肌联素(Myonectin),又称补体C1q/肿瘤坏死因子相关蛋白15(C1q/TNF-related protein 15),是一种新型骨骼肌因子,主要在骨骼肌组织中表达,其表达水平受到运动、肥胖及营养状态等多种因素的影响。Myonectin可作为2型糖尿病和肥胖的有效生...肌联素(Myonectin),又称补体C1q/肿瘤坏死因子相关蛋白15(C1q/TNF-related protein 15),是一种新型骨骼肌因子,主要在骨骼肌组织中表达,其表达水平受到运动、肥胖及营养状态等多种因素的影响。Myonectin可作为2型糖尿病和肥胖的有效生物标志物,然而,目前关于Myonectin的诸多方面仍待深入研究。该文旨在综述影响Myonectin生成的因素、Myonectin的生物学效应及其在机体代谢中的作用,探讨骨骼肌因子与机体代谢系统之间的相互作用,以期为肌少症、骨质疏松症以及代谢性疾病等提供新的治疗思路和策略。展开更多
Iron metabolism is regulated on the cellular and the systemic level. Over the last decade, the liver peptide "hepcidin" has emerged as the body's key irons store regulator. The long postulated "eryt...Iron metabolism is regulated on the cellular and the systemic level. Over the last decade, the liver peptide "hepcidin" has emerged as the body's key irons store regulator. The long postulated "erythroid regulator of iron", however, remained elusive. Last year, evidence was provided, that a previously described myokine "myonectin" may also function as the long sought erythroid regulator of iron. Myonectin was therefore renamed "erythroferrone". This editorial provides a brief discussion on the two functions of erythroferrone and also briefly considers the emerging potential role of transferrin receptor 2 in erythropoiesis.展开更多
文摘肌联素(Myonectin),又称补体C1q/肿瘤坏死因子相关蛋白15(C1q/TNF-related protein 15),是一种新型骨骼肌因子,主要在骨骼肌组织中表达,其表达水平受到运动、肥胖及营养状态等多种因素的影响。Myonectin可作为2型糖尿病和肥胖的有效生物标志物,然而,目前关于Myonectin的诸多方面仍待深入研究。该文旨在综述影响Myonectin生成的因素、Myonectin的生物学效应及其在机体代谢中的作用,探讨骨骼肌因子与机体代谢系统之间的相互作用,以期为肌少症、骨质疏松症以及代谢性疾病等提供新的治疗思路和策略。
文摘Iron metabolism is regulated on the cellular and the systemic level. Over the last decade, the liver peptide "hepcidin" has emerged as the body's key irons store regulator. The long postulated "erythroid regulator of iron", however, remained elusive. Last year, evidence was provided, that a previously described myokine "myonectin" may also function as the long sought erythroid regulator of iron. Myonectin was therefore renamed "erythroferrone". This editorial provides a brief discussion on the two functions of erythroferrone and also briefly considers the emerging potential role of transferrin receptor 2 in erythropoiesis.
