Objective To study the relationship between dyslipidemia and outcome in patients with acute ischemic stroke. Methods Data about 2 568 patients with acute ischemic stroke were collected from 4 hospitals in Shandong Pro...Objective To study the relationship between dyslipidemia and outcome in patients with acute ischemic stroke. Methods Data about 2 568 patients with acute ischemic stroke were collected from 4 hospitals in Shandong Province from January 2006 to December 2008. National Institute of Health Stroke Scale （NIHSS） 〉10 at discharge or death was defined as the outcome. Effect of dyslipidemia on outcome in patients with acute ischemic stroke was analyzed by multivariate logistic regression analysis and propensity score-adjusted analysis, respectively. Results The serum levels of TC, LDL-C, and HDL-C were significantly associated with the outcome in patients with acute ischemic stroke. Multivariate logistic regression analysis and propensity score-adjusted analysis showed that the ORs and 95% CIs were 3.013 （1.259, 7.214）/2.655 （1.298, 5.43）, 3.157 （1.306, 7.631）/3.405 （1.621, 7.154）, and 0.482 （0.245, 0.946）/0.51 （0.282, O.921）, respectively, for patients with acute ischemic stroke. Hosmer-Lemeshow goodness-of-fit test showed no significant difference in observed and predicted risk in patients with acute ischemic stroke （chi-square=8.235, P=0.411）. Conclusion Serum levels of TC, LDL-C, and HDL-C are positively related with the outcome in patients with acute ischemic stroke.展开更多
Objective To observe the long-term efficacy of qibenefiting and yin-nourishing Chinese patent medicines(QYP)for IgA nephropathy(IgAN).Methods Two thousand patients with primary IgAN diagnosed by renal biopsy at three ...Objective To observe the long-term efficacy of qibenefiting and yin-nourishing Chinese patent medicines(QYP)for IgA nephropathy(IgAN).Methods Two thousand patients with primary IgAN diagnosed by renal biopsy at three hospitals were included in this study.Patients were assigned to a treatment group and a control group based on the administration of QYP.Demographic data,pathological outcomes,and differences in Chinese medicine syndromes between the two groups were compared.To control for confounding factors,a 1:1 propensity score matching method was used to match patients,and a multivariate Logistic regression analysis was conducted to explore the factors influencing the efficacy of QYP.Results Among 2000 patients with primary IgAN,491 patients were treated with QYP,while 1509 cases served as the control group..After matching propensity scores between groups,228 cases were included in each group.The median age of patients in the treatment group was 35.5 years(interquartile range:28.0,44.0),urine protein quantification was 1.2(0.7,1.9)g/d,and the eGFR was 84.6(61.2,107.0)mL/min/1.73 m^(2),the fllow-up period was was 32.0(12.0,62.0)months,a total of 21 patients(9.2%)experienced deterioration in renal function after treatment.In the control group,the median age was 34.0(27.0,43.0)years,urine protein quantification was 1.2(0.7,2.1)g/d,and eGFR was 84.8(56.2,112.2)mL/min/1.73 m^(2),the follow-up period was 30.5(12.0,54.8)months,a total of 35 patients(15.4%)experienced deterioration in renal function after treatment.The difference in the rate of renal function deterioration between the two groupswas statistically significant(P<0.05).Multivariable Logistic regression analysis showed that patients with qi and yin deficiency syndrome(OR 1.972,95%CI:1.162-3.346),damp-heat syndrome(OR 1.862,95%Cl:1.093-3.172)and those with crescent formation(0R 1.067,95%Cl:1.020-1.115)were more likely to achieve clinical remission with the use of QYP.Conclusion QYP delays the deterioration of renal function.Treatment with the application of QYP,particularly for patients with damp-heat syndrome and crescentic formation,can facilitate clinical remission in IgAN patients.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.81172761)a Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘Objective To study the relationship between dyslipidemia and outcome in patients with acute ischemic stroke. Methods Data about 2 568 patients with acute ischemic stroke were collected from 4 hospitals in Shandong Province from January 2006 to December 2008. National Institute of Health Stroke Scale （NIHSS） 〉10 at discharge or death was defined as the outcome. Effect of dyslipidemia on outcome in patients with acute ischemic stroke was analyzed by multivariate logistic regression analysis and propensity score-adjusted analysis, respectively. Results The serum levels of TC, LDL-C, and HDL-C were significantly associated with the outcome in patients with acute ischemic stroke. Multivariate logistic regression analysis and propensity score-adjusted analysis showed that the ORs and 95% CIs were 3.013 （1.259, 7.214）/2.655 （1.298, 5.43）, 3.157 （1.306, 7.631）/3.405 （1.621, 7.154）, and 0.482 （0.245, 0.946）/0.51 （0.282, O.921）, respectively, for patients with acute ischemic stroke. Hosmer-Lemeshow goodness-of-fit test showed no significant difference in observed and predicted risk in patients with acute ischemic stroke （chi-square=8.235, P=0.411）. Conclusion Serum levels of TC, LDL-C, and HDL-C are positively related with the outcome in patients with acute ischemic stroke.
文摘Objective To observe the long-term efficacy of qibenefiting and yin-nourishing Chinese patent medicines(QYP)for IgA nephropathy(IgAN).Methods Two thousand patients with primary IgAN diagnosed by renal biopsy at three hospitals were included in this study.Patients were assigned to a treatment group and a control group based on the administration of QYP.Demographic data,pathological outcomes,and differences in Chinese medicine syndromes between the two groups were compared.To control for confounding factors,a 1:1 propensity score matching method was used to match patients,and a multivariate Logistic regression analysis was conducted to explore the factors influencing the efficacy of QYP.Results Among 2000 patients with primary IgAN,491 patients were treated with QYP,while 1509 cases served as the control group..After matching propensity scores between groups,228 cases were included in each group.The median age of patients in the treatment group was 35.5 years(interquartile range:28.0,44.0),urine protein quantification was 1.2(0.7,1.9)g/d,and the eGFR was 84.6(61.2,107.0)mL/min/1.73 m^(2),the fllow-up period was was 32.0(12.0,62.0)months,a total of 21 patients(9.2%)experienced deterioration in renal function after treatment.In the control group,the median age was 34.0(27.0,43.0)years,urine protein quantification was 1.2(0.7,2.1)g/d,and eGFR was 84.8(56.2,112.2)mL/min/1.73 m^(2),the follow-up period was 30.5(12.0,54.8)months,a total of 35 patients(15.4%)experienced deterioration in renal function after treatment.The difference in the rate of renal function deterioration between the two groupswas statistically significant(P<0.05).Multivariable Logistic regression analysis showed that patients with qi and yin deficiency syndrome(OR 1.972,95%CI:1.162-3.346),damp-heat syndrome(OR 1.862,95%Cl:1.093-3.172)and those with crescent formation(0R 1.067,95%Cl:1.020-1.115)were more likely to achieve clinical remission with the use of QYP.Conclusion QYP delays the deterioration of renal function.Treatment with the application of QYP,particularly for patients with damp-heat syndrome and crescentic formation,can facilitate clinical remission in IgAN patients.
