The implementation of multiple pathogen testing is essential for a rapid response to future outbreaks and for reducing disease transmission.This study introduces a 96-channel microfluidic chip,fabricated through a mol...The implementation of multiple pathogen testing is essential for a rapid response to future outbreaks and for reducing disease transmission.This study introduces a 96-channel microfluidic chip,fabricated through a molding process,which enables the batch detection of pathogens.It explores the rapid lysis and elution processes of pathogens within the microfluidic chips to ensure that nucleic acid extraction,elution,and amplification are completed entirely within the chip.This chip can extract nucleic acids from samples in just 10 min,achieving an extraction efficiency comparable to that of traditional in-tube methods.An oil phase is pre-loaded into the chip to effectively prevent aerosol contamination.This approach allows for the simultaneous detection of 21 common respiratory pathogens,with a detection limit of 10 copies per reaction.Furthermore,applications involving clinical samples demonstrate significant practicality.Compared to many traditional in-tube pathogen detection methods and molecular biology technologies that utilize microfluidic chips,this detection chip not only enables simultaneous detection of multiple pathogens but also demonstrates high sensitivity.展开更多
Rice, a global staple food, is critical for food security. The cultivated Oryza sativa, domesticated from wild O. rufipogon, derives~80%of its 993 identified domestication-related genes from O. rufipogon and 20%from S...Rice, a global staple food, is critical for food security. The cultivated Oryza sativa, domesticated from wild O. rufipogon, derives~80%of its 993 identified domestication-related genes from O. rufipogon and 20%from South/Southeast Asian wild O. nivara(Jing et al., 2023). Genes like An-1, BH4, PROG1,SH4, Rc, Rd, and GS3—which regulate awn length, hull color,til er angle, seed shattering, pericarp color, seed length, and thousand-grain weight, respectively—were selected against during domestication to form modern O. sativa(Yu et al., 2021).However, domestication and yield-focused breeding eliminated wild rice's valuable genes(e.g., for disease resistance, stress tolerance, nutrition), narrowing genetic diversity and impeding efforts to meet growing societal demands.展开更多
Herein,an attention-grabbing and up-to-date review related to major multiplexing techniques is presented which in-cludes wavelength division multiplexing(WDM),polarization division multiplexing(PDM),space division mul...Herein,an attention-grabbing and up-to-date review related to major multiplexing techniques is presented which in-cludes wavelength division multiplexing(WDM),polarization division multiplexing(PDM),space division multiplexing(SDM),mode division multiplexing(MDM)and orbital angular momentum multiplexing(OAMM).Multiplexing is a mech-anism by which multiple signals are combined into a shared channel used to showcase the maximum capacity of the op-tical links.However,it is critical to develop hybrid multiplexing methods to allow enhanced channel numbers.In this re-view,we have also included hybrid multiplexing techniques such as WDM-PDM,WDM-MDM and PDM-MDM.It is prob-able to attain N×M channels by utilizing N wavelengths and M guided-modes by simply utilizing hybrid WDM-MDM(de)multiplexers.To the best of our knowledge,this review paper is one of its kind which has highlighted the most prom-inent and recent signs of progress in multiplexing techniques in one place.展开更多
The exponential growth in data traffic has driven significant research into maximizing the capacity of free-space optical(FSO)communication systems.Orbital angular momentum(OAM)multiplexing offers a promising approach...The exponential growth in data traffic has driven significant research into maximizing the capacity of free-space optical(FSO)communication systems.Orbital angular momentum(OAM)multiplexing offers a promising approach by using spatially structured beams with helical wavefronts to achieve higher data transmission rates.However,conventional electronic convolutional-neural-network-based OAM demultiplexing schemes exhibit substantial computational and energy efficiency limitations.展开更多
Advancements in mode-division multiplexing(MDM)techniques,aimed at surpassing the Shannon limit and augmenting transmission capacity,have garnered significant attention in optical fiber communica-tion,propelling the d...Advancements in mode-division multiplexing(MDM)techniques,aimed at surpassing the Shannon limit and augmenting transmission capacity,have garnered significant attention in optical fiber communica-tion,propelling the demand for high-quality multiplexers and demultiplexers.However,the criteria for ideal-mode multiplexers/demultiplexers,such as performance,scalability,compatibility,and ultra-compactness,have only partially been achieved using conventional bulky devices(e.g.,waveguides,grat-ings,and free space optics)—an issue that will substantially restrict the application of MDM techniques.Here,we present a neuro-meta-router(NMR)optimized through deep learning that achieves spatial multi-mode division and supports multi-channel communication,potentially offering scalability,com-patibility,and ultra-compactness.An MDM communication system based on an NMR is theoretically designed and experimentally demonstrated to enable simultaneous and independent multi-dataset transmission,showcasing a capacity of up to 100 gigabits per second(Gbps)and a symbol error rate down to the order of 104,all achieved without any compensation technologies or correlation devices.Our work presents a paradigm that merges metasurfaces,fiber communications,and deep learning,with potential applications in intelligent metasurface-aided optical interconnection,as well as all-optical pat-tern recognition and classification.展开更多
Multiple quantum well(MQW) Ⅲ-nitride diodes that can simultaneously emit and detect light feature an overlapping region between their electroluminescence and responsivity spectra, which allows them to be simultaneous...Multiple quantum well(MQW) Ⅲ-nitride diodes that can simultaneously emit and detect light feature an overlapping region between their electroluminescence and responsivity spectra, which allows them to be simultaneously used as both a transmitter and a receiver in a wireless light communication system. Here, we demonstrate a mobile light communication system using a time-division multiplexing(TDM) scheme to achieve bidirectional data transmission via the same optical channel.Two identical blue MQW diodes are defined by software as a transmitter or a receiver. To address the light alignment issue, an image identification module integrated with a gimbal stabilizer is used to automatically detect the locations of moving targets;thus, underwater audio communication is realized via a mobile blue-light TDM communication mode. This approach not only uses a single link but also integrates mobile nodes in a practical network.展开更多
Introduction: Arbovirus diseases such as dengue and chikungunya threaten public health worldwide. Early and rapid diagnosis and surveillance of dengue virus (DENV) and chikungunya virus (CHIKV) infections are essentia...Introduction: Arbovirus diseases such as dengue and chikungunya threaten public health worldwide. Early and rapid diagnosis and surveillance of dengue virus (DENV) and chikungunya virus (CHIKV) infections are essential to the control of these diseases. In this study, we evaluate the diagnostic performance of our new in-house multiplex RT-qPCR method for detecting DENV serotypes and CHIKV in an external laboratory. Methodology: The evaluation study was conducted on 200 clinical samples of suspected patients for arbovirus disease infection, collected in Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso. Our new multiplex RT-qPCR was compared to the commercial kit, the Zika, Dengue, and Chikungunya (ZDC) Real-Time PCR Assays kit (Bio-Rad, California, USA). Results and Conclusions: Among 200 samples, 21.5% (43/200) were DENV-positive by multiplex RT-qPCR, and 21.5% (43/200) were also DENV-positive by reference real-time RT-PCR. 157 (78.5%) samples tested negative for DENV by both tests (new mRT-qPCR and reference test). The sensitivity and specificity of mRT-qPCR were 100%. The DENV serotypes detected were DENV-1 60.5% (26/43) and DENV-3 39.5% (17/43). CHIKV was not detected in this study. Our new mRT-qPCR is sensitive, cost-effective, simple, and can be used in developing country laboratories.展开更多
The development of optical transmission was summarized. The multiplexing system was show in detail. The concepts, characteristic, key technology, expand trend and application prospect of frequency division multiplexin...The development of optical transmission was summarized. The multiplexing system was show in detail. The concepts, characteristic, key technology, expand trend and application prospect of frequency division multiplexing, time division multiplexing, code division multiplexing and wave division multiplexing were illustrated.展开更多
Dynamically tunable terahertz(THz)beam focusing plays a critical role in emerging applications including reconfigurable imaging,localized spectral analysis,and micro-machining.Conventional methods,however,frequently e...Dynamically tunable terahertz(THz)beam focusing plays a critical role in emerging applications including reconfigurable imaging,localized spectral analysis,and micro-machining.Conventional methods,however,frequently employ complex wavefront modulators and external control algorithms,resulting in increased system footprint and limited tuning efficiency.In this work,we present an all-silicon mechanically rotatable cascaded metasurface capable of dynamic THz beam focusing.By independently adjusting the relative rotation angles between the two metasurface layers,real-time repositioning of the focal spot is achieved for orthogonal circular polarization channels.The proposed design facilitates polarization-division multiplexing without requiring external algorithms or active materials while preserving high focusing efficiency and beam quality across a predefined focal plane.Numerical simulations reveal a quasi-linear shift of the focal position with the rotation angle,with stable focusing efficiency and full-width at half-maximum observed in both polarization channels.This strategy offers an efficient and reliable approach to dynamic wavefront control for compact,reconfigurable THz imaging,sensing,and communication systems.展开更多
Recent advancements in artificial intelligence have transformed three-dimensional(3D)optical imaging and metrology,enabling high-resolution and high-precision 3D surface geometry measurements from one single fringe pa...Recent advancements in artificial intelligence have transformed three-dimensional(3D)optical imaging and metrology,enabling high-resolution and high-precision 3D surface geometry measurements from one single fringe pattern projection.However,the imaging speed of conventional fringe projection profilometry(FPP)remains limited by the native sensor refresh rates due to the inherent"one-to-one"synchronization mechanism between pattern projection and image acquisition in standard structured light techniques.Here,we present dual-frequency angular-multiplexed fringe projection profilometry(DFAMFPP),a deep learning-enabled 3D imaging technique that achieves high-speed,high-precision,and large-depth-range absolute 3D surface measurements at speeds 16 times faster than the sensor's native frame rate.By encoding multi-timeframe 3D information into a single multiplexed image using multiple pairs of dual-frequency fringes,high-accuracy absolute phase maps are reconstructed using specially trained two-stage number-theoretical-based deep neural networks.We validate the effectiveness of DFAMFPP through dynamic scene measurements,achieving 10,000 Hz 3D imaging of a running turbofan engine prototype with only a 625 Hz camera.By overcoming the sensor hardware bottleneck,DFAMFPP significantly advances high-speed and ultra-high-speed 3D imaging,opening new avenues for exploring dynamic processes across diverse scientific disciplines.展开更多
Official and civil information, as distinct information sources, significantly influence public behavior and the dynamics of epidemic transmission. In this paper, we propose a three-layer U_(1)A_(1)U_(1)-U_(2)A_(2)U_(...Official and civil information, as distinct information sources, significantly influence public behavior and the dynamics of epidemic transmission. In this paper, we propose a three-layer U_(1)A_(1)U_(1)-U_(2)A_(2)U_(2)-SIS coupled model to analyze the co-evolution process of official information dissemination, civil information dissemination and epidemic transmission,considering the interdependencies between the information dissemination channels. The first layer describes the official information dissemination process. The second layer models the civil information dissemination process, considering the effects of perceived risk costs and the role of the correlation between official and civil information. The third layer represents the epidemic transmission process, highlighting the impact of the correlation between official and civil information on epidemic transmission. Then, using the microscopic Markov chain approach, we describe the information-epidemic coupled dynamics and derive the epidemic outbreak threshold. Our research demonstrates that a stronger positive correlation between official and civil information raises the epidemic threshold and suppresses the scale of epidemic transmission. Furthermore, individuals' adoption of civil information should involve a more thorough assessment of the infection risk based on their personal circumstances, which can contribute to more effective epidemic control. Moreover, enhancing infected individuals' accurate comprehension of official information can effectively curb the transmission of the epidemic. Our study highlights the importance of both official and civil information dissemination in epidemic management and provides insights for policymakers in developing effective public health and communication strategies.展开更多
Thin-film lithium niobate(TFLN)possesses great potential because it enables high-speed modulation by voltage,which allows higher resolution and lower power consumption for laser beam scanning than direct laser modulat...Thin-film lithium niobate(TFLN)possesses great potential because it enables high-speed modulation by voltage,which allows higher resolution and lower power consumption for laser beam scanning than direct laser modulation.To achieve these functions,a red,green,and blue(RGB)multiplexer using TFLN is required as an important building block for photonic integrated circuits.We fabricated an RGB multiplexer using TFLN and experimentally confirmed its operation.Three different laser lights of red(λ=638 nm),green(λ=520 nm),and blue(λ=473 nm)were successfully coupled as a single laser beam by an RGB multiplexer composed of multimode interferometers.Furthermore,the TFLN was fabricated by sputter deposition,whereas conventionally,it is fabricated via bulk-lithium niobate adhesion to the substrate.The sputterdeposited TFLN is advantageous for large-volume mass production.展开更多
We demonstrate a bipolar graphene/F_(16)CuPc synaptic transistor(GFST)with matched p-type and n-type bipolar properties,which emulates multiplexed neurotransmission of the release of two excitatory neurotransmitters i...We demonstrate a bipolar graphene/F_(16)CuPc synaptic transistor(GFST)with matched p-type and n-type bipolar properties,which emulates multiplexed neurotransmission of the release of two excitatory neurotransmitters in graphene and F_(16)CuPc channels,separately.This process facilitates fast-switching plasticity by altering charge carriers in the separated channels.The complementary neural network for image recognition of Fashion-MNIST dataset was constructed using the matched relative amplitude and plasticity properties of the GFST dominated by holes or electrons to improve the weight regulation and recognition accuracy,achieving a pattern recognition accuracy of 83.23%.These results provide new insights to the construction of future neuromorphic systems.展开更多
Ultrasensitive detection of multiple diseases markers is of great importance in improving diagnostic accuracy,precision,and efficiency.A versatile Au nanozyme Raman probe strategy was employed to develop an ultrasensi...Ultrasensitive detection of multiple diseases markers is of great importance in improving diagnostic accuracy,precision,and efficiency.A versatile Au nanozyme Raman probe strategy was employed to develop an ultrasensitive multiplex surface-enhanced Raman scattering(SERS)immunosensor using encoded silica photonic crystal beads(SPCBs).The efficient Au nanozyme Raman probe strategy was constructed using a robust Au nanozyme with high dual enzyme-like activity and SERS activity.On the one hand,Au nanozyme tags with oxidase-like activity can catalyze the oxidation of Raman-inactive 3,3,5,5-tetramethylbenzidine(TMB)to Raman-active oxidized TMB(ox-TMB)in the presence of O_(2).On the other hand,Au nanozyme tags with peroxidase-like activity can catalyze Raman-inactive TMB to Ramanactive ox-TMB in the presence of H_(2)O_(2).This dual catalysis action results in many Raman-active reporter molecules(ox-TMB)enabling highly sensitive detection.Meanwhile,the Au nanozyme as an extraordinary SERS substrate further enhances the detection signals of these Raman reporter molecules.Using reflection peaks of different SPCBs to encode tumor markers,an ultrasensitive multiplex SERS immunosensor was developed for detection of carcinoembryonic antigen(CEA)and alpha-fetoprotein(AFP),which exhibited wide linear ranges of 0.001-100 ng/m L for CEA and 0.01-1000 ng/m L for AFP,accompanied by low detection limits of 0.66 pg/m L for CEA and 9.5 pg/m L for AFP,respectively.This work demonstrates a universal and promising nanozyme Raman probe strategy to develop ultrasensitive multiplex SERS immunosensors for precise clinical diagnosis of disease.展开更多
Indoor scene semantic segmentation is essential for enabling robots to understand and interact with their environments effectively.However,numerous challenges remain unresolved,particularly in single-robot systems,whi...Indoor scene semantic segmentation is essential for enabling robots to understand and interact with their environments effectively.However,numerous challenges remain unresolved,particularly in single-robot systems,which often struggle with the complexity and variability of indoor scenes.To address these limitations,we introduce a novel multi-robot collaborative framework based on multiplex interactive learning(MPIL)in which each robot specialises in a distinct visual task within a unified multitask architecture.During training,the framework employs task-specific decoders and cross-task feature sharing to enhance collaborative optimisation.At inference time,robots operate independently with optimised models,enabling scalable,asynchronous and efficient deployment in real-world scenarios.Specifically,MPIL employs specially designed modules that integrate RGB and depth data,refine feature representations and facilitate the simultaneous execution of multiple tasks,such as instance segmentation,scene classification and semantic segmentation.By leveraging these modules,distinct agents within multi-robot systems can effectively handle specialised tasks,thereby enhancing the overall system's flexibility and adaptability.This collaborative effort maximises the strengths of each robot,resulting in a more comprehensive understanding of environments.Extensive experiments on two public benchmark datasets demonstrate MPIL's competitive performance compared to state-of-the-art approaches,highlighting the effectiveness and robustness of our multi-robot system in complex indoor environments.展开更多
Adventitious agents,comprising unintentionally introduced microorganisms in the production of biological products,pose a significant challenge in ensuring the safety of gene therapy products.The revised International ...Adventitious agents,comprising unintentionally introduced microorganisms in the production of biological products,pose a significant challenge in ensuring the safety of gene therapy products.The revised International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use(ICH)guildline Q5A(R2)from September 2022 highlights the inclusion of viral vector-based gene therapy products in safety discussions,emphasizing controls in material sourcing,testing,and viral clearance[1].Detecting adventitious virus contamination is complex due to the unique characteristics of gene therapy products and the limitations of routine testing methods.The US Food and Drug Administration(FDA)recommends incorporating routine and specific virus detection methods,including those outlined in various pharmacopeias.Existing control methods have limitations,prompting the need for highly sensitive and broad-spectrum detection approaches.Unlike traditional biological products,gene therapy products primarily consist of live viruses,necessitating methods that distinguish between the main virus and adventitious viruses.Current virus detection techniques,such as polymerase chain reaction(PCR),sequencing,mass spectrometry,and DNA microarrays[2e4],have their drawbacks.展开更多
In this work,a reflective metasurface connector(RMC)and its application for high-density and wideband spacedivision multiplexing(SDM)are demonstrated.This device features single facet metasurface fabrication over an S...In this work,a reflective metasurface connector(RMC)and its application for high-density and wideband spacedivision multiplexing(SDM)are demonstrated.This device features single facet metasurface fabrication over an SOI platform based on a CMOS compatible process.A minimum fiber-to-fiber insertion loss of 2.9 dB at 1598.24 nm is realized for fan-in-fan-out(FIFO)applications between a single-mode fiber(SMF)array and a multicore fiber(MCF).展开更多
Tilted fiber Bragg gratings(TFBGs) have seen rapid development and widespread deployment in diverse sensing applications, ranging from biochemical detection to in-situ monitoring in energy systems. Their ability to ge...Tilted fiber Bragg gratings(TFBGs) have seen rapid development and widespread deployment in diverse sensing applications, ranging from biochemical detection to in-situ monitoring in energy systems. Their ability to generate rich spectral features via cladding mode coupling enables highly sensitive, multi-parameter, and label-free sensing.However, accurate interrogation typically requires broadband spectral measurements to resolve fine spectral structures-posing significant challenges for scalable and cost-effective multiplexing in practical settings.展开更多
Lanthanide(Ln^(3+))-doped luminescent nanocrystals(NCs)with excitation and emission in the second near-infrared biological window(NIRII,1000-1700 nm)have attracted considerable attention in the fields of deep-tissue b...Lanthanide(Ln^(3+))-doped luminescent nanocrystals(NCs)with excitation and emission in the second near-infrared biological window(NIRII,1000-1700 nm)have attracted considerable attention in the fields of deep-tissue bioimaging and non-invasive biodetection,owing to their superior advantages including good photochemical stability,sharp emission peaks,large penetration depth,and high signal-to-noise ratio[1].Conventionally,Yb3t-and Nd3t-sensitized NCs have been utilized as NIR-II luminescent nanoprobes for in vivo bioimaging upon excitation with 980 and 808 nm diode laser,respectively[2].展开更多
In an effort to simplify the procedure and to reduce the cost of fluorescence SSR analysis, the conditions of the multiplex PCR and the multiplex gel electrophoresis were optimized in the genetic analysis of sunflower...In an effort to simplify the procedure and to reduce the cost of fluorescence SSR analysis, the conditions of the multiplex PCR and the multiplex gel electrophoresis were optimized in the genetic analysis of sunflower (Helianthus annuus L.) inbred lines. Results indicated that factors for a successful multiplex PCR assay were related to the cycling touchdown annealing temperature, the balance of primer concentration at the various loci, the concentration of PCR buffer and the Taq DNA polymerase. Based on the optimization, a tailed primer strategy was outlined, and the effective ways were proposed to overcome the troubleshootings commonly encountered in the multiplex PCR and the multiplex gel electrophoresis.展开更多
基金supported by grants from the National Key Research and Development Program of China(Nos.2023YFA0915200,2023YFA0915204)the Equipment Research and Development Projects of the Chinese Academy of Sciences(No.PTYQ2024YZ0010)+3 种基金the Science and Technology Commission of Shanghai Municipality Project(No.XTCX-KJ-2024-038)the Natural Science Foundation of Hebei Province of China(No.H2024206249)the Postdoctoral Fellowship Program of CPSF(No.GZC20232838)Science and Technology Commission of Shanghai Municipality(No.22S31901700).
文摘The implementation of multiple pathogen testing is essential for a rapid response to future outbreaks and for reducing disease transmission.This study introduces a 96-channel microfluidic chip,fabricated through a molding process,which enables the batch detection of pathogens.It explores the rapid lysis and elution processes of pathogens within the microfluidic chips to ensure that nucleic acid extraction,elution,and amplification are completed entirely within the chip.This chip can extract nucleic acids from samples in just 10 min,achieving an extraction efficiency comparable to that of traditional in-tube methods.An oil phase is pre-loaded into the chip to effectively prevent aerosol contamination.This approach allows for the simultaneous detection of 21 common respiratory pathogens,with a detection limit of 10 copies per reaction.Furthermore,applications involving clinical samples demonstrate significant practicality.Compared to many traditional in-tube pathogen detection methods and molecular biology technologies that utilize microfluidic chips,this detection chip not only enables simultaneous detection of multiple pathogens but also demonstrates high sensitivity.
基金supported by the Biological BreedingMajor Projects(2023ZD04076)the National Natural Science Foundation of China(32300312)+2 种基金the Innovation Program of Chinses Academy of Agricultural Sciences(CAAS-CSIAF-202303)the Guangdong Basic and Applied Basic Research Foundation(2020B1515120086)the KeyArea Research and Development Program of Guangdong Province(2021B0707010006)。
文摘Rice, a global staple food, is critical for food security. The cultivated Oryza sativa, domesticated from wild O. rufipogon, derives~80%of its 993 identified domestication-related genes from O. rufipogon and 20%from South/Southeast Asian wild O. nivara(Jing et al., 2023). Genes like An-1, BH4, PROG1,SH4, Rc, Rd, and GS3—which regulate awn length, hull color,til er angle, seed shattering, pericarp color, seed length, and thousand-grain weight, respectively—were selected against during domestication to form modern O. sativa(Yu et al., 2021).However, domestication and yield-focused breeding eliminated wild rice's valuable genes(e.g., for disease resistance, stress tolerance, nutrition), narrowing genetic diversity and impeding efforts to meet growing societal demands.
基金financially supported by the Russian Foundation for Basic Research(grant No.18-29-20045)for WDM,MDM and hybrid WDM-MDM,WDM-PDM sectionsthe Russian Science Foundation(grant No.21-79-20075)for PDM,OAMM and hybrid PDM-MDM sectionsthe Ministry of Science and Higher Education of the Russian Federation under the FSRC"Crystallography and Photonics"of the Russian Academy of Sciences(the state task No.007-GZ/Ch3363/26)for comparative analysis.
文摘Herein,an attention-grabbing and up-to-date review related to major multiplexing techniques is presented which in-cludes wavelength division multiplexing(WDM),polarization division multiplexing(PDM),space division multiplexing(SDM),mode division multiplexing(MDM)and orbital angular momentum multiplexing(OAMM).Multiplexing is a mech-anism by which multiple signals are combined into a shared channel used to showcase the maximum capacity of the op-tical links.However,it is critical to develop hybrid multiplexing methods to allow enhanced channel numbers.In this re-view,we have also included hybrid multiplexing techniques such as WDM-PDM,WDM-MDM and PDM-MDM.It is prob-able to attain N×M channels by utilizing N wavelengths and M guided-modes by simply utilizing hybrid WDM-MDM(de)multiplexers.To the best of our knowledge,this review paper is one of its kind which has highlighted the most prom-inent and recent signs of progress in multiplexing techniques in one place.
文摘The exponential growth in data traffic has driven significant research into maximizing the capacity of free-space optical(FSO)communication systems.Orbital angular momentum(OAM)multiplexing offers a promising approach by using spatially structured beams with helical wavefronts to achieve higher data transmission rates.However,conventional electronic convolutional-neural-network-based OAM demultiplexing schemes exhibit substantial computational and energy efficiency limitations.
基金supported by the National Key Research and Development Program of China(2023YFB2804704)the National Natural Science Foundation of China(12174292,12374278,and 62105250).
文摘Advancements in mode-division multiplexing(MDM)techniques,aimed at surpassing the Shannon limit and augmenting transmission capacity,have garnered significant attention in optical fiber communica-tion,propelling the demand for high-quality multiplexers and demultiplexers.However,the criteria for ideal-mode multiplexers/demultiplexers,such as performance,scalability,compatibility,and ultra-compactness,have only partially been achieved using conventional bulky devices(e.g.,waveguides,grat-ings,and free space optics)—an issue that will substantially restrict the application of MDM techniques.Here,we present a neuro-meta-router(NMR)optimized through deep learning that achieves spatial multi-mode division and supports multi-channel communication,potentially offering scalability,com-patibility,and ultra-compactness.An MDM communication system based on an NMR is theoretically designed and experimentally demonstrated to enable simultaneous and independent multi-dataset transmission,showcasing a capacity of up to 100 gigabits per second(Gbps)and a symbol error rate down to the order of 104,all achieved without any compensation technologies or correlation devices.Our work presents a paradigm that merges metasurfaces,fiber communications,and deep learning,with potential applications in intelligent metasurface-aided optical interconnection,as well as all-optical pat-tern recognition and classification.
基金jointly supported by the National Natural Science Foundation of China (U21A20495)Natural Science Foundation of Jiangsu Province (BG2024023)+1 种基金National Key Research and Development Program of China (2022YFE0112000)111 Project (D17018)。
文摘Multiple quantum well(MQW) Ⅲ-nitride diodes that can simultaneously emit and detect light feature an overlapping region between their electroluminescence and responsivity spectra, which allows them to be simultaneously used as both a transmitter and a receiver in a wireless light communication system. Here, we demonstrate a mobile light communication system using a time-division multiplexing(TDM) scheme to achieve bidirectional data transmission via the same optical channel.Two identical blue MQW diodes are defined by software as a transmitter or a receiver. To address the light alignment issue, an image identification module integrated with a gimbal stabilizer is used to automatically detect the locations of moving targets;thus, underwater audio communication is realized via a mobile blue-light TDM communication mode. This approach not only uses a single link but also integrates mobile nodes in a practical network.
文摘Introduction: Arbovirus diseases such as dengue and chikungunya threaten public health worldwide. Early and rapid diagnosis and surveillance of dengue virus (DENV) and chikungunya virus (CHIKV) infections are essential to the control of these diseases. In this study, we evaluate the diagnostic performance of our new in-house multiplex RT-qPCR method for detecting DENV serotypes and CHIKV in an external laboratory. Methodology: The evaluation study was conducted on 200 clinical samples of suspected patients for arbovirus disease infection, collected in Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso. Our new multiplex RT-qPCR was compared to the commercial kit, the Zika, Dengue, and Chikungunya (ZDC) Real-Time PCR Assays kit (Bio-Rad, California, USA). Results and Conclusions: Among 200 samples, 21.5% (43/200) were DENV-positive by multiplex RT-qPCR, and 21.5% (43/200) were also DENV-positive by reference real-time RT-PCR. 157 (78.5%) samples tested negative for DENV by both tests (new mRT-qPCR and reference test). The sensitivity and specificity of mRT-qPCR were 100%. The DENV serotypes detected were DENV-1 60.5% (26/43) and DENV-3 39.5% (17/43). CHIKV was not detected in this study. Our new mRT-qPCR is sensitive, cost-effective, simple, and can be used in developing country laboratories.
文摘The development of optical transmission was summarized. The multiplexing system was show in detail. The concepts, characteristic, key technology, expand trend and application prospect of frequency division multiplexing, time division multiplexing, code division multiplexing and wave division multiplexing were illustrated.
基金supported by the National Natural Science Foundation of China(Grants U22A2008,12404484,12464016,and 62405219)the Double First Class Joint Special Key Project of Yunnan Science and Technology Department and Yunnan University(Grant 202401BF070001-012)Sichuan Provincial Science and Technology Support Program(Grant 25QNJJ2419).
文摘Dynamically tunable terahertz(THz)beam focusing plays a critical role in emerging applications including reconfigurable imaging,localized spectral analysis,and micro-machining.Conventional methods,however,frequently employ complex wavefront modulators and external control algorithms,resulting in increased system footprint and limited tuning efficiency.In this work,we present an all-silicon mechanically rotatable cascaded metasurface capable of dynamic THz beam focusing.By independently adjusting the relative rotation angles between the two metasurface layers,real-time repositioning of the focal spot is achieved for orthogonal circular polarization channels.The proposed design facilitates polarization-division multiplexing without requiring external algorithms or active materials while preserving high focusing efficiency and beam quality across a predefined focal plane.Numerical simulations reveal a quasi-linear shift of the focal position with the rotation angle,with stable focusing efficiency and full-width at half-maximum observed in both polarization channels.This strategy offers an efficient and reliable approach to dynamic wavefront control for compact,reconfigurable THz imaging,sensing,and communication systems.
基金supported by National Key Research and Development Program of China(2022YFB2804603,2022YFB2804605)National Natural Science Foundation of China(U21B2033)+4 种基金Fundamental Research Funds forthe Central Universities(2023102001,2024202002)National Key Laborato-ry of Shock Wave and Detonation Physics(JCKYS2024212111)China Post-doctoral Science Fund(2023T160318)Open Research Fund of JiangsuKey Laboratory of Spectral Imaging&Intelligent Sense(JSGP202105,JSGP202201)Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX25_0695,SJCX25_0188)。
文摘Recent advancements in artificial intelligence have transformed three-dimensional(3D)optical imaging and metrology,enabling high-resolution and high-precision 3D surface geometry measurements from one single fringe pattern projection.However,the imaging speed of conventional fringe projection profilometry(FPP)remains limited by the native sensor refresh rates due to the inherent"one-to-one"synchronization mechanism between pattern projection and image acquisition in standard structured light techniques.Here,we present dual-frequency angular-multiplexed fringe projection profilometry(DFAMFPP),a deep learning-enabled 3D imaging technique that achieves high-speed,high-precision,and large-depth-range absolute 3D surface measurements at speeds 16 times faster than the sensor's native frame rate.By encoding multi-timeframe 3D information into a single multiplexed image using multiple pairs of dual-frequency fringes,high-accuracy absolute phase maps are reconstructed using specially trained two-stage number-theoretical-based deep neural networks.We validate the effectiveness of DFAMFPP through dynamic scene measurements,achieving 10,000 Hz 3D imaging of a running turbofan engine prototype with only a 625 Hz camera.By overcoming the sensor hardware bottleneck,DFAMFPP significantly advances high-speed and ultra-high-speed 3D imaging,opening new avenues for exploring dynamic processes across diverse scientific disciplines.
基金partially supported by the Project for the National Natural Science Foundation of China (72174121)the Project Soft Science Research of Shanghai (24692116300)the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning。
文摘Official and civil information, as distinct information sources, significantly influence public behavior and the dynamics of epidemic transmission. In this paper, we propose a three-layer U_(1)A_(1)U_(1)-U_(2)A_(2)U_(2)-SIS coupled model to analyze the co-evolution process of official information dissemination, civil information dissemination and epidemic transmission,considering the interdependencies between the information dissemination channels. The first layer describes the official information dissemination process. The second layer models the civil information dissemination process, considering the effects of perceived risk costs and the role of the correlation between official and civil information. The third layer represents the epidemic transmission process, highlighting the impact of the correlation between official and civil information on epidemic transmission. Then, using the microscopic Markov chain approach, we describe the information-epidemic coupled dynamics and derive the epidemic outbreak threshold. Our research demonstrates that a stronger positive correlation between official and civil information raises the epidemic threshold and suppresses the scale of epidemic transmission. Furthermore, individuals' adoption of civil information should involve a more thorough assessment of the infection risk based on their personal circumstances, which can contribute to more effective epidemic control. Moreover, enhancing infected individuals' accurate comprehension of official information can effectively curb the transmission of the epidemic. Our study highlights the importance of both official and civil information dissemination in epidemic management and provides insights for policymakers in developing effective public health and communication strategies.
文摘Thin-film lithium niobate(TFLN)possesses great potential because it enables high-speed modulation by voltage,which allows higher resolution and lower power consumption for laser beam scanning than direct laser modulation.To achieve these functions,a red,green,and blue(RGB)multiplexer using TFLN is required as an important building block for photonic integrated circuits.We fabricated an RGB multiplexer using TFLN and experimentally confirmed its operation.Three different laser lights of red(λ=638 nm),green(λ=520 nm),and blue(λ=473 nm)were successfully coupled as a single laser beam by an RGB multiplexer composed of multimode interferometers.Furthermore,the TFLN was fabricated by sputter deposition,whereas conventionally,it is fabricated via bulk-lithium niobate adhesion to the substrate.The sputterdeposited TFLN is advantageous for large-volume mass production.
基金supported by the Shenzhen Science and Technology Program(No.JCYJ20210324121002008)the National Science Fund for Distinguished Young Scholars of China(No.T2125005)+5 种基金the National Key R&D Program of China(Nos.2022YFE0198200,2022YFA1204500,and 2022YFA1204504)the Natural Science Foundation of Tianjin(Nos.22JCYBJC01290 and 23JCQNJC01440)the Key Project of Natural Science Foundation of Tianjin(No.22JCZDJC00120)the Fundamental Research Funds for the Central Universities,Nankai University(Nos.BEG124901 and BEG124401)the Guangdong Basic and Applied Basic Research Foundation(No.2023A1515110319)the Key Science and Technology Program of Henan Province(No.242102210171).
文摘We demonstrate a bipolar graphene/F_(16)CuPc synaptic transistor(GFST)with matched p-type and n-type bipolar properties,which emulates multiplexed neurotransmission of the release of two excitatory neurotransmitters in graphene and F_(16)CuPc channels,separately.This process facilitates fast-switching plasticity by altering charge carriers in the separated channels.The complementary neural network for image recognition of Fashion-MNIST dataset was constructed using the matched relative amplitude and plasticity properties of the GFST dominated by holes or electrons to improve the weight regulation and recognition accuracy,achieving a pattern recognition accuracy of 83.23%.These results provide new insights to the construction of future neuromorphic systems.
基金financially supported by National Natural Science Foundation of China(Nos.21475116,21575125 and 22474124)the National Natural Science Foundation of Jiangsu Province(Nos.BK20221370,BK20211362)+5 种基金Key University Natural Science Foundation of Jiangsu-Province(No.20KJA150004)the Project for Science and Technology of Yangzhou(No.YZ2022074)the Project for Yangzhou City and Yangzhou University corporation(No.YZ2023204)Cross cooperation project of Subei Peoples’Hospital of Jiangsu Province(No.SBJC220009)the Open Research Fund of State Key Laboratory of Analytical Chemistry for Life Science(No.SKLACLS2405)Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX24_3728)。
文摘Ultrasensitive detection of multiple diseases markers is of great importance in improving diagnostic accuracy,precision,and efficiency.A versatile Au nanozyme Raman probe strategy was employed to develop an ultrasensitive multiplex surface-enhanced Raman scattering(SERS)immunosensor using encoded silica photonic crystal beads(SPCBs).The efficient Au nanozyme Raman probe strategy was constructed using a robust Au nanozyme with high dual enzyme-like activity and SERS activity.On the one hand,Au nanozyme tags with oxidase-like activity can catalyze the oxidation of Raman-inactive 3,3,5,5-tetramethylbenzidine(TMB)to Raman-active oxidized TMB(ox-TMB)in the presence of O_(2).On the other hand,Au nanozyme tags with peroxidase-like activity can catalyze Raman-inactive TMB to Ramanactive ox-TMB in the presence of H_(2)O_(2).This dual catalysis action results in many Raman-active reporter molecules(ox-TMB)enabling highly sensitive detection.Meanwhile,the Au nanozyme as an extraordinary SERS substrate further enhances the detection signals of these Raman reporter molecules.Using reflection peaks of different SPCBs to encode tumor markers,an ultrasensitive multiplex SERS immunosensor was developed for detection of carcinoembryonic antigen(CEA)and alpha-fetoprotein(AFP),which exhibited wide linear ranges of 0.001-100 ng/m L for CEA and 0.01-1000 ng/m L for AFP,accompanied by low detection limits of 0.66 pg/m L for CEA and 9.5 pg/m L for AFP,respectively.This work demonstrates a universal and promising nanozyme Raman probe strategy to develop ultrasensitive multiplex SERS immunosensors for precise clinical diagnosis of disease.
基金supported by the National Natural Science Foundation of China under Grant 62373009.
文摘Indoor scene semantic segmentation is essential for enabling robots to understand and interact with their environments effectively.However,numerous challenges remain unresolved,particularly in single-robot systems,which often struggle with the complexity and variability of indoor scenes.To address these limitations,we introduce a novel multi-robot collaborative framework based on multiplex interactive learning(MPIL)in which each robot specialises in a distinct visual task within a unified multitask architecture.During training,the framework employs task-specific decoders and cross-task feature sharing to enhance collaborative optimisation.At inference time,robots operate independently with optimised models,enabling scalable,asynchronous and efficient deployment in real-world scenarios.Specifically,MPIL employs specially designed modules that integrate RGB and depth data,refine feature representations and facilitate the simultaneous execution of multiple tasks,such as instance segmentation,scene classification and semantic segmentation.By leveraging these modules,distinct agents within multi-robot systems can effectively handle specialised tasks,thereby enhancing the overall system's flexibility and adaptability.This collaborative effort maximises the strengths of each robot,resulting in a more comprehensive understanding of environments.Extensive experiments on two public benchmark datasets demonstrate MPIL's competitive performance compared to state-of-the-art approaches,highlighting the effectiveness and robustness of our multi-robot system in complex indoor environments.
基金financially supported by Beijing Municipal Science&Technology Commission,China(Grant No.:Z221100007922015)Youth Development Research Foundation of National Institutes for Food and Drug Control,China(Grant No.:2020B1).
文摘Adventitious agents,comprising unintentionally introduced microorganisms in the production of biological products,pose a significant challenge in ensuring the safety of gene therapy products.The revised International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use(ICH)guildline Q5A(R2)from September 2022 highlights the inclusion of viral vector-based gene therapy products in safety discussions,emphasizing controls in material sourcing,testing,and viral clearance[1].Detecting adventitious virus contamination is complex due to the unique characteristics of gene therapy products and the limitations of routine testing methods.The US Food and Drug Administration(FDA)recommends incorporating routine and specific virus detection methods,including those outlined in various pharmacopeias.Existing control methods have limitations,prompting the need for highly sensitive and broad-spectrum detection approaches.Unlike traditional biological products,gene therapy products primarily consist of live viruses,necessitating methods that distinguish between the main virus and adventitious viruses.Current virus detection techniques,such as polymerase chain reaction(PCR),sequencing,mass spectrometry,and DNA microarrays[2e4],have their drawbacks.
基金National Key Research and Development Program of China(2023YFB2905502)Explorers Program of Shanghai(Basic Research Funding)(24TS1401000)。
文摘In this work,a reflective metasurface connector(RMC)and its application for high-density and wideband spacedivision multiplexing(SDM)are demonstrated.This device features single facet metasurface fabrication over an SOI platform based on a CMOS compatible process.A minimum fiber-to-fiber insertion loss of 2.9 dB at 1598.24 nm is realized for fan-in-fan-out(FIFO)applications between a single-mode fiber(SMF)array and a multicore fiber(MCF).
文摘Tilted fiber Bragg gratings(TFBGs) have seen rapid development and widespread deployment in diverse sensing applications, ranging from biochemical detection to in-situ monitoring in energy systems. Their ability to generate rich spectral features via cladding mode coupling enables highly sensitive, multi-parameter, and label-free sensing.However, accurate interrogation typically requires broadband spectral measurements to resolve fine spectral structures-posing significant challenges for scalable and cost-effective multiplexing in practical settings.
基金supported by the National Natural Science Foundation of China(Nos.12474418,U22A20398,and 22135008).
文摘Lanthanide(Ln^(3+))-doped luminescent nanocrystals(NCs)with excitation and emission in the second near-infrared biological window(NIRII,1000-1700 nm)have attracted considerable attention in the fields of deep-tissue bioimaging and non-invasive biodetection,owing to their superior advantages including good photochemical stability,sharp emission peaks,large penetration depth,and high signal-to-noise ratio[1].Conventionally,Yb3t-and Nd3t-sensitized NCs have been utilized as NIR-II luminescent nanoprobes for in vivo bioimaging upon excitation with 980 and 808 nm diode laser,respectively[2].
文摘In an effort to simplify the procedure and to reduce the cost of fluorescence SSR analysis, the conditions of the multiplex PCR and the multiplex gel electrophoresis were optimized in the genetic analysis of sunflower (Helianthus annuus L.) inbred lines. Results indicated that factors for a successful multiplex PCR assay were related to the cycling touchdown annealing temperature, the balance of primer concentration at the various loci, the concentration of PCR buffer and the Taq DNA polymerase. Based on the optimization, a tailed primer strategy was outlined, and the effective ways were proposed to overcome the troubleshootings commonly encountered in the multiplex PCR and the multiplex gel electrophoresis.
