Serrated adenocarcinoma is a recently described subset of colorectal cancer(CRC),which account for about10%of all CRCs and follows an alternative pathway in which serrated polyps replace the traditional adenoma as the...Serrated adenocarcinoma is a recently described subset of colorectal cancer(CRC),which account for about10%of all CRCs and follows an alternative pathway in which serrated polyps replace the traditional adenoma as the precursor lesion to CRC.Serrated polyps form a heterogeneous group of colorectal lesions that includes hyperplastic polyps(HPs),sessile serrated adenoma(SSA),traditional serrated adenoma(TSA)and mixed polyps.HPs are the most common serrated polyp followed by SSA and TSA.This distinct histogenesis is believed to have a major influence in prevention strategies,patient prognosis and therapeutic impact.Genetically,serrated polyps exhibited also a distinct pattern,with KRAS and BRAF having an important contribution to its development.Two other molecular changes that have been implicated in the serrated pathway include microsatellite instability and the CpG island methylator phenotype.In the present review we will address the current knowledge of serrated polyps,clinical pathological features and will update the most recent findings of its molecular pathways.The understanding of their biology and malignancy potential is imperative to implement a surveillance approach in order to prevent colorectal cancer development.展开更多
Hepatitis B virus(HBV)infection remains a challenging global health problem,with more than 350 million people chronically infected and at risk of developing hepatocellular carcinoma(HCC).Interactions that occur among ...Hepatitis B virus(HBV)infection remains a challenging global health problem,with more than 350 million people chronically infected and at risk of developing hepatocellular carcinoma(HCC).Interactions that occur among host,environmental,and viral factors determine the natural course and predict the prognosis of patients with chronic HBV infection.In the past decades,several important viral factors of predictive of HCC have been identified,such as high hepatitis B surface antigen level,seropositivity of hepatitis B e antigen,high viral load,viral genotype,and specific viral sequence mutations.Identification of certain viral risk factors for HCC development and stratification of patient risk are very important to perform future surveillance programs.In this article,we thus reviewed the risk of viral factors involved in hepatocarcinogenesis.展开更多
文摘Serrated adenocarcinoma is a recently described subset of colorectal cancer(CRC),which account for about10%of all CRCs and follows an alternative pathway in which serrated polyps replace the traditional adenoma as the precursor lesion to CRC.Serrated polyps form a heterogeneous group of colorectal lesions that includes hyperplastic polyps(HPs),sessile serrated adenoma(SSA),traditional serrated adenoma(TSA)and mixed polyps.HPs are the most common serrated polyp followed by SSA and TSA.This distinct histogenesis is believed to have a major influence in prevention strategies,patient prognosis and therapeutic impact.Genetically,serrated polyps exhibited also a distinct pattern,with KRAS and BRAF having an important contribution to its development.Two other molecular changes that have been implicated in the serrated pathway include microsatellite instability and the CpG island methylator phenotype.In the present review we will address the current knowledge of serrated polyps,clinical pathological features and will update the most recent findings of its molecular pathways.The understanding of their biology and malignancy potential is imperative to implement a surveillance approach in order to prevent colorectal cancer development.
基金Supported by China Ministry of Health,No.W201202Natural Science Foundation of Jiangsu Province,No.BK2012225+1 种基金Foundation of Jiangsu Province,No.WS056National Nature Science Foundation of China,No.81302056
文摘Hepatitis B virus(HBV)infection remains a challenging global health problem,with more than 350 million people chronically infected and at risk of developing hepatocellular carcinoma(HCC).Interactions that occur among host,environmental,and viral factors determine the natural course and predict the prognosis of patients with chronic HBV infection.In the past decades,several important viral factors of predictive of HCC have been identified,such as high hepatitis B surface antigen level,seropositivity of hepatitis B e antigen,high viral load,viral genotype,and specific viral sequence mutations.Identification of certain viral risk factors for HCC development and stratification of patient risk are very important to perform future surveillance programs.In this article,we thus reviewed the risk of viral factors involved in hepatocarcinogenesis.
