Objective To probe into the impacts on the therapeutic effects and endothelin （ET） in multi-infarct dementia （MID） treated with cluster pricking on head points.Methods 60 cases of MID were randomized into acupunct...Objective To probe into the impacts on the therapeutic effects and endothelin （ET） in multi-infarct dementia （MID） treated with cluster pricking on head points.Methods 60 cases of MID were randomized into acupuncture group and western medicine group,treated with cluster pricking on head points and huperzien A tablet respectively.Plasma ET lever,HDS,ADL and CNFDS （clinical neurological functional defect scoring） were determined before treatment,and the statistical analysis showed that there were no significant difference （P〉0.05）.Results In 8-week treatment,ET level in both groups were decreased,but it was decreased much more obviously in acupuncture group,indicating significant difference in the statistical comparison （P〈0.05）.The scores of HDS and ADL were all up in acupuncture and western medicine groups,but the significant statistical difference was obtained in the comparison between acupuncture group and western medicine group （P〈0.05）.In acupuncture group,the result of CNFDS was much down comparing with that before the treatment,indicating significant difference （P〈0.05）;but in western medicine group,there was no significant difference in CNFDS before and after treatment （P〉0.05）,suggesting that acupuncture reduces CNFDS of MID patient,neither for western medicine.Conclusion Cluster pricking on head points improves the intelligence of MID patient,reduces ET level and grades up HDS and ADL,moreover,it reduces CNFDS of MID patients and releases the symptoms.展开更多
Forty patients with multi-infarct dementia (MID) were randomly assigned to the treatment group (25 cases) treated with Jian Nao Ning (健脑宁JNN) and the duxil control group (15 cases). Memory function were assessed at...Forty patients with multi-infarct dementia (MID) were randomly assigned to the treatment group (25 cases) treated with Jian Nao Ning (健脑宁JNN) and the duxil control group (15 cases). Memory function were assessed at baseline and endpoint using memory subscales of a battery of New Psychometric Tests (Chinese version) including mini-mental state examination (MMSE), verbal memory, and non-verbal memory, etc. After treatment, the mean scores of verbal memory in the Hopkins Verbal Learning Test (P<0.05) and total memory scores of memory items (P<0.001) in JNN group increased significantly; and improvement in episodic memory function including story recall (immediate and delayed), delayed word recall, verbal learning and verbal recognition and visual recognition in the JNN group was better than that in the duxil control group, suggesting that JNN can obviously improve memory function for the patients with mild or moderate multi-infarct dementia.展开更多
目的探讨一站式多模态CT检查在不明时间窗急性脑梗死患者溶栓治疗中的应用效果。方法选取2023年1月~2024年6月在我院就诊的60例急性脑梗死患者作为研究对象,根据溶栓治疗时间窗是否明确,分为时间窗不明确者40例和时间窗<4.5 h 20例...目的探讨一站式多模态CT检查在不明时间窗急性脑梗死患者溶栓治疗中的应用效果。方法选取2023年1月~2024年6月在我院就诊的60例急性脑梗死患者作为研究对象,根据溶栓治疗时间窗是否明确,分为时间窗不明确者40例和时间窗<4.5 h 20例。其中,时间窗不明确且经一站式多模态CT检查显示存在缺血半暗带的患者,行重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓治疗,并纳入溶栓组(n=20),将CT血管造影(CTA)检查显示侧支循环良好[Alberta卒中项目早期CT评分(ASPECTS评分)>3]的患者纳入溶栓A组(n=12),CTA检查侧支循环不良(ASPECTS评分≤3)的患者纳入溶栓B组(n=8);时间窗不明确经一站式多模态CT检查不存在缺血半暗带的患者,进行常规药物保守治疗,并纳入保守治疗组(n=20);将时间窗<4.5 h的患者纳入对照组(n=20)并直接行溶栓治疗。比较四组美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin量表(mRS)评分、治疗有效率、预后良好率以及不良反应发生情况。结果治疗后24 h、7 d、14 d,溶栓A组的NIHSS评分均低于溶栓B组、保守治疗组和对照组(P<0.05);治疗后90 d,溶栓A组的mRS评分低于溶栓B组、保守治疗组和对照组(P<0.05);溶栓A组的治疗有效率高于溶栓B组、保守治疗组和对照组(P<0.05);溶栓A组的预后良好率高于溶栓B组、保守治疗组和对照组(P<0.05);四组不良反应发生情况比较,差异无统计学意义(P>0.05)。结论一站式多模态CT指导下溶栓治疗对急性脑梗死患者的效果显著,可改善神经功能,预后与安全性较好。展开更多
文摘Objective To probe into the impacts on the therapeutic effects and endothelin （ET） in multi-infarct dementia （MID） treated with cluster pricking on head points.Methods 60 cases of MID were randomized into acupuncture group and western medicine group,treated with cluster pricking on head points and huperzien A tablet respectively.Plasma ET lever,HDS,ADL and CNFDS （clinical neurological functional defect scoring） were determined before treatment,and the statistical analysis showed that there were no significant difference （P〉0.05）.Results In 8-week treatment,ET level in both groups were decreased,but it was decreased much more obviously in acupuncture group,indicating significant difference in the statistical comparison （P〈0.05）.The scores of HDS and ADL were all up in acupuncture and western medicine groups,but the significant statistical difference was obtained in the comparison between acupuncture group and western medicine group （P〈0.05）.In acupuncture group,the result of CNFDS was much down comparing with that before the treatment,indicating significant difference （P〈0.05）;but in western medicine group,there was no significant difference in CNFDS before and after treatment （P〉0.05）,suggesting that acupuncture reduces CNFDS of MID patient,neither for western medicine.Conclusion Cluster pricking on head points improves the intelligence of MID patient,reduces ET level and grades up HDS and ADL,moreover,it reduces CNFDS of MID patients and releases the symptoms.
文摘Forty patients with multi-infarct dementia (MID) were randomly assigned to the treatment group (25 cases) treated with Jian Nao Ning (健脑宁JNN) and the duxil control group (15 cases). Memory function were assessed at baseline and endpoint using memory subscales of a battery of New Psychometric Tests (Chinese version) including mini-mental state examination (MMSE), verbal memory, and non-verbal memory, etc. After treatment, the mean scores of verbal memory in the Hopkins Verbal Learning Test (P<0.05) and total memory scores of memory items (P<0.001) in JNN group increased significantly; and improvement in episodic memory function including story recall (immediate and delayed), delayed word recall, verbal learning and verbal recognition and visual recognition in the JNN group was better than that in the duxil control group, suggesting that JNN can obviously improve memory function for the patients with mild or moderate multi-infarct dementia.
