Sonic Hedgehog Medulloblastoma(SHH-MB)is one of the four primary molecular subgroups of Medulloblastoma.It is estimated to be responsible for nearly one-third of allMB cases.Using transcriptomic and DNA methylation pr...Sonic Hedgehog Medulloblastoma(SHH-MB)is one of the four primary molecular subgroups of Medulloblastoma.It is estimated to be responsible for nearly one-third of allMB cases.Using transcriptomic and DNA methylation profiling techniques,new developments in this field determined four molecular subtypes for SHH-MB.SHH-MB subtypes show distinct DNAmethylation patterns that allow their discrimination fromoverlapping subtypes and predict clinical outcomes.Class overlapping occurs when two or more classes share common features,making it difficult to distinguish them as separate.Using the DNA methylation dataset,a novel classification technique is presented to address the issue of overlapping SHH-MBsubtypes.Penalizedmultinomial regression(PMR),Tomek links(TL),and singular value decomposition(SVD)were all smoothly integrated into a single framework.SVD and group lasso improve computational efficiency,address the problem of high-dimensional datasets,and clarify class distinctions by removing redundant or irrelevant features that might lead to class overlap.As a method to eliminate the issues of decision boundary overlap and class imbalance in the classification task,TL enhances dataset balance and increases the clarity of decision boundaries through the elimination of overlapping samples.Using fivefold cross-validation,our proposed method(TL-SVDPMR)achieved a remarkable overall accuracy of almost 95%in the classification of SHH-MB molecular subtypes.The results demonstrate the strong performance of the proposed classification model among the various SHH-MB subtypes given a high average of the area under the curve(AUC)values.Additionally,the statistical significance test indicates that TL-SVDPMR is more accurate than both SVM and random forest algorithms in classifying the overlapping SHH-MB subtypes,highlighting its importance for precision medicine applications.Our findings emphasized the success of combining SVD,TL,and PMRtechniques to improve the classification performance for biomedical applications with many features and overlapping subtypes.展开更多
This study investigates the factors that impact farmers'adoption of risk management strategies(RMS)in Pakistan during times of uncertainty.The study examines farmers'adoption of RMS using both multinomial prob...This study investigates the factors that impact farmers'adoption of risk management strategies(RMS)in Pakistan during times of uncertainty.The study examines farmers'adoption of RMS using both multinomial probit(MNP)and multivariate probit(MVP).Data were collected from 382 farmers sampled from four districts in KhyberPakhtunkhwa(KP)province of Pakistan via a multistage sampling technique.This study utilizes the MNP model,considering the assumption of Independence of Irrelevant Alternatives(IIA)and incorporating correlated error terms.The objective is to understand farmers'behavior in risky situations and determine if there is heterogeneity.Results are compared with the MVP model to assess robustness and gain deeper understanding of farmers'decisionmaking processes.The research findings reveal that our results are robust,and farmers behave homogeneously in various RMS scenarios.Farmers adopt RMS individually or in combination to mitigate the adverse effects of natural calamities on their livelihood.The risk-averse farmers,who perceive weather-related risks as a threat,access credits and information,and have farms close to a river are more likely to adopt RMS,irrespective of the format of the strategies available.Moreover,the predicted probabilities and correlation of the RMS and RM categories have strengthened our model estimation.These findings provide insights into the behavior of farmers in adopting RMS which are helpful for policymakers and stakeholders in developing strategies to mitigate the impacts of natural calamities on farmers.展开更多
A geometric framework is proposed for multinomial nonlinear modelsbased on a modified version of the geometric structure presented by Bates & Watts[4]. We use this geometric framework to study some asymptotic infe...A geometric framework is proposed for multinomial nonlinear modelsbased on a modified version of the geometric structure presented by Bates & Watts[4]. We use this geometric framework to study some asymptotic inference in terms ofcurvatures for multinomial nonlinear models. Our previous results [15] for ordinarynonlinear regression models are extended to multinomial nonlinear models.展开更多
We consider testing hypotheses concerning comparing dispersions between two parameter vectors of multinomial distributions in both one-sample and two-sample cases. The comparison criterion is the concept of Schur majo...We consider testing hypotheses concerning comparing dispersions between two parameter vectors of multinomial distributions in both one-sample and two-sample cases. The comparison criterion is the concept of Schur majorization. A new dispersion index is proposed for testing the hypotheses. The corresponding test for the one-sample problem is an exact test. For the two-sample problem, the bootstrap is used to approximate the null distribution of the test statistic and the p-value. We prove that the bootstrap test is asymptotically correct and consistent. Simulation studies for the bootstrap test are reported and a real life example is presented.展开更多
In order to deal with the problems in P2P systems of file sharing such as unreliability of the service,security risk and attacks caused by malicious peers,a novel Trust Model based on Multinomial subjective logic and ...In order to deal with the problems in P2P systems of file sharing such as unreliability of the service,security risk and attacks caused by malicious peers,a novel Trust Model based on Multinomial subjective logic and Risk mechanism(MR-TM) is proposed.According to the multinomial subjective logic theory,the model introduces the risk mechanism.It assesses and quantifies the peers' risk,through computing the resource value,vulnerability,threat level,and finally gets the trust value by the risk value and the reputation value.The introduction of the risk value can reflect the recent behaviors of the peers better and make the system more sensitive to malicious acts.Finally,the effectiveness and feasibility of the model is illustrated by the simulation experiment designed with Peersim.展开更多
Objective:To report the indigenous people's uses of plants from a multidimensional perspective in a remote area where strong ethnobotanical cultural practices prevail. Methods:An ethnobotanical survey was conducte...Objective:To report the indigenous people's uses of plants from a multidimensional perspective in a remote area where strong ethnobotanical cultural practices prevail. Methods:An ethnobotanical survey was conducted in the field during 2014-2016. Ethnobotanical data were gathered from 182 informants through oral interviews and semi-structured questionnaires. The distribution of plants was explored using both descriptive and graphical methods. Further,a Multinomial Logit Specification was applied to find out the probability of the occurrence of diverse utilization of plants in multipurpose domains. Results:The study identified 202 plant species distributed among 71 families and 156 genera. Ethnobotanical data indicate that there are more medicinal(36.96%) uses of plants as compared to all other use categories. The output from the Multinomial Logit Specifications(MLS) model reveals that perennial and non-woody plants are exploited more for medicinal and food uses than annual and woody plants. In the context of ethnomedicinal uses,aerial plant parts particularly leaves are more extensively used for the preparation of herbal recipes as compared to underground parts. Conclusions:The results of the study emphasize the need to create awareness among the local communities about the conservation status of plant species in order to maintain a sustainable resource of plant-derived materials into the future. The novel econometric approach employed in this study adds a new insightful methodology to the existing body of literature in the field of ethnobotany. We strongly recommend conservation measures,alongside phytochemical and pharmacological studies on the useful plant species identified in this study in order to ensure their sustainable and effective utilization.展开更多
In wireless sensor networks(WSNs),nodes are usually powered by batteries.Since the energy consumption directly impacts the network lifespan,energy saving is a vital issue in WSNs,especially in the designing phase of c...In wireless sensor networks(WSNs),nodes are usually powered by batteries.Since the energy consumption directly impacts the network lifespan,energy saving is a vital issue in WSNs,especially in the designing phase of cryptographic algorithms.As a complementary mechanism,reputation has been applied to WSNs.Different from most reputation schemes that were based on beta distribution,negative multinomial distribution was deduced and its feasibility in the reputation modeling was proved.Through comparison tests with beta distribution based reputation in terms of the update computation,results show that the proposed method in this research is more energy-efficient for the reputation update and thus can better prolong the lifespan of WSNs.展开更多
In order to deal with the problems in P2P systems such as unreliability of the Service, security risk and attacks caused by malicious peers, a novel trust model MSL-TM based on the Multinomial Subjective Logic is prop...In order to deal with the problems in P2P systems such as unreliability of the Service, security risk and attacks caused by malicious peers, a novel trust model MSL-TM based on the Multinomial Subjective Logic is proposed. The model uses multinomial ratings and Dirichlet distribution to compute the expectation of the subjective opinion and accordingly draws the peer’s reputation value and risk value, and finally gets the trust value. The decay of time, rating credibility and the risk value are introduced to reflect the recent behaviors of the peers and make the system more sensitive to malicious acts. Finally, the effectiveness and feasibility of the model is illustrated by the simulation experiment designed with peersim.展开更多
Multinomial logistic regression (MNL) is an attractive statistical approach in modeling the vehicle crash severity as it does not require the assumption of normality, linearity, or homoscedasticity compared to other a...Multinomial logistic regression (MNL) is an attractive statistical approach in modeling the vehicle crash severity as it does not require the assumption of normality, linearity, or homoscedasticity compared to other approaches, such as the discriminant analysis which requires these assumptions to be met. Moreover, it produces sound estimates by changing the probability range between 0.0 and 1.0 to log odds ranging from negative infinity to positive infinity, as it applies transformation of the dependent variable to a continuous variable. The estimates are asymptotically consistent with the requirements of the nonlinear regression process. The results of MNL can be interpreted by both the regression coefficient estimates and/or the odd ratios (the exponentiated coefficients) as well. In addition, the MNL can be used to improve the fitted model by comparing the full model that includes all predictors to a chosen restricted model by excluding the non-significant predictors. As such, this paper presents a detailed step by step overview of incorporating the MNL in crash severity modeling, using vehicle crash data of the Interstate I70 in the State of Missouri, USA for the years (2013-2015).展开更多
To stay competitive, the mobile telecommunication companies spend millions of Ghana cedi each year on building long-term relationships with their customers. Marketing managers are constantly challenged with the proble...To stay competitive, the mobile telecommunication companies spend millions of Ghana cedi each year on building long-term relationships with their customers. Marketing managers are constantly challenged with the problem of where to channel the limited resources in order to retain existing customers. This study approaches the customer retention problem in the mobile phone sector from a behavioural perspective, applying the Behavioural Perspective Model as the main analytical framework and further exploits some other factors that influence customer retention. The model includes a set of pre-behaviour and post-behaviour factors to study consumer choice, and explains its relevant drivers in a viable and comprehensive way, grounded in radical behaviourism. Data for the analysis were collected from tertiary students from Accra and Takoradi. Data collected were analysed using the multinomial regression technique. Analysis of the data revealed that the Behaviour setting factor is the only significant element in Behaviour Perspective Model. Further exploitation of behaviour situation revealed that the number of networks a customer uses, previous experience of a customer and customer’s intention are significant factors in determining customer retention in Ghana’s mobile telecommunication industry.展开更多
The aim of this study was to explore the effectiveness of behavioral evaluation measures for predicting drivers＇ subjective drowsiness. Behavioral measures included neck bending angle, back pressure, foot pressure, C...The aim of this study was to explore the effectiveness of behavioral evaluation measures for predicting drivers＇ subjective drowsiness. Behavioral measures included neck bending angle, back pressure, foot pressure, COP （center of pressure） movement on sitting surface and tracking error in driving simulator task. Drowsy states were predicted by means of the multinomial logistic regression model where behavioral measures and subjective evaluation of drowsiness corresponded to independent variables and a dependent variable, respectively. First, we compared the effectiveness of two methods （correlation coefficient-based method and odds ratio-based method） for determining the order of entering behavioral measures into the prediction model. It was found that the prediction accuracy did not differ between both methods. Second, the prediction accuracy was compared among the numbers of behavioral measures. The prediction accuracy did not differ among four, five and six behavioral measures and it was concluded that entering at least four behavioral measures into the prediction model is enough to achieve higher prediction accuracy. Third, the prediction accuracy was compared between the strongly drowsy and the weakly drowsy groups. The prediction accuracy differed between the two groups and the proposed method was effective under the condition where drowsiness was induced to a larger extent.展开更多
Rice straw,a by-product of rice cultivation,is commonly disposed of through open-field burning,which contributes to air pollution and environmental degradation.This study aims to identify the key factors influencing f...Rice straw,a by-product of rice cultivation,is commonly disposed of through open-field burning,which contributes to air pollution and environmental degradation.This study aims to identify the key factors influencing farmers’decisions on rice straw management and to develop policy recommendations that encourage the sustainable utilization of rice straw within the supply chain.A mixed-methods approach was adopted,combining qualitative interviews with nine key informants and a quantitative survey of 585 rice farmers across Thailand.Multinomial Logit Regression(MLR)was employed to analyze farmers’preferences among four management options:burning,composting,animal feeding,and selling.The results reveal that membership in farmer groups,ownership of livestock,access to baling machinery,knowledge,and skills related to straw utilization,ease of field access,availability of storage facilities,engagement in integrated farming,and year-round access to baling services significantly increased the likelihood of choosing sustainable alternatives over the burning straw.These findings underscore the importance of both capacity-building and infrastructure in enabling sustainable practices.Based on these insights,the study proposes a multi-level policy framework to enhance the value creation of rice straw.National policies should focus on expanding access to machinery and supporting innovation,while local governments should facilitate farmer training and improve straw logistics.Strengthening farmer organizations and market connections is also crucial for scaling adoption.Overall,structural integration and stakeholder coordination are key to reducing straw burning and promoting sustainable resource use in rice-producing regions.展开更多
基金funded by the Deanship of Graduate Studies and Scientific Research at Jouf University under grant No.(DGSSR-2024-02-01137).
文摘Sonic Hedgehog Medulloblastoma(SHH-MB)is one of the four primary molecular subgroups of Medulloblastoma.It is estimated to be responsible for nearly one-third of allMB cases.Using transcriptomic and DNA methylation profiling techniques,new developments in this field determined four molecular subtypes for SHH-MB.SHH-MB subtypes show distinct DNAmethylation patterns that allow their discrimination fromoverlapping subtypes and predict clinical outcomes.Class overlapping occurs when two or more classes share common features,making it difficult to distinguish them as separate.Using the DNA methylation dataset,a novel classification technique is presented to address the issue of overlapping SHH-MBsubtypes.Penalizedmultinomial regression(PMR),Tomek links(TL),and singular value decomposition(SVD)were all smoothly integrated into a single framework.SVD and group lasso improve computational efficiency,address the problem of high-dimensional datasets,and clarify class distinctions by removing redundant or irrelevant features that might lead to class overlap.As a method to eliminate the issues of decision boundary overlap and class imbalance in the classification task,TL enhances dataset balance and increases the clarity of decision boundaries through the elimination of overlapping samples.Using fivefold cross-validation,our proposed method(TL-SVDPMR)achieved a remarkable overall accuracy of almost 95%in the classification of SHH-MB molecular subtypes.The results demonstrate the strong performance of the proposed classification model among the various SHH-MB subtypes given a high average of the area under the curve(AUC)values.Additionally,the statistical significance test indicates that TL-SVDPMR is more accurate than both SVM and random forest algorithms in classifying the overlapping SHH-MB subtypes,highlighting its importance for precision medicine applications.Our findings emphasized the success of combining SVD,TL,and PMRtechniques to improve the classification performance for biomedical applications with many features and overlapping subtypes.
文摘This study investigates the factors that impact farmers'adoption of risk management strategies(RMS)in Pakistan during times of uncertainty.The study examines farmers'adoption of RMS using both multinomial probit(MNP)and multivariate probit(MVP).Data were collected from 382 farmers sampled from four districts in KhyberPakhtunkhwa(KP)province of Pakistan via a multistage sampling technique.This study utilizes the MNP model,considering the assumption of Independence of Irrelevant Alternatives(IIA)and incorporating correlated error terms.The objective is to understand farmers'behavior in risky situations and determine if there is heterogeneity.Results are compared with the MVP model to assess robustness and gain deeper understanding of farmers'decisionmaking processes.The research findings reveal that our results are robust,and farmers behave homogeneously in various RMS scenarios.Farmers adopt RMS individually or in combination to mitigate the adverse effects of natural calamities on their livelihood.The risk-averse farmers,who perceive weather-related risks as a threat,access credits and information,and have farms close to a river are more likely to adopt RMS,irrespective of the format of the strategies available.Moreover,the predicted probabilities and correlation of the RMS and RM categories have strengthened our model estimation.These findings provide insights into the behavior of farmers in adopting RMS which are helpful for policymakers and stakeholders in developing strategies to mitigate the impacts of natural calamities on farmers.
文摘A geometric framework is proposed for multinomial nonlinear modelsbased on a modified version of the geometric structure presented by Bates & Watts[4]. We use this geometric framework to study some asymptotic inference in terms ofcurvatures for multinomial nonlinear models. Our previous results [15] for ordinarynonlinear regression models are extended to multinomial nonlinear models.
基金Sponsored by the National NSFC (10771126, 10801130)
文摘We consider testing hypotheses concerning comparing dispersions between two parameter vectors of multinomial distributions in both one-sample and two-sample cases. The comparison criterion is the concept of Schur majorization. A new dispersion index is proposed for testing the hypotheses. The corresponding test for the one-sample problem is an exact test. For the two-sample problem, the bootstrap is used to approximate the null distribution of the test statistic and the p-value. We prove that the bootstrap test is asymptotically correct and consistent. Simulation studies for the bootstrap test are reported and a real life example is presented.
基金Supported by the National Natural Science Foundation of China(No.60873203)the Foundation of Key Laboratory of Aerospace Information Security and Trusted Computting,Ministry of Education(No.AISTC2009_03)+1 种基金Hebei Natural Funds for Distinguished Young Scientists(No. F2010000317)the Natural Science Foundation of Hebei Province(No.F2008000646)
文摘In order to deal with the problems in P2P systems of file sharing such as unreliability of the service,security risk and attacks caused by malicious peers,a novel Trust Model based on Multinomial subjective logic and Risk mechanism(MR-TM) is proposed.According to the multinomial subjective logic theory,the model introduces the risk mechanism.It assesses and quantifies the peers' risk,through computing the resource value,vulnerability,threat level,and finally gets the trust value by the risk value and the reputation value.The introduction of the risk value can reflect the recent behaviors of the peers better and make the system more sensitive to malicious acts.Finally,the effectiveness and feasibility of the model is illustrated by the simulation experiment designed with Peersim.
文摘Objective:To report the indigenous people's uses of plants from a multidimensional perspective in a remote area where strong ethnobotanical cultural practices prevail. Methods:An ethnobotanical survey was conducted in the field during 2014-2016. Ethnobotanical data were gathered from 182 informants through oral interviews and semi-structured questionnaires. The distribution of plants was explored using both descriptive and graphical methods. Further,a Multinomial Logit Specification was applied to find out the probability of the occurrence of diverse utilization of plants in multipurpose domains. Results:The study identified 202 plant species distributed among 71 families and 156 genera. Ethnobotanical data indicate that there are more medicinal(36.96%) uses of plants as compared to all other use categories. The output from the Multinomial Logit Specifications(MLS) model reveals that perennial and non-woody plants are exploited more for medicinal and food uses than annual and woody plants. In the context of ethnomedicinal uses,aerial plant parts particularly leaves are more extensively used for the preparation of herbal recipes as compared to underground parts. Conclusions:The results of the study emphasize the need to create awareness among the local communities about the conservation status of plant species in order to maintain a sustainable resource of plant-derived materials into the future. The novel econometric approach employed in this study adds a new insightful methodology to the existing body of literature in the field of ethnobotany. We strongly recommend conservation measures,alongside phytochemical and pharmacological studies on the useful plant species identified in this study in order to ensure their sustainable and effective utilization.
基金National Natural Science Foundations of China (No.61073177,60905037)
文摘In wireless sensor networks(WSNs),nodes are usually powered by batteries.Since the energy consumption directly impacts the network lifespan,energy saving is a vital issue in WSNs,especially in the designing phase of cryptographic algorithms.As a complementary mechanism,reputation has been applied to WSNs.Different from most reputation schemes that were based on beta distribution,negative multinomial distribution was deduced and its feasibility in the reputation modeling was proved.Through comparison tests with beta distribution based reputation in terms of the update computation,results show that the proposed method in this research is more energy-efficient for the reputation update and thus can better prolong the lifespan of WSNs.
文摘In order to deal with the problems in P2P systems such as unreliability of the Service, security risk and attacks caused by malicious peers, a novel trust model MSL-TM based on the Multinomial Subjective Logic is proposed. The model uses multinomial ratings and Dirichlet distribution to compute the expectation of the subjective opinion and accordingly draws the peer’s reputation value and risk value, and finally gets the trust value. The decay of time, rating credibility and the risk value are introduced to reflect the recent behaviors of the peers and make the system more sensitive to malicious acts. Finally, the effectiveness and feasibility of the model is illustrated by the simulation experiment designed with peersim.
文摘Multinomial logistic regression (MNL) is an attractive statistical approach in modeling the vehicle crash severity as it does not require the assumption of normality, linearity, or homoscedasticity compared to other approaches, such as the discriminant analysis which requires these assumptions to be met. Moreover, it produces sound estimates by changing the probability range between 0.0 and 1.0 to log odds ranging from negative infinity to positive infinity, as it applies transformation of the dependent variable to a continuous variable. The estimates are asymptotically consistent with the requirements of the nonlinear regression process. The results of MNL can be interpreted by both the regression coefficient estimates and/or the odd ratios (the exponentiated coefficients) as well. In addition, the MNL can be used to improve the fitted model by comparing the full model that includes all predictors to a chosen restricted model by excluding the non-significant predictors. As such, this paper presents a detailed step by step overview of incorporating the MNL in crash severity modeling, using vehicle crash data of the Interstate I70 in the State of Missouri, USA for the years (2013-2015).
文摘To stay competitive, the mobile telecommunication companies spend millions of Ghana cedi each year on building long-term relationships with their customers. Marketing managers are constantly challenged with the problem of where to channel the limited resources in order to retain existing customers. This study approaches the customer retention problem in the mobile phone sector from a behavioural perspective, applying the Behavioural Perspective Model as the main analytical framework and further exploits some other factors that influence customer retention. The model includes a set of pre-behaviour and post-behaviour factors to study consumer choice, and explains its relevant drivers in a viable and comprehensive way, grounded in radical behaviourism. Data for the analysis were collected from tertiary students from Accra and Takoradi. Data collected were analysed using the multinomial regression technique. Analysis of the data revealed that the Behaviour setting factor is the only significant element in Behaviour Perspective Model. Further exploitation of behaviour situation revealed that the number of networks a customer uses, previous experience of a customer and customer’s intention are significant factors in determining customer retention in Ghana’s mobile telecommunication industry.
文摘The aim of this study was to explore the effectiveness of behavioral evaluation measures for predicting drivers＇ subjective drowsiness. Behavioral measures included neck bending angle, back pressure, foot pressure, COP （center of pressure） movement on sitting surface and tracking error in driving simulator task. Drowsy states were predicted by means of the multinomial logistic regression model where behavioral measures and subjective evaluation of drowsiness corresponded to independent variables and a dependent variable, respectively. First, we compared the effectiveness of two methods （correlation coefficient-based method and odds ratio-based method） for determining the order of entering behavioral measures into the prediction model. It was found that the prediction accuracy did not differ between both methods. Second, the prediction accuracy was compared among the numbers of behavioral measures. The prediction accuracy did not differ among four, five and six behavioral measures and it was concluded that entering at least four behavioral measures into the prediction model is enough to achieve higher prediction accuracy. Third, the prediction accuracy was compared between the strongly drowsy and the weakly drowsy groups. The prediction accuracy differed between the two groups and the proposed method was effective under the condition where drowsiness was induced to a larger extent.
文摘Rice straw,a by-product of rice cultivation,is commonly disposed of through open-field burning,which contributes to air pollution and environmental degradation.This study aims to identify the key factors influencing farmers’decisions on rice straw management and to develop policy recommendations that encourage the sustainable utilization of rice straw within the supply chain.A mixed-methods approach was adopted,combining qualitative interviews with nine key informants and a quantitative survey of 585 rice farmers across Thailand.Multinomial Logit Regression(MLR)was employed to analyze farmers’preferences among four management options:burning,composting,animal feeding,and selling.The results reveal that membership in farmer groups,ownership of livestock,access to baling machinery,knowledge,and skills related to straw utilization,ease of field access,availability of storage facilities,engagement in integrated farming,and year-round access to baling services significantly increased the likelihood of choosing sustainable alternatives over the burning straw.These findings underscore the importance of both capacity-building and infrastructure in enabling sustainable practices.Based on these insights,the study proposes a multi-level policy framework to enhance the value creation of rice straw.National policies should focus on expanding access to machinery and supporting innovation,while local governments should facilitate farmer training and improve straw logistics.Strengthening farmer organizations and market connections is also crucial for scaling adoption.Overall,structural integration and stakeholder coordination are key to reducing straw burning and promoting sustainable resource use in rice-producing regions.
