Yīn-Chén-Hāo decoction(YCHD) is a traditional Chinese medicine formula composed of capillaris(Artemisia capillaris), gardenia(Gardenia jasminoides), and rhubarb(Rheum rhabarbarum) that is used for the treatment...Yīn-Chén-Hāo decoction(YCHD) is a traditional Chinese medicine formula composed of capillaris(Artemisia capillaris), gardenia(Gardenia jasminoides), and rhubarb(Rheum rhabarbarum) that is used for the treatment of damp-heat jaundice. In modern clinics, YCHD is mostly used for hepatic diseases. This review summarizes the biological activities of YCHD and its medical applications. The main active compounds of YCHD are chlorogenic acid, rhein, geniposide, emodin, and scoparone. The pharmacological actions of YCHD include inhibition of hepatic steatosis, apoptosis, necrosis, anti-inflammation, and immune regulation. YCHD could be developed as a new therapeutic strategy for the treatment of hepatic diseases.展开更多
Unexpected side reaction is discovered from the N-H insertion of phenyl diazoacetates with arylamines in the presence of Rh2(OAc)4 catalyst. This side reaction is not evident with copper catalysts such as Cu(acac)2 or...Unexpected side reaction is discovered from the N-H insertion of phenyl diazoacetates with arylamines in the presence of Rh2(OAc)4 catalyst. This side reaction is not evident with copper catalysts such as Cu(acac)2 or Cu(OTf)2. Good yield of the N-H insertion was obtained by using 0.2% of copper catalyst.展开更多
The mutual destabilization between complex hydrides and lithium amide has been comprehensively reported. In this paper, CeH2 doped Li-Mg-N-H/NaAlH4 composite was successfully synthesized by ball milling Li-Mg-N-H mixt...The mutual destabilization between complex hydrides and lithium amide has been comprehensively reported. In this paper, CeH2 doped Li-Mg-N-H/NaAlH4 composite was successfully synthesized by ball milling Li-Mg-N-H mixture and NaAlH4 in a molar ratio of 1：2. It was found that a total of 5 wt.% of hydrogen could be desorbed from the newly synthesized composite with a three-step reaction. Temperature-programmed-desorption （TPD） measurements showed that the composite ball milled for 10 min began to desorb hydrogen below 100 °C, which was about 75 °C lower than the pristine materials. XRD analysis revealed that NaAlH4 firstly reacted with LiH to yield Na2LiAlH6 and Al below 150 °C, then the newly developed Na2LiAlH6 reacted with Mg（NH2）2 to form NaH, Al, and Li2MgN2H2 in the temperature range of 180–250 °C. From 200 to 300 °C, the newly formed Al and Li2MgN2H2 reacted further to form Li2NH and some stable phase （AlN and Mg3N2）. The H-cycling properties of the composite were further investigated by a standard Sievert’s type apparatus at 150, 200 and 250 °C, respectively. Finally, the reversibility of the newly synthesized composite was discussed.展开更多
基金Supported by the National Natural Science Foundation,No.81273729Major Project of Shanghai Municipal S and T Commission,No.15DZ1900104Innovative Research Team in Universities,Shanghai Municipal Education Commission,Shanghai Key Laboratory of Traditional Chinese Clinical Medicine and Key Disciplines of Liver and Gall Bladder Diseases of State Administration of Traditional Chinese Medicine of the People’s Republic of China
文摘Yīn-Chén-Hāo decoction(YCHD) is a traditional Chinese medicine formula composed of capillaris(Artemisia capillaris), gardenia(Gardenia jasminoides), and rhubarb(Rheum rhabarbarum) that is used for the treatment of damp-heat jaundice. In modern clinics, YCHD is mostly used for hepatic diseases. This review summarizes the biological activities of YCHD and its medical applications. The main active compounds of YCHD are chlorogenic acid, rhein, geniposide, emodin, and scoparone. The pharmacological actions of YCHD include inhibition of hepatic steatosis, apoptosis, necrosis, anti-inflammation, and immune regulation. YCHD could be developed as a new therapeutic strategy for the treatment of hepatic diseases.
基金We are grateful for financial support from the Chinese Academy of Sciences and National Nature Science Foundation of China(20202011).
文摘Unexpected side reaction is discovered from the N-H insertion of phenyl diazoacetates with arylamines in the presence of Rh2(OAc)4 catalyst. This side reaction is not evident with copper catalysts such as Cu(acac)2 or Cu(OTf)2. Good yield of the N-H insertion was obtained by using 0.2% of copper catalyst.
基金Project supported by the Hi-Tech Research and Development Program of China (2009AA034400)the National Basic Research Program of China (2010CB631305) under the Ministry of Science and Technology of China
文摘The mutual destabilization between complex hydrides and lithium amide has been comprehensively reported. In this paper, CeH2 doped Li-Mg-N-H/NaAlH4 composite was successfully synthesized by ball milling Li-Mg-N-H mixture and NaAlH4 in a molar ratio of 1：2. It was found that a total of 5 wt.% of hydrogen could be desorbed from the newly synthesized composite with a three-step reaction. Temperature-programmed-desorption （TPD） measurements showed that the composite ball milled for 10 min began to desorb hydrogen below 100 °C, which was about 75 °C lower than the pristine materials. XRD analysis revealed that NaAlH4 firstly reacted with LiH to yield Na2LiAlH6 and Al below 150 °C, then the newly developed Na2LiAlH6 reacted with Mg（NH2）2 to form NaH, Al, and Li2MgN2H2 in the temperature range of 180–250 °C. From 200 to 300 °C, the newly formed Al and Li2MgN2H2 reacted further to form Li2NH and some stable phase （AlN and Mg3N2）. The H-cycling properties of the composite were further investigated by a standard Sievert’s type apparatus at 150, 200 and 250 °C, respectively. Finally, the reversibility of the newly synthesized composite was discussed.
