To investigate the efficacy of a combination therapy on gluteal muscle contracture, 286 definitely diagnosed patients were subjected to surgical treatment, and then functional exercises and physical therapy. The patie...To investigate the efficacy of a combination therapy on gluteal muscle contracture, 286 definitely diagnosed patients were subjected to surgical treatment, and then functional exercises and physical therapy. The patients with severe symptoms were asked to have a set of specially-designed functional exercises. All the patients were followed up for 3 to 24 months by hospital visit, correspondence or telephone interview. The effective rate was 100%, and the curative rate was up to 94.6%. Few patients developed complications and relapse was rare. It is concluded that the combination therapy, including surgical removal of diseased tissues, functional exercises and physical therapy, is an effective approach for the treatment of severe juvenile gluteal muscle contracture.展开更多
Summary: The operation methods, clinical classification, postoperative function exercise of gluteal muscles contracture were investigated. Clinically and retrospectively, treatment of 1280 patients with gluteal muscle...Summary: The operation methods, clinical classification, postoperative function exercise of gluteal muscles contracture were investigated. Clinically and retrospectively, treatment of 1280 patients with gluteal muscles contracture, being subjected to a 'Z-shaped' release lengthening operation and efficiency exercise, was clearly standardized. All the cases were followed up from 3 months to 2 years with the effective rate being 100 %, the cure rate being 98. 5 %, the recent complications being 5%, and the far complications being 0. 2 %. It was concluded that the clear diagnosis combined with standarized operation and efficiency functional exercise could greatly improve the therapeutic effects of gluteal muscles contracture.展开更多
Objective To determine whether acupotomy ameliorates immobilization-induced muscle contracture and fibrosis via Wnt/β-catenin signaling pathway.Methods Thirty Wistar rats were randomly divided into 5 groups(n=6)by a ...Objective To determine whether acupotomy ameliorates immobilization-induced muscle contracture and fibrosis via Wnt/β-catenin signaling pathway.Methods Thirty Wistar rats were randomly divided into 5 groups(n=6)by a random number table,including control,immobilization,passive stretching,acupotomy,and acupotomy 3 weeks(3-w)groups.The rat model of gastrocnemius contracture was established by immobilizing the right hind limb in plantar flexion for 4 weeks.Rats in the passive stretching group received passive stretching at gastrocnemius,a daily series of 10 repetitions for 30 s each at 30-s intervals for 10 consecutive days.Rats in the acupotomy and acupotomy 3-w groups received acupotomy once and combined with passive stretching at gastrocnemius a daily series of 10 repetitions for 30 s each at 30-s intervals for 10 consecutive days.Additionally,rats in the acupotomy 3-w group were allowed to walk freely for 3 weeks after 10-day therapy.After treatment,range of motion(ROM),gait analysis[i.e.,paw area,stance/swing and maximum ratio of paw area to paw area duration(Max dA/dT)],gastrocnemius wet weight and the ratio of muscle wet weight to body weight(MWW/BW)were tested.Gastrocnemius morphometric and muscle fiber cross-sectional area(CSA)were assessed by hematoxylin-eosin staining.Fibrosis-related mRNA expressions(i.e.,Wnt 1,β-catenin,axin-2,α-smooth muscle actin,fibronectin,and types I and III collagen)were measured using real-time quantitative polymerase chain reactions.Wnt 1,β-catenin and fibronectin concentrations were measured by enzyme-linked immunosorbent assay.Types I and III collagen in the perimysium and endomysium were analyzed using immunofluorescence.Results Compared with the control group,ROM,gait function,muscle weight,MWW/BW and CSA were significantly decreased in the immobilization group(all P<0.01),while protein levels of types I and III collagen,Wnt 1,β-catenin,fibronectin and mRNA levels of fibrosis-related genes were obviously increased(all P<0.01).Treatment with passive stretching or acupotomy restored ROM and gait function and increased muscle wet weight,MWW/BW and CSA(all P<0.05),while protein expression levels of Wnt 1,β-catenin,fibronectin,types I and III collagen and mRNA levels of fibrosis-related genes were remarkably declined compared with the immobilization group(all P<0.05).Compared with passive stretching group,ROM,gait function,MWW was remarkably restored(all P<0.05),and mRNA levels of fibrosis-related genes as well as protein expression levels of Wnt 1,β-catenin,fibronectin,types I and III collagen in the acupotomy group were obviously decreased(all P<0.05).Compared with the acupotomy group,ROM,paw area,Max dA/dT,and MWW were restored(all P<0.05),and mRNA levels of fibrosis-related genes along with protein levels of Wnt 1,β-catenin,fibronectin,types I and III collagen in the acupotomy 3-w group were decreased(P<0.05).Conclusion Improvements in motor function,muscle contractures,and muscle fibrosis induced by acupotomy correlates with the inhibition of Wnt/β-catenin signaling pathway.展开更多
文摘To investigate the efficacy of a combination therapy on gluteal muscle contracture, 286 definitely diagnosed patients were subjected to surgical treatment, and then functional exercises and physical therapy. The patients with severe symptoms were asked to have a set of specially-designed functional exercises. All the patients were followed up for 3 to 24 months by hospital visit, correspondence or telephone interview. The effective rate was 100%, and the curative rate was up to 94.6%. Few patients developed complications and relapse was rare. It is concluded that the combination therapy, including surgical removal of diseased tissues, functional exercises and physical therapy, is an effective approach for the treatment of severe juvenile gluteal muscle contracture.
文摘Summary: The operation methods, clinical classification, postoperative function exercise of gluteal muscles contracture were investigated. Clinically and retrospectively, treatment of 1280 patients with gluteal muscles contracture, being subjected to a 'Z-shaped' release lengthening operation and efficiency exercise, was clearly standardized. All the cases were followed up from 3 months to 2 years with the effective rate being 100 %, the cure rate being 98. 5 %, the recent complications being 5%, and the far complications being 0. 2 %. It was concluded that the clear diagnosis combined with standarized operation and efficiency functional exercise could greatly improve the therapeutic effects of gluteal muscles contracture.
基金Supported by the Beijing University of Chinese Medicine Research Platform Construction Project(No.2023-JYB-KYPT-11)。
文摘Objective To determine whether acupotomy ameliorates immobilization-induced muscle contracture and fibrosis via Wnt/β-catenin signaling pathway.Methods Thirty Wistar rats were randomly divided into 5 groups(n=6)by a random number table,including control,immobilization,passive stretching,acupotomy,and acupotomy 3 weeks(3-w)groups.The rat model of gastrocnemius contracture was established by immobilizing the right hind limb in plantar flexion for 4 weeks.Rats in the passive stretching group received passive stretching at gastrocnemius,a daily series of 10 repetitions for 30 s each at 30-s intervals for 10 consecutive days.Rats in the acupotomy and acupotomy 3-w groups received acupotomy once and combined with passive stretching at gastrocnemius a daily series of 10 repetitions for 30 s each at 30-s intervals for 10 consecutive days.Additionally,rats in the acupotomy 3-w group were allowed to walk freely for 3 weeks after 10-day therapy.After treatment,range of motion(ROM),gait analysis[i.e.,paw area,stance/swing and maximum ratio of paw area to paw area duration(Max dA/dT)],gastrocnemius wet weight and the ratio of muscle wet weight to body weight(MWW/BW)were tested.Gastrocnemius morphometric and muscle fiber cross-sectional area(CSA)were assessed by hematoxylin-eosin staining.Fibrosis-related mRNA expressions(i.e.,Wnt 1,β-catenin,axin-2,α-smooth muscle actin,fibronectin,and types I and III collagen)were measured using real-time quantitative polymerase chain reactions.Wnt 1,β-catenin and fibronectin concentrations were measured by enzyme-linked immunosorbent assay.Types I and III collagen in the perimysium and endomysium were analyzed using immunofluorescence.Results Compared with the control group,ROM,gait function,muscle weight,MWW/BW and CSA were significantly decreased in the immobilization group(all P<0.01),while protein levels of types I and III collagen,Wnt 1,β-catenin,fibronectin and mRNA levels of fibrosis-related genes were obviously increased(all P<0.01).Treatment with passive stretching or acupotomy restored ROM and gait function and increased muscle wet weight,MWW/BW and CSA(all P<0.05),while protein expression levels of Wnt 1,β-catenin,fibronectin,types I and III collagen and mRNA levels of fibrosis-related genes were remarkably declined compared with the immobilization group(all P<0.05).Compared with passive stretching group,ROM,gait function,MWW was remarkably restored(all P<0.05),and mRNA levels of fibrosis-related genes as well as protein expression levels of Wnt 1,β-catenin,fibronectin,types I and III collagen in the acupotomy group were obviously decreased(all P<0.05).Compared with the acupotomy group,ROM,paw area,Max dA/dT,and MWW were restored(all P<0.05),and mRNA levels of fibrosis-related genes along with protein levels of Wnt 1,β-catenin,fibronectin,types I and III collagen in the acupotomy 3-w group were decreased(P<0.05).Conclusion Improvements in motor function,muscle contractures,and muscle fibrosis induced by acupotomy correlates with the inhibition of Wnt/β-catenin signaling pathway.
