AIM： To establish models of portal vein occlusion of hepatic VX2 tumor in rabbits and to evaluate the value of multi-slice CT. METHODS： Forty New Zealand rabbits were divided into 4 groups according to digital table...AIM： To establish models of portal vein occlusion of hepatic VX2 tumor in rabbits and to evaluate the value of multi-slice CT. METHODS： Forty New Zealand rabbits were divided into 4 groups according to digital table： Immediate group （group A; transplantation of tumor immediately after the portal vein occlusion）, 3-wk group （group B; transplantation of tumor at 3 wk after the portal vein occlusion）, negative control group （group C） and positive control group （group D）, 10 rabbits in each group. Hepatic VX2 tumor was transplanted with abdominalembedding innoculation immediately after the portal vein occlusion and at 3 wk after the portal vein occlusion. Meanwhile, they were divided into negative control group （Left external branch of portal vein was occluded by sham-operation, and left exite was embedded and inoculated pseudoly） and positive control group （Transplanted tumor did not suffer from the portal vein occlusion）. All rabbits were scanned with multi-slice CT. RESULTS： All 40 animals were employed in the final analysis without death. Tumor did not grow in both immediate group and 3-wk group. In 3-wk group, left endite was atrophied and growth of tumor was inhibited. The maximal diameter of tumor was significantly smaller than that in positive control group （2.55±0.46 vs 3.59±0.37 cm, t = 5.57, P 〈 0.001）. Incidences of metastasis in the liver and lung were lower in 3-wk group than those in positive control group （10% vs 400, and 90% vs 100%, respectively）. The expression intensities of the vascular endothelium growth factor （VEGF） in groups A, B, C and D were 0.10±0.06, 0.66±0.21, 0.28±0.09 and 1.48±0.32, respectively. VEGF expression level in the test group A was significantly lower than that in the negative control group C （t = 5.07; P 〈 0.001）.In addition, VEGF expression in the test group B was significantly lower than that in the positive control group D （t = 6.38; P 〈 0.001）. Scanning with multi-slice CT showed that displaying rate of hepatic artery branches was obviously lower in grade Ⅲ（40%） than that in grade Ⅰ（70%） and Ⅱ（100%） （P 〈 0.05）; but there was no significant difference in displaying rate of the portal vein at various grades. Values of blood flow （BF） of the liver, blood volume （BV）, mean transit time （MTT） and permeability of vascular surface （PS） were lower in the immediate group and 3-wk group than those in control groups, but values of hepatic arterial fraction （HAF） were increased. Significant positive correlations were existed between BF and BV （r = 0.905, P 〈 0.01）, and between BF and PS （r = 0.967, P 〈 0.01）, between BV and PS （r = 0.889, P 〈 0.01）. A significant negative correlation existed between PV and HAF （r = -0.768, P 〈 0.01）, between PS and HAF （r = -0.557, P 〈 0.01）. The values of BF, BV and PS had a positive correlation with VEGF （rBF = 0.842, rBV = 0.579, rPS = 0.811, P 〈 0.01） . However, there was no significant correlation between the values of MTT and HAF and the VEGF expression （rMTt = 0.066, rHAF = -0.027）. CONCLUSION： Ligating the left external branch of portal vein is an ideal way to establish models of portal vein occlusion in rabbits with hepatic VX2 tumor. Multi slice CT plays a key role in evaluating effect of portal vein occlusion.展开更多
The main goal of this study was to introduce a novel three-dimensional procedure to objectively quantify both inner and outer condylar remodelling on preoperative multi-slice computed tomography （MSCT） and postopera...The main goal of this study was to introduce a novel three-dimensional procedure to objectively quantify both inner and outer condylar remodelling on preoperative multi-slice computed tomography （MSCT） and postoperative cone-beam computed tomography （CBCT） images. Second, the reliability and accuracy of this condylar volume quantification method was assessed. The mandibles of 20 patients （11 female and 9 male） who underwent bimaxillary surgery were semi-automatically extracted from MSCT/CBCT scans and rendered in 3D. The resulting condyles were spatially matched by using an anatomical landmark-based registration procedure. A standardized sphere was created around each condyle, and the condylar bone volume within this selected region of interest was automatically calculated. To investigate the reproducibility of the method, inter- and intra-observer reliability was calculated for assessments made by two experienced radiologists twice five months apart in a set of ten randomly selected patients. To test the accuracy of the bone segmentation, the inner and outer bone structures of one dry mandible, scanned according to the clinical set-up, were compared with the gold standard, micro-CT. Thirty-eight condyles showed a significant （P〈O.05） mean bone volume decrease of 26.4%_ 11.4% （502.9 mm3＋ 268.1 mm3）. No significant effects of side, sex or age were found. Good to excellent （ICC〉 0.6） intra- and inter-observer reliability was observed for both MSCT and CBCT. Moreover, the bone segmentation accuracy was less than one voxel （0.4 mm） for MSCT （0.3 mm __. 0.2 mm） and CBCT （0.4 mm _ 0.3 mm）, thus indicating the clinical potential of this method for objective follow-up in pathological condylar resorption.展开更多
Objective:To investigate the diagnostic value of multi-slice spiral CT(MSCT)for patients with acute appendicitis(AA).Methods:Fifty patients with suspected AA who visited the hospital from January 2023 to January 2025 ...Objective:To investigate the diagnostic value of multi-slice spiral CT(MSCT)for patients with acute appendicitis(AA).Methods:Fifty patients with suspected AA who visited the hospital from January 2023 to January 2025 were selected as samples.All patients underwent MSCT and ultrasound diagnosis,and the diagnostic efficacy of MSCT was analyzed in comparison with pathology.Results:Pathology indicated 40 positive and 10 negative cases,ultrasound indicated 30 positive and 20 negative cases,and MSCT indicated 39 positive and 11 negative cases.The diagnostic efficacy of MSCT was higher than that of ultrasound(P<0.05).The accuracy of pathological classification of MSCT was higher than that of ultrasound(P<0.05).The detection rate of MSCT imaging indicators in AA patients was higher than that in non-AA patients(P<0.05).Conclusion:MSCT has high diagnostic efficacy in AA patients and can assist physicians in determining pathological classification.展开更多
Objective: To study the clinical significance of multi-slice spiral CT 3-dimensional (3D) portography in portal vein tumor thrombosis of hepatocellular cacinoma.Methods: 57 cases undergoing 3D portography were collect...Objective: To study the clinical significance of multi-slice spiral CT 3-dimensional (3D) portography in portal vein tumor thrombosis of hepatocellular cacinoma.Methods: 57 cases undergoing 3D portography were collected, of which 6 cases were normal, 5 cases were subjected to cirrhosis and hypertension of portal vein, 42 cases had portal tumor thrombus of hepatic cancer, and the remaining 4 cases showed lymph node enlargment in hilar of liver. All data of the patients came from conventional multi-slice spiral CT double phase of liver. Contrast media was 1.5–2 ml/kg with the injection rate being 2.5–3 ml/s. Axis and 3D portography was analyzed and compared in 42 cases of portal tumor thrombus of hepatic cancer.Results: According to portal tumor thrombus position, 42 cases were fallen into three categories: left (13 cases), right (20 cases), main (9 cases) of potal vein. There was no difference between axis and 3D portography in displaying portal tumor thrombus of hepatic cancer (P>0.05), but 3D portography showing collateral branches was better than axis portography after main portal vein thrombus.Conclusion: Multi-slice spiral CT 3D portography can display the position and types of portal tumor thrombus of hepatic cancer. 3D combined with axis portography can better evaluate the portal tumor thrombus of hepatic cancer and guide to select the therapies. Key words portal vein - tumor thrombus - multi-slice CT - 3 dimension imaging展开更多
Objective: To evaluate three-dimensional bronchial artery imaging charactersin central lung cancer and applied values with multi-slice spiral CT (MSCT) to provide theoreticalevidence on blood supply and intervention t...Objective: To evaluate three-dimensional bronchial artery imaging charactersin central lung cancer and applied values with multi-slice spiral CT (MSCT) to provide theoreticalevidence on blood supply and intervention therapy. Methods: Eighteen patients with central lungcancer underwent MSCT with real time helical thin-slice CT scanning. Three-dimensional bronchialartery reconstruction was done at the console work-station. The space anatomical characters ofbronchial artery were observed through different rotations. Results: For 6 cases, thethree-dimensional images of bronchial artery (33.33%) could exactly show the origins, the routes(lung inner segment and mediatism segment) and the diameters of bronchial arteries. Vision rate ofbronchial arteries was the highest in pulmonary artery stricture and truncation groups, and thevessels' diameter became larger apparently. These characters demonstrated blood supply of this kindof central lung cancer come from bronchial artery. Volume rendering images were the best ones amongthree-dimensional images. Conclusion: Three-dimensional imaging with MSCT in bronchial artery canreveal the anatomical characters of bronchial artery and provide theoretical evidence on bloodsupply and intervention therapy of central lung cancer.展开更多
Background Many studies have shown that cancer cell differentiation and microvascular invasion play a principle role in cancer progression and metastasis, and non-invasive imaging techniques such as CT, MRI and US ass...Background Many studies have shown that cancer cell differentiation and microvascular invasion play a principle role in cancer progression and metastasis, and non-invasive imaging techniques such as CT, MRI and US assessing the differentiation and the surgical resectibility and the prognosis of cancers are now of great importance. This study aimed to explore the correlation of triple-phase multi-slice CT scan with the histological differentiation and intratumor microvascular/lymphatic invasion of progressive gastric cancer.Methods The present study included 64 patients with gastric cancer, all of whom underwent routinal and dual-phase contrast enhancement multi-slice CT examinations of the upper abdomen before surgery. The post-operative specimens were used for determination of histological differentiation, cancer cell invasion of intratumoral microvascular/lyrnphatic vessel identified by CD34 and D2-40 expression. Correlations between contrast enhancement ratio （CER） of triple-phase multi-slice CT scan in gastric cancer and histological differentiation as well as intraturnoral microvascular/lymphatic invasion were compared and analyzed.Results There was a significant correlation between CER of triple-phase CT scan in gastric cancer and tumor histological differentiation （P〈0.05）. CER of the arterial phase in gastric cancer with intratumoral microvascular invasion was significantly higher than that without invasion （0.61±0.28 vs. 0.46±0.14, P 〈0.05）; CER of the arterial-parenchymal phase was significantly lower in gastric cancer with intratumoral microvascular invasion than that without invasion （1.81±0.39 vs. 2.28±0.80, P〈0.05）. However, CER of the parenchymal phase in gastric cancer with intratumoral lymphatic invasion was significantly higher than that without invasion （1.25±0.57 vs. 1.00±0.35, P〈0.05）.Conclusions CER of triple-phase multi-slice CT scan in gastric cancer is closely correlated with intratumoral microvascular and lymphatic invasion, and also could be used as a marker for histological differentiation.展开更多
Background This study aimed to investigate multi-slice CT contrast-enhanced presentation of gastric cancer and its correlation with histo-differentiation and p53 and P-glycoprotein （P-gp） expression. Methods Sixty-s...Background This study aimed to investigate multi-slice CT contrast-enhanced presentation of gastric cancer and its correlation with histo-differentiation and p53 and P-glycoprotein （P-gp） expression. Methods Sixty-six patients with gastric cancer in the present study underwent a multi-slice CT preoperative routine and dual-phase contrast-enhanced examination of the upper abdomen; postoperative specimens were used to determine histo-differentiation and the expression of p53 and P-gp. The correlation of multi-slice CT contrast-enhanced presentation with histo-differentiation and expression of p53 and P-gp was analyzed. Results The dual-phase contrast-enhanced ratio （CER） was not correlated with the histo-differentiation of gastric cancer （P 〉0.05）. Positive expression of p53 and P-gp was significantly higher in the cases of layered or heterogeneous enhancement than in the cases of homogenous enhancement （P 〈0.05）. Positive expression of p53 was also correlated with the arterial phase CER, tumor size and lymph node metastasis （P 〈0.05）, but not with infiltration thickness of the gastric wall, nor was it correlated with the portal phase CER （P 〉0.05）. Positive expression of P-gp was only correlated with the portal phase CER （P=0.005）. Conclusions Differently enhanced pattern and CER of the arterial and portal phase in gastric cancer correlate with its different histo-differentiation and expression of p53 and P-gp respectively. In addition, tumor size and lymph node metastasis of gastric cancer relate to the expression of p53.展开更多
目的探究低剂量多层螺旋CT(MSCT)与X线在新生儿呼吸窘迫综合征(NRDS)诊断中的应用价值。方法收集2019年1月至2024年2月我院收治的100例NRDS的病例资料,均接受MSCT及X线检查,观察其MSCT及X线特点,评估其两者对NRDS的诊断效能。结果(1)100...目的探究低剂量多层螺旋CT(MSCT)与X线在新生儿呼吸窘迫综合征(NRDS)诊断中的应用价值。方法收集2019年1月至2024年2月我院收治的100例NRDS的病例资料,均接受MSCT及X线检查,观察其MSCT及X线特点,评估其两者对NRDS的诊断效能。结果(1)100例NRDS患儿的MSCT图像中图像质量优42例(42.00%),图像质量良37例(37.00%),图像质量合格20例(20.00%),1例患儿图像质量不合格,图像质量合格率为99.00%,经镇静后重新检查,合格率为100%。100例NRDS患儿中,35例(35.00%)患儿MSCT示双肺野呈大片状,且形状不对称,边缘模糊,形成浸润影,双肺背部肺组织改变更明显;20例(20.00%)患儿MSCT示双肺纹理增多,且纹理模糊,沿肺纹理可见斑点状影或模糊小斑片状影;30例(30.00%)患儿MSCT示双肺呈低透亮度,可见磨玻璃样;15例(15.00%)患儿MSCT示双肺野密度均升高,且呈白肺,其中10例(10.00%)患儿呈现肺组织受压,纵隔移位至健侧表现。(2)100例NRDS患儿中,58例(58.00%)患儿X线示双肺可见广泛细颗粒网状影,心影、横隔均清晰可见,且伴有支气管充气征;42例(42.00%)患儿X线示双肺野一致性密度升高,见“白肺”及明显支气管充气征,心影、横隔边缘难以分辨;(3)以临床诊断为金标准,MSCT诊断NRDS的准确率为91.00%,敏感度为94.31%,特异性为66.67%;X线诊断N R D S的准确率为80.00%,敏感度为85.22%,特异性为41.67%;MSCT+X线对NRDS的诊断效能最高,诊断准确率为97.00%,敏感度为97.73%,特异性为91.67%。结论低剂量MSCT及X线对NRDS均具备良好的诊断价值,且MSCT相较X线诊断效能更高,但两者联合诊断可进一步提高诊断效能。展开更多
文摘AIM： To establish models of portal vein occlusion of hepatic VX2 tumor in rabbits and to evaluate the value of multi-slice CT. METHODS： Forty New Zealand rabbits were divided into 4 groups according to digital table： Immediate group （group A; transplantation of tumor immediately after the portal vein occlusion）, 3-wk group （group B; transplantation of tumor at 3 wk after the portal vein occlusion）, negative control group （group C） and positive control group （group D）, 10 rabbits in each group. Hepatic VX2 tumor was transplanted with abdominalembedding innoculation immediately after the portal vein occlusion and at 3 wk after the portal vein occlusion. Meanwhile, they were divided into negative control group （Left external branch of portal vein was occluded by sham-operation, and left exite was embedded and inoculated pseudoly） and positive control group （Transplanted tumor did not suffer from the portal vein occlusion）. All rabbits were scanned with multi-slice CT. RESULTS： All 40 animals were employed in the final analysis without death. Tumor did not grow in both immediate group and 3-wk group. In 3-wk group, left endite was atrophied and growth of tumor was inhibited. The maximal diameter of tumor was significantly smaller than that in positive control group （2.55±0.46 vs 3.59±0.37 cm, t = 5.57, P 〈 0.001）. Incidences of metastasis in the liver and lung were lower in 3-wk group than those in positive control group （10% vs 400, and 90% vs 100%, respectively）. The expression intensities of the vascular endothelium growth factor （VEGF） in groups A, B, C and D were 0.10±0.06, 0.66±0.21, 0.28±0.09 and 1.48±0.32, respectively. VEGF expression level in the test group A was significantly lower than that in the negative control group C （t = 5.07; P 〈 0.001）.In addition, VEGF expression in the test group B was significantly lower than that in the positive control group D （t = 6.38; P 〈 0.001）. Scanning with multi-slice CT showed that displaying rate of hepatic artery branches was obviously lower in grade Ⅲ（40%） than that in grade Ⅰ（70%） and Ⅱ（100%） （P 〈 0.05）; but there was no significant difference in displaying rate of the portal vein at various grades. Values of blood flow （BF） of the liver, blood volume （BV）, mean transit time （MTT） and permeability of vascular surface （PS） were lower in the immediate group and 3-wk group than those in control groups, but values of hepatic arterial fraction （HAF） were increased. Significant positive correlations were existed between BF and BV （r = 0.905, P 〈 0.01）, and between BF and PS （r = 0.967, P 〈 0.01）, between BV and PS （r = 0.889, P 〈 0.01）. A significant negative correlation existed between PV and HAF （r = -0.768, P 〈 0.01）, between PS and HAF （r = -0.557, P 〈 0.01）. The values of BF, BV and PS had a positive correlation with VEGF （rBF = 0.842, rBV = 0.579, rPS = 0.811, P 〈 0.01） . However, there was no significant correlation between the values of MTT and HAF and the VEGF expression （rMTt = 0.066, rHAF = -0.027）. CONCLUSION： Ligating the left external branch of portal vein is an ideal way to establish models of portal vein occlusion in rabbits with hepatic VX2 tumor. Multi slice CT plays a key role in evaluating effect of portal vein occlusion.
基金the Coordination for the Improvement of Higher Education Personnel(CAPES)programmeScience without borders from Brazilian governmentthe Research Foundation Flanders(FWO)from Flemish government for the fellowship support
文摘The main goal of this study was to introduce a novel three-dimensional procedure to objectively quantify both inner and outer condylar remodelling on preoperative multi-slice computed tomography （MSCT） and postoperative cone-beam computed tomography （CBCT） images. Second, the reliability and accuracy of this condylar volume quantification method was assessed. The mandibles of 20 patients （11 female and 9 male） who underwent bimaxillary surgery were semi-automatically extracted from MSCT/CBCT scans and rendered in 3D. The resulting condyles were spatially matched by using an anatomical landmark-based registration procedure. A standardized sphere was created around each condyle, and the condylar bone volume within this selected region of interest was automatically calculated. To investigate the reproducibility of the method, inter- and intra-observer reliability was calculated for assessments made by two experienced radiologists twice five months apart in a set of ten randomly selected patients. To test the accuracy of the bone segmentation, the inner and outer bone structures of one dry mandible, scanned according to the clinical set-up, were compared with the gold standard, micro-CT. Thirty-eight condyles showed a significant （P〈O.05） mean bone volume decrease of 26.4%_ 11.4% （502.9 mm3＋ 268.1 mm3）. No significant effects of side, sex or age were found. Good to excellent （ICC〉 0.6） intra- and inter-observer reliability was observed for both MSCT and CBCT. Moreover, the bone segmentation accuracy was less than one voxel （0.4 mm） for MSCT （0.3 mm __. 0.2 mm） and CBCT （0.4 mm _ 0.3 mm）, thus indicating the clinical potential of this method for objective follow-up in pathological condylar resorption.
文摘Objective:To investigate the diagnostic value of multi-slice spiral CT(MSCT)for patients with acute appendicitis(AA).Methods:Fifty patients with suspected AA who visited the hospital from January 2023 to January 2025 were selected as samples.All patients underwent MSCT and ultrasound diagnosis,and the diagnostic efficacy of MSCT was analyzed in comparison with pathology.Results:Pathology indicated 40 positive and 10 negative cases,ultrasound indicated 30 positive and 20 negative cases,and MSCT indicated 39 positive and 11 negative cases.The diagnostic efficacy of MSCT was higher than that of ultrasound(P<0.05).The accuracy of pathological classification of MSCT was higher than that of ultrasound(P<0.05).The detection rate of MSCT imaging indicators in AA patients was higher than that in non-AA patients(P<0.05).Conclusion:MSCT has high diagnostic efficacy in AA patients and can assist physicians in determining pathological classification.
文摘Objective: To study the clinical significance of multi-slice spiral CT 3-dimensional (3D) portography in portal vein tumor thrombosis of hepatocellular cacinoma.Methods: 57 cases undergoing 3D portography were collected, of which 6 cases were normal, 5 cases were subjected to cirrhosis and hypertension of portal vein, 42 cases had portal tumor thrombus of hepatic cancer, and the remaining 4 cases showed lymph node enlargment in hilar of liver. All data of the patients came from conventional multi-slice spiral CT double phase of liver. Contrast media was 1.5–2 ml/kg with the injection rate being 2.5–3 ml/s. Axis and 3D portography was analyzed and compared in 42 cases of portal tumor thrombus of hepatic cancer.Results: According to portal tumor thrombus position, 42 cases were fallen into three categories: left (13 cases), right (20 cases), main (9 cases) of potal vein. There was no difference between axis and 3D portography in displaying portal tumor thrombus of hepatic cancer (P>0.05), but 3D portography showing collateral branches was better than axis portography after main portal vein thrombus.Conclusion: Multi-slice spiral CT 3D portography can display the position and types of portal tumor thrombus of hepatic cancer. 3D combined with axis portography can better evaluate the portal tumor thrombus of hepatic cancer and guide to select the therapies. Key words portal vein - tumor thrombus - multi-slice CT - 3 dimension imaging
文摘Objective: To evaluate three-dimensional bronchial artery imaging charactersin central lung cancer and applied values with multi-slice spiral CT (MSCT) to provide theoreticalevidence on blood supply and intervention therapy. Methods: Eighteen patients with central lungcancer underwent MSCT with real time helical thin-slice CT scanning. Three-dimensional bronchialartery reconstruction was done at the console work-station. The space anatomical characters ofbronchial artery were observed through different rotations. Results: For 6 cases, thethree-dimensional images of bronchial artery (33.33%) could exactly show the origins, the routes(lung inner segment and mediatism segment) and the diameters of bronchial arteries. Vision rate ofbronchial arteries was the highest in pulmonary artery stricture and truncation groups, and thevessels' diameter became larger apparently. These characters demonstrated blood supply of this kindof central lung cancer come from bronchial artery. Volume rendering images were the best ones amongthree-dimensional images. Conclusion: Three-dimensional imaging with MSCT in bronchial artery canreveal the anatomical characters of bronchial artery and provide theoretical evidence on bloodsupply and intervention therapy of central lung cancer.
文摘Background Many studies have shown that cancer cell differentiation and microvascular invasion play a principle role in cancer progression and metastasis, and non-invasive imaging techniques such as CT, MRI and US assessing the differentiation and the surgical resectibility and the prognosis of cancers are now of great importance. This study aimed to explore the correlation of triple-phase multi-slice CT scan with the histological differentiation and intratumor microvascular/lymphatic invasion of progressive gastric cancer.Methods The present study included 64 patients with gastric cancer, all of whom underwent routinal and dual-phase contrast enhancement multi-slice CT examinations of the upper abdomen before surgery. The post-operative specimens were used for determination of histological differentiation, cancer cell invasion of intratumoral microvascular/lyrnphatic vessel identified by CD34 and D2-40 expression. Correlations between contrast enhancement ratio （CER） of triple-phase multi-slice CT scan in gastric cancer and histological differentiation as well as intraturnoral microvascular/lymphatic invasion were compared and analyzed.Results There was a significant correlation between CER of triple-phase CT scan in gastric cancer and tumor histological differentiation （P〈0.05）. CER of the arterial phase in gastric cancer with intratumoral microvascular invasion was significantly higher than that without invasion （0.61±0.28 vs. 0.46±0.14, P 〈0.05）; CER of the arterial-parenchymal phase was significantly lower in gastric cancer with intratumoral microvascular invasion than that without invasion （1.81±0.39 vs. 2.28±0.80, P〈0.05）. However, CER of the parenchymal phase in gastric cancer with intratumoral lymphatic invasion was significantly higher than that without invasion （1.25±0.57 vs. 1.00±0.35, P〈0.05）.Conclusions CER of triple-phase multi-slice CT scan in gastric cancer is closely correlated with intratumoral microvascular and lymphatic invasion, and also could be used as a marker for histological differentiation.
文摘Background This study aimed to investigate multi-slice CT contrast-enhanced presentation of gastric cancer and its correlation with histo-differentiation and p53 and P-glycoprotein （P-gp） expression. Methods Sixty-six patients with gastric cancer in the present study underwent a multi-slice CT preoperative routine and dual-phase contrast-enhanced examination of the upper abdomen; postoperative specimens were used to determine histo-differentiation and the expression of p53 and P-gp. The correlation of multi-slice CT contrast-enhanced presentation with histo-differentiation and expression of p53 and P-gp was analyzed. Results The dual-phase contrast-enhanced ratio （CER） was not correlated with the histo-differentiation of gastric cancer （P 〉0.05）. Positive expression of p53 and P-gp was significantly higher in the cases of layered or heterogeneous enhancement than in the cases of homogenous enhancement （P 〈0.05）. Positive expression of p53 was also correlated with the arterial phase CER, tumor size and lymph node metastasis （P 〈0.05）, but not with infiltration thickness of the gastric wall, nor was it correlated with the portal phase CER （P 〉0.05）. Positive expression of P-gp was only correlated with the portal phase CER （P=0.005）. Conclusions Differently enhanced pattern and CER of the arterial and portal phase in gastric cancer correlate with its different histo-differentiation and expression of p53 and P-gp respectively. In addition, tumor size and lymph node metastasis of gastric cancer relate to the expression of p53.
文摘目的探究低剂量多层螺旋CT(MSCT)与X线在新生儿呼吸窘迫综合征(NRDS)诊断中的应用价值。方法收集2019年1月至2024年2月我院收治的100例NRDS的病例资料,均接受MSCT及X线检查,观察其MSCT及X线特点,评估其两者对NRDS的诊断效能。结果(1)100例NRDS患儿的MSCT图像中图像质量优42例(42.00%),图像质量良37例(37.00%),图像质量合格20例(20.00%),1例患儿图像质量不合格,图像质量合格率为99.00%,经镇静后重新检查,合格率为100%。100例NRDS患儿中,35例(35.00%)患儿MSCT示双肺野呈大片状,且形状不对称,边缘模糊,形成浸润影,双肺背部肺组织改变更明显;20例(20.00%)患儿MSCT示双肺纹理增多,且纹理模糊,沿肺纹理可见斑点状影或模糊小斑片状影;30例(30.00%)患儿MSCT示双肺呈低透亮度,可见磨玻璃样;15例(15.00%)患儿MSCT示双肺野密度均升高,且呈白肺,其中10例(10.00%)患儿呈现肺组织受压,纵隔移位至健侧表现。(2)100例NRDS患儿中,58例(58.00%)患儿X线示双肺可见广泛细颗粒网状影,心影、横隔均清晰可见,且伴有支气管充气征;42例(42.00%)患儿X线示双肺野一致性密度升高,见“白肺”及明显支气管充气征,心影、横隔边缘难以分辨;(3)以临床诊断为金标准,MSCT诊断NRDS的准确率为91.00%,敏感度为94.31%,特异性为66.67%;X线诊断N R D S的准确率为80.00%,敏感度为85.22%,特异性为41.67%;MSCT+X线对NRDS的诊断效能最高,诊断准确率为97.00%,敏感度为97.73%,特异性为91.67%。结论低剂量MSCT及X线对NRDS均具备良好的诊断价值,且MSCT相较X线诊断效能更高,但两者联合诊断可进一步提高诊断效能。
