In an open economy,embodied carbon dioxide emissions in international trade should be taken into consideration to scientifically define each country's emissions responsibility.In this study,a multiregional input-o...In an open economy,embodied carbon dioxide emissions in international trade should be taken into consideration to scientifically define each country's emissions responsibility.In this study,a multiregional input-output model is constructed to calculate the embodied carbon dioxide emissions of 25 World Trade Organization members,including China,according to the producer-consumer shared responsibility principle.The study indicates that:it is fairer and more efficient to identify each country's carbon dioxide emissions responsibility according to the shared responsibility principle;China's producer responsibility is 1.4 times that of the USA,while China's consumer responsibility is only one-tenth that of the USA;according to the producer responsibility principle,China shoulders the greatest responsibility.According to the producerconsumer shared responsibility principle,China's responsibility shows a large decrease.Resource endowment,economic development stage,and trade structure account for the abovementioned changes in China's emissions responsibility.展开更多
Objective:This report presents an overview on the progress of clinical trials in Indonesia based on database assessment from clinical trial registries.Methods:Study records that were registered up to December 26,2018,...Objective:This report presents an overview on the progress of clinical trials in Indonesia based on database assessment from clinical trial registries.Methods:Study records that were registered up to December 26,2018,were extracted from three clinical trial registries(ClinicalTrials.gov,ISRCTN registry,and EudraCT)and a clinical trial register(WHO International Clinical Trials Registry Platform(ICTRP))with the keyword“Indonesia”.A total of 505 records comprised of 402 interventional studies and 103 observational studies were found and analyzed.Results:The top five noncommunicable diseases(NCDs)studied were cancers,diabetes,cardiac diseases,hypertension,and gastrointestinal diseases,while the top five infectious diseases(IDs)were malaria,tuberculosis,vaccines for IDs,HIV,and dengue.Remarkably,the proportion of regional studies(within Indonesia only)was higher than that of multiregional studies(including areas outside of Indonesia)in general.This trend became most apparent after the issuance of national regulations on Material Transfer Agreements(MTA)and other rules.Upon closer scrutiny,regional clinical trials and multiregional clinical trials(MRCTs)in Indonesia differed in terms of sponsorship,target population and size,interventions,and study phases.Conclusions:The total number of clinical trials in Indonesia is increasing and is mainly attributed to the growing number of regional clinical trials sponsored from within the country.Interrelated factors have shaped the characteristics of these as compared to the dwindling number of MRCTs.Establishment of a national level of management is an option that can better facilitate both MRCTs as well as regional clinical trials,to better address the national health issues,and to cope with the regulations.展开更多
An efficient multiregion model is introduced to calculate the electromagnetic scattering from a perfectly electrical conducting （PEC） rough surface with or without a PEC target above it. In the multiregion model, th...An efficient multiregion model is introduced to calculate the electromagnetic scattering from a perfectly electrical conducting （PEC） rough surface with or without a PEC target above it. In the multiregion model, the rough surface is split into multiple regions depending on their position along the rough surface. Two intermediate regions are chosen as the dominant region. If a target is located above the rough surface, the target will also be included in the dominant region. The method of moments （MOM） is only adopted on the dominant region to ensure validity. Hence, the new model can greatly reduce the number of unknowns associated with full MOM analysis. The induced electric currents on the other regions are obtained by approximately considering the mutual coupling between different regions along the rough surface. Compared with the published hybrid method, this new model is not only suitable for EM scattering from a target above a rough surface but also applicable for just rough surfaces. Several numerical simulations are presented to show the validity and efficiency of the multiregion model.展开更多
Purpose:The study evaluates the relative roles of Domestic-Funded Enterprises(DFEs)and Foreign-Funded Enterprises(FFEs)across Chinese provinces.It further examines how industrial structures differ by ownership at both...Purpose:The study evaluates the relative roles of Domestic-Funded Enterprises(DFEs)and Foreign-Funded Enterprises(FFEs)across Chinese provinces.It further examines how industrial structures differ by ownership at both regional and national scales.Drawing on these findings,the analysis traces the geographic shift of FFEs and offers evidence-based guidance for shaping foreign investment policy.Design/methodology/approach:This study uses Inter-Country Input-Output(ICIO)and Inter-Region Input-Output(IRIO)tables to build two extended datasets:Ownership-Extended Inter-Country Input-Output(OE-ICIO)and Ownership-Extended Multi-Region Input-Output(OE-IRIO)tables.These are then combined to construct the Regionally-Ownership Dually-Extended Multi-Regional Input-Output(RODE-MRIO)table and Global Domestic and Foreign Enterprises Network(GDFEN)model to explore the industrial relocation trends of FFEs in China.Findings:The results indicate that:(1)From 2010 to 2019,FFEs in China showed an overall decline in influence,profitability,and network robustness.(2)Eastern and developed regions saw a clear retreat of FFEs,with a shift toward domestic control.Central regions and more developed regions played a transitional role.Moreover,western and less developed regions remained stable but still relied on low-end and resource-based activities.(3)FFEs’influence has been gradually shifting towards less-developed central and western provinces due to rising labor costs and stricter environmental regulations.Research limitations:First,only general policy recommendations are proposed,without exploring the design of specific policy instruments.Second,the significant impact of recent trade measures on the behavior of FFEs has not been considered.Third,further research is needed to deepen the analysis by comparing regional ownership dynamics in China with those in other major economies.Practical implications:This research provides valuable insights for policymakers aiming to enhance regional economic development and improve China’s position within Global Value Chains(GVCs).Originality/value:The originality of this paper lies in its development of a new model that combines geographic,sectoral,and ownership dimensions.This model allows for a clearer analysis of the roles of foreign and DFEs in China’s regional economy.It offers insights into industrial transfer trends within global value chains and provides a framework for analyzing and forecasting future shifts.展开更多
The development of spatial interactions of land resources enhances virtual built-up land flow,which contributes to China's inter-regional trade inequality.Little is known about the degree of inequality among regio...The development of spatial interactions of land resources enhances virtual built-up land flow,which contributes to China's inter-regional trade inequality.Little is known about the degree of inequality among regions.This work seeks to estimate the degree of inter-regional trade inequality through environmental-economic benefits.We combined a multiregional input-output model at the city level with a new classification to calculate the virtual built-up land flow among cities and analyzed its implications for the regional economy and carbon balance.The results indicate that developed regions were the main beneficiaries of inter-regional trade,as reflected in land-use efficiency.China's economic hub has been progressively shifting southward,and the inter-regional trade inequality has continuously increased.The flow of virtual service industry land among developed regions rose,while underdeveloped regions remained suppliers of raw materials,further increasing inter-regional trade inequality.展开更多
Understanding the specific metabolic changes in multiple regions of the kidney is crucial to revealing the underlying mechanism and developing effective targets for diabetic nephropathy(DN). In this study, integrated ...Understanding the specific metabolic changes in multiple regions of the kidney is crucial to revealing the underlying mechanism and developing effective targets for diabetic nephropathy(DN). In this study, integrated spatially resolved metabolomics and proteomics combined with mass spectrometry imaging(MSI) revealed a multi-scale region profile of the diabetic kidney. Based on anatomic location, spatial metabolomics revealed eight region-specific metabolite biomarkers uniquely localized to kidney segments, which were closely correlated to the clinical parameters of patients with DN. Specifically, treatment with metformin(MET) enriched inosinic acid, adenosine 3′,5′-diphosphate, nicotinamide adenine dinucleotide(NADH), and hydrated NADH(NADHX) levels in the cortex(Cor) and the outer stripe of kidney medulla(OM) anatomical subregions, while in the inner stripe of kidney medulla(IM) segmentation, the p-cresol sulfate level was downregulated. Comparing differently expressed proteins in each region showed that nephrosis 2(Nphs2) was the highest loading feature. A further region-specific analysis of pathway enrichment characteristics indicated that the purine and ether lipid metabolism pathways were enriched in the Cor and OM regions, whereas the pantothenate and coenzyme A(CoA) biosynthesis pathways were mainly enriched in the IM region in response to MET treatment. Taken together, the spatially segregated metabolomics and proteomics studies reveal MET-mediated proteins and function-specific therapeutic pathways related to the anatomical multiregion of diabetic mouse kidneys.展开更多
文摘In an open economy,embodied carbon dioxide emissions in international trade should be taken into consideration to scientifically define each country's emissions responsibility.In this study,a multiregional input-output model is constructed to calculate the embodied carbon dioxide emissions of 25 World Trade Organization members,including China,according to the producer-consumer shared responsibility principle.The study indicates that:it is fairer and more efficient to identify each country's carbon dioxide emissions responsibility according to the shared responsibility principle;China's producer responsibility is 1.4 times that of the USA,while China's consumer responsibility is only one-tenth that of the USA;according to the producer responsibility principle,China shoulders the greatest responsibility.According to the producerconsumer shared responsibility principle,China's responsibility shows a large decrease.Resource endowment,economic development stage,and trade structure account for the abovementioned changes in China's emissions responsibility.
文摘Objective:This report presents an overview on the progress of clinical trials in Indonesia based on database assessment from clinical trial registries.Methods:Study records that were registered up to December 26,2018,were extracted from three clinical trial registries(ClinicalTrials.gov,ISRCTN registry,and EudraCT)and a clinical trial register(WHO International Clinical Trials Registry Platform(ICTRP))with the keyword“Indonesia”.A total of 505 records comprised of 402 interventional studies and 103 observational studies were found and analyzed.Results:The top five noncommunicable diseases(NCDs)studied were cancers,diabetes,cardiac diseases,hypertension,and gastrointestinal diseases,while the top five infectious diseases(IDs)were malaria,tuberculosis,vaccines for IDs,HIV,and dengue.Remarkably,the proportion of regional studies(within Indonesia only)was higher than that of multiregional studies(including areas outside of Indonesia)in general.This trend became most apparent after the issuance of national regulations on Material Transfer Agreements(MTA)and other rules.Upon closer scrutiny,regional clinical trials and multiregional clinical trials(MRCTs)in Indonesia differed in terms of sponsorship,target population and size,interventions,and study phases.Conclusions:The total number of clinical trials in Indonesia is increasing and is mainly attributed to the growing number of regional clinical trials sponsored from within the country.Interrelated factors have shaped the characteristics of these as compared to the dwindling number of MRCTs.Establishment of a national level of management is an option that can better facilitate both MRCTs as well as regional clinical trials,to better address the national health issues,and to cope with the regulations.
基金Project supported by the National Natural Science Foundation of China (Grant No. 60971067)the Specialized Research Fund for the Doctoral Program of Higher Education,China (Grant No. 20100203110016)the Fundamental Research Funds for the Central Universities,China (Grant No. K50510070001)
文摘An efficient multiregion model is introduced to calculate the electromagnetic scattering from a perfectly electrical conducting （PEC） rough surface with or without a PEC target above it. In the multiregion model, the rough surface is split into multiple regions depending on their position along the rough surface. Two intermediate regions are chosen as the dominant region. If a target is located above the rough surface, the target will also be included in the dominant region. The method of moments （MOM） is only adopted on the dominant region to ensure validity. Hence, the new model can greatly reduce the number of unknowns associated with full MOM analysis. The induced electric currents on the other regions are obtained by approximately considering the mutual coupling between different regions along the rough surface. Compared with the published hybrid method, this new model is not only suitable for EM scattering from a target above a rough surface but also applicable for just rough surfaces. Several numerical simulations are presented to show the validity and efficiency of the multiregion model.
基金supported by National Natural Science Foundation of China(72471007)Beijing Municipal Social Science Foundation Planning Project(23ZGB005)Humanities and Social Science Foundation of Ministry of Education of the People's Republic of China(Grant No.23YJAZH041).
文摘Purpose:The study evaluates the relative roles of Domestic-Funded Enterprises(DFEs)and Foreign-Funded Enterprises(FFEs)across Chinese provinces.It further examines how industrial structures differ by ownership at both regional and national scales.Drawing on these findings,the analysis traces the geographic shift of FFEs and offers evidence-based guidance for shaping foreign investment policy.Design/methodology/approach:This study uses Inter-Country Input-Output(ICIO)and Inter-Region Input-Output(IRIO)tables to build two extended datasets:Ownership-Extended Inter-Country Input-Output(OE-ICIO)and Ownership-Extended Multi-Region Input-Output(OE-IRIO)tables.These are then combined to construct the Regionally-Ownership Dually-Extended Multi-Regional Input-Output(RODE-MRIO)table and Global Domestic and Foreign Enterprises Network(GDFEN)model to explore the industrial relocation trends of FFEs in China.Findings:The results indicate that:(1)From 2010 to 2019,FFEs in China showed an overall decline in influence,profitability,and network robustness.(2)Eastern and developed regions saw a clear retreat of FFEs,with a shift toward domestic control.Central regions and more developed regions played a transitional role.Moreover,western and less developed regions remained stable but still relied on low-end and resource-based activities.(3)FFEs’influence has been gradually shifting towards less-developed central and western provinces due to rising labor costs and stricter environmental regulations.Research limitations:First,only general policy recommendations are proposed,without exploring the design of specific policy instruments.Second,the significant impact of recent trade measures on the behavior of FFEs has not been considered.Third,further research is needed to deepen the analysis by comparing regional ownership dynamics in China with those in other major economies.Practical implications:This research provides valuable insights for policymakers aiming to enhance regional economic development and improve China’s position within Global Value Chains(GVCs).Originality/value:The originality of this paper lies in its development of a new model that combines geographic,sectoral,and ownership dimensions.This model allows for a clearer analysis of the roles of foreign and DFEs in China’s regional economy.It offers insights into industrial transfer trends within global value chains and provides a framework for analyzing and forecasting future shifts.
基金supported by the National Natural Science Foundation of China(No.41871179)the China Postdoctoral Science Foundation under Grant(No.2024M751047).
文摘The development of spatial interactions of land resources enhances virtual built-up land flow,which contributes to China's inter-regional trade inequality.Little is known about the degree of inequality among regions.This work seeks to estimate the degree of inter-regional trade inequality through environmental-economic benefits.We combined a multiregional input-output model at the city level with a new classification to calculate the virtual built-up land flow among cities and analyzed its implications for the regional economy and carbon balance.The results indicate that developed regions were the main beneficiaries of inter-regional trade,as reflected in land-use efficiency.China's economic hub has been progressively shifting southward,and the inter-regional trade inequality has continuously increased.The flow of virtual service industry land among developed regions rose,while underdeveloped regions remained suppliers of raw materials,further increasing inter-regional trade inequality.
基金support from the Program of Natural Science Foundation of State (Grant Nos.81973745 and 82104733)the Hainan Province "Nanhai New Star" Science and Technology Innovation Talent Platform Project by Hainan Provincial Department of Science and Technology (NHXXRCXM202317)the Natural Science Foundation of Heilongjiang Province (YQ2019H030)。
文摘Understanding the specific metabolic changes in multiple regions of the kidney is crucial to revealing the underlying mechanism and developing effective targets for diabetic nephropathy(DN). In this study, integrated spatially resolved metabolomics and proteomics combined with mass spectrometry imaging(MSI) revealed a multi-scale region profile of the diabetic kidney. Based on anatomic location, spatial metabolomics revealed eight region-specific metabolite biomarkers uniquely localized to kidney segments, which were closely correlated to the clinical parameters of patients with DN. Specifically, treatment with metformin(MET) enriched inosinic acid, adenosine 3′,5′-diphosphate, nicotinamide adenine dinucleotide(NADH), and hydrated NADH(NADHX) levels in the cortex(Cor) and the outer stripe of kidney medulla(OM) anatomical subregions, while in the inner stripe of kidney medulla(IM) segmentation, the p-cresol sulfate level was downregulated. Comparing differently expressed proteins in each region showed that nephrosis 2(Nphs2) was the highest loading feature. A further region-specific analysis of pathway enrichment characteristics indicated that the purine and ether lipid metabolism pathways were enriched in the Cor and OM regions, whereas the pantothenate and coenzyme A(CoA) biosynthesis pathways were mainly enriched in the IM region in response to MET treatment. Taken together, the spatially segregated metabolomics and proteomics studies reveal MET-mediated proteins and function-specific therapeutic pathways related to the anatomical multiregion of diabetic mouse kidneys.
