BACKGROUND R2^(*)estimation reflects the paramagnetism of the tumor tissue,which may be used to differentiate between benign and malignant liver lesions when contrast agents are contraindicated.AIM To investigate whet...BACKGROUND R2^(*)estimation reflects the paramagnetism of the tumor tissue,which may be used to differentiate between benign and malignant liver lesions when contrast agents are contraindicated.AIM To investigate whether R2^(*)derived from multi-echo Dixon imaging can aid differentiating benign from malignant focal liver lesions(FLLs)and the impact of 2D region of interest(2D-ROI)and volume of interest(VOI)on the outcomes.METHODS We retrospectively enrolled 73 patients with 108 benign or malignant FLLs.All patients underwent conventional abdominal magnetic resonance imaging and multi-echo Dixon imaging.Two radiologists independently measured the mean R2^(*)values of lesions using 2D-ROI and VOI approaches.The Bland-Altman plot was used to determine the interobserver agreement between R2^(*)measurements.Intraclass correlation coefficient(ICC)was used to determine the reliability between the two readers.Mean R2^(*)values were compared between benign and malignant FFLs using the nonparametric Mann-Whitney test.Receiver operating characteristic curve analysis was used to determine the diagnostic performance of R2^(*)in differentiation between benign and malignant FFLs.We compared the diagnostic performance of R2^(*)measured by 2D-ROI and VOI approaches.RESULTS This study included 30 benign and 78 malignant FLLs.The interobserver reproducibility of R2^(*)measurements was excellent for the 2D-ROI(ICC=0.994)and VOI(ICC=0.998)methods.Bland-Altman analysis also demonstrated excellent agreement.Mean R2^(*)was significantly higher for malignant than benign FFLs as measured by 2D-ROI(P<0.001)and VOI(P<0.001).The area under the curve(AUC)of R2^(*)measured by 2D-ROI was 0.884 at a cut-off of 25.2/s,with a sensitivity of 84.6%and specificity of 80.0%for differentiating benign from malignant FFLs.R2^(*)measured by VOI yielded an AUC of 0.875 at a cut-off of 26.7/s in distinguishing benign from malignant FFLs,with a sensitivity of 85.9%and specificity of 76.7%.The AUCs of R2^(*)were not significantly different between the 2D-ROI and VOI methods.CONCLUSION R2^(*)derived from multi-echo Dixon imaging whether by 2D-ROI or VOI can aid in differentiation between benign and malignant FLLs.展开更多
目的:探讨3.0 T MRI三维多回波恢复梯度回波序列(3D_MERGE)与肩关节常规序列肩袖图像质量间的差异。方法:2019年6月至2019年8月于昆山市中医医院招募40名健康志愿者完成肩关节MRI常规序列及3D_MERGE序列成像。3D_MERGE序列于冠状位采集...目的:探讨3.0 T MRI三维多回波恢复梯度回波序列(3D_MERGE)与肩关节常规序列肩袖图像质量间的差异。方法:2019年6月至2019年8月于昆山市中医医院招募40名健康志愿者完成肩关节MRI常规序列及3D_MERGE序列成像。3D_MERGE序列于冠状位采集并作与常规序列同扫描方位(轴位、斜冠位、斜矢位)和肩袖肌腱长轴位的后处理重建。两观察者分别对两种序列所获图像进行图像质量主观评分;比较各年龄组两观察者对两种序列图像质量的主观评分间的差异和两观察者图像质量主观评分间的一致性。分析两种序列图像质量主观评分均值间的差异;分析3D_MERGE序列图像在肩袖各组成肌腱[冈上肌肌腱(SST)、冈下肌肌腱(IST)、肩胛下肌肌腱(SCT)和小圆肌肌腱(TMT)]图像质量主观评分均值间的差异。图像质量的客观评价以SST为参考,计算信噪比(SNR)和对比噪声比(CNR)并进行比较分析。结果:(1)两观察者对3D_MERGE序列和常规序列图像质量主观评分在各年龄组间差异均无统计学意义(t=-0.894~0.284,均P>0.05);(2)两观察者一致性比较:3D_MERGE序列和常规序列一致性均强(κ值均>0.80,均P<0.05);(3)3D_MERGE序列图像质量主观评分的均值均高于常规序列(均P<0.05);(4)3D_MERGE序列肩袖图像质量主观评分比较:(1)SST,长轴位和斜冠位高于轴位和斜矢位(均P<0.05);(2)IST,斜矢位高于轴位和斜冠位(均P<0.05);(3)SCT,长轴位、斜矢位和轴位均高于斜冠位(均P<0.05);(4)TMT,长轴位、斜矢位、轴位和斜冠位间差异无统计学意义(P=0.140);(5)3D_MERGE序列肩袖肌腱SNR及相关CNR均高于常规序列的对应值(均P<0.05)。结论:3D_MERGE序列肩袖图像质量评价在两观察者间的一致性强,主、客观图像质量均优于常规序列,可用于肩袖MR成像。展开更多
文摘BACKGROUND R2^(*)estimation reflects the paramagnetism of the tumor tissue,which may be used to differentiate between benign and malignant liver lesions when contrast agents are contraindicated.AIM To investigate whether R2^(*)derived from multi-echo Dixon imaging can aid differentiating benign from malignant focal liver lesions(FLLs)and the impact of 2D region of interest(2D-ROI)and volume of interest(VOI)on the outcomes.METHODS We retrospectively enrolled 73 patients with 108 benign or malignant FLLs.All patients underwent conventional abdominal magnetic resonance imaging and multi-echo Dixon imaging.Two radiologists independently measured the mean R2^(*)values of lesions using 2D-ROI and VOI approaches.The Bland-Altman plot was used to determine the interobserver agreement between R2^(*)measurements.Intraclass correlation coefficient(ICC)was used to determine the reliability between the two readers.Mean R2^(*)values were compared between benign and malignant FFLs using the nonparametric Mann-Whitney test.Receiver operating characteristic curve analysis was used to determine the diagnostic performance of R2^(*)in differentiation between benign and malignant FFLs.We compared the diagnostic performance of R2^(*)measured by 2D-ROI and VOI approaches.RESULTS This study included 30 benign and 78 malignant FLLs.The interobserver reproducibility of R2^(*)measurements was excellent for the 2D-ROI(ICC=0.994)and VOI(ICC=0.998)methods.Bland-Altman analysis also demonstrated excellent agreement.Mean R2^(*)was significantly higher for malignant than benign FFLs as measured by 2D-ROI(P<0.001)and VOI(P<0.001).The area under the curve(AUC)of R2^(*)measured by 2D-ROI was 0.884 at a cut-off of 25.2/s,with a sensitivity of 84.6%and specificity of 80.0%for differentiating benign from malignant FFLs.R2^(*)measured by VOI yielded an AUC of 0.875 at a cut-off of 26.7/s in distinguishing benign from malignant FFLs,with a sensitivity of 85.9%and specificity of 76.7%.The AUCs of R2^(*)were not significantly different between the 2D-ROI and VOI methods.CONCLUSION R2^(*)derived from multi-echo Dixon imaging whether by 2D-ROI or VOI can aid in differentiation between benign and malignant FLLs.
文摘目的:探讨3.0 T MRI三维多回波恢复梯度回波序列(3D_MERGE)与肩关节常规序列肩袖图像质量间的差异。方法:2019年6月至2019年8月于昆山市中医医院招募40名健康志愿者完成肩关节MRI常规序列及3D_MERGE序列成像。3D_MERGE序列于冠状位采集并作与常规序列同扫描方位(轴位、斜冠位、斜矢位)和肩袖肌腱长轴位的后处理重建。两观察者分别对两种序列所获图像进行图像质量主观评分;比较各年龄组两观察者对两种序列图像质量的主观评分间的差异和两观察者图像质量主观评分间的一致性。分析两种序列图像质量主观评分均值间的差异;分析3D_MERGE序列图像在肩袖各组成肌腱[冈上肌肌腱(SST)、冈下肌肌腱(IST)、肩胛下肌肌腱(SCT)和小圆肌肌腱(TMT)]图像质量主观评分均值间的差异。图像质量的客观评价以SST为参考,计算信噪比(SNR)和对比噪声比(CNR)并进行比较分析。结果:(1)两观察者对3D_MERGE序列和常规序列图像质量主观评分在各年龄组间差异均无统计学意义(t=-0.894~0.284,均P>0.05);(2)两观察者一致性比较:3D_MERGE序列和常规序列一致性均强(κ值均>0.80,均P<0.05);(3)3D_MERGE序列图像质量主观评分的均值均高于常规序列(均P<0.05);(4)3D_MERGE序列肩袖图像质量主观评分比较:(1)SST,长轴位和斜冠位高于轴位和斜矢位(均P<0.05);(2)IST,斜矢位高于轴位和斜冠位(均P<0.05);(3)SCT,长轴位、斜矢位和轴位均高于斜冠位(均P<0.05);(4)TMT,长轴位、斜矢位、轴位和斜冠位间差异无统计学意义(P=0.140);(5)3D_MERGE序列肩袖肌腱SNR及相关CNR均高于常规序列的对应值(均P<0.05)。结论:3D_MERGE序列肩袖图像质量评价在两观察者间的一致性强,主、客观图像质量均优于常规序列,可用于肩袖MR成像。
