Effective treatment of subcutaneous tumors remains a focal point in cancer therapy.Photothermal therapy,a novel therapeutic approach,has emerged as a promising alternative,offering a less invasive option for the treat...Effective treatment of subcutaneous tumors remains a focal point in cancer therapy.Photothermal therapy,a novel therapeutic approach,has emerged as a promising alternative,offering a less invasive option for the treatment of subcutaneous tumors.This study reports the exploration of novel supramolecular halogen-bonded organic frameworks(XOFs)based on[N…Br^(+)…N]halogen bonds through the ligand exchange strategy and their application in photothermal therapy.Through ligand exchange,XOF(Br)-TPy was successfully prepared,and its structure and properties were thoroughly characterized using NMR,XPS,FT-IR,and XRD techniques.Due to their cationic characteristics,these XOFs serve as effective carriers for the photothermal agent IR820.In vitro experiments demonstrated that the IR820@XOF(Br)-TPy composite exhibits excellent photothermal conversion efficiency under NIR irradiation,effectively inducing tumor cell ablation.Furthermore,in vivo studies confirmed the remarkable antitumor efficacy of the composite material in a subcutaneous tumor model.This work demonstrates that the ligand exchange strategy is a versatile and facile approach for constructing XOFs(Br)and provides a novel strategy for developing advanced photothermal therapeutic agents with significant application potential.展开更多
Aromatic nitro compounds present substantial health and environmental concerns due to their toxic nature and potential explosive properties.Consequently,the development of host–vip molecular recognition systems for...Aromatic nitro compounds present substantial health and environmental concerns due to their toxic nature and potential explosive properties.Consequently,the development of host–vip molecular recognition systems for these compounds serves a dual-purpose:enabling the fabrication of high-performance sensors for detection and guiding the design of efficient adsorbents for environmental remediation.This study investigated the host–vip recognition behavior of perethylated pillar[n]arenes toward two aromatic nitro molecules,1-chloro-2,4-dinitrobenzene and picric acid.Various techniques including^(1)H NMR,2D NOESY NMR,and UV-vis spectroscopy were employed to explore the binding behavior between pillararenes and aromatic nitro vips in solution.Moreover,valuable single crystal structures were obtained to elucidate the distinct solid-state assembly behaviors of these vips with different pillararenes.The assembled solid-state supramolecular structures observed encompassed a 1:1 host–vip inclusion complex,an external binding complex,and an exo-wall tessellation complex.Furthermore,based on the findings from these systems,a pillararene-based test paper was developed for efficient picric acid detection,and the removal of picric acid from solution was also achieved using pillararenes powder.This research provides novel insights into the development of diverse host–vip systems toward hazardous compounds,offering potential applications in environmental protection and explosive detection domains.展开更多
Based on the crystal structures of two cucurbit[6]uril/calix[n]arene-based supramolecular frameworks reported by Long and co-workers,we further investigated the interactions of cucurbit[6]uril with 4-sulfocalix[4]aren...Based on the crystal structures of two cucurbit[6]uril/calix[n]arene-based supramolecular frameworks reported by Long and co-workers,we further investigated the interactions of cucurbit[6]uril with 4-sulfocalix[4]arene and 4-sulfocalix[6]arene using ^(1)H NMR spectroscopy and isothermal titration calorimetry(ITC),respectively.Moreover,solid fluorescent materials were prepared via the adsorption of fluorescent dyes by these porous supramolecular frameworks,which exhibit a selective response to certain volatile organic compounds.展开更多
基金supported by the National Natural Science Foundation of China(Nos.22371218,82271518,21801194)Xianyang Bureau of Science and Technology(No.L2024-QCY-ZYYJJQ-260)+2 种基金The Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University(No.JCRCFZ-2022-030)Guiding Projects of Traditional Chinese Medicine in 2023~2024 by Hubei Provincial Administration of Traditional Chinese Medicine(No.ZY2023F038)the support of the Core Facility of Wuhan University and the Large-scale Instrument and Equipment Sharing Foundation of Wuhan University。
文摘Effective treatment of subcutaneous tumors remains a focal point in cancer therapy.Photothermal therapy,a novel therapeutic approach,has emerged as a promising alternative,offering a less invasive option for the treatment of subcutaneous tumors.This study reports the exploration of novel supramolecular halogen-bonded organic frameworks(XOFs)based on[N…Br^(+)…N]halogen bonds through the ligand exchange strategy and their application in photothermal therapy.Through ligand exchange,XOF(Br)-TPy was successfully prepared,and its structure and properties were thoroughly characterized using NMR,XPS,FT-IR,and XRD techniques.Due to their cationic characteristics,these XOFs serve as effective carriers for the photothermal agent IR820.In vitro experiments demonstrated that the IR820@XOF(Br)-TPy composite exhibits excellent photothermal conversion efficiency under NIR irradiation,effectively inducing tumor cell ablation.Furthermore,in vivo studies confirmed the remarkable antitumor efficacy of the composite material in a subcutaneous tumor model.This work demonstrates that the ligand exchange strategy is a versatile and facile approach for constructing XOFs(Br)and provides a novel strategy for developing advanced photothermal therapeutic agents with significant application potential.
基金supported by the fundamental research funds of Zhejiang Sci-Tech University(No.22212286-Y)the Natural Science Foundation of Zhejiang Province(No.LQ24B040003)。
文摘Aromatic nitro compounds present substantial health and environmental concerns due to their toxic nature and potential explosive properties.Consequently,the development of host–vip molecular recognition systems for these compounds serves a dual-purpose:enabling the fabrication of high-performance sensors for detection and guiding the design of efficient adsorbents for environmental remediation.This study investigated the host–vip recognition behavior of perethylated pillar[n]arenes toward two aromatic nitro molecules,1-chloro-2,4-dinitrobenzene and picric acid.Various techniques including^(1)H NMR,2D NOESY NMR,and UV-vis spectroscopy were employed to explore the binding behavior between pillararenes and aromatic nitro vips in solution.Moreover,valuable single crystal structures were obtained to elucidate the distinct solid-state assembly behaviors of these vips with different pillararenes.The assembled solid-state supramolecular structures observed encompassed a 1:1 host–vip inclusion complex,an external binding complex,and an exo-wall tessellation complex.Furthermore,based on the findings from these systems,a pillararene-based test paper was developed for efficient picric acid detection,and the removal of picric acid from solution was also achieved using pillararenes powder.This research provides novel insights into the development of diverse host–vip systems toward hazardous compounds,offering potential applications in environmental protection and explosive detection domains.
基金the financial support of National Natural Science Foundation of China(Nos.51663005,21761007 and21871064)Science and Technology Plan Project of Guizhou Province(Nos.20175788 and 20185781)+2 种基金the Creative Research Groups of Guizhou Provincial Education Department(No.2017028)the Innovation Program for High-level Talents of Guizhou Province(No.20165657)“Chun-Hui” Fund of Chinese Ministry of Education(No.Z2017005)。
文摘Based on the crystal structures of two cucurbit[6]uril/calix[n]arene-based supramolecular frameworks reported by Long and co-workers,we further investigated the interactions of cucurbit[6]uril with 4-sulfocalix[4]arene and 4-sulfocalix[6]arene using ^(1)H NMR spectroscopy and isothermal titration calorimetry(ITC),respectively.Moreover,solid fluorescent materials were prepared via the adsorption of fluorescent dyes by these porous supramolecular frameworks,which exhibit a selective response to certain volatile organic compounds.
