Mononuclear complex {[Cu(N-men)2(cda)2]·[Cu(N-men)2]-(ClO4)2} was synthesized by sodium carbamyldicyanomethanide Na(cda), N-methylethylenediamine and hydrate copper perchlorate. The crystal belongs to the triclin...Mononuclear complex {[Cu(N-men)2(cda)2]·[Cu(N-men)2]-(ClO4)2} was synthesized by sodium carbamyldicyanomethanide Na(cda), N-methylethylenediamine and hydrate copper perchlorate. The crystal belongs to the triclinic system, space group P 1 with a = 7.229(2), b = 8.114(2), c = 15.936(4) A, α = 80.511(4), β = 78.993(4), r= 72.118(4)°, V = 867.6(3) A3, Z = 1, C20H44Cl2Cu2N14O10, Mr = 838.68, Dc = 1.605 g/cm3, F(000) = 434 and μ = 1.449 mm-1. The structure was refined to R = 0.0480 and wR = 0.1289 for 2503 observed reflections (I > 2σ(I)). In the complex there exist two kinds of coordination models for Cu (II) ions. One is that the Cu (II) ion is coordinated by four nitrogen atoms which are from two N-men molecules, and a slightly distorted square planar coordinate environment is formed around the Cu (II) ion; the other is that the Cu (II) ion is coordinated by six nitrogen atoms, of which four are from two N-men molecules and the left from nitrile groups, resulting in a distorted octahedron around the Cu (II) ion. The deposition number of the crystal at CCDC is 161868.展开更多
[目的]3-(3′,4′-次甲二氧苯基)-N-正丙基丙烯酰胺是具有广谱抑菌活性的化合物,将其研制成优良环保剂型悬浮剂,可为实现田间应用提供技术依据。[方法]采用湿法研磨制备了12种不同配方的悬浮剂,通过质量指标检测确定最佳配方,测定其表...[目的]3-(3′,4′-次甲二氧苯基)-N-正丙基丙烯酰胺是具有广谱抑菌活性的化合物,将其研制成优良环保剂型悬浮剂,可为实现田间应用提供技术依据。[方法]采用湿法研磨制备了12种不同配方的悬浮剂,通过质量指标检测确定最佳配方,测定其表面张力及其在黄瓜叶面的动态接触角,并开展了防治黄瓜白粉病田间药效试验。[结果]最佳配方为3-(3′,4′-次甲二氧苯基)-N-正丙基丙烯酰胺40%(折百)、S043%、D4252%、W071%、乙二醇3%、硅酸镁铝0.4%、黄原胶0.12%、B150.12%、消泡剂X600.3%、水补足。此悬浮剂在有效成分0.27 g a.i./L时的表面张力以及在黄瓜叶面的动态接触角均小于对照药剂40%苯醚甲环唑SC,表明其具有良好的润湿性能。在有效成分0.27 g a.i./L下的防效为88.38%,与对照药剂25%嘧菌酯SC 0.20 g a.i./L相当,且对黄瓜安全。[结论]制备悬浮剂为类白色均匀悬浮液,流动性好,粒径合格,悬浮率稳定在98.5%左右,pH为4.09,黏度为452 mPa·s,入水分散性合格,热储、低温及冻融稳定性良好,未出现沉淀,各项指标均达标,对黄瓜白粉病防效优良,具有良好的开发应用前景。展开更多
Fluorinated fused azobenzene boron(FBAz)is a novel electron-deficient building block for polymer electron acceptors in all-polymer solar cells(all-PSC).The B←N bridging units impart a fixed configuration and low-lyin...Fluorinated fused azobenzene boron(FBAz)is a novel electron-deficient building block for polymer electron acceptors in all-polymer solar cells(all-PSC).The B←N bridging units impart a fixed configuration and low-lying LUMO/HOMO energy.Three polymer acceptor materials(P2f,P3f and P5f)with different fluorine substitution positions by copolymerizing FBAz with indacenodithiophene(IDT),are synthesized and investigated to study the influence of fluorinated forms on the all-polymer solar cell performance.The FBAz units are synthesized in just three steps,facilitating the straightforward production of polymer acceptors P2f,P3f,and P5f.These acceptors exhibit strong light absorption in the visible to near-infrared range of 500-1000nm and possess suitable LUMO/HOMO energy levels of-3.99/-5.66 eV which are very complementary to that(E_(LUMO/HOMO)=-3.59/-5.20 eV)of the widely-used polymer donor poly[(ethylhexylthiophenyl)-benzodithiophene-(ethylhexyl)-thienothiophene](PTB7-Th).All-polymer solar cells(all-PSCs)with PTB7-Th as electron donor and P3f as electron acceptor exhibits highest power conversion efficiencies(PCE)2.70%.When PC_(61)BM is added as the third component,the device efficiency can reach 5.36%.These preliminary results indicate that FBAz is a promising strong electron acceptor for the development of n-type polymer semiconductors,especially in organic photovoltaics(OPVs).To the best of our knowledge,this is the first example demonstrating the unique photovoltaic properties of the N=N double bond as an acceptor material.展开更多
目的:研究胃萎方对信号转导及转录激活蛋白3(Signal Transducer and Activator of Transcription 3,STAT3)/核因子-κB(Nuclear Factor-κB,NF-κB)信号通路的调控作用,探讨胃萎方对胃癌前病变(Precancerous Lesion of Gastric Cancer,P...目的:研究胃萎方对信号转导及转录激活蛋白3(Signal Transducer and Activator of Transcription 3,STAT3)/核因子-κB(Nuclear Factor-κB,NF-κB)信号通路的调控作用,探讨胃萎方对胃癌前病变(Precancerous Lesion of Gastric Cancer,PLGC)的疗效及作用机制。方法:从70只雄性Wistar大鼠中随机选择20只作为空白组,其余50只为造模组。采用N-甲基-N’-硝基-N-亚硝基胍(MNNG)诱导GPL大鼠实验模型。14周后,对随机选择的造模组大鼠10只进行胃组织学分析,确认造模成功,造模组剩余40只大鼠随机分为模型组、胃萎方治疗组各20只。使用胃萎方干预后,观察大鼠体质量增长、胃黏膜组织结构变化,以及血清胃蛋白酶原(Pepsinogen,PG)Ⅰ,PGⅡ和胃泌素的浓度,并检测NF-κB p65和STAT3的基因及蛋白表达。结果:与空白组比较,模型组大鼠体质量增长缓慢,胃黏膜组织细胞异型增生明显,血清PGⅠ、胃泌素水平和PGⅠ/PGⅡ比值显著降低,胃黏膜NF-κB/STAT3信号通路被激活;与模型组比较,胃萎方治疗组大鼠整体情况改善,胃黏膜组织结构重塑、萎缩性胃黏膜和非典型腺上皮减少,PGⅠ/PGⅡ比值和胃泌素水平增加(P<0.01),NF-κB p65和STAT3的mRNA及蛋白的表达受到一定程度的抑制(P<0.05)。结论:胃萎方能够通过抑制NF-κB/STAT3信号通路逆转MNNG诱导的大鼠GPL,为胃萎方的临床应用提供了基础证据。展开更多
基金This work was supported by the Natural Science Foundation of Shandong province as the key project(No.Z99B02)general project(No.Q98B02118)
文摘Mononuclear complex {[Cu(N-men)2(cda)2]·[Cu(N-men)2]-(ClO4)2} was synthesized by sodium carbamyldicyanomethanide Na(cda), N-methylethylenediamine and hydrate copper perchlorate. The crystal belongs to the triclinic system, space group P 1 with a = 7.229(2), b = 8.114(2), c = 15.936(4) A, α = 80.511(4), β = 78.993(4), r= 72.118(4)°, V = 867.6(3) A3, Z = 1, C20H44Cl2Cu2N14O10, Mr = 838.68, Dc = 1.605 g/cm3, F(000) = 434 and μ = 1.449 mm-1. The structure was refined to R = 0.0480 and wR = 0.1289 for 2503 observed reflections (I > 2σ(I)). In the complex there exist two kinds of coordination models for Cu (II) ions. One is that the Cu (II) ion is coordinated by four nitrogen atoms which are from two N-men molecules, and a slightly distorted square planar coordinate environment is formed around the Cu (II) ion; the other is that the Cu (II) ion is coordinated by six nitrogen atoms, of which four are from two N-men molecules and the left from nitrile groups, resulting in a distorted octahedron around the Cu (II) ion. The deposition number of the crystal at CCDC is 161868.
文摘[目的]3-(3′,4′-次甲二氧苯基)-N-正丙基丙烯酰胺是具有广谱抑菌活性的化合物,将其研制成优良环保剂型悬浮剂,可为实现田间应用提供技术依据。[方法]采用湿法研磨制备了12种不同配方的悬浮剂,通过质量指标检测确定最佳配方,测定其表面张力及其在黄瓜叶面的动态接触角,并开展了防治黄瓜白粉病田间药效试验。[结果]最佳配方为3-(3′,4′-次甲二氧苯基)-N-正丙基丙烯酰胺40%(折百)、S043%、D4252%、W071%、乙二醇3%、硅酸镁铝0.4%、黄原胶0.12%、B150.12%、消泡剂X600.3%、水补足。此悬浮剂在有效成分0.27 g a.i./L时的表面张力以及在黄瓜叶面的动态接触角均小于对照药剂40%苯醚甲环唑SC,表明其具有良好的润湿性能。在有效成分0.27 g a.i./L下的防效为88.38%,与对照药剂25%嘧菌酯SC 0.20 g a.i./L相当,且对黄瓜安全。[结论]制备悬浮剂为类白色均匀悬浮液,流动性好,粒径合格,悬浮率稳定在98.5%左右,pH为4.09,黏度为452 mPa·s,入水分散性合格,热储、低温及冻融稳定性良好,未出现沉淀,各项指标均达标,对黄瓜白粉病防效优良,具有良好的开发应用前景。
基金supported by the National Natural Science Foundation of China(No.22375123)the Shuguang Program of Shanghai Education Development Foundation,the Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(No.2022SXTD012)。
文摘Fluorinated fused azobenzene boron(FBAz)is a novel electron-deficient building block for polymer electron acceptors in all-polymer solar cells(all-PSC).The B←N bridging units impart a fixed configuration and low-lying LUMO/HOMO energy.Three polymer acceptor materials(P2f,P3f and P5f)with different fluorine substitution positions by copolymerizing FBAz with indacenodithiophene(IDT),are synthesized and investigated to study the influence of fluorinated forms on the all-polymer solar cell performance.The FBAz units are synthesized in just three steps,facilitating the straightforward production of polymer acceptors P2f,P3f,and P5f.These acceptors exhibit strong light absorption in the visible to near-infrared range of 500-1000nm and possess suitable LUMO/HOMO energy levels of-3.99/-5.66 eV which are very complementary to that(E_(LUMO/HOMO)=-3.59/-5.20 eV)of the widely-used polymer donor poly[(ethylhexylthiophenyl)-benzodithiophene-(ethylhexyl)-thienothiophene](PTB7-Th).All-polymer solar cells(all-PSCs)with PTB7-Th as electron donor and P3f as electron acceptor exhibits highest power conversion efficiencies(PCE)2.70%.When PC_(61)BM is added as the third component,the device efficiency can reach 5.36%.These preliminary results indicate that FBAz is a promising strong electron acceptor for the development of n-type polymer semiconductors,especially in organic photovoltaics(OPVs).To the best of our knowledge,this is the first example demonstrating the unique photovoltaic properties of the N=N double bond as an acceptor material.
文摘目的:研究胃萎方对信号转导及转录激活蛋白3(Signal Transducer and Activator of Transcription 3,STAT3)/核因子-κB(Nuclear Factor-κB,NF-κB)信号通路的调控作用,探讨胃萎方对胃癌前病变(Precancerous Lesion of Gastric Cancer,PLGC)的疗效及作用机制。方法:从70只雄性Wistar大鼠中随机选择20只作为空白组,其余50只为造模组。采用N-甲基-N’-硝基-N-亚硝基胍(MNNG)诱导GPL大鼠实验模型。14周后,对随机选择的造模组大鼠10只进行胃组织学分析,确认造模成功,造模组剩余40只大鼠随机分为模型组、胃萎方治疗组各20只。使用胃萎方干预后,观察大鼠体质量增长、胃黏膜组织结构变化,以及血清胃蛋白酶原(Pepsinogen,PG)Ⅰ,PGⅡ和胃泌素的浓度,并检测NF-κB p65和STAT3的基因及蛋白表达。结果:与空白组比较,模型组大鼠体质量增长缓慢,胃黏膜组织细胞异型增生明显,血清PGⅠ、胃泌素水平和PGⅠ/PGⅡ比值显著降低,胃黏膜NF-κB/STAT3信号通路被激活;与模型组比较,胃萎方治疗组大鼠整体情况改善,胃黏膜组织结构重塑、萎缩性胃黏膜和非典型腺上皮减少,PGⅠ/PGⅡ比值和胃泌素水平增加(P<0.01),NF-κB p65和STAT3的mRNA及蛋白的表达受到一定程度的抑制(P<0.05)。结论:胃萎方能够通过抑制NF-κB/STAT3信号通路逆转MNNG诱导的大鼠GPL,为胃萎方的临床应用提供了基础证据。
