Osteoarthritis is among the leading causes of disability worldwide,and no pharmacological therapies currently exist to reverse its progression.This lack of therapies is primarily attributed to the inadequacies of conv...Osteoarthritis is among the leading causes of disability worldwide,and no pharmacological therapies currently exist to reverse its progression.This lack of therapies is primarily attributed to the inadequacies of conventional in vitro models of joint physiology and pathology,which significantly hinder advancements in disease mechanism research and drug development.As an emerging in vitro joint model,joint-on-a-chip(JoC)technology allows low-cost,efficient simulation of physiological and pathological joint activities,making it a focal point of current research.Cartilage,subchondral bone,and synovium are among the key tissues required for constructing in vitro joint models,with cartilage playing a central load-bearing role in joint movement.This article provides a detailed overview of the structure and function of these tissues,with an emphasis on the load-bearing mechanisms of cartilage,and identifies the microenvironmental characteristics that JoC should aim to replicate.Subsequently,we review the current types of JoC and highlight their core challenge:the seamless integration of multi-tissue co-culture with specific mechanical stimulation.To address this issue,we propose potential solutions and present a conceptual design for a JoC prototype.Finally,we discuss the challenges and issues related to the outlook for JoC.Our ultimate goal is to develop a JoC capable of replicating the key microenvironments of joints,serving as a high-performance in vitro joint model to advance the study of disease mechanisms and facilitate drug development.展开更多
近日,郑州大学网络空间安全学院在医学图像处理方向取得进展,相关研究成果以题为“PointFormer:Keypoint-Guided Transformer for Simultaneous Nuclei Segmentation and Classification in Multi-Tissue Histology Images”的论文在线...近日,郑州大学网络空间安全学院在医学图像处理方向取得进展,相关研究成果以题为“PointFormer:Keypoint-Guided Transformer for Simultaneous Nuclei Segmentation and Classification in Multi-Tissue Histology Images”的论文在线发表在国际权威期刊《IEEE Transactions on Image Processing》(中科院一区TOP,CCF-A类期刊,IF=10.8)和以题为“SimCMC:A Simple Compact Multiview Contrastive Framework for Self-supervised Early Alzheimer’s Disease Diagnosis”的论文在线发表在国际权威期刊《IEEE Transactions on Instrumentation and Measurement》(中科院二区TOP,IF=5.6)。展开更多
The interface between soft and hard tissues is constituted by a gradient change of cell types and matrix compositions that are optimally designed for proper load transmission and injury protection.In the musculoskelet...The interface between soft and hard tissues is constituted by a gradient change of cell types and matrix compositions that are optimally designed for proper load transmission and injury protection.In the musculoskeletal system,the soft-hard tissue interfaces at tendon-bone,ligament-bone,and meniscus-bone have been extensively researched as regenerative targets.Similarly,extensive research efforts have been made to guide the regeneration of multi-tissue complexes in periodontium.However,the other soft-hard tissue interfaces in the dental and craniofacial system have been somewhat neglected.This review discusses the clinical significance of developing regenerative strategies for soft-hard tissue interfaces in the dental and craniofacial system.It also discusses the research progress in the field focused on bioengineering approaches using 3D scaffolds equipped with spatially controlled bioactivities.The remaining challenges,future perspectives,and considerations for the clinical translation of bioactive scaffolds are also discussed.展开更多
基金supported by the National Natural Science Foundation of China(12202302,12272253)Natural Science Foundation of Shanxi Province,China(202403021223002)+1 种基金Sanjin Talents Program for Science and Technology Innovation Teams of Shanxi Province(SJYC2024493)the CUHK Peter Hung Pain Research Institute(PHPRI/2024/122)。
文摘Osteoarthritis is among the leading causes of disability worldwide,and no pharmacological therapies currently exist to reverse its progression.This lack of therapies is primarily attributed to the inadequacies of conventional in vitro models of joint physiology and pathology,which significantly hinder advancements in disease mechanism research and drug development.As an emerging in vitro joint model,joint-on-a-chip(JoC)technology allows low-cost,efficient simulation of physiological and pathological joint activities,making it a focal point of current research.Cartilage,subchondral bone,and synovium are among the key tissues required for constructing in vitro joint models,with cartilage playing a central load-bearing role in joint movement.This article provides a detailed overview of the structure and function of these tissues,with an emphasis on the load-bearing mechanisms of cartilage,and identifies the microenvironmental characteristics that JoC should aim to replicate.Subsequently,we review the current types of JoC and highlight their core challenge:the seamless integration of multi-tissue co-culture with specific mechanical stimulation.To address this issue,we propose potential solutions and present a conceptual design for a JoC prototype.Finally,we discuss the challenges and issues related to the outlook for JoC.Our ultimate goal is to develop a JoC capable of replicating the key microenvironments of joints,serving as a high-performance in vitro joint model to advance the study of disease mechanisms and facilitate drug development.
文摘近日,郑州大学网络空间安全学院在医学图像处理方向取得进展,相关研究成果以题为“PointFormer:Keypoint-Guided Transformer for Simultaneous Nuclei Segmentation and Classification in Multi-Tissue Histology Images”的论文在线发表在国际权威期刊《IEEE Transactions on Image Processing》(中科院一区TOP,CCF-A类期刊,IF=10.8)和以题为“SimCMC:A Simple Compact Multiview Contrastive Framework for Self-supervised Early Alzheimer’s Disease Diagnosis”的论文在线发表在国际权威期刊《IEEE Transactions on Instrumentation and Measurement》(中科院二区TOP,IF=5.6)。
基金partially supported by NIH Grants 1R01DE029321 to CHL.
文摘The interface between soft and hard tissues is constituted by a gradient change of cell types and matrix compositions that are optimally designed for proper load transmission and injury protection.In the musculoskeletal system,the soft-hard tissue interfaces at tendon-bone,ligament-bone,and meniscus-bone have been extensively researched as regenerative targets.Similarly,extensive research efforts have been made to guide the regeneration of multi-tissue complexes in periodontium.However,the other soft-hard tissue interfaces in the dental and craniofacial system have been somewhat neglected.This review discusses the clinical significance of developing regenerative strategies for soft-hard tissue interfaces in the dental and craniofacial system.It also discusses the research progress in the field focused on bioengineering approaches using 3D scaffolds equipped with spatially controlled bioactivities.The remaining challenges,future perspectives,and considerations for the clinical translation of bioactive scaffolds are also discussed.
