The diagnosis and effective management of inflammatory bowel disease(IBD) requires a combination clinical, endoscopic, histological, biological, and imaging data. While endoscopy and biopsy remains the gold standard f...The diagnosis and effective management of inflammatory bowel disease(IBD) requires a combination clinical, endoscopic, histological, biological, and imaging data. While endoscopy and biopsy remains the gold standard for diagnosis of IBD, imaging plays a central role in the assessment of extra mural disease, in disease surveillance and in the assessment of response to medical treatments, which are often expensive. Imaging is also vital in the detection and diagnosis of disease related complications, both acute and chronic. In this review, we will describe, with illustrative images, the imaging features of IBD in adults, with emphasis on upto-date imaging techniques focusing predominantly on cross sectional imaging and new magnetic resonance imaging techniques.展开更多
Aneurysmal change of saphenous vein grafts （SVG） is a rare condition that predominantly develops 10-20 years after coronary artery bypass graft （CABG）. Natural course includes mechanical complications due to mass ...Aneurysmal change of saphenous vein grafts （SVG） is a rare condition that predominantly develops 10-20 years after coronary artery bypass graft （CABG）. Natural course includes mechanical complications due to mass effect, myocardial infarction and aneurysmal rupture. Aneurysmectomy can be considered when it induces such complications. We demonstrate complete set of diagnosis, treatment and post-operative imaging of a huge SVG aneurysm that was successfully treated with surgical resection.展开更多
A clinical approach to new cardiomyopathy entails defining patient phenotype and disease pathophysiology.After echocardiography,invasive assessments to define hemodynamics and coronary anatomy are usually pursued.In s...A clinical approach to new cardiomyopathy entails defining patient phenotype and disease pathophysiology.After echocardiography,invasive assessments to define hemodynamics and coronary anatomy are usually pursued.In selected non-ischemic cases,endomyocardial biopsies are performed in search for an etiology.Fortunately,advances in cardiac imaging allow for a multifaceted cardiac evaluation in a single study,reducing cost,lead time to diagnosis,and procedural adverse events while still providing supreme accuracy.展开更多
Accurate diagnosis of tumors needs much detailed information. However, available single imaging modality cannot provide complete or comprehensive data. Nanomedicine is the application of nanotechnology to medicine, an...Accurate diagnosis of tumors needs much detailed information. However, available single imaging modality cannot provide complete or comprehensive data. Nanomedicine is the application of nanotechnology to medicine, and multimodality imaging based on nanoparticles has been receiving extensive attention. This new hybrid imaging technology could provide complementary information from different imaging modalities using only a single injection of contrast agent. In this review, we introduce recent developments in multifunctional nanoparticles and their biomedical applications to multimodal imaging and theragnosis as nanomedicine. Most of the reviewed studies are based on the intrinsic properties of nanoparticles and their application in clinical imaging technology. The imaging techniques include positron emission tomography, single-photon emission computed tomography, computerized tomography, magnetic resonance imaging, optical imaging, and ultrasound imaging.展开更多
Infective endocarditis is one of the leading life-threatening infections around the world.With the exponential growth in the field of transcatheter interventions and advances in specialized surgical techniques,the num...Infective endocarditis is one of the leading life-threatening infections around the world.With the exponential growth in the field of transcatheter interventions and advances in specialized surgical techniques,the number of prosthetic valves and cardiac implantable devices has significantly increased.This has led to a steep rise in the number of cases of prosthetic valve endocarditis(PVE)comprising up to 30%of all cases.Clinical guidelines rely on the use of the modified Duke criteria;however,the diagnostic sensitivity of the modified Duke criteria is reduced in the context of PVE.This is in part attributed to prosthesis related artifact which greatly affects the ability of echocardiography to detect early infective changes related to PVE in certain cases.There has been increasing recognition of the roles of complementary imaging modalities and updates in international society recommendations.Prompt diagnosis and treatment can prevent the devastating consequences of this condition.Imaging modalities such as cardiac computed tomography and 18-fluorodeoxyglucose positron emission tomography/computed tomography are diagnostic tools that provide a complementary role to echocardiography in aiding diagnosis,pre-operative planning,and treatment decisionmaking process in these challenging cases.Understanding the strengths and limitations of these adjuvant imaging modalities is crucial for the implementation of appropriate imaging modalities in clinical practice.展开更多
Pamiparib is a potent and selective oral poly(adenosine diphosphate(ADP)-ribose)-polymerase(PARP)1/2inhibitor(PARPi).Pamiparib has good bioavailability and shows greater cytotoxic potency and similar DNA-trapping capa...Pamiparib is a potent and selective oral poly(adenosine diphosphate(ADP)-ribose)-polymerase(PARP)1/2inhibitor(PARPi).Pamiparib has good bioavailability and shows greater cytotoxic potency and similar DNA-trapping capacity compared to olaparib.It is not affected by adenosine triphosphate(ATP)-binding cassette transporters.展开更多
The phenotypes of the adenine-to-guanine transition at position 3243 of mitochondrial DNA(m.3243A>G)are highly variable,with different symptoms observed in different patients.These include mitochondrial encephalomy...The phenotypes of the adenine-to-guanine transition at position 3243 of mitochondrial DNA(m.3243A>G)are highly variable,with different symptoms observed in different patients.These include mitochondrial encephalomyopathy,lactic acidosis,and stroke-like episodes(MELAS);maternally inherited diabetes and deafness syndrome(MIDD);other syndromic conditions;or non-syndromic mitochondrial disorders.Renal involvement associated with this mutation generally manifests as subnephrotic proteinuria,progressive deterioration of kidney function,and increased morbidity.The retinopathies linked to the m.3243A>G mutation have heterogeneous presentations,characterized by variable degrees of retinal pigment epithelium(RPE)atrophy and hyperpigmentation at the posterior pole.As a severe phenotype of the m.3243A>G mutation,MELAS combined with focal and segmental glomerulosclerosis(FSGS)is rare.We herein firstly reported in detail the ophthalmic manifestations of a patient with this condition.Additionally,we reviewed the literature on fundus,ophthalmic electrophysiology,and optical coherence tomography(OCT)findings related to the m.3243A>G mutation.展开更多
Osteosarcoma is the most common primary bone tumor with high malignancy.It is particularly necessary to achieve rapid and accurate diagnosis in its intraoperative examination and early diagnosis.Accordingly,the multim...Osteosarcoma is the most common primary bone tumor with high malignancy.It is particularly necessary to achieve rapid and accurate diagnosis in its intraoperative examination and early diagnosis.Accordingly,the multimodal microscopic imaging diagnosis system constructed by bright field,spontaneous fluorescence and polarized light microscopic imaging was used to study the pathological mechanism of osteosarcoma from the tissue microenvironment level and achieve rapid and accurate diagnosis.First,the multimodal microscopic images of normal and osteosarcoma tissue slices were collected to characterize the overall morphology of the tissue microenvironment of the samples,the arrangement structure of collagen fibers and the content and distribution of endogenous fluorescent substances.Second,based on the correlation and complementarity of the feature information contained in the three single-mode images,combined with convolutional neural network(CNN)and image fusion methods,a multimodal intelligent diagnosis model was constructed to effectively improve the information utilization and diagnosis accuracy.The accuracy and true positivity of the multimodal diagnostic model were significantly improved to 0.8495 and 0.9412,respectively,compared to those of the single-modal models.Besides,the difference of tissue microenvironments before and after cancerization can be used as a basis for cancer diagnosis,and the information extraction and intelligent diagnosis of osteosarcoma tissue can be achieved by using multimodal microscopic imaging technology combined with deep learning,which significantly promoted the application of tissue microenvironment in pathological examination.This diagnostic system relies on its advantages of simple operation,high efficiency and accuracy and high cost-effectiveness,and has enormous clinical application potential and research significance.展开更多
BACKGROUND Congenital renal arteriovenous fistula(RAVF)is a clinically rare condition and frequently missed and misdiagnosed.Multimodal imaging techniques can pro-vide more detailed diagnostic information to help phys...BACKGROUND Congenital renal arteriovenous fistula(RAVF)is a clinically rare condition and frequently missed and misdiagnosed.Multimodal imaging techniques can pro-vide more detailed diagnostic information to help physicians more accurately diagnose and treat diseases.Combining imaging methods to diagnose RAVF has rarely been reported.CASE SUMMARY A 69-year-old female patient presented with gross hematuria that had persisted for 10 days.The patient underwent ultrasound examinations of the kidneys and renal blood vessels,enhanced computed tomography,three-dimensional com-puted tomography angiography,and digital subtraction angiography of the renal arteries.These revealed dilatation of the left renal vein and abnormal shunting between the left renal artery and vein.The patient was diagnosed with a left RAVF using combined multimodal imaging techniques.The patient was treated with left renal artery embolization immediately after renal arteriography.Hema-turia resolved following the left renal artery embolization without serious bleeding or other complications.The patient made a full recovery after one year of postoperative follow-up.CONCLUSION Multimodal imaging techniques complement each other when diagnosing RAVF,providing detailed diagnostic information that can aid in accurate diagnosis and treatment.In addition,this case reminds the sonographer to pay more attention to the color doppler flow imaging and blood flow spectrum when examining the kidney,so as to avoid misdiagnosis of renal cystic lesions as renal cysts and missed diagnosis of RAVF.展开更多
BACKGROUND Rectal cancer is one of the common digestive system malignant tumors around the world.Its early diagnosis and staging are crucial for rectal cancer treatment and prognosis.In recent years,tumor markers have...BACKGROUND Rectal cancer is one of the common digestive system malignant tumors around the world.Its early diagnosis and staging are crucial for rectal cancer treatment and prognosis.In recent years,tumor markers have gradually received attention in early screening,treatment monitoring and prognostic evaluation of cancer,but their predictive role in rectal cancer staging and differentiation is still unclear.AIM To assess the prognostic value of tumor markers alpha-fetoprotein(AFP)cancer antigen 72-4(CA72-4),carbohydrate antigen 19-9(CA19-9),and carcinoembryonic antigen(CEA),alongside multimodal magnetic resonance imaging(MRI),for staging and differentiating rectal cancer in patients.METHODS This study retrospectively analyzed 167 patients with rectal cancer who were treated at our institution from January 2020 to December 2024.Each patient underwent serological testing and multimodal MRI for diagnosis.Histopathological examination after surgical resection or imaging based on follow-up was used as the gold standard.According to the T stage and differentiation degree,patients were divided into low stage group(T1-T2)and high stage group(T3-T4).In addition,they were divided into low-differentiation groups and high-differentiation groups according to their differentiation degree.We compared the accuracy,sensitivity and specificity of tumor marker levels and MRI in rectal cancer stage and differentiation.RESULTS The study's findings indicate that in the context of rectal cancer T staging,there is substantial concordance between MRI and clinicopathological assessments,with a Kappa coefficient of 0.789(P<0.001).Similarly,for various degrees of tumor differentiation,MRI and clinicopathological evaluations demonstrated substantial agreement,with a Kappa coefficient of 0.651(P<0.001).Notably,the concentrations of tumor markers CA19-9,CA72-4,CEA,and AFP were significantly elevated in the T3-T4 stage compared to the T1-T2 stage.Furthermore,these markers were significantly higher in the low-differentiation group compared to the high-differentiation group(P<0.05).The combined use of tumor markers and MRI for preoperative T staging of rectal cancer yielded a diagnostic sensitivity of 93.7%and a specificity of 94.6%,as evidenced by the receiver operating characteristic analysis,with an area under the curve of 0.947.For tumor differentiation,the diagnostic sensitivity and specificity were 93.6%and 97.1%,respectively,with an area under the curve of 0.978(95%confidence interval:0.946-1.000),surpassing the accuracy of individual detection methods.CONCLUSION The CA19-9,CA72-4,CEA and AFP tumor markers combined with multimodal MRI have high sensitivity and specificity in diagnosing rectal cancer stage and differentiation.Their diagnostic efficacy is significantly better than that of single tests,which can effectively improve the predictive ability of rectal cancer stage and differentiation,provide a more reliable diagnostic reference for clinical practice,and have important clinical significance.展开更多
AIM:To describe the multimodal imaging features,treatment,and outcomes of patients diagnosed with adultonset Coats disease.METHODS:This retrospective study included patients first diagnosed with Coats disease at≥18 y...AIM:To describe the multimodal imaging features,treatment,and outcomes of patients diagnosed with adultonset Coats disease.METHODS:This retrospective study included patients first diagnosed with Coats disease at≥18 years of age between September 2017 and September 2021.Some patients received anti-vascular endothelial growth factor(VEGF)therapy(conbercept,0.5 mg)as the initial treatment,which was combined with laser photocoagulation as needed.All the patients underwent best corrected visual acuity(BCVA)and intraocular pressure examinations,fundus color photography,spontaneous fluorescence tests,fundus fluorescein angiography,optical coherence tomography(OCT),OCT angiography,and other examinations.BCVA alterations and multimodal image findings in the affected eyes following treatment were compared and the prognostic factors were analyzed.RESULTS:The study included 15 patients who were aged 24-72(57.33±12.61)y at presentation.Systemic hypertension was the most common associated systemic condition,occurring in 13(86.7%)patients.Baseline BCVA ranged from 2.0 to 5.0(4.0±1.1),which showed improvement following treatment(4.2±1.0).Multimodal imaging revealed retinal telangiectasis in 13 patients(86.7%),patchy hemorrhage in 5 patients(33.3%),and stage 2B disease(Shield’s staging criteria)in 11 patients(73.3%).OCT revealed that the baseline central macular thickness(CMT)ranged from 129 to 964μm(473.0±230.1μm),with 13 patients(86.7%)exhibiting a baseline CMT exceeding 250μm.Furthermore,8 patients(53.3%)presented with an epiretinal membrane at baseline or during follow-up.Hyper-reflective scars were observed on OCT in five patients(33.3%)with poor visual prognosis.Vision deteriorated in one patient who did not receive treatment.Final vision was stable in three patients who received laser treatment,whereas improvement was observed in one of two patients who received anti-VEGF therapy alone.In addition,8 of 9 patients(88.9%)who received laser treatment and conbercept exhibited stable or improved BCVA.CONCLUSION:Multimodal imaging can help diagnose adult-onset Coats disease.Anti-VEGF treatment combined with laser therapy can be an option for improving or maintaining BCVA and resolving macular edema.The final visual outcome depends on macular involvement and the disease stage.展开更多
BACKGROUND Giant cell tumor of bone is a locally aggressive and rarely metastasizing tumor,and also a potential malignant tumor that may develop into a primary malignant giant cell tumor.AIM To evaluate the role of mu...BACKGROUND Giant cell tumor of bone is a locally aggressive and rarely metastasizing tumor,and also a potential malignant tumor that may develop into a primary malignant giant cell tumor.AIM To evaluate the role of multimodal imaging in the diagnosis of giant cell tumors of bone.METHODS The data of 32 patients with giant cell tumor of bone confirmed by core-needle biopsy or surgical pathology at our hospital between March 2018 and March 2023 were retrospectively selected.All the patients with giant cell tumors of the bone were examined by X-ray,computed tomography(CT)and magnetic resonance imaging(MRI),and 7 of them were examined by positron emission tomography(PET)-CT.RESULTS X-ray imaging can provide overall information on giant cell tumor lesions.CT and MRI can reveal the characteristics of the internal structure of the tumor as well as the adjacent relationships of the tumor,and these methods have unique advantages for diagnosing tumors and determining the scope of surgery.PET-CT can detect small lesions and is highly valuable for identifying benign and malignant tumors to aid in the early diagnosis of metastasis.CONCLUSION Multimodal imaging plays an important role in the diagnosis of giant cell tumor of bone and can provide a reference for the treatment of giant cell tumors.展开更多
BACKGROUND The rare co-occurrence of oligodendroglioma and arteriovenous malformation(AVM)in the same intracranial location.CASE SUMMARY In a 61-year-old man presenting with progressive headaches,is described in this ...BACKGROUND The rare co-occurrence of oligodendroglioma and arteriovenous malformation(AVM)in the same intracranial location.CASE SUMMARY In a 61-year-old man presenting with progressive headaches,is described in this case study.Preoperative multimodal imaging techniques(computed tomography,magnetic resonance imaging,magnetic resonance spectroscopy,digital subtraction angiography,and computed tomography angiography)were employed to detect hemorrhage,cystic and solid lesions,and arteriovenous shunting in the right temporal lobe.The patient underwent right temporal craniotomy for lesion removal,and postoperative pathological analysis confirmed the presence of oligodendroglioma(World Health Organization grade II,not otherwise specified)and AVM.CONCLUSION The preoperative utilization of multimodal imaging examination can help clinicians reduce the likelihood of misdiagnosis or oversight of these conditions,and provides important information for subsequent treatment.This case supports the feasibility of craniotomy for the removal of glioma with AVM.展开更多
Autoimmune pancreatitis(AIP)is a special type of chronic pancreatitis with cli-nical symptoms of obstructive jaundice and abdominal discomfort;this condition is caused by autoimmunity and marked by pancreatic fibrosis...Autoimmune pancreatitis(AIP)is a special type of chronic pancreatitis with cli-nical symptoms of obstructive jaundice and abdominal discomfort;this condition is caused by autoimmunity and marked by pancreatic fibrosis and dysfunction.Previous studies have revealed a close relationship between early pancreatic atrophy and the incidence rate of diabetes in type 1 AIP patients receiving steroid treatment.Shimada et al performed a long-term follow-up study and reported that the pancreatic volume(PV)of these patients initially exponentially decreased but then slowly decreased,which was considered to be an important factor related to diabetes;moreover,serum IgG4 levels were positively correlated with PV during follow-up.In this letter,regarding the original study presented by Shimada et al,we present our insights and discuss how multimodal medical imaging and arti-ficial intelligence can be used to better assess the relationship between pancreatic morphological changes and diabetes in patients with AIP.展开更多
Right-sided infective endocarditis is an increasingly recognized disease entity,with tricuspid valve being most frequently involved.Risk factors for tricuspid valve endocarditis(TVIE)include intravenous drug use,cardi...Right-sided infective endocarditis is an increasingly recognized disease entity,with tricuspid valve being most frequently involved.Risk factors for tricuspid valve endocarditis(TVIE)include intravenous drug use,cardiac implantable electronic devices and indwelling catheters.Staphylococcus aureus is the predominant causative organism in TVIE.The diagnosis of infective endocarditis(IE)is based on clinical manifestations,blood cultures,and the presence of valvular vegetations detected by echocardiography.Complementary imaging is helpful when there is ongoing clinical suspicion for IE following initially negative echocardiography.Multislice computed tomography allows for assessment of extra-cardiac complications in TVIE,including pulmonary septic emboli.18F-fluorodeoxyglucose positron emission tomography/computed tomography and radiolabelled white blood cell,single-photon emission computed tomography provide important clinical information concerning the presence of IE in right-sided prosthetic valves or cardiac implantable electronic devices.The aim of this review is to provide an update on TVIE,discussing the role of multimodality imaging in TVIE and the management of these patients.展开更多
Fourier Ptychographic Microscopy(FPM)is a high-throughput computational optical imaging technology reported in 2013.It effectively breaks through the trade-off between high-resolution imaging and wide-field imaging.In...Fourier Ptychographic Microscopy(FPM)is a high-throughput computational optical imaging technology reported in 2013.It effectively breaks through the trade-off between high-resolution imaging and wide-field imaging.In recent years,it has been found that FPM is not only a tool to break through the trade-off between field of view and spatial resolution,but also a paradigm to break through those trade-off problems,thus attracting extensive attention.Compared with previous reviews,this review does not introduce its concept,basic principles,optical system and series of applications once again,but focuses on elaborating the three major difficulties faced by FPM technology in the process from“looking good”in the laboratory to“working well”in practical applications:mismatch between numerical model and physical reality,long reconstruction time and high computing power demand,and lack of multi-modal expansion.It introduces how to achieve key technological innovations in FPM through the dual drive of Artificial Intelligence(AI)and physics,including intelligent reconstruction algorithms introducing machine learning concepts,optical-algorithm co-design,fusion of frequency domain extrapolation methods and generative adversarial networks,multi-modal imaging schemes and data fusion enhancement,etc.,gradually solving the difficulties of FPM technology.Conversely,this review deeply considers the unique value of FPM technology in potentially feeding back to the development of“AI+optics”,such as providing AI benchmark tests under physical constraints,inspirations for the balance of computing power and bandwidth in miniaturized intelligent microscopes,and photoelectric hybrid architectures.Finally,it introduces the industrialization path and frontier directions of FPM technology,pointing out that with the promotion of the dual drive of AI and physics,it will generate a large number of industrial application case,and looks forward to the possibilities of future application scenarios and expansions,for instance,body fluid biopsy and point-of-care testing at the grassroots level represent the expansion of the growth market.展开更多
Tears of peroneus brevis tendon represent a cause of underdiagnosed lateral ankle pain and instability.The typical clinical presentation is retro-malleolar pain,in some cases associated with palpable swelling around t...Tears of peroneus brevis tendon represent a cause of underdiagnosed lateral ankle pain and instability.The typical clinical presentation is retro-malleolar pain,in some cases associated with palpable swelling around the fibular malleolus,pain during activities and difficulty in walking.We present a case of peroneus brevis split lesion with superior peroneal retinaculum avulsion in a young athlete who referred to the emergency ward of our hospital for left ankle pain after an inversion injury.An early diagnosis allowed treating the injury and promptly resuming sport activity,after rehabilitation training.Surgical reconstruction key-points and postsurgical follow-up were also discussed.A late diagnosis would have caused a symptomatology worsening and an increased recovery time.展开更多
Objective To develop a multimodal imaging atlas of a rat brain-computer interface(BCI)that incorporates brain,arterial,bone tissue and a BCI device using mixed reality(MR)for three-dimensional(3D)visualization.Methods...Objective To develop a multimodal imaging atlas of a rat brain-computer interface(BCI)that incorporates brain,arterial,bone tissue and a BCI device using mixed reality(MR)for three-dimensional(3D)visualization.Methods An invasive BCI was implanted in the left visual cortex of 4-week-old Sprague–Dawley rats.Multimodal imaging techniques,including micro-CT and 9.0 T MRI,were used to acquire images of the rat cranial bone structure,vascular distribution,brain tissue functional zones,and BCI device before and after implantation.Using 3D-slicer software,the images were fused through spatial transformations,followed by image segmentation and 3D model reconstruction.The HoloLens platform was employed for MR visualization.Results This study constructed a multimodal imaging atlas for rats that included the skull,brain tissue,arterial tissue,and BCI device coupled with MR technology to create an interactive 3D anatomical model.Conclusions This multimodal 3D atlas provides an objective and stable reference for exploring complex relationships between brain tissue structure and function,enhancing the understanding of the operational principles of BCIs.This is the first multimodal 3D imaging atlas related to a BCI created using Sprague–Dawley rats.展开更多
With rapid urbanization,fires pose significant challenges in urban governance.Traditional fire detection methods often struggle to detect smoke in complex urban scenes due to environmental interferences and variations...With rapid urbanization,fires pose significant challenges in urban governance.Traditional fire detection methods often struggle to detect smoke in complex urban scenes due to environmental interferences and variations in viewing angles.This study proposes a novel multimodal smoke detection method that fuses infrared and visible imagery using a transformer-based deep learning model.By capturing both thermal and visual cues,our approach significantly enhances the accuracy and robustness of smoke detection in business parks scenes.We first established a dual-view dataset comprising infrared and visible light videos,implemented an innovative image feature fusion strategy,and designed a deep learning model based on the transformer architecture and attention mechanism for smoke classification.Experimental results demonstrate that our method outperforms existing methods,under the condition of multi-view input,it achieves an accuracy rate of 90.88%,precision rate of 98.38%,recall rate of 92.41%and false positive and false negative rates both below 5%,underlining the effectiveness of the proposed multimodal and multi-view fusion approach.The attention mechanism plays a crucial role in improving detection performance,particularly in identifying subtle smoke features.展开更多
Objective:The study aimed to report the distinctive fundus appearance of bilateral asymmetric choroidal melanocytosis and reviewed the clinical and multimodal imaging characteristics to differentiate choroidal melanoc...Objective:The study aimed to report the distinctive fundus appearance of bilateral asymmetric choroidal melanocytosis and reviewed the clinical and multimodal imaging characteristics to differentiate choroidal melanocytosis from malignant pigmented retinal lesions.Methods:An observational case report and literature review.Results:A 60-year-old patient underwent comprehensive ophthalmologic examinations.Underfunduscopic examination,bilateral choroidal melanocytosis with asymmetry choroidal pigmentation change was observed.In the right eye,there was diffuse darker coloration extending from posterior pole to the mid-peripheral retina.In the left eye,flat patches of choroidal hyperpigmentation were present,involving superior and inferior hemisphere region,while other regions were depigmented.Spectral-domain optical coherence tomography revealed that the layers of retina and choroid were basically normal,with no elevation of the retinal pigment epithelium.Near infrared reflectance images provided a clearer view of mottled focal hyperpigmentation area,which corresponded to the choroidal hyperpigmentation.Conclusions:This case highlights the effectiveness of multimodal imaging in distinguishing choroidal melanocytosis from malignant entities.It emphasizes the crucial role of multimodal imaging in guiding clinical management to prevent vision-threatening complications and monitor potential malignant transformation.展开更多
文摘The diagnosis and effective management of inflammatory bowel disease(IBD) requires a combination clinical, endoscopic, histological, biological, and imaging data. While endoscopy and biopsy remains the gold standard for diagnosis of IBD, imaging plays a central role in the assessment of extra mural disease, in disease surveillance and in the assessment of response to medical treatments, which are often expensive. Imaging is also vital in the detection and diagnosis of disease related complications, both acute and chronic. In this review, we will describe, with illustrative images, the imaging features of IBD in adults, with emphasis on upto-date imaging techniques focusing predominantly on cross sectional imaging and new magnetic resonance imaging techniques.
文摘Aneurysmal change of saphenous vein grafts （SVG） is a rare condition that predominantly develops 10-20 years after coronary artery bypass graft （CABG）. Natural course includes mechanical complications due to mass effect, myocardial infarction and aneurysmal rupture. Aneurysmectomy can be considered when it induces such complications. We demonstrate complete set of diagnosis, treatment and post-operative imaging of a huge SVG aneurysm that was successfully treated with surgical resection.
文摘A clinical approach to new cardiomyopathy entails defining patient phenotype and disease pathophysiology.After echocardiography,invasive assessments to define hemodynamics and coronary anatomy are usually pursued.In selected non-ischemic cases,endomyocardial biopsies are performed in search for an etiology.Fortunately,advances in cardiac imaging allow for a multifaceted cardiac evaluation in a single study,reducing cost,lead time to diagnosis,and procedural adverse events while still providing supreme accuracy.
文摘Accurate diagnosis of tumors needs much detailed information. However, available single imaging modality cannot provide complete or comprehensive data. Nanomedicine is the application of nanotechnology to medicine, and multimodality imaging based on nanoparticles has been receiving extensive attention. This new hybrid imaging technology could provide complementary information from different imaging modalities using only a single injection of contrast agent. In this review, we introduce recent developments in multifunctional nanoparticles and their biomedical applications to multimodal imaging and theragnosis as nanomedicine. Most of the reviewed studies are based on the intrinsic properties of nanoparticles and their application in clinical imaging technology. The imaging techniques include positron emission tomography, single-photon emission computed tomography, computerized tomography, magnetic resonance imaging, optical imaging, and ultrasound imaging.
文摘Infective endocarditis is one of the leading life-threatening infections around the world.With the exponential growth in the field of transcatheter interventions and advances in specialized surgical techniques,the number of prosthetic valves and cardiac implantable devices has significantly increased.This has led to a steep rise in the number of cases of prosthetic valve endocarditis(PVE)comprising up to 30%of all cases.Clinical guidelines rely on the use of the modified Duke criteria;however,the diagnostic sensitivity of the modified Duke criteria is reduced in the context of PVE.This is in part attributed to prosthesis related artifact which greatly affects the ability of echocardiography to detect early infective changes related to PVE in certain cases.There has been increasing recognition of the roles of complementary imaging modalities and updates in international society recommendations.Prompt diagnosis and treatment can prevent the devastating consequences of this condition.Imaging modalities such as cardiac computed tomography and 18-fluorodeoxyglucose positron emission tomography/computed tomography are diagnostic tools that provide a complementary role to echocardiography in aiding diagnosis,pre-operative planning,and treatment decisionmaking process in these challenging cases.Understanding the strengths and limitations of these adjuvant imaging modalities is crucial for the implementation of appropriate imaging modalities in clinical practice.
基金supported in part by funding from BeiGene,Ltd.,USA(Grant No.:KPR081)with additional support from the Alessandra Bono Foundation,Italy.
文摘Pamiparib is a potent and selective oral poly(adenosine diphosphate(ADP)-ribose)-polymerase(PARP)1/2inhibitor(PARPi).Pamiparib has good bioavailability and shows greater cytotoxic potency and similar DNA-trapping capacity compared to olaparib.It is not affected by adenosine triphosphate(ATP)-binding cassette transporters.
基金Supported by the Clinical Research Plan of SHDC(No.SHDC2020CR6029).
文摘The phenotypes of the adenine-to-guanine transition at position 3243 of mitochondrial DNA(m.3243A>G)are highly variable,with different symptoms observed in different patients.These include mitochondrial encephalomyopathy,lactic acidosis,and stroke-like episodes(MELAS);maternally inherited diabetes and deafness syndrome(MIDD);other syndromic conditions;or non-syndromic mitochondrial disorders.Renal involvement associated with this mutation generally manifests as subnephrotic proteinuria,progressive deterioration of kidney function,and increased morbidity.The retinopathies linked to the m.3243A>G mutation have heterogeneous presentations,characterized by variable degrees of retinal pigment epithelium(RPE)atrophy and hyperpigmentation at the posterior pole.As a severe phenotype of the m.3243A>G mutation,MELAS combined with focal and segmental glomerulosclerosis(FSGS)is rare.We herein firstly reported in detail the ophthalmic manifestations of a patient with this condition.Additionally,we reviewed the literature on fundus,ophthalmic electrophysiology,and optical coherence tomography(OCT)findings related to the m.3243A>G mutation.
基金the National Natural Science Foundation of China(62375127,82272664)Hunan Provincial Natural Science Foundation of China(2022JJ30843)+5 种基金the Science and Technology Development Fund Guided by Central Govern-ment(2021Szvup169)the Scientic Research Program of Hunan Provincial Health Commission(B202304077077)the Fundamental Research Funds for the Central Universities(NS2022035)Prospective Layout Special Fund of Nanjing University of Aero-nautics and Astronautics(ILA-22022)Graduate Research and Innovation Program of Nanjing University of Aeronautics and Astronautics(xcxjh20220328)Experimental Technology Research and Development Project of NUAA(No.SYJS202303Z)for the grant。
文摘Osteosarcoma is the most common primary bone tumor with high malignancy.It is particularly necessary to achieve rapid and accurate diagnosis in its intraoperative examination and early diagnosis.Accordingly,the multimodal microscopic imaging diagnosis system constructed by bright field,spontaneous fluorescence and polarized light microscopic imaging was used to study the pathological mechanism of osteosarcoma from the tissue microenvironment level and achieve rapid and accurate diagnosis.First,the multimodal microscopic images of normal and osteosarcoma tissue slices were collected to characterize the overall morphology of the tissue microenvironment of the samples,the arrangement structure of collagen fibers and the content and distribution of endogenous fluorescent substances.Second,based on the correlation and complementarity of the feature information contained in the three single-mode images,combined with convolutional neural network(CNN)and image fusion methods,a multimodal intelligent diagnosis model was constructed to effectively improve the information utilization and diagnosis accuracy.The accuracy and true positivity of the multimodal diagnostic model were significantly improved to 0.8495 and 0.9412,respectively,compared to those of the single-modal models.Besides,the difference of tissue microenvironments before and after cancerization can be used as a basis for cancer diagnosis,and the information extraction and intelligent diagnosis of osteosarcoma tissue can be achieved by using multimodal microscopic imaging technology combined with deep learning,which significantly promoted the application of tissue microenvironment in pathological examination.This diagnostic system relies on its advantages of simple operation,high efficiency and accuracy and high cost-effectiveness,and has enormous clinical application potential and research significance.
文摘BACKGROUND Congenital renal arteriovenous fistula(RAVF)is a clinically rare condition and frequently missed and misdiagnosed.Multimodal imaging techniques can pro-vide more detailed diagnostic information to help physicians more accurately diagnose and treat diseases.Combining imaging methods to diagnose RAVF has rarely been reported.CASE SUMMARY A 69-year-old female patient presented with gross hematuria that had persisted for 10 days.The patient underwent ultrasound examinations of the kidneys and renal blood vessels,enhanced computed tomography,three-dimensional com-puted tomography angiography,and digital subtraction angiography of the renal arteries.These revealed dilatation of the left renal vein and abnormal shunting between the left renal artery and vein.The patient was diagnosed with a left RAVF using combined multimodal imaging techniques.The patient was treated with left renal artery embolization immediately after renal arteriography.Hema-turia resolved following the left renal artery embolization without serious bleeding or other complications.The patient made a full recovery after one year of postoperative follow-up.CONCLUSION Multimodal imaging techniques complement each other when diagnosing RAVF,providing detailed diagnostic information that can aid in accurate diagnosis and treatment.In addition,this case reminds the sonographer to pay more attention to the color doppler flow imaging and blood flow spectrum when examining the kidney,so as to avoid misdiagnosis of renal cystic lesions as renal cysts and missed diagnosis of RAVF.
基金Supported by the Zhejiang Provincial Natural Science Foundation of China,No.LTGY24H160006Jiaxing Medical Key Discipline,No.2023-ZC-015.
文摘BACKGROUND Rectal cancer is one of the common digestive system malignant tumors around the world.Its early diagnosis and staging are crucial for rectal cancer treatment and prognosis.In recent years,tumor markers have gradually received attention in early screening,treatment monitoring and prognostic evaluation of cancer,but their predictive role in rectal cancer staging and differentiation is still unclear.AIM To assess the prognostic value of tumor markers alpha-fetoprotein(AFP)cancer antigen 72-4(CA72-4),carbohydrate antigen 19-9(CA19-9),and carcinoembryonic antigen(CEA),alongside multimodal magnetic resonance imaging(MRI),for staging and differentiating rectal cancer in patients.METHODS This study retrospectively analyzed 167 patients with rectal cancer who were treated at our institution from January 2020 to December 2024.Each patient underwent serological testing and multimodal MRI for diagnosis.Histopathological examination after surgical resection or imaging based on follow-up was used as the gold standard.According to the T stage and differentiation degree,patients were divided into low stage group(T1-T2)and high stage group(T3-T4).In addition,they were divided into low-differentiation groups and high-differentiation groups according to their differentiation degree.We compared the accuracy,sensitivity and specificity of tumor marker levels and MRI in rectal cancer stage and differentiation.RESULTS The study's findings indicate that in the context of rectal cancer T staging,there is substantial concordance between MRI and clinicopathological assessments,with a Kappa coefficient of 0.789(P<0.001).Similarly,for various degrees of tumor differentiation,MRI and clinicopathological evaluations demonstrated substantial agreement,with a Kappa coefficient of 0.651(P<0.001).Notably,the concentrations of tumor markers CA19-9,CA72-4,CEA,and AFP were significantly elevated in the T3-T4 stage compared to the T1-T2 stage.Furthermore,these markers were significantly higher in the low-differentiation group compared to the high-differentiation group(P<0.05).The combined use of tumor markers and MRI for preoperative T staging of rectal cancer yielded a diagnostic sensitivity of 93.7%and a specificity of 94.6%,as evidenced by the receiver operating characteristic analysis,with an area under the curve of 0.947.For tumor differentiation,the diagnostic sensitivity and specificity were 93.6%and 97.1%,respectively,with an area under the curve of 0.978(95%confidence interval:0.946-1.000),surpassing the accuracy of individual detection methods.CONCLUSION The CA19-9,CA72-4,CEA and AFP tumor markers combined with multimodal MRI have high sensitivity and specificity in diagnosing rectal cancer stage and differentiation.Their diagnostic efficacy is significantly better than that of single tests,which can effectively improve the predictive ability of rectal cancer stage and differentiation,provide a more reliable diagnostic reference for clinical practice,and have important clinical significance.
文摘AIM:To describe the multimodal imaging features,treatment,and outcomes of patients diagnosed with adultonset Coats disease.METHODS:This retrospective study included patients first diagnosed with Coats disease at≥18 years of age between September 2017 and September 2021.Some patients received anti-vascular endothelial growth factor(VEGF)therapy(conbercept,0.5 mg)as the initial treatment,which was combined with laser photocoagulation as needed.All the patients underwent best corrected visual acuity(BCVA)and intraocular pressure examinations,fundus color photography,spontaneous fluorescence tests,fundus fluorescein angiography,optical coherence tomography(OCT),OCT angiography,and other examinations.BCVA alterations and multimodal image findings in the affected eyes following treatment were compared and the prognostic factors were analyzed.RESULTS:The study included 15 patients who were aged 24-72(57.33±12.61)y at presentation.Systemic hypertension was the most common associated systemic condition,occurring in 13(86.7%)patients.Baseline BCVA ranged from 2.0 to 5.0(4.0±1.1),which showed improvement following treatment(4.2±1.0).Multimodal imaging revealed retinal telangiectasis in 13 patients(86.7%),patchy hemorrhage in 5 patients(33.3%),and stage 2B disease(Shield’s staging criteria)in 11 patients(73.3%).OCT revealed that the baseline central macular thickness(CMT)ranged from 129 to 964μm(473.0±230.1μm),with 13 patients(86.7%)exhibiting a baseline CMT exceeding 250μm.Furthermore,8 patients(53.3%)presented with an epiretinal membrane at baseline or during follow-up.Hyper-reflective scars were observed on OCT in five patients(33.3%)with poor visual prognosis.Vision deteriorated in one patient who did not receive treatment.Final vision was stable in three patients who received laser treatment,whereas improvement was observed in one of two patients who received anti-VEGF therapy alone.In addition,8 of 9 patients(88.9%)who received laser treatment and conbercept exhibited stable or improved BCVA.CONCLUSION:Multimodal imaging can help diagnose adult-onset Coats disease.Anti-VEGF treatment combined with laser therapy can be an option for improving or maintaining BCVA and resolving macular edema.The final visual outcome depends on macular involvement and the disease stage.
基金Supported by the Technology Innovation Leading Program of Shaanxi,No.2023KXJ-095the Shaanxi Provincial People's Hospital Science and Technology Talent Support Program for Elite Talents,No.2021JY-38 and No.2021JY-50the Shaanxi Provincial People's Hospital Science and Technology Development Incubation Foundation,No.2023YJY-39.
文摘BACKGROUND Giant cell tumor of bone is a locally aggressive and rarely metastasizing tumor,and also a potential malignant tumor that may develop into a primary malignant giant cell tumor.AIM To evaluate the role of multimodal imaging in the diagnosis of giant cell tumors of bone.METHODS The data of 32 patients with giant cell tumor of bone confirmed by core-needle biopsy or surgical pathology at our hospital between March 2018 and March 2023 were retrospectively selected.All the patients with giant cell tumors of the bone were examined by X-ray,computed tomography(CT)and magnetic resonance imaging(MRI),and 7 of them were examined by positron emission tomography(PET)-CT.RESULTS X-ray imaging can provide overall information on giant cell tumor lesions.CT and MRI can reveal the characteristics of the internal structure of the tumor as well as the adjacent relationships of the tumor,and these methods have unique advantages for diagnosing tumors and determining the scope of surgery.PET-CT can detect small lesions and is highly valuable for identifying benign and malignant tumors to aid in the early diagnosis of metastasis.CONCLUSION Multimodal imaging plays an important role in the diagnosis of giant cell tumor of bone and can provide a reference for the treatment of giant cell tumors.
文摘BACKGROUND The rare co-occurrence of oligodendroglioma and arteriovenous malformation(AVM)in the same intracranial location.CASE SUMMARY In a 61-year-old man presenting with progressive headaches,is described in this case study.Preoperative multimodal imaging techniques(computed tomography,magnetic resonance imaging,magnetic resonance spectroscopy,digital subtraction angiography,and computed tomography angiography)were employed to detect hemorrhage,cystic and solid lesions,and arteriovenous shunting in the right temporal lobe.The patient underwent right temporal craniotomy for lesion removal,and postoperative pathological analysis confirmed the presence of oligodendroglioma(World Health Organization grade II,not otherwise specified)and AVM.CONCLUSION The preoperative utilization of multimodal imaging examination can help clinicians reduce the likelihood of misdiagnosis or oversight of these conditions,and provides important information for subsequent treatment.This case supports the feasibility of craniotomy for the removal of glioma with AVM.
文摘Autoimmune pancreatitis(AIP)is a special type of chronic pancreatitis with cli-nical symptoms of obstructive jaundice and abdominal discomfort;this condition is caused by autoimmunity and marked by pancreatic fibrosis and dysfunction.Previous studies have revealed a close relationship between early pancreatic atrophy and the incidence rate of diabetes in type 1 AIP patients receiving steroid treatment.Shimada et al performed a long-term follow-up study and reported that the pancreatic volume(PV)of these patients initially exponentially decreased but then slowly decreased,which was considered to be an important factor related to diabetes;moreover,serum IgG4 levels were positively correlated with PV during follow-up.In this letter,regarding the original study presented by Shimada et al,we present our insights and discuss how multimodal medical imaging and arti-ficial intelligence can be used to better assess the relationship between pancreatic morphological changes and diabetes in patients with AIP.
文摘Right-sided infective endocarditis is an increasingly recognized disease entity,with tricuspid valve being most frequently involved.Risk factors for tricuspid valve endocarditis(TVIE)include intravenous drug use,cardiac implantable electronic devices and indwelling catheters.Staphylococcus aureus is the predominant causative organism in TVIE.The diagnosis of infective endocarditis(IE)is based on clinical manifestations,blood cultures,and the presence of valvular vegetations detected by echocardiography.Complementary imaging is helpful when there is ongoing clinical suspicion for IE following initially negative echocardiography.Multislice computed tomography allows for assessment of extra-cardiac complications in TVIE,including pulmonary septic emboli.18F-fluorodeoxyglucose positron emission tomography/computed tomography and radiolabelled white blood cell,single-photon emission computed tomography provide important clinical information concerning the presence of IE in right-sided prosthetic valves or cardiac implantable electronic devices.The aim of this review is to provide an update on TVIE,discussing the role of multimodality imaging in TVIE and the management of these patients.
基金National Natural Science Foundation of China(No.12574332)the Space Optoelectronic Measurement and Perception Lab.,Beijing Institute of Control Engineering(No.LabSOMP-2023-10)Major Science and Technology Innovation Program of Xianyang City(No.L2024-ZDKJ-ZDCGZH-0021)。
文摘Fourier Ptychographic Microscopy(FPM)is a high-throughput computational optical imaging technology reported in 2013.It effectively breaks through the trade-off between high-resolution imaging and wide-field imaging.In recent years,it has been found that FPM is not only a tool to break through the trade-off between field of view and spatial resolution,but also a paradigm to break through those trade-off problems,thus attracting extensive attention.Compared with previous reviews,this review does not introduce its concept,basic principles,optical system and series of applications once again,but focuses on elaborating the three major difficulties faced by FPM technology in the process from“looking good”in the laboratory to“working well”in practical applications:mismatch between numerical model and physical reality,long reconstruction time and high computing power demand,and lack of multi-modal expansion.It introduces how to achieve key technological innovations in FPM through the dual drive of Artificial Intelligence(AI)and physics,including intelligent reconstruction algorithms introducing machine learning concepts,optical-algorithm co-design,fusion of frequency domain extrapolation methods and generative adversarial networks,multi-modal imaging schemes and data fusion enhancement,etc.,gradually solving the difficulties of FPM technology.Conversely,this review deeply considers the unique value of FPM technology in potentially feeding back to the development of“AI+optics”,such as providing AI benchmark tests under physical constraints,inspirations for the balance of computing power and bandwidth in miniaturized intelligent microscopes,and photoelectric hybrid architectures.Finally,it introduces the industrialization path and frontier directions of FPM technology,pointing out that with the promotion of the dual drive of AI and physics,it will generate a large number of industrial application case,and looks forward to the possibilities of future application scenarios and expansions,for instance,body fluid biopsy and point-of-care testing at the grassroots level represent the expansion of the growth market.
文摘Tears of peroneus brevis tendon represent a cause of underdiagnosed lateral ankle pain and instability.The typical clinical presentation is retro-malleolar pain,in some cases associated with palpable swelling around the fibular malleolus,pain during activities and difficulty in walking.We present a case of peroneus brevis split lesion with superior peroneal retinaculum avulsion in a young athlete who referred to the emergency ward of our hospital for left ankle pain after an inversion injury.An early diagnosis allowed treating the injury and promptly resuming sport activity,after rehabilitation training.Surgical reconstruction key-points and postsurgical follow-up were also discussed.A late diagnosis would have caused a symptomatology worsening and an increased recovery time.
基金supported by the National Natural Science Foundation of China(No.82172524 and No.81974355)National Innovation Platform Development Program(No.2020021105012440),China+3 种基金Major Program of Hubei Province(No.2021BEA161),ChinaMajor Key Project of Hubei Province(No.JD2023BAA005),ChinaWuhan Union Hospital Free Innovation Preliminary Research Fund(No.2024XHYN047),ChinaJoint Funds for the Innovation of Science and Technology(No.2024Y9062),Fujian Province,China.
文摘Objective To develop a multimodal imaging atlas of a rat brain-computer interface(BCI)that incorporates brain,arterial,bone tissue and a BCI device using mixed reality(MR)for three-dimensional(3D)visualization.Methods An invasive BCI was implanted in the left visual cortex of 4-week-old Sprague–Dawley rats.Multimodal imaging techniques,including micro-CT and 9.0 T MRI,were used to acquire images of the rat cranial bone structure,vascular distribution,brain tissue functional zones,and BCI device before and after implantation.Using 3D-slicer software,the images were fused through spatial transformations,followed by image segmentation and 3D model reconstruction.The HoloLens platform was employed for MR visualization.Results This study constructed a multimodal imaging atlas for rats that included the skull,brain tissue,arterial tissue,and BCI device coupled with MR technology to create an interactive 3D anatomical model.Conclusions This multimodal 3D atlas provides an objective and stable reference for exploring complex relationships between brain tissue structure and function,enhancing the understanding of the operational principles of BCIs.This is the first multimodal 3D imaging atlas related to a BCI created using Sprague–Dawley rats.
基金supported by the National Natural Science Foundation of China(32171797)Chunhui Project Foundation of the Education Department of China(HZKY20220026).
文摘With rapid urbanization,fires pose significant challenges in urban governance.Traditional fire detection methods often struggle to detect smoke in complex urban scenes due to environmental interferences and variations in viewing angles.This study proposes a novel multimodal smoke detection method that fuses infrared and visible imagery using a transformer-based deep learning model.By capturing both thermal and visual cues,our approach significantly enhances the accuracy and robustness of smoke detection in business parks scenes.We first established a dual-view dataset comprising infrared and visible light videos,implemented an innovative image feature fusion strategy,and designed a deep learning model based on the transformer architecture and attention mechanism for smoke classification.Experimental results demonstrate that our method outperforms existing methods,under the condition of multi-view input,it achieves an accuracy rate of 90.88%,precision rate of 98.38%,recall rate of 92.41%and false positive and false negative rates both below 5%,underlining the effectiveness of the proposed multimodal and multi-view fusion approach.The attention mechanism plays a crucial role in improving detection performance,particularly in identifying subtle smoke features.
基金found by the Key Research and Development Program of the Ministry of Science and Technology(2022YFF1202901)the National Natural Science Foundation of China(82171404)+3 种基金the Natural Science Foundation of Guangdong Province of China(2023A1515011529)the Science and Technology Planning Project of Guangzhou City(2023A03J0181,2024A04J6481)the Fundamental Research Funds for the Central Universities(22yklj04)the Research Start-up Founds of Sun Yat-sen University(Funded Talent[2020]18).
文摘Objective:The study aimed to report the distinctive fundus appearance of bilateral asymmetric choroidal melanocytosis and reviewed the clinical and multimodal imaging characteristics to differentiate choroidal melanocytosis from malignant pigmented retinal lesions.Methods:An observational case report and literature review.Results:A 60-year-old patient underwent comprehensive ophthalmologic examinations.Underfunduscopic examination,bilateral choroidal melanocytosis with asymmetry choroidal pigmentation change was observed.In the right eye,there was diffuse darker coloration extending from posterior pole to the mid-peripheral retina.In the left eye,flat patches of choroidal hyperpigmentation were present,involving superior and inferior hemisphere region,while other regions were depigmented.Spectral-domain optical coherence tomography revealed that the layers of retina and choroid were basically normal,with no elevation of the retinal pigment epithelium.Near infrared reflectance images provided a clearer view of mottled focal hyperpigmentation area,which corresponded to the choroidal hyperpigmentation.Conclusions:This case highlights the effectiveness of multimodal imaging in distinguishing choroidal melanocytosis from malignant entities.It emphasizes the crucial role of multimodal imaging in guiding clinical management to prevent vision-threatening complications and monitor potential malignant transformation.
