[目的]3-(3′,4′-次甲二氧苯基)-N-正丙基丙烯酰胺是具有广谱抑菌活性的化合物,将其研制成优良环保剂型悬浮剂,可为实现田间应用提供技术依据。[方法]采用湿法研磨制备了12种不同配方的悬浮剂,通过质量指标检测确定最佳配方,测定其表...[目的]3-(3′,4′-次甲二氧苯基)-N-正丙基丙烯酰胺是具有广谱抑菌活性的化合物,将其研制成优良环保剂型悬浮剂,可为实现田间应用提供技术依据。[方法]采用湿法研磨制备了12种不同配方的悬浮剂,通过质量指标检测确定最佳配方,测定其表面张力及其在黄瓜叶面的动态接触角,并开展了防治黄瓜白粉病田间药效试验。[结果]最佳配方为3-(3′,4′-次甲二氧苯基)-N-正丙基丙烯酰胺40%(折百)、S043%、D4252%、W071%、乙二醇3%、硅酸镁铝0.4%、黄原胶0.12%、B150.12%、消泡剂X600.3%、水补足。此悬浮剂在有效成分0.27 g a.i./L时的表面张力以及在黄瓜叶面的动态接触角均小于对照药剂40%苯醚甲环唑SC,表明其具有良好的润湿性能。在有效成分0.27 g a.i./L下的防效为88.38%,与对照药剂25%嘧菌酯SC 0.20 g a.i./L相当,且对黄瓜安全。[结论]制备悬浮剂为类白色均匀悬浮液,流动性好,粒径合格,悬浮率稳定在98.5%左右,pH为4.09,黏度为452 mPa·s,入水分散性合格,热储、低温及冻融稳定性良好,未出现沉淀,各项指标均达标,对黄瓜白粉病防效优良,具有良好的开发应用前景。展开更多
Mononuclear complex {[Cu(N-men)2(cda)2]·[Cu(N-men)2]-(ClO4)2} was synthesized by sodium carbamyldicyanomethanide Na(cda), N-methylethylenediamine and hydrate copper perchlorate. The crystal belongs to the triclin...Mononuclear complex {[Cu(N-men)2(cda)2]·[Cu(N-men)2]-(ClO4)2} was synthesized by sodium carbamyldicyanomethanide Na(cda), N-methylethylenediamine and hydrate copper perchlorate. The crystal belongs to the triclinic system, space group P 1 with a = 7.229(2), b = 8.114(2), c = 15.936(4) A, α = 80.511(4), β = 78.993(4), r= 72.118(4)°, V = 867.6(3) A3, Z = 1, C20H44Cl2Cu2N14O10, Mr = 838.68, Dc = 1.605 g/cm3, F(000) = 434 and μ = 1.449 mm-1. The structure was refined to R = 0.0480 and wR = 0.1289 for 2503 observed reflections (I > 2σ(I)). In the complex there exist two kinds of coordination models for Cu (II) ions. One is that the Cu (II) ion is coordinated by four nitrogen atoms which are from two N-men molecules, and a slightly distorted square planar coordinate environment is formed around the Cu (II) ion; the other is that the Cu (II) ion is coordinated by six nitrogen atoms, of which four are from two N-men molecules and the left from nitrile groups, resulting in a distorted octahedron around the Cu (II) ion. The deposition number of the crystal at CCDC is 161868.展开更多
Fluorinated fused azobenzene boron(FBAz)is a novel electron-deficient building block for polymer electron acceptors in all-polymer solar cells(all-PSC).The B←N bridging units impart a fixed configuration and low-lyin...Fluorinated fused azobenzene boron(FBAz)is a novel electron-deficient building block for polymer electron acceptors in all-polymer solar cells(all-PSC).The B←N bridging units impart a fixed configuration and low-lying LUMO/HOMO energy.Three polymer acceptor materials(P2f,P3f and P5f)with different fluorine substitution positions by copolymerizing FBAz with indacenodithiophene(IDT),are synthesized and investigated to study the influence of fluorinated forms on the all-polymer solar cell performance.The FBAz units are synthesized in just three steps,facilitating the straightforward production of polymer acceptors P2f,P3f,and P5f.These acceptors exhibit strong light absorption in the visible to near-infrared range of 500-1000nm and possess suitable LUMO/HOMO energy levels of-3.99/-5.66 eV which are very complementary to that(E_(LUMO/HOMO)=-3.59/-5.20 eV)of the widely-used polymer donor poly[(ethylhexylthiophenyl)-benzodithiophene-(ethylhexyl)-thienothiophene](PTB7-Th).All-polymer solar cells(all-PSCs)with PTB7-Th as electron donor and P3f as electron acceptor exhibits highest power conversion efficiencies(PCE)2.70%.When PC_(61)BM is added as the third component,the device efficiency can reach 5.36%.These preliminary results indicate that FBAz is a promising strong electron acceptor for the development of n-type polymer semiconductors,especially in organic photovoltaics(OPVs).To the best of our knowledge,this is the first example demonstrating the unique photovoltaic properties of the N=N double bond as an acceptor material.展开更多
目的:研究胃萎方对信号转导及转录激活蛋白3(Signal Transducer and Activator of Transcription 3,STAT3)/核因子-κB(Nuclear Factor-κB,NF-κB)信号通路的调控作用,探讨胃萎方对胃癌前病变(Precancerous Lesion of Gastric Cancer,P...目的:研究胃萎方对信号转导及转录激活蛋白3(Signal Transducer and Activator of Transcription 3,STAT3)/核因子-κB(Nuclear Factor-κB,NF-κB)信号通路的调控作用,探讨胃萎方对胃癌前病变(Precancerous Lesion of Gastric Cancer,PLGC)的疗效及作用机制。方法:从70只雄性Wistar大鼠中随机选择20只作为空白组,其余50只为造模组。采用N-甲基-N’-硝基-N-亚硝基胍(MNNG)诱导GPL大鼠实验模型。14周后,对随机选择的造模组大鼠10只进行胃组织学分析,确认造模成功,造模组剩余40只大鼠随机分为模型组、胃萎方治疗组各20只。使用胃萎方干预后,观察大鼠体质量增长、胃黏膜组织结构变化,以及血清胃蛋白酶原(Pepsinogen,PG)Ⅰ,PGⅡ和胃泌素的浓度,并检测NF-κB p65和STAT3的基因及蛋白表达。结果:与空白组比较,模型组大鼠体质量增长缓慢,胃黏膜组织细胞异型增生明显,血清PGⅠ、胃泌素水平和PGⅠ/PGⅡ比值显著降低,胃黏膜NF-κB/STAT3信号通路被激活;与模型组比较,胃萎方治疗组大鼠整体情况改善,胃黏膜组织结构重塑、萎缩性胃黏膜和非典型腺上皮减少,PGⅠ/PGⅡ比值和胃泌素水平增加(P<0.01),NF-κB p65和STAT3的mRNA及蛋白的表达受到一定程度的抑制(P<0.05)。结论:胃萎方能够通过抑制NF-κB/STAT3信号通路逆转MNNG诱导的大鼠GPL,为胃萎方的临床应用提供了基础证据。展开更多
文摘[目的]3-(3′,4′-次甲二氧苯基)-N-正丙基丙烯酰胺是具有广谱抑菌活性的化合物,将其研制成优良环保剂型悬浮剂,可为实现田间应用提供技术依据。[方法]采用湿法研磨制备了12种不同配方的悬浮剂,通过质量指标检测确定最佳配方,测定其表面张力及其在黄瓜叶面的动态接触角,并开展了防治黄瓜白粉病田间药效试验。[结果]最佳配方为3-(3′,4′-次甲二氧苯基)-N-正丙基丙烯酰胺40%(折百)、S043%、D4252%、W071%、乙二醇3%、硅酸镁铝0.4%、黄原胶0.12%、B150.12%、消泡剂X600.3%、水补足。此悬浮剂在有效成分0.27 g a.i./L时的表面张力以及在黄瓜叶面的动态接触角均小于对照药剂40%苯醚甲环唑SC,表明其具有良好的润湿性能。在有效成分0.27 g a.i./L下的防效为88.38%,与对照药剂25%嘧菌酯SC 0.20 g a.i./L相当,且对黄瓜安全。[结论]制备悬浮剂为类白色均匀悬浮液,流动性好,粒径合格,悬浮率稳定在98.5%左右,pH为4.09,黏度为452 mPa·s,入水分散性合格,热储、低温及冻融稳定性良好,未出现沉淀,各项指标均达标,对黄瓜白粉病防效优良,具有良好的开发应用前景。
基金This work was supported by the Natural Science Foundation of Shandong province as the key project(No.Z99B02)general project(No.Q98B02118)
文摘Mononuclear complex {[Cu(N-men)2(cda)2]·[Cu(N-men)2]-(ClO4)2} was synthesized by sodium carbamyldicyanomethanide Na(cda), N-methylethylenediamine and hydrate copper perchlorate. The crystal belongs to the triclinic system, space group P 1 with a = 7.229(2), b = 8.114(2), c = 15.936(4) A, α = 80.511(4), β = 78.993(4), r= 72.118(4)°, V = 867.6(3) A3, Z = 1, C20H44Cl2Cu2N14O10, Mr = 838.68, Dc = 1.605 g/cm3, F(000) = 434 and μ = 1.449 mm-1. The structure was refined to R = 0.0480 and wR = 0.1289 for 2503 observed reflections (I > 2σ(I)). In the complex there exist two kinds of coordination models for Cu (II) ions. One is that the Cu (II) ion is coordinated by four nitrogen atoms which are from two N-men molecules, and a slightly distorted square planar coordinate environment is formed around the Cu (II) ion; the other is that the Cu (II) ion is coordinated by six nitrogen atoms, of which four are from two N-men molecules and the left from nitrile groups, resulting in a distorted octahedron around the Cu (II) ion. The deposition number of the crystal at CCDC is 161868.
基金supported by the National Natural Science Foundation of China(No.22375123)the Shuguang Program of Shanghai Education Development Foundation,the Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(No.2022SXTD012)。
文摘Fluorinated fused azobenzene boron(FBAz)is a novel electron-deficient building block for polymer electron acceptors in all-polymer solar cells(all-PSC).The B←N bridging units impart a fixed configuration and low-lying LUMO/HOMO energy.Three polymer acceptor materials(P2f,P3f and P5f)with different fluorine substitution positions by copolymerizing FBAz with indacenodithiophene(IDT),are synthesized and investigated to study the influence of fluorinated forms on the all-polymer solar cell performance.The FBAz units are synthesized in just three steps,facilitating the straightforward production of polymer acceptors P2f,P3f,and P5f.These acceptors exhibit strong light absorption in the visible to near-infrared range of 500-1000nm and possess suitable LUMO/HOMO energy levels of-3.99/-5.66 eV which are very complementary to that(E_(LUMO/HOMO)=-3.59/-5.20 eV)of the widely-used polymer donor poly[(ethylhexylthiophenyl)-benzodithiophene-(ethylhexyl)-thienothiophene](PTB7-Th).All-polymer solar cells(all-PSCs)with PTB7-Th as electron donor and P3f as electron acceptor exhibits highest power conversion efficiencies(PCE)2.70%.When PC_(61)BM is added as the third component,the device efficiency can reach 5.36%.These preliminary results indicate that FBAz is a promising strong electron acceptor for the development of n-type polymer semiconductors,especially in organic photovoltaics(OPVs).To the best of our knowledge,this is the first example demonstrating the unique photovoltaic properties of the N=N double bond as an acceptor material.
文摘目的:研究胃萎方对信号转导及转录激活蛋白3(Signal Transducer and Activator of Transcription 3,STAT3)/核因子-κB(Nuclear Factor-κB,NF-κB)信号通路的调控作用,探讨胃萎方对胃癌前病变(Precancerous Lesion of Gastric Cancer,PLGC)的疗效及作用机制。方法:从70只雄性Wistar大鼠中随机选择20只作为空白组,其余50只为造模组。采用N-甲基-N’-硝基-N-亚硝基胍(MNNG)诱导GPL大鼠实验模型。14周后,对随机选择的造模组大鼠10只进行胃组织学分析,确认造模成功,造模组剩余40只大鼠随机分为模型组、胃萎方治疗组各20只。使用胃萎方干预后,观察大鼠体质量增长、胃黏膜组织结构变化,以及血清胃蛋白酶原(Pepsinogen,PG)Ⅰ,PGⅡ和胃泌素的浓度,并检测NF-κB p65和STAT3的基因及蛋白表达。结果:与空白组比较,模型组大鼠体质量增长缓慢,胃黏膜组织细胞异型增生明显,血清PGⅠ、胃泌素水平和PGⅠ/PGⅡ比值显著降低,胃黏膜NF-κB/STAT3信号通路被激活;与模型组比较,胃萎方治疗组大鼠整体情况改善,胃黏膜组织结构重塑、萎缩性胃黏膜和非典型腺上皮减少,PGⅠ/PGⅡ比值和胃泌素水平增加(P<0.01),NF-κB p65和STAT3的mRNA及蛋白的表达受到一定程度的抑制(P<0.05)。结论:胃萎方能够通过抑制NF-κB/STAT3信号通路逆转MNNG诱导的大鼠GPL,为胃萎方的临床应用提供了基础证据。
