BACKGROUND Patients with end-stage liver disease usually have varying degrees of malnutrition,and severe malnutrition may affect the prognosis of patients after liver transplantation(LT).However,there is no recommende...BACKGROUND Patients with end-stage liver disease usually have varying degrees of malnutrition,and severe malnutrition may affect the prognosis of patients after liver transplantation(LT).However,there is no recommended standard for the nutrition assessment of patients waiting for LT,and it is unknown whether malnutrition has an impact on the occurrence of postoperative complications.AIM The study aim was to investigate the value of the controlling nutritional status(CONUT)score and psoas muscle thickness per height(PMTH)in predicting prognosis in LT.METHODS We retrospectively analyzed the clinical data of 313 patients who underwent classic orthotopic LT from January 2016 to December 2018 in Tianjin First Central Hospital affiliated with Tianjin Medical University.The CONUT score is derived from the preoperative serum albumin and total cholesterol levels,and total lymphocyte count.Patients were divided into low(≤4),medium(5–8),and high(9–12)CONUT score groups perioperative characteristics,Clavien-Dindo grade III/IV/V postoperative complications,graft loss and infection,and cumulative postoperative survival in the three groups were compared 3 mo after LT.PMTH was calculated as the ratio of the transverse thickness of the psoas muscle in the umbilical plane to the height of the patient.The cutoff values of receiver operating characteristic curves were determined separately for men and women.The values were 14.1 cm/m2 for women and 17.9 cm/m2 for men.The patients were then divided into low and high PMTH groups by the cutoff values.The comparison of data between the two groups was the same as above.RESULTS Patients with medium and high CONUT scores had lower preoperative serum hemoglobin,more intraoperative red blood cell(RBC)transfusions,longer postoperative intensive care unit stay and hospital stays,higher 7 and 14 preoperative-day serum bilirubin levels,and a higher incidence of postoperative grade III/IV complications and infections than patients with low CONUT scores.Differences in the 3-mo cumulative survival among the three groups were not significant.Patients with a low PMTH had higher preoperative serum urea nitrogen,more intraoperative packed RBC and frozen plasma transfusions,longer times to postoperative ventilator extubation,higher incidence of total postoperative complications,and a lower 3-mo cumulative survival than those with a high PMTH.CONCLUSION A CONUT score≥5 and a low PMTH were both associated with poor prognosis in LT.The CONUT score had no predictive value for short-term patient survival after LT,but the PMTH was predictive of short-term patient survival after LT.展开更多
Publisher Correction to:Journal of Science in Sport and Exercise https://doi.org/10.1007/s42978-022-00200-1 In this article,Charlie Ottinger,Raad Gheith,Matthew Ste-fan,Ryan Lowery,and Jacob Wilson at Research Divisio...Publisher Correction to:Journal of Science in Sport and Exercise https://doi.org/10.1007/s42978-022-00200-1 In this article,Charlie Ottinger,Raad Gheith,Matthew Ste-fan,Ryan Lowery,and Jacob Wilson at Research Division,Applied Science and Performance Institute;and Salvatore LoDuca at Offset Ventures LLC were missing from the author list.展开更多
Objective:To evaluate the efficacy and safety of transcutaneous electrical acupoint stimulation(TEAS)for muscle atrophy in patients with immobilization after surgical fixation of foot and ankle fractures.Methods:This ...Objective:To evaluate the efficacy and safety of transcutaneous electrical acupoint stimulation(TEAS)for muscle atrophy in patients with immobilization after surgical fixation of foot and ankle fractures.Methods:This was a two-arm randomized controlled trial wherein 80 patients were recruited and divided into control(n=40)and intervention(n=40)groups.The control group received conventional orthopedic treatment,whereas the intervention group received TEAS and conventional treatment.The intervention group received TEAS 3 times a week for 30 min each time for 8 weeks.The primary out-comes were muscle thickness(MT)and cross-sectional area(CSA)of the rectus femoris and gastroc-nemius muscles,whereas the secondary outcome measure was echo intensity(EI).Data were collected before the fixation operations(baseline assessment)and 4 and 8 weeks after intervention.Results:Compared with baseline,the MT and CSA were reduced in both groups by the end of treatment,whereas EI increased in both groups.At week 4,the reduction in the rectus femoris CSA in the inter-vention group was significantly lower than that in the control group(P=0.02);however,the between-group differences in the MT and EI(all P>0.05)were not significant.No serious adverse events were observed in either group.Conclusion:Our study showed that TEAS can improve muscle atrophy by attenuating the decline in the muscle CSA.Because this was only a pilot trial,subsequent studies will need longer follow-ups and larger sample sizes.展开更多
The purpose of this study was to examine the relationship between field-based simplified approaches and knee extensor muscle strength/size in young men. Knee extensor muscle thickness （MT） of 104 healthy university ...The purpose of this study was to examine the relationship between field-based simplified approaches and knee extensor muscle strength/size in young men. Knee extensor muscle thickness （MT） of 104 healthy university freshmen was measured at the anterior half of thigh length; maximal voluntary isometric contraction （MVIC） was measured when subjects performed knee extension. Field-based simplified approaches [sit-to-stand, standing long jump （SLJ）, handgrip and upper-leg-50% （thigh） girth] were also measured. MVIC was correlated with SLJ （r = 0.361, P 〈 0.001）, handgrip （r = 0.523, P 〈 0.001） and thigh girth （r = 0.401, P 〈 0.001）, but not with the sit-to-stand test （r = 0.126, P 〉 0.05）. MT was correlated with handgrip （r = 0.317, P 〈 0.001） and thigh girth （r = 0.632, P 〈 0.001）, but not with SLJ （r = 0.038, P 〉 0.05） or the sit-to-stand test （r = 0.145, P 〉 0.05）. A stepwise multiple-regression analysis was applied to the predictor thigh girth to predict knee extensor MT （R2 = 0.399）. To predict knee extensor MVIC, the predictor handgrip, thigh girth and SLJ were applied （R2 = 0.381）. In conclusion, knee extensor muscle strength/size could be evaluated by the field-based simplified approaches, in particular by the thigh girth measurement, which may be major determinant to maintain activities of daily living for healthy young men. However, the 4 field-based simplified approaches appear to be still not of high impact.展开更多
基金Nation Natural Science Foundation of China(General Program),No.81870444Natural Science Foundation of Tianjin,No.17JCQNJC12800.
文摘BACKGROUND Patients with end-stage liver disease usually have varying degrees of malnutrition,and severe malnutrition may affect the prognosis of patients after liver transplantation(LT).However,there is no recommended standard for the nutrition assessment of patients waiting for LT,and it is unknown whether malnutrition has an impact on the occurrence of postoperative complications.AIM The study aim was to investigate the value of the controlling nutritional status(CONUT)score and psoas muscle thickness per height(PMTH)in predicting prognosis in LT.METHODS We retrospectively analyzed the clinical data of 313 patients who underwent classic orthotopic LT from January 2016 to December 2018 in Tianjin First Central Hospital affiliated with Tianjin Medical University.The CONUT score is derived from the preoperative serum albumin and total cholesterol levels,and total lymphocyte count.Patients were divided into low(≤4),medium(5–8),and high(9–12)CONUT score groups perioperative characteristics,Clavien-Dindo grade III/IV/V postoperative complications,graft loss and infection,and cumulative postoperative survival in the three groups were compared 3 mo after LT.PMTH was calculated as the ratio of the transverse thickness of the psoas muscle in the umbilical plane to the height of the patient.The cutoff values of receiver operating characteristic curves were determined separately for men and women.The values were 14.1 cm/m2 for women and 17.9 cm/m2 for men.The patients were then divided into low and high PMTH groups by the cutoff values.The comparison of data between the two groups was the same as above.RESULTS Patients with medium and high CONUT scores had lower preoperative serum hemoglobin,more intraoperative red blood cell(RBC)transfusions,longer postoperative intensive care unit stay and hospital stays,higher 7 and 14 preoperative-day serum bilirubin levels,and a higher incidence of postoperative grade III/IV complications and infections than patients with low CONUT scores.Differences in the 3-mo cumulative survival among the three groups were not significant.Patients with a low PMTH had higher preoperative serum urea nitrogen,more intraoperative packed RBC and frozen plasma transfusions,longer times to postoperative ventilator extubation,higher incidence of total postoperative complications,and a lower 3-mo cumulative survival than those with a high PMTH.CONCLUSION A CONUT score≥5 and a low PMTH were both associated with poor prognosis in LT.The CONUT score had no predictive value for short-term patient survival after LT,but the PMTH was predictive of short-term patient survival after LT.
文摘Publisher Correction to:Journal of Science in Sport and Exercise https://doi.org/10.1007/s42978-022-00200-1 In this article,Charlie Ottinger,Raad Gheith,Matthew Ste-fan,Ryan Lowery,and Jacob Wilson at Research Division,Applied Science and Performance Institute;and Salvatore LoDuca at Offset Ventures LLC were missing from the author list.
基金supported by the funded project(HYZHX M05005)in the field of space medical experiments of manned spaceflight engineering.
文摘Objective:To evaluate the efficacy and safety of transcutaneous electrical acupoint stimulation(TEAS)for muscle atrophy in patients with immobilization after surgical fixation of foot and ankle fractures.Methods:This was a two-arm randomized controlled trial wherein 80 patients were recruited and divided into control(n=40)and intervention(n=40)groups.The control group received conventional orthopedic treatment,whereas the intervention group received TEAS and conventional treatment.The intervention group received TEAS 3 times a week for 30 min each time for 8 weeks.The primary out-comes were muscle thickness(MT)and cross-sectional area(CSA)of the rectus femoris and gastroc-nemius muscles,whereas the secondary outcome measure was echo intensity(EI).Data were collected before the fixation operations(baseline assessment)and 4 and 8 weeks after intervention.Results:Compared with baseline,the MT and CSA were reduced in both groups by the end of treatment,whereas EI increased in both groups.At week 4,the reduction in the rectus femoris CSA in the inter-vention group was significantly lower than that in the control group(P=0.02);however,the between-group differences in the MT and EI(all P>0.05)were not significant.No serious adverse events were observed in either group.Conclusion:Our study showed that TEAS can improve muscle atrophy by attenuating the decline in the muscle CSA.Because this was only a pilot trial,subsequent studies will need longer follow-ups and larger sample sizes.
文摘The purpose of this study was to examine the relationship between field-based simplified approaches and knee extensor muscle strength/size in young men. Knee extensor muscle thickness （MT） of 104 healthy university freshmen was measured at the anterior half of thigh length; maximal voluntary isometric contraction （MVIC） was measured when subjects performed knee extension. Field-based simplified approaches [sit-to-stand, standing long jump （SLJ）, handgrip and upper-leg-50% （thigh） girth] were also measured. MVIC was correlated with SLJ （r = 0.361, P 〈 0.001）, handgrip （r = 0.523, P 〈 0.001） and thigh girth （r = 0.401, P 〈 0.001）, but not with the sit-to-stand test （r = 0.126, P 〉 0.05）. MT was correlated with handgrip （r = 0.317, P 〈 0.001） and thigh girth （r = 0.632, P 〈 0.001）, but not with SLJ （r = 0.038, P 〉 0.05） or the sit-to-stand test （r = 0.145, P 〉 0.05）. A stepwise multiple-regression analysis was applied to the predictor thigh girth to predict knee extensor MT （R2 = 0.399）. To predict knee extensor MVIC, the predictor handgrip, thigh girth and SLJ were applied （R2 = 0.381）. In conclusion, knee extensor muscle strength/size could be evaluated by the field-based simplified approaches, in particular by the thigh girth measurement, which may be major determinant to maintain activities of daily living for healthy young men. However, the 4 field-based simplified approaches appear to be still not of high impact.
