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Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury 被引量:1
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作者 Xizi Song Ruixin Li +6 位作者 Xiaolei Chu Qi Li Ruihua Li Qingwen Li Kai-Yu Tong Xiaosong Gu Dong Ming 《Neural Regeneration Research》 SCIE CAS 2025年第10期2807-2822,共16页
Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and disabilities.Research on the pathogenesis of peripheral nerve injury has focused on pathological changes... Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and disabilities.Research on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target organs.This has led to restrictions on current therapeutic approaches.In this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target organs.After peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal cord.The nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury site.Corresponding damage to target organs can occur,including skeletal muscle atrophy and sensory receptor disruption.We then provide a brief review of the research advances in therapeutic approaches to peripheral nerve injury.The main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical exercise.However,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ pathway.Therefore,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery. 展开更多
关键词 central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach
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A novel carrier interleaved PWM method for four-level nested neutralpoint-clamped inverters 被引量:1
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作者 Wei Zhou Jupeng Pang +3 位作者 Mingzhe Wu Chao Wang Kui Wang Yongdong Li 《iEnergy》 2025年第1期65-76,共12页
The four-level nested neutral-point-clamped(4L-NNPC)inverter is a competitive topology among the various medium-voltage multilevel converters,and its main issue is flying-capacitor voltage unbalance.In this article,a ... The four-level nested neutral-point-clamped(4L-NNPC)inverter is a competitive topology among the various medium-voltage multilevel converters,and its main issue is flying-capacitor voltage unbalance.In this article,a novel carrier-interleaved pulse width modulation(CIPWM)method that satisfies the volt-sec balance principle is proposed with an advanced carrier distribution rule.By adopting the proposed CIPWM method,the redundant switching states of 4L-NNPC inverters can be evenly distributed into the output PWM waveform in each carrier period,and natural flying-capacitor voltage balance can be achieved.Furthermore,an active balancing strategy is also proposed to eliminate the voltage unbalance caused by nonideal factors,which is realized by simply adjusting the duty cycle and with no need to adjust the redundant switching states for 4L-NNPC inverters.The simulation and experimental results verify the effectiveness of the proposed CIPWM method and the flying-capacitor voltage balancing strategy. 展开更多
关键词 Multilevel converters capacitor voltage balance pulse width modulation
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Multilevel structured CuCoP with synergistic catalytic active site designed for hydrogen evolution coupled gluconic acid synthesis
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作者 Xiang-Dong Ma Rui Liu +2 位作者 Shan Yue Hai-Jiao Xie Xiao-Hong Xia 《Rare Metals》 2025年第5期3141-3155,共15页
Hydrogen production coupled with small molecule oxidation derived by renewable energy power has been widely studied as an effective method to reduce energy consumption and prepare added value production.Here,the coppe... Hydrogen production coupled with small molecule oxidation derived by renewable energy power has been widely studied as an effective method to reduce energy consumption and prepare added value production.Here,the copper-cobalt phosphide with a multilevel structure has been designed based on the hard and soft acids and bases theory.The nanocone composed of lamellas presented a sharp tip,which a positive effect on the mass transfer enhanced by a local electric field,and the nanolamellas contain CoP/Cu_(3)P interface provide the highly selective active site for the gluconic acid(GNA)synthesis and hydrogen evolution.The catalyst can drive hydrogen evolution at 5 A·cm^(-2)up to 437 h without active decay,and the electrocatalytic glucose oxidation at anode presents high efficiency due to Cu(I)introduction and the synergetic effect between interfaces.Density functional theory(DFT)calculation shows that water splitting more readily occurs at the CoP,which provides adsorbed H and-OH for hydrogen evolution and glucose oxidation,respectively,and glucose adsorption more readily occurs at the Cu_(3)P,which presents lower conversion energy for high value-added GNA.Efficient hydrogen evolution and glucose conversion indicate its high intrinsic activity and synergetic effect.This work provides a special interface construction strategy for the catalytic conversion of hydrogen and small molecules. 展开更多
关键词 ELECTROCATALYSIS Glucose oxidation Hydrogen evolution Multilevel structure Synergetic effect
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Ultralong room temperature phosphorescence and broad color-tunability persistent luminescence via new strategy
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作者 Hong Yao Feixiang Yang +5 位作者 Jianpeng Hu Wenyu Cao Shuning Qin Tai-Bao Wei Bingbing Shi Qi Lin 《Chinese Chemical Letters》 2025年第6期434-438,共5页
Pure organic materials with ultralong room-temperature phosphorescence(RTP)and persistent luminescence in broad color gamut exhibit tremendous potential and broad application prospects due to their unique optical prop... Pure organic materials with ultralong room-temperature phosphorescence(RTP)and persistent luminescence in broad color gamut exhibit tremendous potential and broad application prospects due to their unique optical properties.This article proposes a simple strategy,polyatomic synergistic effect,to endow persistent luminescent materials with ultralong lifetime and broad color-tunability through polyatomic synergistic effect and non-traditional phosphorescence resonance energy transfer(PRET).By leveraging the polyatomic synergistic effect to enhance the intersystem crossing(ISC)in bibenzimidazole(BBI)derivatives and suppress the non-radiative transition process,ultralong persistent room-temperature phosphorescence has been successfully achieved after incorporating BBI-Cl-M into poly(methyl methacrylate)(PMMA)to form a rigid matrix(BBI-Cl-M@PMMA).Specifically,the ester functionalized bibenzimidazole with modified chlorine on molecular skeleton(BBI-Cl-M)demonstrates a remarkable phosphorescent lifetime(τp)of up to 256.4 ms.In addition,the behaviors and mechanism of RTP via polyatomic synergistic effect have been further understood by theoretical calculation and single crystal analysis.Subsequently,utilizing BBI-Cl-M as the energy donor and Rhodamine B(RB)as the energy acceptor,persistent and multicolor organic afterglow covering from green to red has been realized successfully by simply regulating the doping composition and concentration of PRET systems.These RTP materials have also been applied in underwater afterglow emission and multilevel anti-counterfeiting technology successfully. 展开更多
关键词 Polyatomic synergistic effect RTP PRET Multilevel anti-counterfeiting Underwater phosphorescence
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Nonlinear multilevel seemingly unrelated height-diameter and crown length mixed-effects models for the southern Transylvanian forests,Romania
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作者 Albert Ciceu Stefan Leca +1 位作者 Ovidiu Badea Lauri Mehtatalo 《Forest Ecosystems》 2025年第4期630-641,共12页
In this study,we used an extensive sampling network established in central Romania to develop tree height and crown length models.Our analysis included more than 18,000 tree measurements from five different species.In... In this study,we used an extensive sampling network established in central Romania to develop tree height and crown length models.Our analysis included more than 18,000 tree measurements from five different species.Instead of building univariate models for each response variable,we employed a multivariate approach using seemingly unrelated mixed-effects models.These models incorporated variables related to species mixture,tree and stand size,competition,and stand structure.With the inclusion of additional variables in the multivariate seemingly unrelated mixed-effects models,the accuracy of the height prediction models improved by over 10% for all species,whereas the improvement in the crown length models was considerably smaller.Our findings indicate that trees in mixed stands tend to have shorter heights but longer crowns than those in pure stands.We also observed that trees in homogeneous stand structures have shorter crown lengths than those in heterogeneous stands.By employing a multivariate mixed-effects modelling framework,we were able to perform cross-model random-effect predictions,leading to a significant increase in accuracy when both responses were used to calibrate the model.In contrast,the improvement in accuracy was marginal when only height was used for calibration.We demonstrate how multivariate mixed-effects models can be effectively used to develop multi-response allometric models that can be easily calibrated with a limited number of observations while simultaneously achieving better-aligned projections. 展开更多
关键词 Multivariate model Cross-model calibration Crown allometry Multilevel model Mixed stands Heterogeneous stand structure
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Design of Serially Concatenated Two-Level Polar Coded Modulation System with Low-Complexity
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作者 Zhou Lin Liao Guojun +3 位作者 Xu Lei An Ran Xie Xianzhong Wang Xi 《China Communications》 2025年第1期102-110,共9页
Multilevel coding(MLC)is a commonly used polar coded modulation scheme,but challenging to implement in engineering due to its high complexity and long decoding delay for high-order modulations.To address these limitat... Multilevel coding(MLC)is a commonly used polar coded modulation scheme,but challenging to implement in engineering due to its high complexity and long decoding delay for high-order modulations.To address these limitations,a novel two-level serially concatenated MLC scheme,in which the bitlevels with similar reliability are bundled and transmitted together,is proposed.The proposed scheme hierarchically protects the two bit-level sets:the bitlevel sets at the higher level are sufficiently reliable and do not require excessive resources for protection,whereas only the bit-level sets at the lower level are encoded by polar codes.The proposed scheme has the advantages of low power consumption,low delay and high reliability.Moreover,an optimized constellation signal labeling rule that can enhance the performance is proposed.Finally,the superiority of the proposed scheme is validated through the theoretical analysis and simulation results.Compared with the bit interleaving coding modulation(BICM)scheme,under 256-quadrature amplitude modulation(QAM),the proposed scheme attains a performance gain of 1.0 dB while reducing the decoding complexity by 54.55%. 展开更多
关键词 bit-interleaved coded modulation high-order modulation multilevel coding polar codes
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Online evaluation method for MMC submodule capacitor aging based on CapAgingNet
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作者 Xinlan Deng Youhan Deng +3 位作者 Liang Qin Weiwei Yao Min He Kaipei Liu 《Global Energy Interconnection》 2025年第3期420-432,共13页
Submodule capacitor aging poses significant challenges to the safe operation of modular multilevel converter(MMC)systems.Traditional detection methods rely predominantly on offline tests,lacking real-time evaluation c... Submodule capacitor aging poses significant challenges to the safe operation of modular multilevel converter(MMC)systems.Traditional detection methods rely predominantly on offline tests,lacking real-time evaluation capabilities.Moreover,existing online approaches require additional sampling channels,thereby increasing system complexity and costs.To address these issues,this paper proposes an online evaluation method for submodule capacitor aging based on CapAgingNet.Initially,an MMC system simulation platform is developed to examine the effects of submodule capacitor aging on system operational characteristics and to create a dataset of submodule capacitor switching states.Subsequently,the CapAgingNet model is introduced,incorporating key technical modules to enhance performance:the Deep Stem module,which extracts larger receptive fields through multiple convolution layers and mitigates the impact of data sparsity in capacitor aging on feature extraction;the efficient channel attention(ECA)module,utilizing onedimensional convolution for dynamic weighting to adjust the importance of each channel,thereby enhancing the ability of the model to process high-dimensional features in capacitor aging data;and the multiscale feature fusion(MSF)module,which integrates capacitor aging information across different scales by combining fine-grained and coarse-grained features,thus improving the capacity of the model to capture high-frequency variation characteristics.The experimental results reveal that the CapAgingNet model achieves a TOP-1 accuracy of 95.32%and a macro-averaged F1 score of 95.49%on the test set,thereby providing effective technical support for online monitoring of submodule capacitor aging. 展开更多
关键词 Modular multilevel converter Capacitor aging Condition monitoring Fault diagnosis
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Chemical Fermentation PoreCreation on Multilevel Bio‑Carbon Structure with In Situ Ni-Fe Alloy Loading for Superior Oxygen Evolution Reaction Electrocatalysis
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作者 Qiaoling Kang Mengfei Su +3 位作者 Yana Luo Ting Wang Feng Gao Qingyi Lu 《Nano-Micro Letters》 2025年第11期191-206,共16页
In the quest for high-efficiency and cost-effective catalysts for the oxygen evolution reaction(OER),a novel biomass-driven strategy is developed to fabricate a unique one-dimensional rod-arrays@two-dimensional interl... In the quest for high-efficiency and cost-effective catalysts for the oxygen evolution reaction(OER),a novel biomass-driven strategy is developed to fabricate a unique one-dimensional rod-arrays@two-dimensional interlaced-sheets(C_(1D@2D))network.A groundbreaking chemical fermentation(CF)pore-generation mechanism,proposed for the first time for creating nanopores within carbon structures,is based on the optimal balance between gasification and solidification.This mechanism not only results in a distinctive C_(1D@2D) multilevel network with nanoscale,intersecting and freely flowing channels but also introduces a novel concept for in situ,extensive and hierarchical pore formation.The unique architecture,combined with the homogeneous dispersion of Ni-Fe nanoparticles,facilitates easy electrolyte penetration and provides abundant active sites for the anchoring and dispersion of reactive molecules or ions.Consequently,the Ni-Fe@C_(1D@2D) porous network demonstrates an exceptional OER electrocatalytic performance,achieving a record-low overpotential of 165 mV at 10 mA cm^(−2)and maintaining long-term stability for over 90 h.Theoretical calculations reveal that the porous structure markedly strengthens the interaction between alloy nanoparticles and the carbon matrix,thereby significantly boosting their electrocatalytic activity and stability.These findings unequivocally validate the CF pore-generation mechanism as a powerful and innovative strategy for designing highly efficient functional nanostructures. 展开更多
关键词 Ni-Fe alloys Multilevel porous network Chemical fermentation pore creation Ultra-low overpotential Oxygen evolution reaction electrocatalysts
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Multistage seismic damage constitutive model and parameter calibration of reinforced concrete columns 被引量:6
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作者 Xing Chenxi Shu Yiwei +1 位作者 Zhu Xiaojie Zhong Jian 《Journal of Southeast University(English Edition)》 EI CAS 2024年第4期386-395,共10页
The road traffic network contains a large number of bridges,and calculating bridge damage using refined models demands significant time and resources.Therefore,developing a rapid evaluation method for the seismic capa... The road traffic network contains a large number of bridges,and calculating bridge damage using refined models demands significant time and resources.Therefore,developing a rapid evaluation method for the seismic capacity of regular bridges has become a crucial scientific challenge.This study presents an approach in which the ductile column is represented by a single degree-of-freedom model with elastic-plastic constitutive characteristics.Utilizing an uncoupled multivariate power function model and a plastic hinge model,a multidimensional power function model for section hierarchical curvature is constructed.Subsequently,the seismic multistage damage constitutive model(SMSD-CM)of member hierarchy is deduced and calibrated through theoretical methods.This model efficiently derives the trilinear constitutive model of components by inputting several crucial parameters.The SMSD-CM accurately simulates the hysteretic curve and displacement time-history under actual seismic conditions and aligns well with pushover analysis results from tests.The efficiency,ease of operation,and accuracy make the model suitable for rapid evaluation of the seismic capacity of regular bridges within the road traffic network. 展开更多
关键词 moment-curvature analysis fragility analysis curvature ductility seismic multilevel damage trilinear model
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Multilevel carbon architecture of subnanoscopic silicon for fast‐charging high‐energy‐density lithium‐ion batteries 被引量:2
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作者 Meisheng Han Yongbiao Mu +2 位作者 Lei Wei Lin Zeng Tianshou Zhao 《Carbon Energy》 SCIE EI CAS CSCD 2024年第4期256-268,共13页
Silicon(Si)is widely used as a lithium‐ion‐battery anode owing to its high capacity and abundant crustal reserves.However,large volume change upon cycling and poor conductivity of Si cause rapid capacity decay and p... Silicon(Si)is widely used as a lithium‐ion‐battery anode owing to its high capacity and abundant crustal reserves.However,large volume change upon cycling and poor conductivity of Si cause rapid capacity decay and poor fast‐charging capability limiting its commercial applications.Here,we propose a multilevel carbon architecture with vertical graphene sheets(VGSs)grown on surfaces of subnanoscopically and homogeneously dispersed Si–C composite nanospheres,which are subsequently embedded into a carbon matrix(C/VGSs@Si–C).Subnanoscopic C in the Si–C nanospheres,VGSs,and carbon matrix form a three‐dimensional conductive and robust network,which significantly improves the conductivity and suppresses the volume expansion of Si,thereby boosting charge transport and improving electrode stability.The VGSs with vast exposed edges considerably increase the contact area with the carbon matrix and supply directional transport channels through the entire material,which boosts charge transport.The carbon matrix encapsulates VGSs@Si–C to decrease the specific surface area and increase tap density,thus yielding high first Coulombic efficiency and electrode compaction density.Consequently,C/VGSs@Si–C delivers excellent Li‐ion storage performances under industrial electrode conditions.In particular,the full cells show high energy densities of 603.5 Wh kg^(−1)and 1685.5 Wh L^(−1)at 0.1 C and maintain 80.7%of the energy density at 3 C. 展开更多
关键词 fast charging high energy densities lithium‐ion batteries multilevel carbon architecture subnanoscopic silicon anode
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Aerodynamic/stealth design of S-duct inlet based on discrete adjoint method 被引量:2
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作者 Jun DENG Ke ZHAO +4 位作者 Lin ZHOU Wei ZHANG Bowen SHU Jiangtao HUANG Zhenghong GAO 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第4期725-746,共22页
It is a major challenge for the airframe-inlet design of modern combat aircrafts,as the flow and electromagnetic wave propagation in the inlet of stealth aircraft are very complex.In this study,an aerodynamic/stealth ... It is a major challenge for the airframe-inlet design of modern combat aircrafts,as the flow and electromagnetic wave propagation in the inlet of stealth aircraft are very complex.In this study,an aerodynamic/stealth optimization design method for an S-duct inlet is proposed.The upwind scheme is introduced to the aerodynamic adjoint equation to resolve the shock wave and flow separation.The multilevel fast multipole algorithm(MLFMA)is utilized for the stealth adjoint equation.A dorsal S-duct inlet of flying wing layout is optimized to improve the aerodynamic and stealth characteristics.Both the aerodynamic and stealth characteristics of the inlet are effectively improved.Finally,the optimization results are analyzed,and it shows that the main contradiction between aerodynamic characteristics and stealth characteristics is the centerline and crosssectional area.The S-duct is smoothed,and the cross-sectional area is increased to improve the aerodynamic characteristics,while it is completely opposite for the stealth design.The radar cross section(RCS)is reduced by phase cancelation for low frequency conditions.The method is suitable for the aerodynamic/stealth design of the aircraft airframe-inlet system. 展开更多
关键词 S-duct inlet aerodynamic/stealth optimization design discrete adjoint upwind scheme multilevel fast multipole algorithm(MLFMA)
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Two-dimensional bifunctional electrocatalyst(Mo-NiFe-LDH)with multilevel structure for highly efficient overall water splitting 被引量:1
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作者 Bao-Jie Zhang Bin Chang +6 位作者 Shi-Peng Qiu Gang Zhao Xiao Wang Xi-Jin Xu Lan Mu Wen-Bo Liao Xiao-Jing Dong 《Rare Metals》 SCIE EI CAS CSCD 2024年第6期2613-2622,共10页
To effectively address energy challenges,it is crucial to explore efficient and stable bifunctional nonprecious metal catalysts.In this study,a Mo-doped nickeliron layered double hydroxide with flower-cluster architec... To effectively address energy challenges,it is crucial to explore efficient and stable bifunctional nonprecious metal catalysts.In this study,a Mo-doped nickeliron layered double hydroxide with flower-cluster architecture was successfully prepared by a one-step hydrothermal method,which demonstrated a good water splitting performance.After an appropriate amount of Mo doping,some lattice distortions in the material provided reactive sites for the adsorption and conversion of intermediates,thus optimising the charge distribution of the material.Moreover,the multidimensional void structures formed after doping had a larger specific surface area and accelerated the penetration of the electrolyte,which significantly improved the activity of the catalyst in alkaline media.At 10 mA·cm^(-2),the hydrogen and oxygen evolution overpotentials of Mo-doped nickel-iron double hydroxides(Mo-NiFe LDH/NF-0.2)were 167 and 220 mV,respectively,with an excellent durability up to 24 h.When the Mo-NiFe LDH/NF-0,2 catalyst was used as the cathode and anode of an electrolytic cell,the catalyst achieved a current density of 10 mA·cm^(-2)at an applied voltage of 1.643 V.This study provides a novel approach for designing excellent bifunctional electrocatalysts containing nonprecious metals. 展开更多
关键词 Bifunctional electrocatalysts 2D multilevel structure Overall water splitting Mo-doped Ni-Fe LDH
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Multilevel Micro Structures of the Clam Make the Sealing Even Tighter
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作者 Daobing Chen Xiaolong Zhang +6 位作者 Junqiu Zhang Zhiwu Han Ruteng Wang Zhen Lin Yifeng Lei Longjian Xue Sheng Liu 《Journal of Bionic Engineering》 SCIE EI CSCD 2024年第3期1442-1452,共11页
Excellent fluid sealing performance is crucial to ensuring the safety of important equipment,especially in aerospace field,such as space capsule and fuel chamber.The frequently opening and closing of the sealing devic... Excellent fluid sealing performance is crucial to ensuring the safety of important equipment,especially in aerospace field,such as space capsule and fuel chamber.The frequently opening and closing of the sealing devices is particularly important.Driven by this background,clams(Mactra chinensis)which can open and close their double shells with superior sealing performance,are studied in this work.Here,we show that the clam’s sealing ability is the result of its unique multilevel intermeshing microstructures,including hinge teeth and micro-blocks.These microstructures,which resemble gear teeth,engage with each other when the shell closes,forming a tight structure that prevents the infiltration of water from the outside.Furthermore,the presence of micron blocks prevents the penetration of finer liquids.The simulation results of the bionic end seal components show that the multilevel microstructure has a superior sealing effect.This research is expected to be applied to undersea vehicles that require frequent door opening and closing. 展开更多
关键词 Multilevel micro structures Opening and closing components CLAM SEALING BIONIC
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Harmonic Impedance Modeling and Oscillation Analysis of Modular Multilevel Converter
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作者 Wang Yuhong Chen Wensheng +2 位作者 Gao Shilin Liao Jianquan Cheng Yangfan 《系统仿真学报》 CAS CSCD 北大核心 2024年第12期2755-2770,共16页
To facilitate rapid analysis of the oscillation stability mechanism in modular multilevel converter-based high voltage direct current(MMC-HVDC)systems and streamline the simulation process for determining MMC impedanc... To facilitate rapid analysis of the oscillation stability mechanism in modular multilevel converter-based high voltage direct current(MMC-HVDC)systems and streamline the simulation process for determining MMC impedance characteristics,a simplified mathematical simulation model for MMC closed-loop impedance is developed using the harmonic state space method.This model considers various control strategies and includes both AC-side and DC-side impedance models.By applying a Nyquist criterion-based impedance analysis method,the stability mechanisms on the AC and DC sides of the MMC are examined.In addition,a data-driven oscillation stability analysis method is also proposed,leveraging a global sensitivity algorithm based on fast model results to identify key parameters influencing MMC oscillation stability.Based on sensitivity analysis results,a parameter adjustment strategy for oscillation suppression is proposed.The simulation results from the MATLAB/Simulinkbased MMC model validate the effectiveness of the proposed method. 展开更多
关键词 modular multilevel converter impedance modeling harmonic state space global sensitivity impedance analysis
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The advantages of multi-level omics research on stem cell-based therapies for ischemic stroke
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作者 Yiqing Wang Chuheng Chang +2 位作者 Renzhi Wang Xiaoguang Li Xinjie Bao 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第9期1998-2003,共6页
Stem cell transplantation is a potential therapeutic strategy for ischemic stroke. However, despite many years of preclinical research, the application of stem cells is still limited to the clinical trial stage. Altho... Stem cell transplantation is a potential therapeutic strategy for ischemic stroke. However, despite many years of preclinical research, the application of stem cells is still limited to the clinical trial stage. Although stem cell therapy can be highly beneficial in promoting functional recovery, the precise mechanisms of action that are responsible for this effect have yet to be fully elucidated. Omics analysis provides us with a new perspective to investigate the physiological mechanisms and multiple functions of stem cells in ischemic stroke. Transcriptomic, proteomic, and metabolomic analyses have become important tools for discovering biomarkers and analyzing molecular changes under pathological conditions. Omics analysis could help us to identify new pathways mediated by stem cells for the treatment of ischemic stroke via stem cell therapy, thereby facilitating the translation of stem cell therapies into clinical use. In this review, we summarize the pathophysiology of ischemic stroke and discuss recent progress in the development of stem cell therapies for the treatment of ischemic stroke by applying multi-level omics. We also discuss changes in RNAs, proteins, and metabolites in the cerebral tissues and body fluids under stroke conditions and following stem cell treatment, and summarize the regulatory factors that play a key role in stem cell therapy. The exploration of stem cell therapy at the molecular level will facilitate the clinical application of stem cells and provide new treatment possibilities for the complete recovery of neurological function in patients with ischemic stroke. 展开更多
关键词 ischemic stroke mesenchymal stem cells metabolomics multilevel omics neural stem/progenitor cells NEUROINFLAMMATION PATHOPHYSIOLOGY proteomics stem cell therapy TRANSCRIPTOMES
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On the Use of Monotonicity-Preserving Interpolatory Techniques in Multilevel Schemes for Balance Laws
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作者 Antonio Baeza Rosa Donat Anna Martinez-Gavara 《Communications on Applied Mathematics and Computation》 EI 2024年第2期1319-1341,共23页
Cost-effective multilevel techniques for homogeneous hyperbolic conservation laws are very successful in reducing the computational cost associated to high resolution shock capturing numerical schemes.Because they do ... Cost-effective multilevel techniques for homogeneous hyperbolic conservation laws are very successful in reducing the computational cost associated to high resolution shock capturing numerical schemes.Because they do not involve any special data structure,and do not induce savings in memory requirements,they are easily implemented on existing codes and are recommended for 1D and 2D simulations when intensive testing is required.The multilevel technique can also be applied to balance laws,but in this case,numerical errors may be induced by the technique.We present a series of numerical tests that point out that the use of monotonicity-preserving interpolatory techniques eliminates the numerical errors observed when using the usual 4-point centered Lagrange interpolation,and leads to a more robust multilevel code for balance laws,while maintaining the efficiency rates observed forhyperbolic conservation laws. 展开更多
关键词 Hyperbolic balance laws Well-balanced schemes Multilevel schemes Harten's multiresolution
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Stock trend prediction method coupled with multilevel indicators
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作者 Liu Yu Pan Yuting Liu Xiaoxing 《Journal of Southeast University(English Edition)》 EI CAS 2024年第4期425-431,共7页
To systematically incorporate multiple influencing factors,the coupled-state frequency memory(Co-SFM)network is proposed.This model integrates Copula estimation with neural networks,fusing multilevel data information,... To systematically incorporate multiple influencing factors,the coupled-state frequency memory(Co-SFM)network is proposed.This model integrates Copula estimation with neural networks,fusing multilevel data information,which is then fed into downstream learning modules.Co-SFM employs an upstream fusion module to incorporate multilevel data,thereby constructing a macro-plate-micro data structure.This configuration helps identify and integrate characteristics from different data levels,facilitating a deeper understanding of the internal links within the financial system.In the downstream model,Co-SFM uses a state-frequency memory network to mine hidden frequency information within stock prices,and the multifrequency patterns of sequential data are modeled.Empirical results show that Co-SFM s prediction accuracy for stock price trends is significantly better than that of other models.This is especially evident in multistep medium and long-term trend predictions,where integrating multilevel data results in notably improved accuracy. 展开更多
关键词 stock trend prediction multilevel indicators COPULA state-frequency memory network
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Multilevel Modeling Approach for Hierarchical Data an Empirical Investigation
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作者 Hiba Faisal Muhammad Zakria +1 位作者 Nazakat Ali Nimra Khalid 《Open Journal of Statistics》 2024年第6期689-720,共32页
Multilevel modeling (MLM) has emerged as a powerful statistical framework for analyzing complex data structures with nested relationships. With its hierarchical modeling approach, MLM enables researchers to account fo... Multilevel modeling (MLM) has emerged as a powerful statistical framework for analyzing complex data structures with nested relationships. With its hierarchical modeling approach, MLM enables researchers to account for dependencies and variations within and between different levels of a hierarchy. By explicitly modeling these relationships, MLM provides a robust and accurate analysis of data. It has become increasingly popular in the field of education. MLM enables the investigation of various research issues, the evaluation of individual and group-level indicators, and the calculation of both fixed and random effects. Overall, MLM revolutionizes data analysis by uncovering patterns, understanding contextual effects, and making more precise statistical inferences in complex datasets. For fitting multilevel models in R, use lmer function provided by lme4 package. Through this examination, the use of a multilevel model is expected to increase and revolutionize data analysis and decision-making. The Constrained Intermediate Model (CIM) and Augmented Intermediate model (AIM) deviation are compared using the Likelihood-ratio (LR) test and the ANOVA function. This study analyzes student results from the University of Agriculture Faisalabad, collected via stratified random sampling. A linear mixed-effect model under multilevel modeling estimates the impact on CGPA, considering department, gender, intermediate marks, and entry test scores. These results indicate that Entry test is a significant predictor of CGPA, but the effect of department identifier CMC on CGPA is not statistically significant. 展开更多
关键词 Multilevel Modeling Hierarchical Modeling Intraclass Correlation Coefficient Design Effect Augmented Intermediate Model
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Application of Power Electronics Converters in Renewable Energy
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作者 Tao Cheng 《Journal of Electronic Research and Application》 2024年第4期101-107,共7页
Against the backdrop of global energy shortages and increasingly severe environmental pollution,renewable energy is gradually becoming a significant direction for future energy development.Power electronics converters... Against the backdrop of global energy shortages and increasingly severe environmental pollution,renewable energy is gradually becoming a significant direction for future energy development.Power electronics converters,as the core technology for energy conversion and control,play a crucial role in enhancing the efficiency and stability of renewable energy systems.This paper explores the basic principles and functions of power electronics converters and their specific applications in photovoltaic power generation,wind power generation,and energy storage systems.Additionally,it analyzes the current innovations in high-efficiency energy conversion,multilevel conversion technology,and the application of new materials and devices.By studying these technologies,the aim is to promote the widespread application of power electronics converters in renewable energy systems and provide theoretical and technical support for achieving sustainable energy development. 展开更多
关键词 Power electronics converters Renewable energy Photovoltaic power generation Wind power generation Energy storage systems High-efficiency energy conversion Multilevel conversion New materials New devices
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