shenfu coal was extracted with 0S2, n-hexane, benzene sequentially. The extracts were analyzed with GC/MS. It is presented that group seperation of soluble organic compounds in the coal can be achieved by fractionated... Shenfu coal was extracted with 0S2, n-hexane, benzene sequentially. The extracts were analyzed with GC/MS. It is presented that group seperation of soluble organic compounds in the coal can be achieved by fractionated extraction using different solvents. Main components in CS2 soluble fraction from Shenfu coal are alkyl-substituted arenes. Aliphatic hydrocarbons are overwhelmingly predominant in n-hexane-soluble fraction. Dito tricyclic aramatic hydrocarbons are identified in benzene-soluble fraction. The molecular structures detection of 2, 4, 6-trichlorobenzenamine and 3, 3', 4, 4', 5, 5'-hexachloro-1, 1'- biphenyl and 2-chlorocyclohexanol firstly provide information for existence form of chlorine in coal. 展开更多
关键词 solvent fractionated extraction chemical constituent GC/MS
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Efficient prediction of gaseous n-hexane removal in two-phase partitioning bioreactors with silicone oil based on the mechanism and kinetic models
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作者 Lichao Lu Tuo Ju +6 位作者 Yangdan Fang Jingtao Hu Zhuqiu Sun Zhuowei Cheng Qian Li Jianmeng Chen Dong-zhi Chen 《Journal of Environmental Sciences》 2025年第8期729-740,共12页
Two-phase partitioning bioreactors(TPPBs)have been widely used because they overcome the mass-transfer limitation of hydrophobic volatile organic compounds(VOCs)in waste gas biological treatments.Understanding the mec... Two-phase partitioning bioreactors(TPPBs)have been widely used because they overcome the mass-transfer limitation of hydrophobic volatile organic compounds(VOCs)in waste gas biological treatments.Understanding the mechanisms of mass-transfer enhancement in TPPBs would enable efficient predictions for further industrial applications.In this study,influences of gradually increasing silicone oil ratio on the TPPB was explored,and a 94.35%reduction of the n-hexane partition coefficient was observed with 0.1 vol.%silicone,which increased to 80.7%along with a 40-fold removal efficiency enhancement in the stabilised removal period.The elimination capacity increased from 1.47 to 148.35 g/(m^(3)·h),i.e.a 101-fold increase compared with that of the single-phase reactors,when 10 vol.%(3 Critical Micelle Concentration)silicone oil was added.The significantly promoted partition coefficient was the main reason for the mass transfer enhancement,which covered the negative influences of the decreased total mass-transfer coefficient with increasing silicone oil volume ratio.The gradually rising stirring rate was benefit to the n-hexane removal,which became negative when the dominant resistance shifted from mass transfer to biodegradation.Moreover,a mass-transfer-reaction kinetic model of the TPPB was constructed based on the balance of n-hexane concentration,dissolved oxygen and biomass.Similar to the mechanism,the partition factor was predicted sensitive to the removal performance,and another five sensitive parameters were found simultaneously.This forecasting method enables the optimisation of TPPB performance and provides theoretical support for hydrophobic VOCs degradation. 展开更多
关键词 Mass transfer n-hexane Two-phase partitioning bioreactors Silicone oil
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Estimates for p-adic fractional integral operator with rough kernels on grand p-adic Herz-type spaces
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作者 XIA Xiaoxi ZHOU Jiang 《中山大学学报(自然科学版)(中英文)》 北大核心 2026年第2期153-159,共7页
The goal of this paper is to establish the boundedness of the p-adic fractional integral operator with rough kernel I_(β,Ω′)^(p)and its commutators generated by b∈Λ_(γ)(Q_(p)^(n))(0<γ<1)and the I_(β,Ω′... The goal of this paper is to establish the boundedness of the p-adic fractional integral operator with rough kernel I_(β,Ω′)^(p)and its commutators generated by b∈Λ_(γ)(Q_(p)^(n))(0<γ<1)and the I_(β,Ω′)^(p) on grand p-adic Herz spaces. 展开更多
关键词 Lipschitz spaces grand p-adic Herz spaces p-adic fractional integral operator COMMUTATORS
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Lipschitz Estimates for the Commutators of Fractional Hardy and Hardy-Littlewood-Pólya Operators on Grand p-adic Variable Herz Spaces
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作者 常云鹏 武江龙 《数学进展》 北大核心 2026年第2期419-430,共12页
In this article,we prove the boundedness for commutators of fractional Hardy and Hardy-Littlewood-Pólya operators on grand p-adic variable Herz spaces,where the symbols of the commutators belong to Lipschitz spaces.
关键词 p-adic field fractional Hardy operator Hardy-Littlewood-Pólya operator grand variable Herz space commutator
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Fractional calculus approach to RT-IN enzymatic competition in modulating HIV replication dynamics
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作者 Tushar Ghosh Oluwole Daniel Makinde +1 位作者 WANG Shu Priti Kumar Roy 《Applied Mathematics(A Journal of Chinese Universities)》 2026年第1期225-254,共30页
HIV infection continues to pose a significant global health challenge,with subSaharan Africa bearing a disproportionate burden.The replication cycle of HIV is fundamentally driven by intricate molecular interactions.T... HIV infection continues to pose a significant global health challenge,with subSaharan Africa bearing a disproportionate burden.The replication cycle of HIV is fundamentally driven by intricate molecular interactions.This study investigates the competitive biochemical interplay between reverse transcriptase(RT)and integrase(IN)enzymes,employing a fractional calculus framework to model their mutual inhibitory effects.Through the application of fixed-point theory and Picard stability analysis,the existence,uniqueness,and stability of the fractional-order system are rigorously established.The role of RT-IN enzymatic competition in influencing HIV replication dynamics is elucidated through global sensitivity analysis using Latin Hypercube Sampling.Furthermore,the model incorporates memory-dependent characteristics by examining three distinct fractional operators,namely,the Caputo,Caputo-Fabrizio,and Atangana-Baleanu operators in the Caputo sense,thereby elucidating their respective influences on system behavior.The Atangana-Baleanu operator,in particular,demonstrates an enhanced capacity to capture the complex,synergistic processes underpinning HIV progression.This research provides a critical nexus between molecular virology and applied mathematics,offering foundational insights for the advancement of more precise and targeted therapeutic strategies against HIV. 展开更多
关键词 HIV biochemical interaction physical interaction fractional calculus Sumudu transformation LHS PRCC
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A Fractional-Order Study for Bicomplex Haemorrhagic Infection in Several Populations Conditions
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作者 Muhammad Farman Muhammad Hashir Zubair +2 位作者 Hua Li Kottakkaran Sooppy Nisar Mohamad Hafez 《Computer Modeling in Engineering & Sciences》 2026年第1期926-953,共28页
Lassa Fever(LF)is a viral hemorrhagic illness transmitted via rodents and is endemic in West Africa,causing thousands of deaths annually.This study develops a dynamic model of Lassa virus transmission,capturing the pr... Lassa Fever(LF)is a viral hemorrhagic illness transmitted via rodents and is endemic in West Africa,causing thousands of deaths annually.This study develops a dynamic model of Lassa virus transmission,capturing the progression of the disease through susceptible,exposed,infected,and recovered populations.The focus is on simulating this model using the fractional Caputo derivative,allowing both qualitative and quantitative analyses of boundedness,positivity,and solution uniqueness.Fixed-point theory and Lipschitz conditions are employed to confirm the existence and uniqueness of solutions,while Lyapunov functions establish the global stability of both disease-free and endemic equilibria.The study further examines the role of the Caputo operator by solving the generalized power-law kernel via a two-step Lagrange polynomial method.This approach offers practical advantages in handling additional data points in integral forms,though Newton polynomial-based schemes are generally more accurate and can outperform Lagrange-based Adams-Bashforth methods.Graphical simulations validate the proposed numerical approach for different fractional orders(ν)and illustrate the influence of model parameters on disease dynamics.Results indicate that increasing the fractional order accelerates the decline of Lassa fever in both human and rodent populations.Moreover,fractional-order modeling provides more nuanced insights than traditional integer-order models,suggesting potential improvements for medical intervention strategies.The study demonstrates that carefully chosen fractional orders can optimize convergence and enhance the predictive capacity of Lassa fever models,offering a promising direction for future research in epidemiological modeling. 展开更多
关键词 Lassa fever mathematical model caputo fractional operator lyapunov stability
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CT-derived fractional flow reserve combined with atherosclerotic extent to determine long-term outcomes in diabetic patients with coronary artery disease
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作者 Zhi-Qiang WANG Zhen-Nan LI +1 位作者 Zhi-Hui HOU Bin LU 《Journal of Geriatric Cardiology》 2026年第1期27-35,共9页
Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value ... Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value of CT-FFR combined with CCTA–defined atherosclerotic extent in diabetic patients with coronary artery disease(CAD).Methods A retrospective pooled analysis of individual patient data was performed. Deep-learning-based vessel-specific CTFFR was calculated. All patients enrolled were followed-up for at least 5 years. Predictive abilities for major adverse cardiac events(MACE) were compared among three models(model 1), constructed using clinical variables;model 2, model 1+CCTA–derived atherosclerotic extent(Leiden risk score);and model 3, model 2+CT-FFR.Results A total of 480 diabetic patients [median age, 61(55–66) years;52.9% men] were included. During a median follow-up time of 2197(2126–2355) days, 55 patients(11.5%) experienced MACE. In multivariate-adjusted Cox models, Leiden risk score(HR: 1.06;95% CI: 1.01–1.11;P = 0.013) and CT-FFR ≤ 0.80(HR: 6.54;95% CI: 3.18–13.45;P < 0.001) were the independent predictors. The discriminant ability was higher in model 2 than in model 1(C-index, 0.75 vs. 0.63;P < 0.001) and was further promoted by adding CT-FFR to model 3(C-index, 0.81 vs. 0.75;P = 0.002). Net reclassification improvement(NRI) was 0.19(P = 0.009) for model 2 beyond model 1. Of note, adding CT-FFR to model 3 also exhibited significantly improved reclassification compared with model 2(NRI = 0.14;P = 0.011).Conclusion In diabetic patients with CAD, CT-FFR provides robust and incremental prognostic information for predicting longterm outcomes. The combined model exhibits improved prediction abilities, which is beneficial for risk stratification. 展开更多
关键词 fractional flow reserve ct ffr coronary artery disease cad methods tomography angiography ccta derived coronary artery disease atherosclerotic extent fractional flow reserve diabetic patients coronary computed tomography angiography
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Molecular composition of water soluble fraction of petroleum products and crude oils:Insights into groundwater contamination potential and environmental forensics
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作者 Wang Yu Yuruo Wan +3 位作者 Wei Zhou Jiayi An Liting Tian Jie Ma 《Journal of Environmental Sciences》 2026年第1期437-444,共8页
Petroleum leakage is a major groundwater contamination source,with chemical composition of water soluble fractions(WSFs)from diverse oil sources significantly impacting groundwater quality and source identification.Th... Petroleum leakage is a major groundwater contamination source,with chemical composition of water soluble fractions(WSFs)from diverse oil sources significantly impacting groundwater quality and source identification.The aim of this study was to assess impact of 15 diverse oils on groundwater quality and environmental forensics based on oil-water equilibrium experiments.Our results indicate that contamination of groundwater by gasoline and naphtha is primarily attributed to volatile hydrocarbons,while pollution from diesel,kerosene,and crude oil is predominantly from non-hydrocarbons.Rapid determination of the extent of non-hydrocarbon pollution in WSFs was achieved through a new quantitative index.Gasoline and naphtha exhibited the highest groundwater contamination potential while kerosene and light crude oils were also likely to cause groundwater contamina-tion.Although volatile hydrocarbons in the WSFs of diesel and jet fuel do not easily exceed current regulatory standards,unregulated non-hydrocarbons may pose a more severe contamination risk to groundwater.Notably,the presence of significant benzene and toluene,hydrogenation and alkylation products(e.g.,C4-C5 alkylben-zenes,alkylindenes,alkyltetralins,and dihydro-indenes),cycloalkanes in WSFs can effectively be utilized for preliminary source identification of light distillates,middle distillates,and crude oils,respectively. 展开更多
关键词 Petroleum hydrocarbons Water soluble fraction Contaminated sites Groundwater contamination Source identification
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Prediction of lithium content in typical mountainous clay in Xinjiang,China using fractional derivatives and feature extraction
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作者 JIANG Guo CUI Shichao +6 位作者 CHEN Xi CHEN Xi WANG Jinlin CHEN Tao ZHOU Shuguang ZHANG Zhengfeng XU Xiaozhi 《Journal of Mountain Science》 2026年第2期545-558,共14页
Lithium(Li)is an‘emerging'environmental pollutant,especially in soil,which is a great concern because it can endanger human health through the food chain.Compared with traditional chemical analyses,hyperspectral ... Lithium(Li)is an‘emerging'environmental pollutant,especially in soil,which is a great concern because it can endanger human health through the food chain.Compared with traditional chemical analyses,hyperspectral techniques have achieved many exciting results in soil metal monitoring due to their advantages of being fast and non-destructive.However,insufficient attention has been paid to lithium in soil,and the feasibility of its estimation using hyperspectral techniques needs to be investigated.We studied 97 soil samples from claytype lithium mines in the Ertanggou area of the East Tianshan Mountains of Xinjiang to explore the effects of spectral resolution,fractional order derivatives(FOD),and characteristic band selection on the estimation accuracy of clay Li content,to obtain a fast and effective method for estimating clay Li content.Finally,we developed a new method for rapid and nondestructive estimation of soil lithium content.We have obtained some important results from the study.Spectral resolution exerts a significant impact on model performance,and its reduction usually leads to a decline in model performance.For the full band,the models constructed with low-order derivatives were superior to those with high-order derivatives,and the best model was obtained at the 0.4-order derivative(coefficient of determination(R^(2))and relative predictive deviation(RPD)of 0.777 and 2.118,respectively).In the characteristic bands,the lower order is sensitive to the visible-near-infrared range,and the higher order is sensitive to the short-wave infrared range,and the model constructed with the higher-order derivatives outperforms the lower-order derivatives.In this study,the combination of FOD and Random Forest(RF)can significantly improve the model performance,with R^(2),Relative Root Mean Squared Error(RRMSE),and RPD being 0.849,1.526,and 2.574,respectively.Therefore,this research provides a theoretical basis and technical reference for imaging hyperspectral exploration of anomalous areas of clay-type Li resources. 展开更多
关键词 Hyperspectral remote sensing fractional order Derivatives Random Forest LITHIUM Soil pollutant
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Global Optimization Algorithm for Minimizing Linear Fractional Programming
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作者 ZHAO Peng SHEN Pei-ping ZHONG Zhe-wei 《Chinese Quarterly Journal of Mathematics》 2026年第1期50-59,共10页
In this paper,we study a class of Linear Fractional Programming on a nonempty bounded set,called the Problem(LFP),and design a branch and bound algorithm to find the global optimal solution of the problem(LFP).First,w... In this paper,we study a class of Linear Fractional Programming on a nonempty bounded set,called the Problem(LFP),and design a branch and bound algorithm to find the global optimal solution of the problem(LFP).First,we convert the problem(LFP)to the equivalent problem(EP2).Secondly,by applying the linear relaxation technique to the problem(EP2),the linear relaxation programming problem(LRP2Y)was obtained.Then,the overall framework of the algorithm is given,and the convergence and complexity of the algorithm are analyzed.Finally,experimental results are listed to illustrate the effectiveness of the algorithm. 展开更多
关键词 Global optimization Linear fractional Programming Branch and bound algorithm Linear relaxation
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Land use type shapes carbon pathways in Tibetan alpine ecosystems:Characterization of ^(13)C abundance in aggregates and density fractions
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作者 Xin Wan Dangjun Wang +7 位作者 Junya Li Shuaiwen Zhang Linyang Li Minghui He Zhiguo Li Hao Jiang Peng Chen Yi Liu 《Journal of Integrative Agriculture》 2026年第2期448-459,共12页
Insight into the carbon turnover in soil aggregates and density fractions is essential for reducing the uncertainty in estimating carbon pools on the Tibetan Plateau,and how they vary with land use type is unclear.In ... Insight into the carbon turnover in soil aggregates and density fractions is essential for reducing the uncertainty in estimating carbon pools on the Tibetan Plateau,and how they vary with land use type is unclear.In this study,the effect of land use type on carbon storage and fractionation was quantified based on organic carbon and its^(13)C abundance at the microscale of soil aggregates and density fractions in Tibetan alpine ecosystems.The sequence of soil aggregate destruction in the land use types of plantation(13.1%)<shrubland(32.7%)<grassland(47.9%)<farmland(61.8%)shows that plantations strengthen the soil structure.Plantation land had a greater contribution of light fraction organic carbon(28.3%)but a lower contribution of mineral-associated organic carbon(40.6%)to the carbon stock compared to farmland(13.5 and 70.3%).Interestingly,plantation land enhanced the aggregational differentiation of organic carbon and^(13)C in each density fraction,whereas no such phenomenon existed in the soil organic carbon.Carbon isotope analyses revealed that carbon transfer in the plantation land occurred from the light fraction in macroaggregates(–24.9‰)to the mineral-associated fraction in microaggregates(–19.9‰).When compared to the other three land use types,the low transferability of carbon in aggregates and density fractions in plantation land provides a stable carbon pool for the Tibetan Plateau.This study shows that plantations can mitigate global climate change by slowing carbon transfer and increasing carbon storage at the microscale of aggregates and density fractions in alpine regions. 展开更多
关键词 land use type soil aggregate density fractions carbon transfer Tibetan Plateau
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POHOZAEV MINIMIZERS FOR FRACTIONAL CHOQUARD EQUATIONS WITH MASS-SUPERCRITICAL NONLINEARITY
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作者 Liju WU Jiankang XIA 《Acta Mathematica Scientia》 2026年第1期164-188,共25页
We investigate the constrained fractional Choquard equation■where m>0,N>2s with s∈(0,1)being the order of the fractional Laplacian operator and I_(α)forα∈(0,N)denotes the Riesz potential.The parameterμ∈ℝa... We investigate the constrained fractional Choquard equation■where m>0,N>2s with s∈(0,1)being the order of the fractional Laplacian operator and I_(α)forα∈(0,N)denotes the Riesz potential.The parameterμ∈ℝappears as a Lagrange multiplier.By imposing general mass-supercritical conditions on F,we confirm the existence of normalized solutions that characterize the global minimizer on the Pohozaev manifold.Our proof does not depend on the assumption that all weak solutions satisfy the Pohozaev identity,a challenge that remains unsolved for this doubly nonlocal equation. 展开更多
关键词 nonlinear fractional Choquard equation double nonlocality super-critical mass normalized solutions Pohozaev minimizer
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Tribological Properties and Wear Mechanisms of SiCp/6092Al Composites with Different Volume Fractions
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作者 WANG Dongliang DOU Jianming +2 位作者 ZHANG Jilin YI Xiangbin MA Furong 《Journal of Wuhan University of Technology(Materials Science)》 2026年第2期323-332,共10页
SiCp-reinforced 6092Al composites with volume fractions of 25%and 60%were prepared using a powder metallurgy method.Their friction and wear characteristics were analyzed using a reciprocating friction and wear testing... SiCp-reinforced 6092Al composites with volume fractions of 25%and 60%were prepared using a powder metallurgy method.Their friction and wear characteristics were analyzed using a reciprocating friction and wear testing machine under loads of 20 to 50 N against YG6 cemented carbide.The experimental results show that the friction coefficients of all samples increase with increasing load.The 25vol%composite exhibits the lowest friction coefficient(0.1669-0.2716),while the 60vol%composite exhibits the highest(0.3237-0.3990),with the 6092 aluminum alloy falling between the two.The wear volume and specific wear rate also increase with load,but the composites with a higher Si C content demonstrate smaller increments,with the 60vol%composite exhibiting superior wear resistance.Under a 30 N load,the wear scars of the 60vol%composite show a significant increase in the contents of elements such as C,Co,W,and O,indicating more severe wear of the counterpart material.Scanning electron microscopy(SEM)reveals wear mechanisms including adhesive wear,two-body sliding and three-body rolling wear of particles,and delamination. 展开更多
关键词 SiCp/6092Al composites wear mechanisms different volume fractions tribological properties
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Developments in the applications of density functional theory to fractional quantum Hall systems
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作者 Yi Yang Yayun Hu Zi-Xiang Hu 《Communications in Theoretical Physics》 2026年第2期220-230,共11页
The fractional quantum Hall effect remains a captivating area in condensed matter physics,characterized by strongly correlated topological order,which manifests as fractionalized excitations and anyonic statistics.Num... The fractional quantum Hall effect remains a captivating area in condensed matter physics,characterized by strongly correlated topological order,which manifests as fractionalized excitations and anyonic statistics.Numerical simulations,such as exact diagonalization,density matrix renormalization groups,matrix product states,and Monte Carlo methods are essential for examining the properties of strongly correlated systems.Recently,density functional theory has been employed in this field within the framework of composite fermion theory.This paper systematically evaluates how density functional theory approaches have addressed fundamental challenges in fractional quantum Hall systems,including ground state and low-energy excitations.Special attention is given to the insights provided by density functional theory regarding composite fermion behavior,edge effects,and the nature of fractional charge and magnetoroton excitations.The discussion critically examines both the advantages and limitations of these approaches,while highlighting the productive interplay between numerical simulations and theoretical models.Future directions are explored,particularly the promising potential of time-dependent density functional theory for modeling non-equilibrium dynamics in quantum Hall systems. 展开更多
关键词 composite fermions fractional quantum Hall effect density functional theory low-lying excitations topological physics
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The Immunomodulatory,Anti-Tumor,and Metabolic Regulatory Effects of Fraction D of Polysaccharide from Grifola frondosa:Clinical Experiments and Mechanistic Insights
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作者 Nurfarih Hanna Mohd Zarif Fikri Bin Mohd +1 位作者 Muhammad Nabil Fikri Bin Mohd Nurfarazuna Binti Mohd Fadrol 《Proceedings of Anticancer Research》 2026年第1期84-93,共10页
Grifola frondosa(Maitake)is traditionally valued for its health benefits,with polysaccharides being key bioactive components.This paper investigates a specific subfraction,Fraction D(GFP-D),evaluating its clinical eff... Grifola frondosa(Maitake)is traditionally valued for its health benefits,with polysaccharides being key bioactive components.This paper investigates a specific subfraction,Fraction D(GFP-D),evaluating its clinical effects and mechanisms in immune enhancement,adjunctive anti-tumor activity,and regulation of glucose/lipid metabolism.Three clinical trials were conducted.In an immune study,120 healthy volunteers(CD4+T cell count 500–1000 cells/μL)received 150 mg/day GFP-D for 8 weeks,resulting in significant increases in CD4+T cells(from 632±95 to 812±108 cells/μL,28.5%increase,within the physiological activation range),CD4+/CD8+ratio,NK cell activity,IL-2,and IFN-γ(all P<0.001 vs.placebo).An anti-tumor study with 80 advanced cancer patients(stratified by age,tumor stage,and histotype)showed that adding 1000 mg/day GFP-D to chemotherapy improved objective response rate(52.5%vs.30.0%,P=0.036,95%CI:1.02–3.87),one-year progression-free survival(55.8%vs.33.3%,P=0.022),and preserved immune parameters versus chemotherapy alone.A metabolic study in 90 type 2 diabetes patients found that 400 mg/day GFP-D for 12 weeks significantly lowered fasting glucose,HbA1c,total cholesterol,triglycerides,and LDL-C,while raising HDL-C(from 1.0±0.2 to 1.2±0.2 mmol/L,20%increase,supported by increased AMPK phosphorylation).Mechanistically,immune enhancement involves macrophage/dendritic cell activation via Dectin-1/TLR4 receptors(confirmed by increased receptor expression and downstream signaling molecules),promoting cytokine-driven T/NK cell responses.Anti-tumor effects stem from immunomodulation,direct induction of cancer cell apoptosis(via mitochondrial/caspase pathways,verified by increased Bax/Bcl-2 ratio and caspase-3 activation),and angiogenesis inhibition by downregulating VEGF.Metabolic benefits are linked to AMPK pathway activation in liver/muscle(confirmed by increased p-AMPK/AMPK ratio),enhancing glucose uptake and inhibiting gluconeogenesis/lipogenesis,alongside modulation of gut microbiota(increased Bifidobacterium and Lactobacillus abundance).All trials reported no severe adverse events related to GFP-D;liver/kidney function parameters(ALT,AST,creatinine,urea nitrogen)remained within normal ranges throughout the intervention.Collectively,GFP-D emerges as a multi-functional bioactive agent with substantial therapeutic potential. 展开更多
关键词 Grifola frondosa Maitake polysaccharide fraction D Immune modulation Adjunctive cancer therapy Glycemic control Lipid metabolism Clinical trial Mechanism of action
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A_(α)-Spectral Conditions for(a,b,k)-Factor-Critical Graphs and Fractional ID-[a,b]-Factor-Critical Covered Graphs
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作者 Yonglei CHEN Fei WEN 《Journal of Mathematical Research with Applications》 2026年第1期1-12,共12页
In this paper,we first give a sufficient condition for a graph being fractional ID-[a,b]-factor-critical covered in terms of its independence number and minimum degree,which partially answers the problem posed by Sizh... In this paper,we first give a sufficient condition for a graph being fractional ID-[a,b]-factor-critical covered in terms of its independence number and minimum degree,which partially answers the problem posed by Sizhong Zhou,Hongxia Liu and Yang Xu(2022).Then,an A_(α)-spectral condition is given to ensure that G is a fractional ID-[a,b]-factor-critical covered graph and an(a,b,k)-factor-critical graph,respectively.In fact,(a,b,k)-factor-critical graph is a graph which has an[a,b]-factor for k=0.Thus,these above results extend the results of Jia Wei and Shenggui Zhang(2023)and Ao Fan,Ruifang Liu and Guoyan Ao(2023)in some sense. 展开更多
关键词 A_(α)-spectral radius (a b k)-factor fractional(g f)-factor ID-factor-critical graph independence number
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Study on the Inhibitory Mechanism of Sophora japonica N-hexane Extract on Microcystis aeruginosa 被引量:4
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作者 周晓见 夏洁 +3 位作者 靳翠丽 缪莉 董昆明 封克 《Agricultural Science & Technology》 CAS 2011年第10期1543-1546,共4页
[Objective] The research aimed to analyze the inhibitory mechanism of Sophora japonica n-hexane extract which significantly inhibited Microcystis aeruginosa in the prior research.[Method] S.japonica n-hexane extract w... [Objective] The research aimed to analyze the inhibitory mechanism of Sophora japonica n-hexane extract which significantly inhibited Microcystis aeruginosa in the prior research.[Method] S.japonica n-hexane extract was used to treat M.aeruginosa.By inspecting chlorophyll a content,protein content,cell membrane permeability and superoxide dismutase(SOD) activity,the inhibitory mechanism of S.japonica n-hexane extract on M.aeruginosa was analyzed initially.[Result] S.japonica n-hexane extract destroyed the cell membrane system of M.aeruginosa,and increased the cell membrane permeability.The contents of chlorophyll a and protein respectively declined to 10% and 50% of that in the control group after cultivated for 7 d,which indicated the photosynthetic reaction system of M.aeruginosa was destroyed.In addition,under the effect of S.japonica n-hexane extract,SOD activity of M.aeruginosa increased in the early period and decreased in the latter period.[Conclusion] The possible inhibitory mechanism of S.japonica n-hexane extract on M.aeruginosa was destroying the cell membrane to increase the membrane permeability;destroying the photosynthetic reaction system to decrease the contents of photosynthetic pigment and protein;making SOD activity showing the phased variation. 展开更多
关键词 S.japonica M.aeruginosa n-hexane extract Inhibitory mechanism
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Effect of secondary pore distribution on adsorption diffusion performance of n-hexane on 5A zeolite pellets 被引量:1
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作者 杜旭东 刘宗健 +2 位作者 崔群 王海燕 姚虎卿 《Journal of Southeast University(English Edition)》 EI CAS 2011年第3期284-289,共6页
Adsorption rates of n-hexane on the 5A zeolite at 100 to 300 ℃ and 0.01 to 10 kPa are determined by an intelligent gravimetric analyzer (IGA-100), and the adsorption diffusion performance of n-hexane on 5A zeolite ... Adsorption rates of n-hexane on the 5A zeolite at 100 to 300 ℃ and 0.01 to 10 kPa are determined by an intelligent gravimetric analyzer (IGA-100), and the adsorption diffusion performance of n-hexane on 5A zeolite pellets with different secondary pore distributions is analyzed. The results indicate that 5A-1 and 5A-6 zeolites have similar micropore and mesopore size distribution, while the 5A-6 zeolite has a larger secondary pore volume when the pore diameter is between 0.1 and 1 μm and more secondary pores when the pore diameter is less than 0.01 μm. The effective diffusion coefficient of nhexane on the 5A-6 zeolite pellet is 10 ^-6 to 10 4 cm^2/s, about 2 to 5 times higher than that on the 5A-1 zeolite. The effective diffusion coefficient of n-hexane on the 5A-1 zeolite pellet improves from 5 × 10^-7 to 2 × 10 6cm^2/s when the temperature increases from 100 to 300 ~C. However, the effective diffusion coefficient of n-hexane on the 5A-6 zeolite remains almost unchanged at different temperatures. The molecular average free path of n-hexane decreases from 627.15-963.28 to 0.63-0, 96 Ixm with the adsorption pressure increasing from 0.01 to 10 kPa. Such a flee path is close to the secondary pore diameter, resulting in significant Knudsen diffusion in the secondary pores. Thus, the effective diffusion coefficient of n-hexane on the 5A zeolite pellets increases before 1 kPa and decreases after 1 kPa. 展开更多
关键词 5A zeolite pore structure secondary pore DIFFUSION n-hexane
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GC-MS Analysis of Essential oil and n-Hexane Extract from Moso Bamboo 被引量:2
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作者 刘志明 任海青 《Agricultural Science & Technology》 CAS 2012年第5期993-996,共4页
[Objective] This study aimed to analyze the chemical composition and yield of essential oil and n-hexane extract from moso bamboo to find active compounds with potential value. [Method] Essential oil and n-hexane extr... [Objective] This study aimed to analyze the chemical composition and yield of essential oil and n-hexane extract from moso bamboo to find active compounds with potential value. [Method] Essential oil and n-hexane extract were respectively extracted from moso bamboo of four different ages by using hydrodistillation and ultrasonic-assisted extraction with n-hexane, and analyzed with gas chromatography/mass spectrometry (GC/MS). [Result] The results show that cedrol (46.39%) is the first principal volatile component in essential oil of the middle stem of 7-year old moso bamboo; dibutyl phthalate (59.46%) is the first principal volatile component in n-hexane extract of the middle stem of 3-year old moso bamboo; yield of n-hexane extract is higher than that of essential oil from moso bamboo. [Conclusion] Cedrol is an active compound with potential value. 展开更多
关键词 Moso bamboo HYDRODISTILLATION Ultrasonic assistance n-hexane extract Gas chromatography/mass spectrometry (GC/MS)
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