The naturally fermented Inner Mongolian cheese’s flavor and nutritional value make it a popular choice among customers.In this work,to create multi-functional peptides that have taste and biological activity,peptidom...The naturally fermented Inner Mongolian cheese’s flavor and nutritional value make it a popular choice among customers.In this work,to create multi-functional peptides that have taste and biological activity,peptidomics and bioinformatics were used to screen flavor peptides from Inner Mongolian cheese and further assess their antioxidant and angiotensin I-converting enzyme(ACE)inhibitory properties.According to sensory data,YH8 and IL7 had detectable bitter tastes with low thresholds of 0.03 and 0.06 mmol/L,respectively.With an umami threshold range of 0.24‒0.81 mmol/L,VQ6,FK13,HP13 and QT14 exhibited a range of flavors dominated by umami,including sweet,bitter,salty,sour and kokumi.Antioxidant activity wise,YH8,VQ6,HP13 and QT14 were well represented.The above-mentioned peptides all had some ACE inhibitory effect.The bitter peptide IL7(IC_(50)=0.08 mmol/L)had the highest level of ACE inhibitory activity,followed by YH8(IC_(50)=0.33 mmol/L).These multi-functional peptides,which have been assessed for bioactive and taste features in Inner Mongolian cheese,may have positive impacts on health and harmonize the cheese’s overall flavor.These results suggest that some flavor peptides produced in fermented foods might be with bioactivities while providing a basis for the exploration and application of multi-functional peptides.展开更多
Figure 6(a)in the paper[Chin.Phys.B 33074203(2024)]was incorrect due to editorial oversight.The correct figure is provided.This modification does not affect the result presented in the paper.
Photonic spin Hall effect(PSHE), as a novel physical effect in light–matter interaction, provides an effective metrological method for characterizing the tiny variation in refractive index(RI). In this work, we propo...Photonic spin Hall effect(PSHE), as a novel physical effect in light–matter interaction, provides an effective metrological method for characterizing the tiny variation in refractive index(RI). In this work, we propose a multi-functional PSHE sensor based on VO_(2), a material that can reveal the phase transition behavior. By applying thermal control, the mutual transformation into different phase states of VO_(2) can be realized, which contributes to the flexible switching between multiple RI sensing tasks. When VO_(2) is insulating, the ultrasensitive detection of glucose concentrations in human blood is achieved. When VO_(2) is in a mixed phase, the structure can be designed to distinguish between the normal cells and cancer cells through no-label and real-time monitoring. When VO_(2) is metallic, the proposed PSHE sensor can act as an RI indicator for gas analytes. Compared with other multi-functional sensing devices with the complex structures, our design consists of only one analyte and two VO_(2) layers, which is very simple and elegant. Therefore, the proposed VO_(2)-based PSHE sensor has outstanding advantages such as small size, high sensitivity, no-label, and real-time detection, providing a new approach for investigating tunable multi-functional sensors.展开更多
腺病毒(Adenovirus,Ad)是一类无包膜的双链DNA病毒,能广泛感染脊椎动物,导致从轻症到严重的感染。腺病毒通过其纤突蛋白与宿主细胞表面受体结合,柯萨奇-腺病毒受体(Coxsackievirus and adenovirus receptor,CAR)是主要的介导者。CAR是...腺病毒(Adenovirus,Ad)是一类无包膜的双链DNA病毒,能广泛感染脊椎动物,导致从轻症到严重的感染。腺病毒通过其纤突蛋白与宿主细胞表面受体结合,柯萨奇-腺病毒受体(Coxsackievirus and adenovirus receptor,CAR)是主要的介导者。CAR是一种高度保守的跨膜蛋白,在多种脊椎动物中发挥关键作用。文章聚焦于CAR的生物学功能和结构特征,探讨其在腺病毒感染机制中的核心作用;重点分析了CAR与人腺病毒、禽腺病毒及其他物种腺病毒的相互作用及功能差异,揭示腺病毒与宿主受体结合的多样性和复杂性。此外,文章讨论了CAR在基因治疗中的应用前景,特别是利用CAR介导的腺病毒载体递送抗癌基因和免疫调节基因的研究进展。同时,调控CAR表达水平及阻断其与病毒结合的策略被认为是优化腺病毒治疗的重要方向。文章通过总结现有研究成果,深化了对腺病毒感染机制的认识,并为基因治疗及相关疾病的治疗策略提供了重要的理论依据和实践参考。展开更多
基金supported by the central government and guides local funds for science and technology development(2022ZY0109).
文摘The naturally fermented Inner Mongolian cheese’s flavor and nutritional value make it a popular choice among customers.In this work,to create multi-functional peptides that have taste and biological activity,peptidomics and bioinformatics were used to screen flavor peptides from Inner Mongolian cheese and further assess their antioxidant and angiotensin I-converting enzyme(ACE)inhibitory properties.According to sensory data,YH8 and IL7 had detectable bitter tastes with low thresholds of 0.03 and 0.06 mmol/L,respectively.With an umami threshold range of 0.24‒0.81 mmol/L,VQ6,FK13,HP13 and QT14 exhibited a range of flavors dominated by umami,including sweet,bitter,salty,sour and kokumi.Antioxidant activity wise,YH8,VQ6,HP13 and QT14 were well represented.The above-mentioned peptides all had some ACE inhibitory effect.The bitter peptide IL7(IC_(50)=0.08 mmol/L)had the highest level of ACE inhibitory activity,followed by YH8(IC_(50)=0.33 mmol/L).These multi-functional peptides,which have been assessed for bioactive and taste features in Inner Mongolian cheese,may have positive impacts on health and harmonize the cheese’s overall flavor.These results suggest that some flavor peptides produced in fermented foods might be with bioactivities while providing a basis for the exploration and application of multi-functional peptides.
文摘Figure 6(a)in the paper[Chin.Phys.B 33074203(2024)]was incorrect due to editorial oversight.The correct figure is provided.This modification does not affect the result presented in the paper.
基金Project supported by the National Natural Science Foundation of China(Grant No.NSFC 12175107)the Natural Science Foundation of Nanjing Vocational University of Industry Technology,China(Grant No.YK22-02-08)+3 种基金the Qing Lan Project of Jiangsu Province,Chinathe Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(Grant No.KYCX23_0964)the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20230347)the Fund from the Research Center of Industrial Perception and Intelligent Manufacturing Equipment Engineering of Jiangsu Province,China(Grant No.ZK21-05-09)。
文摘Photonic spin Hall effect(PSHE), as a novel physical effect in light–matter interaction, provides an effective metrological method for characterizing the tiny variation in refractive index(RI). In this work, we propose a multi-functional PSHE sensor based on VO_(2), a material that can reveal the phase transition behavior. By applying thermal control, the mutual transformation into different phase states of VO_(2) can be realized, which contributes to the flexible switching between multiple RI sensing tasks. When VO_(2) is insulating, the ultrasensitive detection of glucose concentrations in human blood is achieved. When VO_(2) is in a mixed phase, the structure can be designed to distinguish between the normal cells and cancer cells through no-label and real-time monitoring. When VO_(2) is metallic, the proposed PSHE sensor can act as an RI indicator for gas analytes. Compared with other multi-functional sensing devices with the complex structures, our design consists of only one analyte and two VO_(2) layers, which is very simple and elegant. Therefore, the proposed VO_(2)-based PSHE sensor has outstanding advantages such as small size, high sensitivity, no-label, and real-time detection, providing a new approach for investigating tunable multi-functional sensors.
文摘腺病毒(Adenovirus,Ad)是一类无包膜的双链DNA病毒,能广泛感染脊椎动物,导致从轻症到严重的感染。腺病毒通过其纤突蛋白与宿主细胞表面受体结合,柯萨奇-腺病毒受体(Coxsackievirus and adenovirus receptor,CAR)是主要的介导者。CAR是一种高度保守的跨膜蛋白,在多种脊椎动物中发挥关键作用。文章聚焦于CAR的生物学功能和结构特征,探讨其在腺病毒感染机制中的核心作用;重点分析了CAR与人腺病毒、禽腺病毒及其他物种腺病毒的相互作用及功能差异,揭示腺病毒与宿主受体结合的多样性和复杂性。此外,文章讨论了CAR在基因治疗中的应用前景,特别是利用CAR介导的腺病毒载体递送抗癌基因和免疫调节基因的研究进展。同时,调控CAR表达水平及阻断其与病毒结合的策略被认为是优化腺病毒治疗的重要方向。文章通过总结现有研究成果,深化了对腺病毒感染机制的认识,并为基因治疗及相关疾病的治疗策略提供了重要的理论依据和实践参考。
