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Using AdaBoost Meta-Learning Algorithm for Medical News Multi-Document Summarization 被引量:1
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作者 Mahdi Gholami Mehr 《Intelligent Information Management》 2013年第6期182-190,共9页
Automatic text summarization involves reducing a text document or a larger corpus of multiple documents to a short set of sentences or paragraphs that convey the main meaning of the text. In this paper, we discuss abo... Automatic text summarization involves reducing a text document or a larger corpus of multiple documents to a short set of sentences or paragraphs that convey the main meaning of the text. In this paper, we discuss about multi-document summarization that differs from the single one in which the issues of compression, speed, redundancy and passage selection are critical in the formation of useful summaries. Since the number and variety of online medical news make them difficult for experts in the medical field to read all of the medical news, an automatic multi-document summarization can be useful for easy study of information on the web. Hence we propose a new approach based on machine learning meta-learner algorithm called AdaBoost that is used for summarization. We treat a document as a set of sentences, and the learning algorithm must learn to classify as positive or negative examples of sentences based on the score of the sentences. For this learning task, we apply AdaBoost meta-learning algorithm where a C4.5 decision tree has been chosen as the base learner. In our experiment, we use 450 pieces of news that are downloaded from different medical websites. Then we compare our results with some existing approaches. 展开更多
关键词 multi-document SUMMARIZATION Machine Learning Decision Trees ADABOOST C4.5 MEDICAL Document SUMMARIZATION
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Density peaks clustering based integrate framework for multi-document summarization 被引量:3
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作者 BaoyanWang Jian Zhang +1 位作者 Yi Liu Yuexian Zou 《CAAI Transactions on Intelligence Technology》 2017年第1期26-30,共5页
We present a novel unsupervised integrated score framework to generate generic extractive multi- document summaries by ranking sentences based on dynamic programming (DP) strategy. Considering that cluster-based met... We present a novel unsupervised integrated score framework to generate generic extractive multi- document summaries by ranking sentences based on dynamic programming (DP) strategy. Considering that cluster-based methods proposed by other researchers tend to ignore informativeness of words when they generate summaries, our proposed framework takes relevance, diversity, informativeness and length constraint of sentences into consideration comprehensively. We apply Density Peaks Clustering (DPC) to get relevance scores and diversity scores of sentences simultaneously. Our framework produces the best performance on DUC2004, 0.396 of ROUGE-1 score, 0.094 of ROUGE-2 score and 0.143 of ROUGE-SU4 which outperforms a series of popular baselines, such as DUC Best, FGB [7], and BSTM [10]. 展开更多
关键词 multi-document summarization Integrated score framework Density peaks clustering Sentences rank
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Constructing a taxonomy to support multi-document summarization of dissertation abstracts
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作者 KHOO Christopher S.G. GOH Dion H. 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2005年第11期1258-1267,共10页
This paper reports part of a study to develop a method for automatic multi-document summarization. The current focus is on dissertation abstracts in the field of sociology. The summarization method uses macro-level an... This paper reports part of a study to develop a method for automatic multi-document summarization. The current focus is on dissertation abstracts in the field of sociology. The summarization method uses macro-level and micro-level discourse structure to identify important information that can be extracted from dissertation abstracts, and then uses a variable-based framework to integrate and organize extracted information across dissertation abstracts. This framework focuses more on research concepts and their research relationships found in sociology dissertation abstracts and has a hierarchical structure. A taxonomy is constructed to support the summarization process in two ways: (1) helping to identify important concepts and relations expressed in the text, and (2) providing a structure for linking similar concepts in different abstracts. This paper describes the variable-based framework and the summarization process, and then reports the construction of the taxonomy for supporting the summarization process. An example is provided to show how to use the constructed taxonomy to identify important concepts and integrate the concepts extracted from different abstracts. 展开更多
关键词 Text summarization Automatic multi-document summarization Variable-based framework Digital library
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Automatic Multi-Document Summarization Based on Keyword Density and Sentence-Word Graphs
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作者 YE Feiyue XU Xinchen 《Journal of Shanghai Jiaotong university(Science)》 EI 2018年第4期584-592,共9页
As a fundamental and effective tool for document understanding and organization, multi-document summarization enables better information services by creating concise and informative reports for large collections of do... As a fundamental and effective tool for document understanding and organization, multi-document summarization enables better information services by creating concise and informative reports for large collections of documents. In this paper, we propose a sentence-word two layer graph algorithm combining with keyword density to generate the multi-document summarization, known as Graph & Keywordp. The traditional graph methods of multi-document summarization only consider the influence of sentence and word in all documents rather than individual documents. Therefore, we construct multiple word graph and extract right keywords in each document to modify the sentence graph and to improve the significance and richness of the summary. Meanwhile, because of the differences in the words importance in documents, we propose to use keyword density for the summaries to provide rich content while using a small number of words. The experiment results show that the Graph & Keywordp method outperforms the state of the art systems when tested on the Duc2004 data set. Key words: multi-document, graph algorithm, keyword density, Graph & Keywordp, Due2004 展开更多
关键词 multi-document graph algorithm keyword density Graph & Keywordρ Duc2004
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Unsupervised Graph-Based Tibetan Multi-Document Summarization
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作者 Xiaodong Yan Yiqin Wang +3 位作者 Wei Song Xiaobing Zhao A.Run Yang Yanxing 《Computers, Materials & Continua》 SCIE EI 2022年第10期1769-1781,共13页
Text summarization creates subset that represents the most important or relevant information in the original content,which effectively reduce information redundancy.Recently neural network method has achieved good res... Text summarization creates subset that represents the most important or relevant information in the original content,which effectively reduce information redundancy.Recently neural network method has achieved good results in the task of text summarization both in Chinese and English,but the research of text summarization in low-resource languages is still in the exploratory stage,especially in Tibetan.What’s more,there is no large-scale annotated corpus for text summarization.The lack of dataset severely limits the development of low-resource text summarization.In this case,unsupervised learning approaches are more appealing in low-resource languages as they do not require labeled data.In this paper,we propose an unsupervised graph-based Tibetan multi-document summarization method,which divides a large number of Tibetan news documents into topics and extracts the summarization of each topic.Summarization obtained by using traditional graph-based methods have high redundancy and the division of documents topics are not detailed enough.In terms of topic division,we adopt two level clustering methods converting original document into document-level and sentence-level graph,next we take both linguistic and deep representation into account and integrate external corpus into graph to obtain the sentence semantic clustering.Improve the shortcomings of the traditional K-Means clustering method and perform more detailed clustering of documents.Then model sentence clusters into graphs,finally remeasure sentence nodes based on the topic semantic information and the impact of topic features on sentences,higher topic relevance summary is extracted.In order to promote the development of Tibetan text summarization,and to meet the needs of relevant researchers for high-quality Tibetan text summarization datasets,this paper manually constructs a Tibetan summarization dataset and carries out relevant experiments.The experiment results show that our method can effectively improve the quality of summarization and our method is competitive to previous unsupervised methods. 展开更多
关键词 multi-document summarization text clustering topic feature fusion graphic model
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TWO-STAGE SENTENCE SELECTION APPROACH FOR MULTI-DOCUMENT SUMMARIZATION
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作者 Zhang Shu Zhao Tiejun Zheng Dequan Zhao Hua 《Journal of Electronics(China)》 2008年第4期562-567,共6页
Compared with the traditional method of adding sentences to get summary in multi-document summarization,a two-stage sentence selection approach based on deleting sentences in acandidate sentence set to generate summar... Compared with the traditional method of adding sentences to get summary in multi-document summarization,a two-stage sentence selection approach based on deleting sentences in acandidate sentence set to generate summary is proposed,which has two stages,the acquisition of acandidate sentence set and the optimum selection of sentence.At the first stage,the candidate sentenceset is obtained by redundancy-based sentence selection approach.At the second stage,optimum se-lection of sentences is proposed to delete sentences in the candidate sentence set according to itscontribution to the whole set until getting the appointed summary length.With a test corpus,theROUGE value of summaries gotten by the proposed approach proves its validity,compared with thetraditional method of sentence selection.The influence of the token chosen in the two-stage sentenceselection approach on the quality of the generated summaries is analyzed. 展开更多
关键词 TWO-STAGE Sentence selection approach multi-document summarization
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Research on multi-document summarization based on latent semantic indexing
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作者 秦兵 刘挺 +1 位作者 张宇 李生 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2005年第1期91-94,共4页
A multi-document summarization method based on Latent Semantic Indexing (LSI) is proposed. The method combines several reports on the same issue into a matrix of terms and sentences, and uses a Singular Value Decompos... A multi-document summarization method based on Latent Semantic Indexing (LSI) is proposed. The method combines several reports on the same issue into a matrix of terms and sentences, and uses a Singular Value Decomposition (SVD) to reduce the dimension of the matrix and extract features, and then the sentence similarity is computed. The sentences are clustered according to similarity of sentences. The centroid sentences are selected from each class. Finally, the selected sentences are ordered to generate the summarization. The evaluation and results are presented, which prove that the proposed methods are efficient. 展开更多
关键词 multi-document summarization LSI (latent semantic indexing) CLUSTERING
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Multi-Document Summarization Model Based on Integer Linear Programming
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作者 Rasim Alguliev Ramiz Aliguliyev Makrufa Hajirahimova 《Intelligent Control and Automation》 2010年第2期105-111,共7页
This paper proposes an extractive generic text summarization model that generates summaries by selecting sentences according to their scores. Sentence scores are calculated using their extensive coverage of the main c... This paper proposes an extractive generic text summarization model that generates summaries by selecting sentences according to their scores. Sentence scores are calculated using their extensive coverage of the main content of the text, and summaries are created by extracting the highest scored sentences from the original document. The model formalized as a multiobjective integer programming problem. An advantage of this model is that it can cover the main content of source (s) and provide less redundancy in the generated sum- maries. To extract sentences which form a summary with an extensive coverage of the main content of the text and less redundancy, have been used the similarity of sentences to the original document and the similarity between sentences. Performance evaluation is conducted by comparing summarization outputs with manual summaries of DUC2004 dataset. Experiments showed that the proposed approach outperforms the related methods. 展开更多
关键词 multi-document SUMMARIZATION Content COVERAGE LESS REDUNDANCY INTEGER Linear Programming
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Evidence Summary for Discharge Preparation Services in Patients After Total Knee Arthroplasty
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作者 Jiapei Li Jiuqun Li Jinli Wang 《Journal of Clinical and Nursing Research》 2026年第1期96-107,共12页
Objective:To systematically summarize and evaluate the evidence on discharge preparation services for patients undergoing total knee arthroplasty,providing an evidence-based foundation for developing scientific and st... Objective:To systematically summarize and evaluate the evidence on discharge preparation services for patients undergoing total knee arthroplasty,providing an evidence-based foundation for developing scientific and standardized discharge preparation intervention programs in clinical practice.Methods:Following the“5S”evidence model,literature such as guidelines,expert consensuses,evidence summaries and randomized controlled trials related to discharge preparation services for total knee arthroplasty patients were retrieved from relevant websites and databases,both domestic and international,from database inception to August 31,2025.Two researchers independently screened the literature,conducted quality appraisals,and extracted and synthesized the evidence.Results:A total of 15 articles were included,comprising 3 guidelines,4 expert consensuses,3 evidence summaries,3 systematic reviews and 2 randomized controlled trials.Ultimately,23 pieces of evidence were summarized across five aspects.Conclusion:This study synthesizes the evidence on discharge preparation services for patients undergoing total knee arthroplasty.It is recommended that healthcare professionals apply this evidence in clinical practice,considering specific circumstances and patient needs. 展开更多
关键词 Total knee arthroplasty Discharge preparation service Evidence summary Evidence-based nursing REHABILITATION
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Chinese multi-document personal name disambiguation 被引量:8
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作者 Wang Houfeng(王厚峰) Mei Zheng 《High Technology Letters》 EI CAS 2005年第3期280-283,共4页
This paper presents a new approach to determining whether an interested personal name across doeuments refers to the same entity. Firstly,three vectors for each text are formed: the personal name Boolean vectors deno... This paper presents a new approach to determining whether an interested personal name across doeuments refers to the same entity. Firstly,three vectors for each text are formed: the personal name Boolean vectors denoting whether a personal name occurs the text the biographical word Boolean vector representing title, occupation and so forth, and the feature vector with real values. Then, by combining a heuristic strategy based on Boolean vectors with an agglomeratie clustering algorithm based on feature vectors, it seeks to resolve multi-document personal name coreference. Experimental results show that this approach achieves a good performance by testing on "Wang Gang" corpus. 展开更多
关键词 personal name disambiguation Chinese multi-document heuristic strategy. agglomerative clustering
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Multi-Head Encoder Shared Model Integrating Intent and Emotion for Dialogue Summarization
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作者 Xinlai Xing Junliang Chen +2 位作者 Xiaochuan Zhang Shuran Zhou Runqing Zhang 《Computers, Materials & Continua》 2025年第2期2275-2292,共18页
In task-oriented dialogue systems, intent, emotion, and actions are crucial elements of user activity. Analyzing the relationships among these elements to control and manage task-oriented dialogue systems is a challen... In task-oriented dialogue systems, intent, emotion, and actions are crucial elements of user activity. Analyzing the relationships among these elements to control and manage task-oriented dialogue systems is a challenging task. However, previous work has primarily focused on the independent recognition of user intent and emotion, making it difficult to simultaneously track both aspects in the dialogue tracking module and to effectively utilize user emotions in subsequent dialogue strategies. We propose a Multi-Head Encoder Shared Model (MESM) that dynamically integrates features from emotion and intent encoders through a feature fusioner. Addressing the scarcity of datasets containing both emotion and intent labels, we designed a multi-dataset learning approach enabling the model to generate dialogue summaries encompassing both user intent and emotion. Experiments conducted on the MultiWoZ and MELD datasets demonstrate that our model effectively captures user intent and emotion, achieving extremely competitive results in dialogue state tracking tasks. 展开更多
关键词 Dialogue summaries dialogue state tracking emotion recognition task-oriented dialogue system pre-trained language model
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胃肠道肿瘤腹腔热灌注化疗临床应用及管理
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作者 朱丽 鲁志卉 +6 位作者 高雅欣 王怡萱 孙雯馨 徐丰 江为 吴静 王桂华 《中华消化外科杂志》 北大核心 2026年第1期110-117,共8页
胃肠道肿瘤发病率与病死率高,腹膜转移和局部复发影响患者长期生存。有研究结果显示:腹腔热灌注化疗(HIPEC)预防和治疗胃肠道肿瘤腹膜转移优势显著,可延长患者生存时间,且安全性可接受。然而,HIPEC临床应用管理与操作流程等存在争议与挑... 胃肠道肿瘤发病率与病死率高,腹膜转移和局部复发影响患者长期生存。有研究结果显示:腹腔热灌注化疗(HIPEC)预防和治疗胃肠道肿瘤腹膜转移优势显著,可延长患者生存时间,且安全性可接受。然而,HIPEC临床应用管理与操作流程等存在争议与挑战,限制其推广应用。笔者系统评价HIPEC相关临床指南与专家共识,总结其在胃肠道肿瘤中应用及管理证据,为临床实践提供循证医学依据。未来研究聚焦肿瘤类型特异性治疗、多维度疗效预测标志物开发及多模态技术整合等,通过建立“分子分型-动态监测-精准干预”的闭环管理体系,推动HIPEC向个体化、精准化、智能化方向发展。 展开更多
关键词 胃肿瘤 肠肿瘤 腹腔热灌注化疗 证据总结 循证医学
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护士用药中断管理的最佳证据总结
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作者 杨艳丽 王青 +4 位作者 马尚红 杨庆红 丁晓彤 王娟 李峥 《中华护理教育》 2026年第1期85-94,共10页
目的系统归纳护士用药中断管理的最佳证据,为临床实践提供指导。方法遵循“5S”循证模型,系统检索中英文数据库、指南相关网站和中断网站(Interruptions.net)中与用药中断管理相关的文献,包括临床决策、最佳实践、临床实践指南、系统评... 目的系统归纳护士用药中断管理的最佳证据,为临床实践提供指导。方法遵循“5S”循证模型,系统检索中英文数据库、指南相关网站和中断网站(Interruptions.net)中与用药中断管理相关的文献,包括临床决策、最佳实践、临床实践指南、系统评价、证据总结、专家共识及原始研究。检索时限为建库至2024年12月31日。2名研究者根据明确的纳入和排除标准,独立进行文献筛选、质量评价、证据提取和汇总。结果最终纳入33篇文献,包括2篇系统评价、3篇随机对照试验和28篇类实验研究。从组织层(5条)、管理层(7条)、个人层(5条)3个维度归纳出17条推荐意见,内容涵盖标准化流程、环境优化、多学科协作及用药中断管理培训等关键要素。结论基于现有证据,建议从优化用药安全环境、引入用药安全管理系统、强化用药中断管理培训及开展患者和家属中断管理教育等方面入手,有效降低用药中断相关差错发生率,切实保障患者用药安全。 展开更多
关键词 用药中断管理 安全管理 循证护理学 证据总结
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脊柱外科围术期血糖管理证据总结
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作者 张静 李昕 +4 位作者 董璐 唐群群 郑玲 周佳佳 陈迎霞 《循证护理》 2026年第6期1120-1126,共7页
目的:系统检索并整合国内外脊柱外科围术期血糖管理的循证证据,为临床医护人员提供针对性的血糖管理实践指导。方法:按照“6S”证据模型,全面检索决策系统、国内外指南网、专业学会网站及中英文数据库。检索时限为建库至2025年5月28日... 目的:系统检索并整合国内外脊柱外科围术期血糖管理的循证证据,为临床医护人员提供针对性的血糖管理实践指导。方法:按照“6S”证据模型,全面检索决策系统、国内外指南网、专业学会网站及中英文数据库。检索时限为建库至2025年5月28日。对纳入文献进行质量评价、证据提取与汇总。结果:共纳入15篇文献,包括1篇临床决策、6篇指南、5篇专家共识、3篇随机对照试验。从术前、术中、术后、特殊人群、出院后血糖管理5个方面总结了19条证据。结论:本研究形成的脊柱外科围术期血糖管理证据可为临床规范脊柱外科围术期的血糖管理、减少血糖波动引发的并发症、促进病人快速康复、制订精准化管理方案提供循证依据。 展开更多
关键词 脊柱外科 围术期 血糖管理 证据总结 循证护理
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心房颤动射频消融术后病人运动康复的最佳证据总结
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作者 秦彩萍 陈月香 史珣瑜 《循证护理》 2026年第2期228-234,共7页
目的:检索、评价并总结心房颤动射频消融术后病人运动康复的最佳证据,为开展康复锻炼提供依据。方法:计算机检索UpToDate、英国国家卫生与临床优化研究所(NICE)、苏格兰校际指南网(SIGN)、医脉通、美国心脏病协会(ACC)、欧洲心脏病学会(... 目的:检索、评价并总结心房颤动射频消融术后病人运动康复的最佳证据,为开展康复锻炼提供依据。方法:计算机检索UpToDate、英国国家卫生与临床优化研究所(NICE)、苏格兰校际指南网(SIGN)、医脉通、美国心脏病协会(ACC)、欧洲心脏病学会(ESC)、Cochrane Library、PubMed、EMbase、BMJ Best Practice、Web of Science、OVID、中国知网(CNKI)及中国生物医学文献数据库(CBM)中有关心房颤动射频消融术后病人运动康复的相关证据。检索时限为建库至2024年6月30日。由2名接受过循证培训的研究人员独立对文献进行质量评价和证据级别评定。结果:共纳入10篇文献,包括专家共识3篇、指南2篇、系统评价2篇和随机对照试验3篇。总结了关于运动获益、运动时机、运动评估、运动方式、运动强度、运动时间及频率、运动管理、运动效果评价8个方面,共24条最佳证据。结论:本研究总结了心房颤动射频消融术后病人运动康复的证据,建议临床医护人员应用证据时应根据实际情况充分评估病人的运动能力、运动习惯、运动偏好,为病人制订安全、科学、个体化的运动计划,指导心房颤动射频消融术后病人合理运动,促进病人康复。 展开更多
关键词 心房颤动 射频消融术 运动康复 证据总结 循证护理
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基于护理助手App的BOPPPS教学模式在新入职护士规范化培训中的应用
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作者 王瑞方 郭珂清 +5 位作者 杜章楠 冯珊珊 孙艳丽 郭军芳 魏华 丁敬艳 《河南医学研究》 2026年第1期183-188,共6页
目的探讨基于护理助手App的导学互动的加式教育(BOPPPS)教学模式在新入职护士规范化培训中的应用效果。方法前瞻性以濮阳市安阳地区医院2023年9月新入职规范化培训护士86名为研究对象,采用抓取随机球法分为对照组和试验组,各43名。对照... 目的探讨基于护理助手App的导学互动的加式教育(BOPPPS)教学模式在新入职护士规范化培训中的应用效果。方法前瞻性以濮阳市安阳地区医院2023年9月新入职规范化培训护士86名为研究对象,采用抓取随机球法分为对照组和试验组,各43名。对照组采用传统教学模式,试验组采用基于护理助手App的BOPPPS教学模式。比较两组新入职护士规培出科考试成绩、护士临床实践能力评价量表、护理人员自主学习能力评价量表、临床护理带教老师行为评价量表、教学效果满意度量表评分。结果试验组新入职护士的基础知识、案例分析及总成绩分别为(50.46±4.35)分、(33.10±3.68)分、(84.32±8.26)分,高于对照组的(47.30±5.12)分、(29.54±3.05)分、(77.18±6.44)分,差异有统计学意义(P<0.05);试验组新入职护士的临床实践能力中核心制度、岗位职责、工作能力、疾病护理、技术操作、常用化验检查结果解读、常用药物相关知识、护理文书、应急能力评分分别为(7.68±1.26)分、(8.12±0.92)分、(8.30±0.86)分、(8.03±0.94)分、(7.89±1.36)分、(8.21±0.87)分、(7.65±1.14)分、(7.42±1.35)分、(7.58±1.29)分,高于对照组的(6.95±1.35)分、(7.02±1.35)分、(6.58±1.33)分、(6.45±1.29)分、(6.54±1.02)分、(7.38±1.12)分、(6.98±1.02)分、(6.59±1.10)分、(6.87±1.13)分,差异有统计学意义(P<0.05),劳动纪律评分为(6.34±1.36)分与(6.02±1.52)分比较,差异无统计学意义(P>0.05);试验组新入职护士的自主学习能力中自我动机信念、自我监控与调节、任务分析、自我评价及总分分别为(58.45±4.36)分、(38.98±5.02)分、(22.36±3.75)分、(15.24±2.20)分、(133.87±12.58)分,高于对照组的(50.62±5.48)分、(34.25±4.76)分、(16.84±3.02)分、(12.45±2.14)分、(113.50±10.46)分,差异有统计学意义(P<0.05);试验组临床护理带教老师行为中教学技巧、与学生的关系、知识与技能、个性及总分分别为(103.64±5.29)分、(52.87±4.55)分、(43.15±3.18)分、(48.62±4.24)分、(247.18±21.60)分,高于对照组的(90.48±6.45)分、(45.52±4.86)分、(38.74±3.20)分、(44.59±5.84)分、(215.72±20.53)分,差异有统计学意义(P<0.05);试验组新入职护士的教育效果满意度(97.67%)高于对照组(81.40%),差异有统计学意义(P<0.05)。结论基于护理助手App的BOPPPS教学模式有利于提升临床带教老师行为能力,提高新入职护士的综合素质及教学满意度。 展开更多
关键词 导学互动的加式教育 手机 教学 护士 规范化培训
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多组学拓展骨质疏松症的新治疗靶点:亚洲、欧洲项目组数据分析
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作者 陈勇喜 《中国组织工程研究》 北大核心 2026年第24期6382-6389,共8页
背景:随着中国老龄化进程的加快,骨质疏松症患者也逐渐增多,而全基因组关联研究和单细胞转录测序的发展使得研究者们可通过将各组学研究数据相结合以发现更多与骨质疏松症相关的基因。目的:通过整合亚洲、欧洲人群的全基因组关联研究和... 背景:随着中国老龄化进程的加快,骨质疏松症患者也逐渐增多,而全基因组关联研究和单细胞转录测序的发展使得研究者们可通过将各组学研究数据相结合以发现更多与骨质疏松症相关的基因。目的:通过整合亚洲、欧洲人群的全基因组关联研究和转录组学,基于汇总统计数据的孟德尔随机化拓展骨质疏松症新的治疗靶点。方法:通过整合来自多个组织(血液、肌肉-骨骼)的顺式表达数量性状位点和蛋白质数量性状位点数据集(基因-组织表达项目组V.8选取了人类血液与骨骼-肌肉两种组织的表达数量性状位点数据集,基因-组织表达项目组是研究基因表达在不同组织/器官中变异及其与遗传调控关系的大型国际合作项目)及骨质疏松症全基因组关联研究数据(FinnGen数据库2021年发布的关于欧洲人种骨质疏松症的全基因组关联研究数据,FinnGen是芬兰的一个大型基因组研究项目);从日本生物银行数据库获取的2020年发布关于东亚人群的大规模全基因组关联研究,是日本主导的大规模人群队列研究项目,使用基于汇总统计数据的孟德尔随机化方法来鉴定骨质疏松症的相关基因,并使用共定位分析、单细胞测序及富集分析对已鉴定出的相关基因做进一步分析。所有数据均来自于已发表的研究或公开可用的数据,均已提供伦理审批书和知情同意书。结果与结论:①基于汇总统计数据的孟德尔随机化分析一共确定了64个(去除重复基因后)与骨质疏松症显著相关的基因,其中人类白细胞抗原(HLA)等位基因HLA-DQA1、HLA-DQA2、HLA-DQB1、HLA-DQB2和HLA-DRB5在2个结局数据集中得到了相互验证,具有显著相关性;②进一步的共定位分析表明,HLA-DQA2、HLA-DQB1具有共定位的证据(后验概率PPH4>0.8);③蛋白质数量性状位点分析结果表明,血浆中高水平的HLA-DQA2与骨质疏松症风险降低相关;④在单细胞测序分析方面,在骨质疏松症的免疫微环境中,树突状细胞、B细胞、巨噬细胞和中性粒细胞丰度较其他细胞群明显升高;⑤富集分析结果表明,鉴定出的基因在组织相容性复合物Ⅱ分子抗原呈递途径富集;⑥此次研究通过生物信息学结合亚洲、欧洲人群的全基因组关联数据,初步确定了几个以前尚未报道过的与骨质疏松症相关的基因,研究者们可在临床试验中进一步探索上述基因作为骨质疏松症新的治疗途径的潜力。 展开更多
关键词 全基因组关联研究 单细胞测序 骨质疏松症 基于汇总数据的孟德尔随机化
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美军军士院校教育探析
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作者 崔学军 马林 李大伟 《高教学刊》 2026年第6期1-4,共4页
美军军士院校教育较为完备,军士学员教育训练探索改革起步早、发展快,形成许多宝贵经验,积累可资学习借鉴的鲜明做法。重构重塑后的我军士官院校教育,必须紧跟新时代未来战争创新人才需求,贯彻“洋为中用”的原则,吸取美军成功经验,借... 美军军士院校教育较为完备,军士学员教育训练探索改革起步早、发展快,形成许多宝贵经验,积累可资学习借鉴的鲜明做法。重构重塑后的我军士官院校教育,必须紧跟新时代未来战争创新人才需求,贯彻“洋为中用”的原则,吸取美军成功经验,借鉴有益做法,加速我军士官院校教育转型重塑,培养更多能打仗、打胜仗的高素质专业化世界一流新型士官人才。 展开更多
关键词 美军军士院校 教育训练 经验总结 作战能力 军士教育
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婴幼儿肝移植术中低体温预防的证据总结与审查指标构建
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作者 陈国立 黄一乐 杨艳 《军事护理》 北大核心 2026年第3期26-30,共5页
目的 总结婴幼儿肝移植术中低体温预防的相关证据并制订审查指标,为临床开展循证实践提供参考。方法 系统检索国内外数据库中有关婴幼儿肝移植术中低体温预防的相关证据,检索时限为2000年1月1日至2024年12月31日。总结证据并构建婴幼儿... 目的 总结婴幼儿肝移植术中低体温预防的相关证据并制订审查指标,为临床开展循证实践提供参考。方法 系统检索国内外数据库中有关婴幼儿肝移植术中低体温预防的相关证据,检索时限为2000年1月1日至2024年12月31日。总结证据并构建婴幼儿肝移植术中低体温预防的审查指标。结果 最终纳入19篇文献,包括5篇指南、2篇系统评价、6篇证据总结、1篇专家共识、5篇随机对照试验,形成风险评估、术前体温监测与预保温、术中体温监测与干预、术后管理、质量控制5个主题,共37条证据,确立了16条审查指标。结论 总结的最佳证据为婴幼儿术中低体温的预防提供了参考,护理人员应用时可借助审查指标进行基线审查,依据审查结果选用证据,减少婴幼儿术中低体温的发生,保障围术期患儿安全。 展开更多
关键词 婴幼儿 肝移植 低体温 证据总结 审查指标
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先天性心脏病患儿行开胸手术后疼痛管理的最佳证据总结
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作者 杨静然 马芳 +2 位作者 王渝 张义美 周敏 《中国全科医学》 北大核心 2026年第11期1473-1480,共8页
背景先天性心脏病患儿行开胸手术后疼痛的规范化管理十分重要,目前尚未形成系统的针对先天性心脏病患儿行开胸手术后疼痛管理的最佳证据。目的对先天性心脏病患儿行开胸手术后疼痛管理的最佳证据进行总结,为临床实践提供循证依据。方法... 背景先天性心脏病患儿行开胸手术后疼痛的规范化管理十分重要,目前尚未形成系统的针对先天性心脏病患儿行开胸手术后疼痛管理的最佳证据。目的对先天性心脏病患儿行开胸手术后疼痛管理的最佳证据进行总结,为临床实践提供循证依据。方法系统检索UpToDate临床顾问、BMJ最佳临床实践、国际指南协作网、美国国立指南库、英国国家卫生与临床优化研究所、医脉通指南网、Cochrane Library、PubMed、Web of Science、Embase、CINAHL、万方数据知识服务平台、维普网、中国知网、中国生物医学文献服务系统及美国心脏病协会、美国心血管学会、欧洲心脏病协会、美国疼痛协会、加拿大安大略注册护士协会网站,获取关于先天性心脏病患儿行开胸手术后疼痛管理的临床决策、指南、专家共识、证据总结、系统评价及随机对照试验,检索时限为建库至2025-01-01,进行方法学质量评价后,依据主题对证据提取和汇总。结果共纳入15篇文献,其中指南1篇,专家共识1篇,系统评价3篇,随机对照试验10篇,通过阅读、提取、归纳最终总结了疼痛管理原则、疼痛评估、药物止痛策略、非药物止痛策略4个方面的26条证据。结论形成先天性心脏病患儿行开胸手术后疼痛管理中关于疼痛管理原则、疼痛评估、药物止痛策略、非药物止痛策略的最佳证据,可为临床医务工作者提供证据支持,提高临床护理质量。 展开更多
关键词 心脏缺损 先天性 儿童 开胸手术 疼痛管理 证据总结
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