The detection and characterization of non-metallic inclusions are essential for clean steel production.Recently,imaging analysis combined with high-dimensional data processing of metallic materials using artificial in...The detection and characterization of non-metallic inclusions are essential for clean steel production.Recently,imaging analysis combined with high-dimensional data processing of metallic materials using artificial intelligence(AI)-based machine learning(ML)has developed rapidly.This technique has achieved impressive results in the field of inclusion classification in process metallurgy.The present study surveys the ML modeling of inclusion prediction in advanced steels,including the detection,classification,and feature prediction of inclusions in different steel grades.Studies on clean steel with different features based on data and image analysis via ML are summarized.Regarding the data analysis,the inclusion prediction methodology based on ML establishes a connection between the experimental parameters and inclusion characteristics and analyzes the importance of the experimental parameters.Regarding the image analysis,the focus is placed on the classification of different types of inclusions via deep learning,in comparison with data analysis.Finally,further development of inclusion analyses using ML-based methods is recommended.This work paves the way for the application of AIbased methodologies for ultraclean-steel studies from a sustainable metallurgy perspective.展开更多
Biomedical big data,characterized by its massive scale,multi-dimensionality,and heterogeneity,offers novel perspectives for disease research,elucidates biological principles,and simultaneously prompts changes in relat...Biomedical big data,characterized by its massive scale,multi-dimensionality,and heterogeneity,offers novel perspectives for disease research,elucidates biological principles,and simultaneously prompts changes in related research methodologies.Biomedical ontology,as a shared formal conceptual system,not only offers standardized terms for multi-source biomedical data but also provides a solid data foundation and framework for biomedical research.In this review,we summarize enrichment analysis and deep learning for biomedical ontology based on its structure and semantic annotation properties,highlighting how technological advancements are enabling the more comprehensive use of ontology information.Enrichment analysis represents an important application of ontology to elucidate the potential biological significance for a particular molecular list.Deep learning,on the other hand,represents an increasingly powerful analytical tool that can be more widely combined with ontology for analysis and prediction.With the continuous evolution of big data technologies,the integration of these technologies with biomedical ontologies is opening up exciting new possibilities for advancing biomedical research.展开更多
Joint Multimodal Aspect-based Sentiment Analysis(JMASA)is a significant task in the research of multimodal fine-grained sentiment analysis,which combines two subtasks:Multimodal Aspect Term Extraction(MATE)and Multimo...Joint Multimodal Aspect-based Sentiment Analysis(JMASA)is a significant task in the research of multimodal fine-grained sentiment analysis,which combines two subtasks:Multimodal Aspect Term Extraction(MATE)and Multimodal Aspect-oriented Sentiment Classification(MASC).Currently,most existing models for JMASA only perform text and image feature encoding from a basic level,but often neglect the in-depth analysis of unimodal intrinsic features,which may lead to the low accuracy of aspect term extraction and the poor ability of sentiment prediction due to the insufficient learning of intra-modal features.Given this problem,we propose a Text-Image Feature Fine-grained Learning(TIFFL)model for JMASA.First,we construct an enhanced adjacency matrix of word dependencies and adopt graph convolutional network to learn the syntactic structure features for text,which addresses the context interference problem of identifying different aspect terms.Then,the adjective-noun pairs extracted from image are introduced to enable the semantic representation of visual features more intuitive,which addresses the ambiguous semantic extraction problem during image feature learning.Thereby,the model performance of aspect term extraction and sentiment polarity prediction can be further optimized and enhanced.Experiments on two Twitter benchmark datasets demonstrate that TIFFL achieves competitive results for JMASA,MATE and MASC,thus validating the effectiveness of our proposed methods.展开更多
App reviews are crucial in influencing user decisions and providing essential feedback for developers to improve their products.Automating the analysis of these reviews is vital for efficient review management.While t...App reviews are crucial in influencing user decisions and providing essential feedback for developers to improve their products.Automating the analysis of these reviews is vital for efficient review management.While traditional machine learning(ML)models rely on basic word-based feature extraction,deep learning(DL)methods,enhanced with advanced word embeddings,have shown superior performance.This research introduces a novel aspectbased sentiment analysis(ABSA)framework to classify app reviews based on key non-functional requirements,focusing on usability factors:effectiveness,efficiency,and satisfaction.We propose a hybrid DL model,combining BERT(Bidirectional Encoder Representations from Transformers)with BiLSTM(Bidirectional Long Short-Term Memory)and CNN(Convolutional Neural Networks)layers,to enhance classification accuracy.Comparative analysis against state-of-the-art models demonstrates that our BERT-BiLSTM-CNN model achieves exceptional performance,with precision,recall,F1-score,and accuracy of 96%,87%,91%,and 94%,respectively.Thesignificant contributions of this work include a refined ABSA-based relabeling framework,the development of a highperformance classifier,and the comprehensive relabeling of the Instagram App Reviews dataset.These advancements provide valuable insights for software developers to enhance usability and drive user-centric application development.展开更多
Joint roughness coefficient(JRC)is the most commonly used parameter for quantifying surface roughness of rock discontinuities in practice.The system composed of multiple roughness statistical parameters to measure JRC...Joint roughness coefficient(JRC)is the most commonly used parameter for quantifying surface roughness of rock discontinuities in practice.The system composed of multiple roughness statistical parameters to measure JRC is a nonlinear system with a lot of overlapping information.In this paper,a dataset of eight roughness statistical parameters covering 112 digital joints is established.Then,the principal component analysis method is introduced to extract the significant information,which solves the information overlap problem of roughness characterization.Based on the two principal components of extracted features,the white shark optimizer algorithm was introduced to optimize the extreme gradient boosting model,and a new machine learning(ML)prediction model was established.The prediction accuracy of the new model and the other 17 models was measured using statistical metrics.The results show that the prediction result of the new model is more consistent with the real JRC value,with higher recognition accuracy and generalization ability.展开更多
Integrating multiple medical imaging techniques,including Magnetic Resonance Imaging(MRI),Computed Tomography,Positron Emission Tomography(PET),and ultrasound,provides a comprehensive view of the patient health status...Integrating multiple medical imaging techniques,including Magnetic Resonance Imaging(MRI),Computed Tomography,Positron Emission Tomography(PET),and ultrasound,provides a comprehensive view of the patient health status.Each of these methods contributes unique diagnostic insights,enhancing the overall assessment of patient condition.Nevertheless,the amalgamation of data from multiple modalities presents difficulties due to disparities in resolution,data collection methods,and noise levels.While traditional models like Convolutional Neural Networks(CNNs)excel in single-modality tasks,they struggle to handle multi-modal complexities,lacking the capacity to model global relationships.This research presents a novel approach for examining multi-modal medical imagery using a transformer-based system.The framework employs self-attention and cross-attention mechanisms to synchronize and integrate features across various modalities.Additionally,it shows resilience to variations in noise and image quality,making it adaptable for real-time clinical use.To address the computational hurdles linked to transformer models,particularly in real-time clinical applications in resource-constrained environments,several optimization techniques have been integrated to boost scalability and efficiency.Initially,a streamlined transformer architecture was adopted to minimize the computational load while maintaining model effectiveness.Methods such as model pruning,quantization,and knowledge distillation have been applied to reduce the parameter count and enhance the inference speed.Furthermore,efficient attention mechanisms such as linear or sparse attention were employed to alleviate the substantial memory and processing requirements of traditional self-attention operations.For further deployment optimization,researchers have implemented hardware-aware acceleration strategies,including the use of TensorRT and ONNX-based model compression,to ensure efficient execution on edge devices.These optimizations allow the approach to function effectively in real-time clinical settings,ensuring viability even in environments with limited resources.Future research directions include integrating non-imaging data to facilitate personalized treatment and enhancing computational efficiency for implementation in resource-limited environments.This study highlights the transformative potential of transformer models in multi-modal medical imaging,offering improvements in diagnostic accuracy and patient care outcomes.展开更多
Seismic fragility analysis(SFA)is known as an effective probabilistic-based approach used to evaluate seismic fragility.There are various sources of uncertainties associated with this approach.A nuclear power plant(NP...Seismic fragility analysis(SFA)is known as an effective probabilistic-based approach used to evaluate seismic fragility.There are various sources of uncertainties associated with this approach.A nuclear power plant(NPP)system is an extremely important infrastructure and contains many structural uncertainties due to construction issues or structural deterioration during service.Simulation of structural uncertainties effects is a costly and time-consuming endeavor.A novel approach to SFA for the NPP considering structural uncertainties based on the damage state is proposed and examined.The results suggest that considering the structural uncertainties is essential in assessing the fragility of the NPP structure,and the impact of structural uncertainties tends to increase with the state of damage.Subsequently,machine learning(ML)is found to be superior in high-precision damage state identification of the NPP for reducing the time of nonlinear time-history analysis(NLTHA)and could be applied in the damage state-based SFA.Also,the impact of various sources of uncertainties is investigated through sensitivity analysis.The Sobol and Shapley additive explanations(SHAP)method can be complementary to each other and able to solve the problem of quantifying seismic and structural uncertainties simultaneously and the interaction effect of each parameter.展开更多
Sentiment Analysis,a significant domain within Natural Language Processing(NLP),focuses on extracting and interpreting subjective information-such as emotions,opinions,and attitudes-from textual data.With the increasi...Sentiment Analysis,a significant domain within Natural Language Processing(NLP),focuses on extracting and interpreting subjective information-such as emotions,opinions,and attitudes-from textual data.With the increasing volume of user-generated content on social media and digital platforms,sentiment analysis has become essential for deriving actionable insights across various sectors.This study presents a systematic literature review of sentiment analysis methodologies,encompassing traditional machine learning algorithms,lexicon-based approaches,and recent advancements in deep learning techniques.The review follows a structured protocol comprising three phases:planning,execution,and analysis/reporting.During the execution phase,67 peer-reviewed articles were initially retrieved,with 25 meeting predefined inclusion and exclusion criteria.The analysis phase involved a detailed examination of each study’s methodology,experimental setup,and key contributions.Among the deep learning models evaluated,Long Short-Term Memory(LSTM)networks were identified as the most frequently adopted architecture for sentiment classification tasks.This review highlights current trends,technical challenges,and emerging opportunities in the field,providing valuable guidance for future research and development in applications such as market analysis,public health monitoring,financial forecasting,and crisis management.展开更多
3-Nitro-1,2,4-triazol-5-one(NTO)is a typical high-energy,low-sensitivity explosive,and accurate concentration monitoring is critical for crystallization process control.In this study,a high-precision quantitative anal...3-Nitro-1,2,4-triazol-5-one(NTO)is a typical high-energy,low-sensitivity explosive,and accurate concentration monitoring is critical for crystallization process control.In this study,a high-precision quantitative analytical model for NTO concentration in ethanol solutions was developed by integrating real-time ATR-FTIR spectroscopy with chemometric and machine learning techniques.Dynamic spectral data were obtained by designing multi-concentration gradient heating-cooling cycle experiments,abnormal samples were eliminated using the isolation forest algorithm,and the effects of various preprocessing methods on model performance were systematically evaluated.The results show that partial least squares regression(PLSR)exhibits superior generalization ability compared to other models.Vibrational bands corresponding to C=O and–NO_(2)were identified as key predictors for concentration estimation.This work provides an efficient and reliable solution for real-time concentration monitoring during NTO crystallization and holds significant potential for process analytical applications in energetic material manufacturing.展开更多
In order to gain insight into the current research status and development trend of problem-based learning(PBL)in colleges and universities,this study employs the bibliometric method to conduct statistical and analytic...In order to gain insight into the current research status and development trend of problem-based learning(PBL)in colleges and universities,this study employs the bibliometric method to conduct statistical and analytical studies based on the examination of journal papers and review papers within the Web of Science(WOS)database.The objective is to provide a reference point for research in related fields.The findings indicate a sustained expansion in PBL research output at universities,with the United States accounting for most documents in the field,while European research institutions such as Aalborg University and Maastricht University are at the forefront.Nevertheless,the density of collaborative networks between authors is relatively low,and cross-institutional and interdisciplinary collaboration still requires further strengthening.The majority of research results are published in academic journals such as Academic Medicine and the International Journal of Sustainability in Higher Education.Presently,the focal point of PBL research in colleges and universities is undergoing a transition from a“single-discipline focus”to an“interdisciplinary integration.”This integration is profoundly intertwined with the nascent fields of modern educational technology and education for sustainable development,thereby offering a novel avenue for the advancement of pedagogical approaches and educational equity.展开更多
BACKGROUND Colorectal cancer(CRC)is the third-most prevalent cancer and the cancer with the second-highest mortality rate worldwide,representing a high public health burden.Deep learning(DL)offers advantages in the di...BACKGROUND Colorectal cancer(CRC)is the third-most prevalent cancer and the cancer with the second-highest mortality rate worldwide,representing a high public health burden.Deep learning(DL)offers advantages in the diagnosis,identification,localization,classification and prognosis of CRC patients.However,few bibliometric analyses of research hotspots and trends in the field have been performed.AIM To use bibliometric approaches to analyze and visualize the current research state and development trend of DL in CRC as well as to anticipate future research directions and hotspots.METHODS Datasets were retrieved from the Web of Science Core Collection for the period January 2011 to December 2023.Scimago Graphica(1.0.45),VOSviewer(1.6.20)and CiteSpace(6.3.1)were used to analyze and visualize the nation,institution,journal,author,reference and keyword indicators.Origin(2022)was utilized for plotting,and Excel(2021)was used to construct the tables.RESULTS A total of 1275 publications in 538 journals from 74 countries and 2267 institutions were collected.The number of annual publications has increased over time.China(371,29.1%),the United States(265,20.8%)and Japan(155,12.2%)contributed significantly to the number of articles published,accounting for 62.1%of the total publications.The United States had the strongest ties to other nations.Sun Yat-sen University in China had the highest number of publications(32).The journal with the most publications was Scientific Reports(34,Q2),whereas Gastrointestinal Endoscopy had the most co-citations(1053,Q1).Kather JN,was the author with the most articles(12)and co-citations(287).The most frequently cited reference was Deep Residual Learning for Image Recognition.Keywords were divided into six clusters,with“colorectal cancer”(12.34)having the highest outbreak intensity.CONCLUSION This study highlights the current status and most active directions of the use of DL in CRC.This approach has important applications in the identification,diagnosis,localization,classification and prognosis of the disease and will remain a central focus in the future.展开更多
BACKGROUND Congestive hepatopathy,also known as nutmeg liver,is liver damage secondary to chronic heart failure(HF).Its morphological characteristics in terms of medical imaging are not defined and remain unclear.AIM ...BACKGROUND Congestive hepatopathy,also known as nutmeg liver,is liver damage secondary to chronic heart failure(HF).Its morphological characteristics in terms of medical imaging are not defined and remain unclear.AIM To leverage machine learning to capture imaging features of congestive hepatopathy using incidentally acquired computed tomography(CT)scans.METHODS We retrospectively analyzed 179 chronic HF patients who underwent echocardiography and CT within one year.Right HF severity was classified into three grades.Liver CT images at the paraumbilical vein level were used to develop a ResNet-based machine learning model to predict tricuspid regurgitation(TR)severity.Model accuracy was compared with that of six gastroenterology and four radiology experts.RESULTS In the included patients,120 were male(mean age:73.1±14.4 years).The accuracy of the results predicting TR severity from a single CT image for the machine learning model was significantly higher than the average accuracy of the experts.The model was found to be exceptionally reliable for predicting severe TR.CONCLUSION Deep learning models,particularly those using ResNet architectures,can help identify morphological changes associated with TR severity,aiding in early liver dysfunction detection in patients with HF,thereby improving outcomes.展开更多
Carbon nanotube-reinforced cement composites have gained significant attention due to their enhanced mechanical properties,particularly in compressive and flexural strength.Despite extensive research,the influence of ...Carbon nanotube-reinforced cement composites have gained significant attention due to their enhanced mechanical properties,particularly in compressive and flexural strength.Despite extensive research,the influence of various parameters on these properties remains inadequately understood,primarily due to the complex interactions within the composites.This study addresses this gap by employingmachine learning techniques to conduct a sensitivity analysis on the compressive and flexural strength of carbon nanotube-reinforced cement composites.It systematically evaluates nine data-preprocessing techniques and benchmarks eleven machine-learning algorithms to reveal tradeoffs between predictive accuracy and computational complexity,which has not previously been explored in carbon nanotube-reinforced cement composite research.In this regard,four main factors are considered in the sensitivity analysis,which are the machine learning model type,the data pre-processing technique,and the effect of the concrete constituent materials on the compressive and flexural strength both globally through feature importance assessment and locally through partial dependence analysis.Accordingly,this research optimizes ninety-nine models representing combinations of eleven machine learning algorithms and nine data preprocessing techniques to accurately predict the mechanical properties of carbon nanotube-reinforced cement composites.Moreover,the study aims to unravel the relationships between different parameters and their impact on the composite’s strength by utilizing feature importance and partial dependence analyses.This research is crucial as it provides a comprehensive understanding of the factors influencing the performance of carbon nanotube-reinforced cement composites,which is vital for their efficient design and application in construction.The use of machine learning in this context not only enhances predictive accuracy but also offers insights that are often challenging to obtain through traditional experimental methods.The findings contribute to the field by highlighting the potential of advanced data-driven approaches in optimizing and understanding advanced composite materials,paving the way for more durable and resilient construction materials.展开更多
The authors regret that the original publication of this paper did not include Jawad Fayaz as a co-author.After further discussions and a thorough review of the research contributions,it was agreed that his significan...The authors regret that the original publication of this paper did not include Jawad Fayaz as a co-author.After further discussions and a thorough review of the research contributions,it was agreed that his significant contributions to the foundational aspects of the research warranted recognition,and he has now been added as a co-author.展开更多
The prediction of pregnancy-related hazards must be accurate and timely to safeguard mother and fetal health.This study aims to enhance risk prediction in pregnancywith a novel deep learningmodel based on a Long Short...The prediction of pregnancy-related hazards must be accurate and timely to safeguard mother and fetal health.This study aims to enhance risk prediction in pregnancywith a novel deep learningmodel based on a Long Short-Term Memory(LSTM)generator,designed to capture temporal relationships in cardiotocography(CTG)data.This methodology integrates CTG signals with demographic characteristics and utilizes preprocessing techniques such as noise reduction,normalization,and segmentation to create high-quality input for themodel.It uses convolutional layers to extract spatial information,followed by LSTM layers to model sequences for superior predictive performance.The overall results show that themodel is robust,with an accuracy of 91.5%,precision of 89.8%,recall of 90.4%,and F1-score of 90.1%that outperformed the corresponding baselinemodels,CNN(Convolutional Neural Network)and traditional RNN(Recurrent Neural Network),by 2.3%and 6.1%,respectively.Rather,the ability to detect pregnancy-related abnormalities has considerable therapeutic potential,with the possibility for focused treatments and individualized maternal healthcare approaches,the research team concluded.展开更多
Soil desiccation cracking is ubiquitous in nature and has significantpotential impacts on the engineering geological properties of soils.Previous studies have extensively examined various factors affecting soil cracki...Soil desiccation cracking is ubiquitous in nature and has significantpotential impacts on the engineering geological properties of soils.Previous studies have extensively examined various factors affecting soil cracking behavior through a numerous small-sample experiments.However,experimental studies alone cannot accurately describe soil cracking behavior.In this study,we firstly propose a modeling framework for predicting the surface crack ratio of soil desiccation cracking based on machine learning and interpretable analysis.The framework utilizes 1040 sets of soil cracking experimental data and employs random forest(RF),extreme gradient boosting(XGBoost),and artificialneural network(ANN)models to predict the surface crack ratio of soil desiccation cracking.To clarify the influenceof input features on soil cracking behavior,feature importance and Shapley additive explanations(SHAP)are applied for interpretability analysis.The results reveal that ensemble methods(RF and XGBoost)provide better predictive performance than the deep learning model(ANN).The feature importance analysis shows that soil desiccation cracking is primarily influencedby initial water content,plasticity index,finalwater content,liquid limit,sand content,clay content and thickness.Moreover,SHAP-based interpretability analysis further explores how soil cracking responds to various input variables.This study provides new insight into the evolution of soil cracking behavior,enhancing the understanding of its physical mechanisms and facilitating the assessment of potential regional development of soil desiccation cracking.展开更多
Accurate determination of rock mass parameters is essential for ensuring the accuracy of numericalsimulations. Displacement back-analysis is the most widely used method;however, the reliability of thecurrent approache...Accurate determination of rock mass parameters is essential for ensuring the accuracy of numericalsimulations. Displacement back-analysis is the most widely used method;however, the reliability of thecurrent approaches remains unsatisfactory. Therefore, in this paper, a multistage rock mass parameterback-analysis method, that considers the construction process and displacement losses is proposed andimplemented through the coupling of numerical simulation, auto-machine learning (AutoML), andmulti-objective optimization algorithms (MOOAs). First, a parametric modeling platform for mechanizedtwin tunnels is developed, generating a dataset through extensive numerical simulations. Next, theAutoML method is utilized to establish a surrogate model linking rock parameters and displacements.The tunnel construction process is divided into multiple stages, transforming the rock mass parameterback-analysis into a multi-objective optimization problem, for which multi-objective optimization algorithmsare introduced to obtain the rock mass parameters. The newly proposed rock mass parameterback-analysis method is validated in a mechanized twin tunnel project, and its accuracy and effectivenessare demonstrated. Compared with traditional single-stage back-analysis methods, the proposedmodel decreases the average absolute percentage error from 12.73% to 4.34%, significantly improving theaccuracy of the back-analysis. Moreover, although the accuracy of back analysis significantly increaseswith the number of construction stages considered, the back analysis time is acceptable. This studyprovides a new method for displacement back analysis that is efficient and accurate, thereby paving theway for precise parameter determination in numerical simulations.展开更多
Dear Editor,This letter introduces a novel approach to address the bearings-only target motion analysis(BO-TMA)problem by incorporating deep reinforcement learning(DRL)techniques.Conventional methods often exhibit bia...Dear Editor,This letter introduces a novel approach to address the bearings-only target motion analysis(BO-TMA)problem by incorporating deep reinforcement learning(DRL)techniques.Conventional methods often exhibit biases and struggle to achieve accurate results,especially when confronted with high levels of noise.In this letter,we formulate the BO-TMA problem as a Markov decision process(MDP)and process it within a DRL framework.Simulation results demonstrate that the proposed DRL-based estimator achieves reduced bias and lower errors compared to existing estimators.展开更多
Medical image analysis has become a cornerstone of modern healthcare,driven by the exponential growth of data from imaging modalities such as MRI,CT,PET,ultrasound,and X-ray.Traditional machine learning methods have m...Medical image analysis has become a cornerstone of modern healthcare,driven by the exponential growth of data from imaging modalities such as MRI,CT,PET,ultrasound,and X-ray.Traditional machine learning methods have made early contributions;however,recent advancements in deep learning(DL)have revolutionized the field,offering state-of-the-art performance in image classification,segmentation,detection,fusion,registration,and enhancement.This comprehensive review presents an in-depth analysis of deep learning methodologies applied across medical image analysis tasks,highlighting both foundational models and recent innovations.The article begins by introducing conventional techniques and their limitations,setting the stage for DL-based solutions.Core DL architectures,including Convolutional Neural Networks(CNNs),Recurrent Neural Networks(RNNs),Generative Adversarial Networks(GANs),Vision Transformers(ViTs),and hybrid models,are discussed in detail,including their advantages and domain-specific adaptations.Advanced learning paradigms such as semi-supervised learning,selfsupervised learning,and few-shot learning are explored for their potential to mitigate data annotation challenges in clinical datasets.This review further categorizes major tasks in medical image analysis,elaborating on how DL techniques have enabled precise tumor segmentation,lesion detection,modality fusion,super-resolution,and robust classification across diverse clinical settings.Emphasis is placed on applications in oncology,cardiology,neurology,and infectious diseases,including COVID-19.Challenges such as data scarcity,label imbalance,model generalizability,interpretability,and integration into clinical workflows are critically examined.Ethical considerations,explainable AI(XAI),federated learning,and regulatory compliance are discussed as essential components of real-world deployment.Benchmark datasets,evaluation metrics,and comparative performance analyses are presented to support future research.The article concludes with a forward-looking perspective on the role of foundation models,multimodal learning,edge AI,and bio-inspired computing in the future of medical imaging.Overall,this review serves as a valuable resource for researchers,clinicians,and developers aiming to harness deep learning for intelligent,efficient,and clinically viable medical image analysis.展开更多
Ferroptosis,a type of cell death that mainly involves iron metabolism imbalance and lipid peroxidation,is strongly correlated with the phagocytic response caused by bleeding after spinal cord injury.Thus,in this study...Ferroptosis,a type of cell death that mainly involves iron metabolism imbalance and lipid peroxidation,is strongly correlated with the phagocytic response caused by bleeding after spinal cord injury.Thus,in this study,bulk RNA sequencing data(GSE47681 and GSE5296)and single-cell RNA sequencing data(GSE162610)were acquired from gene expression databases.We then conducted differential analysis and immune infiltration analysis.Atf3 and Piezo1 were identified as key ferroptosis genes through random forest and least absolute shrinkage and selection operator algorithms.Further analysis of single-cell RNA sequencing data revealed a close relationship between ferroptosis and cell types such as macrophages/microglia and their intrinsic state transition processes.Differences in transcription factor regulation and intercellular communication networks were found in ferroptosis-related cells,confirming the high expression of Atf3 and Piezo1 in these cells.Molecular docking analysis confirmed that the proteins encoded by these genes can bind cycloheximide.In a mouse model of T8 spinal cord injury,low-dose cycloheximide treatment was found to improve neurological function,decrease levels of the pro-inflammatory cytokine inducible nitric oxide synthase,and increase levels of the anti-inflammatory cytokine arginase 1.Correspondingly,the expression of the ferroptosis-related gene Gpx4 increased in macrophages/microglia,while the expression of Acsl4 decreased.Our findings reveal the important role of ferroptosis in the treatment of spinal cord injury,identify the key cell types and genes involved in ferroptosis after spinal cord injury,and validate the efficacy of potential drug therapies,pointing to new directions in the treatment of spinal cord injury.展开更多
基金support from the National Key Research and Development Program of China(No.2024YFB3713705)is acknowledgedWangzhong Mu would like to acknowledge the Strategic Mobility,Sweden(SSF,No.SM22-0039)+1 种基金the Swedish Foundation for International Cooperation in Research and Higher Education(STINT,No.IB2022-9228)the Jernkontoret(Sweden)for supporting this clean steel research.Gonghao Lian would like to acknowledge China Scholarship Council(CSC,No.202306080032).
文摘The detection and characterization of non-metallic inclusions are essential for clean steel production.Recently,imaging analysis combined with high-dimensional data processing of metallic materials using artificial intelligence(AI)-based machine learning(ML)has developed rapidly.This technique has achieved impressive results in the field of inclusion classification in process metallurgy.The present study surveys the ML modeling of inclusion prediction in advanced steels,including the detection,classification,and feature prediction of inclusions in different steel grades.Studies on clean steel with different features based on data and image analysis via ML are summarized.Regarding the data analysis,the inclusion prediction methodology based on ML establishes a connection between the experimental parameters and inclusion characteristics and analyzes the importance of the experimental parameters.Regarding the image analysis,the focus is placed on the classification of different types of inclusions via deep learning,in comparison with data analysis.Finally,further development of inclusion analyses using ML-based methods is recommended.This work paves the way for the application of AIbased methodologies for ultraclean-steel studies from a sustainable metallurgy perspective.
基金supported by the National Natural Science Foundation of China(61902095).
文摘Biomedical big data,characterized by its massive scale,multi-dimensionality,and heterogeneity,offers novel perspectives for disease research,elucidates biological principles,and simultaneously prompts changes in related research methodologies.Biomedical ontology,as a shared formal conceptual system,not only offers standardized terms for multi-source biomedical data but also provides a solid data foundation and framework for biomedical research.In this review,we summarize enrichment analysis and deep learning for biomedical ontology based on its structure and semantic annotation properties,highlighting how technological advancements are enabling the more comprehensive use of ontology information.Enrichment analysis represents an important application of ontology to elucidate the potential biological significance for a particular molecular list.Deep learning,on the other hand,represents an increasingly powerful analytical tool that can be more widely combined with ontology for analysis and prediction.With the continuous evolution of big data technologies,the integration of these technologies with biomedical ontologies is opening up exciting new possibilities for advancing biomedical research.
基金supported by the Science and Technology Project of Henan Province(No.222102210081).
文摘Joint Multimodal Aspect-based Sentiment Analysis(JMASA)is a significant task in the research of multimodal fine-grained sentiment analysis,which combines two subtasks:Multimodal Aspect Term Extraction(MATE)and Multimodal Aspect-oriented Sentiment Classification(MASC).Currently,most existing models for JMASA only perform text and image feature encoding from a basic level,but often neglect the in-depth analysis of unimodal intrinsic features,which may lead to the low accuracy of aspect term extraction and the poor ability of sentiment prediction due to the insufficient learning of intra-modal features.Given this problem,we propose a Text-Image Feature Fine-grained Learning(TIFFL)model for JMASA.First,we construct an enhanced adjacency matrix of word dependencies and adopt graph convolutional network to learn the syntactic structure features for text,which addresses the context interference problem of identifying different aspect terms.Then,the adjective-noun pairs extracted from image are introduced to enable the semantic representation of visual features more intuitive,which addresses the ambiguous semantic extraction problem during image feature learning.Thereby,the model performance of aspect term extraction and sentiment polarity prediction can be further optimized and enhanced.Experiments on two Twitter benchmark datasets demonstrate that TIFFL achieves competitive results for JMASA,MATE and MASC,thus validating the effectiveness of our proposed methods.
基金supported by the Deanship of Scientific Research(DSR)at King Abdulaziz University,Jeddah,under grant no.(GPIP:13-612-2024).
文摘App reviews are crucial in influencing user decisions and providing essential feedback for developers to improve their products.Automating the analysis of these reviews is vital for efficient review management.While traditional machine learning(ML)models rely on basic word-based feature extraction,deep learning(DL)methods,enhanced with advanced word embeddings,have shown superior performance.This research introduces a novel aspectbased sentiment analysis(ABSA)framework to classify app reviews based on key non-functional requirements,focusing on usability factors:effectiveness,efficiency,and satisfaction.We propose a hybrid DL model,combining BERT(Bidirectional Encoder Representations from Transformers)with BiLSTM(Bidirectional Long Short-Term Memory)and CNN(Convolutional Neural Networks)layers,to enhance classification accuracy.Comparative analysis against state-of-the-art models demonstrates that our BERT-BiLSTM-CNN model achieves exceptional performance,with precision,recall,F1-score,and accuracy of 96%,87%,91%,and 94%,respectively.Thesignificant contributions of this work include a refined ABSA-based relabeling framework,the development of a highperformance classifier,and the comprehensive relabeling of the Instagram App Reviews dataset.These advancements provide valuable insights for software developers to enhance usability and drive user-centric application development.
基金funding from the National Natural Science Foundation of China (Grant No.42277175)the pilot project of cooperation between the Ministry of Natural Resources and Hunan Province“Research and demonstration of key technologies for comprehensive remote sensing identification of geological hazards in typical regions of Hunan Province” (Grant No.2023ZRBSHZ056)the National Key Research and Development Program of China-2023 Key Special Project (Grant No.2023YFC2907400).
文摘Joint roughness coefficient(JRC)is the most commonly used parameter for quantifying surface roughness of rock discontinuities in practice.The system composed of multiple roughness statistical parameters to measure JRC is a nonlinear system with a lot of overlapping information.In this paper,a dataset of eight roughness statistical parameters covering 112 digital joints is established.Then,the principal component analysis method is introduced to extract the significant information,which solves the information overlap problem of roughness characterization.Based on the two principal components of extracted features,the white shark optimizer algorithm was introduced to optimize the extreme gradient boosting model,and a new machine learning(ML)prediction model was established.The prediction accuracy of the new model and the other 17 models was measured using statistical metrics.The results show that the prediction result of the new model is more consistent with the real JRC value,with higher recognition accuracy and generalization ability.
基金supported by the Deanship of Research and Graduate Studies at King Khalid University under Small Research Project grant number RGP1/139/45.
文摘Integrating multiple medical imaging techniques,including Magnetic Resonance Imaging(MRI),Computed Tomography,Positron Emission Tomography(PET),and ultrasound,provides a comprehensive view of the patient health status.Each of these methods contributes unique diagnostic insights,enhancing the overall assessment of patient condition.Nevertheless,the amalgamation of data from multiple modalities presents difficulties due to disparities in resolution,data collection methods,and noise levels.While traditional models like Convolutional Neural Networks(CNNs)excel in single-modality tasks,they struggle to handle multi-modal complexities,lacking the capacity to model global relationships.This research presents a novel approach for examining multi-modal medical imagery using a transformer-based system.The framework employs self-attention and cross-attention mechanisms to synchronize and integrate features across various modalities.Additionally,it shows resilience to variations in noise and image quality,making it adaptable for real-time clinical use.To address the computational hurdles linked to transformer models,particularly in real-time clinical applications in resource-constrained environments,several optimization techniques have been integrated to boost scalability and efficiency.Initially,a streamlined transformer architecture was adopted to minimize the computational load while maintaining model effectiveness.Methods such as model pruning,quantization,and knowledge distillation have been applied to reduce the parameter count and enhance the inference speed.Furthermore,efficient attention mechanisms such as linear or sparse attention were employed to alleviate the substantial memory and processing requirements of traditional self-attention operations.For further deployment optimization,researchers have implemented hardware-aware acceleration strategies,including the use of TensorRT and ONNX-based model compression,to ensure efficient execution on edge devices.These optimizations allow the approach to function effectively in real-time clinical settings,ensuring viability even in environments with limited resources.Future research directions include integrating non-imaging data to facilitate personalized treatment and enhancing computational efficiency for implementation in resource-limited environments.This study highlights the transformative potential of transformer models in multi-modal medical imaging,offering improvements in diagnostic accuracy and patient care outcomes.
基金National Natural Science Foundation of China under Grant Nos.52208191 and 51908397Shanxi Province Science Foundation for Youths under Grant No.201901D211025China Postdoctoral Science Foundation under Grant No.2020M670695。
文摘Seismic fragility analysis(SFA)is known as an effective probabilistic-based approach used to evaluate seismic fragility.There are various sources of uncertainties associated with this approach.A nuclear power plant(NPP)system is an extremely important infrastructure and contains many structural uncertainties due to construction issues or structural deterioration during service.Simulation of structural uncertainties effects is a costly and time-consuming endeavor.A novel approach to SFA for the NPP considering structural uncertainties based on the damage state is proposed and examined.The results suggest that considering the structural uncertainties is essential in assessing the fragility of the NPP structure,and the impact of structural uncertainties tends to increase with the state of damage.Subsequently,machine learning(ML)is found to be superior in high-precision damage state identification of the NPP for reducing the time of nonlinear time-history analysis(NLTHA)and could be applied in the damage state-based SFA.Also,the impact of various sources of uncertainties is investigated through sensitivity analysis.The Sobol and Shapley additive explanations(SHAP)method can be complementary to each other and able to solve the problem of quantifying seismic and structural uncertainties simultaneously and the interaction effect of each parameter.
基金supported by the“Technology Commercialization Collaboration Platform Construction”project of the Innopolis Foundation(Project Number:2710033536)the Competitive Research Fund of The University of Aizu,Japan.
文摘Sentiment Analysis,a significant domain within Natural Language Processing(NLP),focuses on extracting and interpreting subjective information-such as emotions,opinions,and attitudes-from textual data.With the increasing volume of user-generated content on social media and digital platforms,sentiment analysis has become essential for deriving actionable insights across various sectors.This study presents a systematic literature review of sentiment analysis methodologies,encompassing traditional machine learning algorithms,lexicon-based approaches,and recent advancements in deep learning techniques.The review follows a structured protocol comprising three phases:planning,execution,and analysis/reporting.During the execution phase,67 peer-reviewed articles were initially retrieved,with 25 meeting predefined inclusion and exclusion criteria.The analysis phase involved a detailed examination of each study’s methodology,experimental setup,and key contributions.Among the deep learning models evaluated,Long Short-Term Memory(LSTM)networks were identified as the most frequently adopted architecture for sentiment classification tasks.This review highlights current trends,technical challenges,and emerging opportunities in the field,providing valuable guidance for future research and development in applications such as market analysis,public health monitoring,financial forecasting,and crisis management.
基金supported by the Aeronautical Science Foundation of China(Grant No.20230018072011)。
文摘3-Nitro-1,2,4-triazol-5-one(NTO)is a typical high-energy,low-sensitivity explosive,and accurate concentration monitoring is critical for crystallization process control.In this study,a high-precision quantitative analytical model for NTO concentration in ethanol solutions was developed by integrating real-time ATR-FTIR spectroscopy with chemometric and machine learning techniques.Dynamic spectral data were obtained by designing multi-concentration gradient heating-cooling cycle experiments,abnormal samples were eliminated using the isolation forest algorithm,and the effects of various preprocessing methods on model performance were systematically evaluated.The results show that partial least squares regression(PLSR)exhibits superior generalization ability compared to other models.Vibrational bands corresponding to C=O and–NO_(2)were identified as key predictors for concentration estimation.This work provides an efficient and reliable solution for real-time concentration monitoring during NTO crystallization and holds significant potential for process analytical applications in energetic material manufacturing.
文摘In order to gain insight into the current research status and development trend of problem-based learning(PBL)in colleges and universities,this study employs the bibliometric method to conduct statistical and analytical studies based on the examination of journal papers and review papers within the Web of Science(WOS)database.The objective is to provide a reference point for research in related fields.The findings indicate a sustained expansion in PBL research output at universities,with the United States accounting for most documents in the field,while European research institutions such as Aalborg University and Maastricht University are at the forefront.Nevertheless,the density of collaborative networks between authors is relatively low,and cross-institutional and interdisciplinary collaboration still requires further strengthening.The majority of research results are published in academic journals such as Academic Medicine and the International Journal of Sustainability in Higher Education.Presently,the focal point of PBL research in colleges and universities is undergoing a transition from a“single-discipline focus”to an“interdisciplinary integration.”This integration is profoundly intertwined with the nascent fields of modern educational technology and education for sustainable development,thereby offering a novel avenue for the advancement of pedagogical approaches and educational equity.
基金Supported by Science and Technology Project of Huzhou City,Zhejiang Province,No.2023GY33.
文摘BACKGROUND Colorectal cancer(CRC)is the third-most prevalent cancer and the cancer with the second-highest mortality rate worldwide,representing a high public health burden.Deep learning(DL)offers advantages in the diagnosis,identification,localization,classification and prognosis of CRC patients.However,few bibliometric analyses of research hotspots and trends in the field have been performed.AIM To use bibliometric approaches to analyze and visualize the current research state and development trend of DL in CRC as well as to anticipate future research directions and hotspots.METHODS Datasets were retrieved from the Web of Science Core Collection for the period January 2011 to December 2023.Scimago Graphica(1.0.45),VOSviewer(1.6.20)and CiteSpace(6.3.1)were used to analyze and visualize the nation,institution,journal,author,reference and keyword indicators.Origin(2022)was utilized for plotting,and Excel(2021)was used to construct the tables.RESULTS A total of 1275 publications in 538 journals from 74 countries and 2267 institutions were collected.The number of annual publications has increased over time.China(371,29.1%),the United States(265,20.8%)and Japan(155,12.2%)contributed significantly to the number of articles published,accounting for 62.1%of the total publications.The United States had the strongest ties to other nations.Sun Yat-sen University in China had the highest number of publications(32).The journal with the most publications was Scientific Reports(34,Q2),whereas Gastrointestinal Endoscopy had the most co-citations(1053,Q1).Kather JN,was the author with the most articles(12)and co-citations(287).The most frequently cited reference was Deep Residual Learning for Image Recognition.Keywords were divided into six clusters,with“colorectal cancer”(12.34)having the highest outbreak intensity.CONCLUSION This study highlights the current status and most active directions of the use of DL in CRC.This approach has important applications in the identification,diagnosis,localization,classification and prognosis of the disease and will remain a central focus in the future.
基金Supported by Grant-in-Aid for Research on Hepatitis from the Japan Agency for Medical Research and Development,No.24fk0210128h0002Grant-in-Aid for Scientific Research,No.KAKENHI-23K07372.
文摘BACKGROUND Congestive hepatopathy,also known as nutmeg liver,is liver damage secondary to chronic heart failure(HF).Its morphological characteristics in terms of medical imaging are not defined and remain unclear.AIM To leverage machine learning to capture imaging features of congestive hepatopathy using incidentally acquired computed tomography(CT)scans.METHODS We retrospectively analyzed 179 chronic HF patients who underwent echocardiography and CT within one year.Right HF severity was classified into three grades.Liver CT images at the paraumbilical vein level were used to develop a ResNet-based machine learning model to predict tricuspid regurgitation(TR)severity.Model accuracy was compared with that of six gastroenterology and four radiology experts.RESULTS In the included patients,120 were male(mean age:73.1±14.4 years).The accuracy of the results predicting TR severity from a single CT image for the machine learning model was significantly higher than the average accuracy of the experts.The model was found to be exceptionally reliable for predicting severe TR.CONCLUSION Deep learning models,particularly those using ResNet architectures,can help identify morphological changes associated with TR severity,aiding in early liver dysfunction detection in patients with HF,thereby improving outcomes.
文摘Carbon nanotube-reinforced cement composites have gained significant attention due to their enhanced mechanical properties,particularly in compressive and flexural strength.Despite extensive research,the influence of various parameters on these properties remains inadequately understood,primarily due to the complex interactions within the composites.This study addresses this gap by employingmachine learning techniques to conduct a sensitivity analysis on the compressive and flexural strength of carbon nanotube-reinforced cement composites.It systematically evaluates nine data-preprocessing techniques and benchmarks eleven machine-learning algorithms to reveal tradeoffs between predictive accuracy and computational complexity,which has not previously been explored in carbon nanotube-reinforced cement composite research.In this regard,four main factors are considered in the sensitivity analysis,which are the machine learning model type,the data pre-processing technique,and the effect of the concrete constituent materials on the compressive and flexural strength both globally through feature importance assessment and locally through partial dependence analysis.Accordingly,this research optimizes ninety-nine models representing combinations of eleven machine learning algorithms and nine data preprocessing techniques to accurately predict the mechanical properties of carbon nanotube-reinforced cement composites.Moreover,the study aims to unravel the relationships between different parameters and their impact on the composite’s strength by utilizing feature importance and partial dependence analyses.This research is crucial as it provides a comprehensive understanding of the factors influencing the performance of carbon nanotube-reinforced cement composites,which is vital for their efficient design and application in construction.The use of machine learning in this context not only enhances predictive accuracy but also offers insights that are often challenging to obtain through traditional experimental methods.The findings contribute to the field by highlighting the potential of advanced data-driven approaches in optimizing and understanding advanced composite materials,paving the way for more durable and resilient construction materials.
文摘The authors regret that the original publication of this paper did not include Jawad Fayaz as a co-author.After further discussions and a thorough review of the research contributions,it was agreed that his significant contributions to the foundational aspects of the research warranted recognition,and he has now been added as a co-author.
文摘The prediction of pregnancy-related hazards must be accurate and timely to safeguard mother and fetal health.This study aims to enhance risk prediction in pregnancywith a novel deep learningmodel based on a Long Short-Term Memory(LSTM)generator,designed to capture temporal relationships in cardiotocography(CTG)data.This methodology integrates CTG signals with demographic characteristics and utilizes preprocessing techniques such as noise reduction,normalization,and segmentation to create high-quality input for themodel.It uses convolutional layers to extract spatial information,followed by LSTM layers to model sequences for superior predictive performance.The overall results show that themodel is robust,with an accuracy of 91.5%,precision of 89.8%,recall of 90.4%,and F1-score of 90.1%that outperformed the corresponding baselinemodels,CNN(Convolutional Neural Network)and traditional RNN(Recurrent Neural Network),by 2.3%and 6.1%,respectively.Rather,the ability to detect pregnancy-related abnormalities has considerable therapeutic potential,with the possibility for focused treatments and individualized maternal healthcare approaches,the research team concluded.
基金supported by the National Key Research and Development Program of China(Grant Nos.2023YFC3707900 and 2024YFC3012700)the National Natural Science Foundation of China(Grant No.42230710).
文摘Soil desiccation cracking is ubiquitous in nature and has significantpotential impacts on the engineering geological properties of soils.Previous studies have extensively examined various factors affecting soil cracking behavior through a numerous small-sample experiments.However,experimental studies alone cannot accurately describe soil cracking behavior.In this study,we firstly propose a modeling framework for predicting the surface crack ratio of soil desiccation cracking based on machine learning and interpretable analysis.The framework utilizes 1040 sets of soil cracking experimental data and employs random forest(RF),extreme gradient boosting(XGBoost),and artificialneural network(ANN)models to predict the surface crack ratio of soil desiccation cracking.To clarify the influenceof input features on soil cracking behavior,feature importance and Shapley additive explanations(SHAP)are applied for interpretability analysis.The results reveal that ensemble methods(RF and XGBoost)provide better predictive performance than the deep learning model(ANN).The feature importance analysis shows that soil desiccation cracking is primarily influencedby initial water content,plasticity index,finalwater content,liquid limit,sand content,clay content and thickness.Moreover,SHAP-based interpretability analysis further explores how soil cracking responds to various input variables.This study provides new insight into the evolution of soil cracking behavior,enhancing the understanding of its physical mechanisms and facilitating the assessment of potential regional development of soil desiccation cracking.
基金supported by the National Natural Science Foundation of China(Grant Nos.52090081,52079068)the State Key Laboratory of Hydroscience and Hydraulic Engineering(Grant No.2021-KY-04).
文摘Accurate determination of rock mass parameters is essential for ensuring the accuracy of numericalsimulations. Displacement back-analysis is the most widely used method;however, the reliability of thecurrent approaches remains unsatisfactory. Therefore, in this paper, a multistage rock mass parameterback-analysis method, that considers the construction process and displacement losses is proposed andimplemented through the coupling of numerical simulation, auto-machine learning (AutoML), andmulti-objective optimization algorithms (MOOAs). First, a parametric modeling platform for mechanizedtwin tunnels is developed, generating a dataset through extensive numerical simulations. Next, theAutoML method is utilized to establish a surrogate model linking rock parameters and displacements.The tunnel construction process is divided into multiple stages, transforming the rock mass parameterback-analysis into a multi-objective optimization problem, for which multi-objective optimization algorithmsare introduced to obtain the rock mass parameters. The newly proposed rock mass parameterback-analysis method is validated in a mechanized twin tunnel project, and its accuracy and effectivenessare demonstrated. Compared with traditional single-stage back-analysis methods, the proposedmodel decreases the average absolute percentage error from 12.73% to 4.34%, significantly improving theaccuracy of the back-analysis. Moreover, although the accuracy of back analysis significantly increaseswith the number of construction stages considered, the back analysis time is acceptable. This studyprovides a new method for displacement back analysis that is efficient and accurate, thereby paving theway for precise parameter determination in numerical simulations.
基金supported by the Zhejiang Provincial Natural Science Foundation of China(LZ23F030006)the National Natural Science Foundation of China(62173299,U23B2060)+1 种基金the Joint Fund of Ministry of Education for Pre-Research of Equipment(8091B022147,8091B032234,8091B042220)the Fundamental Research Funds for Xi’an Jiaotong University(xtr072022001).
文摘Dear Editor,This letter introduces a novel approach to address the bearings-only target motion analysis(BO-TMA)problem by incorporating deep reinforcement learning(DRL)techniques.Conventional methods often exhibit biases and struggle to achieve accurate results,especially when confronted with high levels of noise.In this letter,we formulate the BO-TMA problem as a Markov decision process(MDP)and process it within a DRL framework.Simulation results demonstrate that the proposed DRL-based estimator achieves reduced bias and lower errors compared to existing estimators.
文摘Medical image analysis has become a cornerstone of modern healthcare,driven by the exponential growth of data from imaging modalities such as MRI,CT,PET,ultrasound,and X-ray.Traditional machine learning methods have made early contributions;however,recent advancements in deep learning(DL)have revolutionized the field,offering state-of-the-art performance in image classification,segmentation,detection,fusion,registration,and enhancement.This comprehensive review presents an in-depth analysis of deep learning methodologies applied across medical image analysis tasks,highlighting both foundational models and recent innovations.The article begins by introducing conventional techniques and their limitations,setting the stage for DL-based solutions.Core DL architectures,including Convolutional Neural Networks(CNNs),Recurrent Neural Networks(RNNs),Generative Adversarial Networks(GANs),Vision Transformers(ViTs),and hybrid models,are discussed in detail,including their advantages and domain-specific adaptations.Advanced learning paradigms such as semi-supervised learning,selfsupervised learning,and few-shot learning are explored for their potential to mitigate data annotation challenges in clinical datasets.This review further categorizes major tasks in medical image analysis,elaborating on how DL techniques have enabled precise tumor segmentation,lesion detection,modality fusion,super-resolution,and robust classification across diverse clinical settings.Emphasis is placed on applications in oncology,cardiology,neurology,and infectious diseases,including COVID-19.Challenges such as data scarcity,label imbalance,model generalizability,interpretability,and integration into clinical workflows are critically examined.Ethical considerations,explainable AI(XAI),federated learning,and regulatory compliance are discussed as essential components of real-world deployment.Benchmark datasets,evaluation metrics,and comparative performance analyses are presented to support future research.The article concludes with a forward-looking perspective on the role of foundation models,multimodal learning,edge AI,and bio-inspired computing in the future of medical imaging.Overall,this review serves as a valuable resource for researchers,clinicians,and developers aiming to harness deep learning for intelligent,efficient,and clinically viable medical image analysis.
基金supported by the National Natural Science Foundation of China,No.81972073(to HZ)a grant from the Taishan Scholars Program ofShandong Province-Young Taishan Scholars,No.tsqn201909197(to HZ)+1 种基金a grant from Tianjin Key Medical Discipline(Specialty)Construct Project,No.TJYXZDXK-027A(to SF)a grant from Academic Expert International Innovation Summit,No.22JRRCRC00010(to SF).
文摘Ferroptosis,a type of cell death that mainly involves iron metabolism imbalance and lipid peroxidation,is strongly correlated with the phagocytic response caused by bleeding after spinal cord injury.Thus,in this study,bulk RNA sequencing data(GSE47681 and GSE5296)and single-cell RNA sequencing data(GSE162610)were acquired from gene expression databases.We then conducted differential analysis and immune infiltration analysis.Atf3 and Piezo1 were identified as key ferroptosis genes through random forest and least absolute shrinkage and selection operator algorithms.Further analysis of single-cell RNA sequencing data revealed a close relationship between ferroptosis and cell types such as macrophages/microglia and their intrinsic state transition processes.Differences in transcription factor regulation and intercellular communication networks were found in ferroptosis-related cells,confirming the high expression of Atf3 and Piezo1 in these cells.Molecular docking analysis confirmed that the proteins encoded by these genes can bind cycloheximide.In a mouse model of T8 spinal cord injury,low-dose cycloheximide treatment was found to improve neurological function,decrease levels of the pro-inflammatory cytokine inducible nitric oxide synthase,and increase levels of the anti-inflammatory cytokine arginase 1.Correspondingly,the expression of the ferroptosis-related gene Gpx4 increased in macrophages/microglia,while the expression of Acsl4 decreased.Our findings reveal the important role of ferroptosis in the treatment of spinal cord injury,identify the key cell types and genes involved in ferroptosis after spinal cord injury,and validate the efficacy of potential drug therapies,pointing to new directions in the treatment of spinal cord injury.
