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基于UPLC-Orbitrap Fusion Lumos Tribrid-MS的女贞子酒蒸前后血清药物化学对比分析
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作者 刘昊霖 郑历史 +3 位作者 孙淑仃 赵迪 李焕茹 冯素香 《中华中医药学刊》 北大核心 2026年第1期175-186,I0027,共13页
目的基于超高效液相色谱-四极杆-静电场轨道阱-线性离子阱质谱法(ultra performance liquid chromatography-orbitrap fusion lumos tribrid-mass spectrometry,UPLC-Orbitrap Fusion Lumos Tribrid-MS)对大鼠灌胃女贞子、酒女贞子水提... 目的基于超高效液相色谱-四极杆-静电场轨道阱-线性离子阱质谱法(ultra performance liquid chromatography-orbitrap fusion lumos tribrid-mass spectrometry,UPLC-Orbitrap Fusion Lumos Tribrid-MS)对大鼠灌胃女贞子、酒女贞子水提液后血清中的移行成分进行对比分析。方法雄性Sprague-Dawley(SD)大鼠随机分为空白组、女贞子组(10.8 g·kg^(-1)·d^(-1))和酒女贞子组(10.8 g·kg^(-1)·d^(-1)),每组6只,给药组分别灌胃给予女贞子、酒女贞子水提液,空白组灌胃等体积纯净水,早晚各1次,连续5 d,末次给药1 h后腹主动脉取血,制备血清样品。采用Accucore^(TM) C_(18)(100 mm×2.1 mm,2.6μm)色谱柱,流动相为乙腈(A)-0.1%甲酸水(B),梯度洗脱(0~5 min,95%B→85%B;5~10 min,85%B→73%B;10~24 min,73%B→15%B),流速0.2 mL·min^(-1),进样量5μL,正、负离子模式扫描,扫描范围m/z 120~1200。采用Compound Discoverer 3.3软件,根据质谱数据和相关文献对女贞子、酒女贞子入血原型成分和代谢产物进行分析鉴定;采用多元统计分析方法对比女贞子、酒女贞子含药血清间的差异性成分。结果在给予女贞子水提液大鼠血清中共鉴定得到64个入血成分,包括40个原型成分和24个代谢产物;在给予酒女贞子水提液大鼠血清中共鉴定得到57个入血成分,包括35个原型成分和22个代谢产物。原型成分主要包括苯乙醇苷类、环烯醚萜类、三萜类、黄酮类等,代谢途径主要包括羟基化、甲基化、葡萄糖醛酸化等。根据变量重要性投影(variable importance in projection,VIP)值>1,t检验(Student's t test)结果P<0.05筛选出特女贞苷、女贞苷酸等12个差异性入血成分,其中7个原型成分、5个代谢产物。结论女贞子酒蒸后血清移行成分发生明显改变,可为阐明女贞子、酒女贞子药效物质基础提供理论依据。 展开更多
关键词 女贞子 炮制 血清药物化学 UPLC-Orbitrap fusion Lumos Tribrid-MS 多元统计分析
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Effect of Addition of Er-TiB_(2)Dual-Phase Nanoparticles on Strength-Ductility of Al-Mn-Mg-Sc-Zr Alloy Prepared by Laser Powder Bed Fusion
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作者 Li Suli Zhang Yanze +5 位作者 Yang Mengjia Zhang Longbo Xie Qidong Yang Laixia MaoFeng Chen Zhen 《稀有金属材料与工程》 北大核心 2026年第1期9-17,共9页
A dual-phase synergistic enhancement method was adopted to strengthen the Al-Mn-Mg-Sc-Zr alloy fabricated by laser powder bed fusion(LPBF)by leveraging the unique advantages of Er and TiB_(2).Spherical powders of 0.5w... A dual-phase synergistic enhancement method was adopted to strengthen the Al-Mn-Mg-Sc-Zr alloy fabricated by laser powder bed fusion(LPBF)by leveraging the unique advantages of Er and TiB_(2).Spherical powders of 0.5wt%Er-1wt%TiB_(2)/Al-Mn-Mg-Sc-Zr nanocomposite were prepared using vacuum homogenization technique,and the density of samples prepared through the LPBF process reached 99.8%.The strengthening and toughening mechanisms of Er-TiB_(2)were investigated.The results show that Al_(3)Er diffraction peaks are detected by X-ray diffraction analysis,and texture strength decreases according to electron backscatter diffraction results.The added Er and TiB_(2)nano-reinforcing phases act as heterogeneous nucleation sites during the LPBF forming process,hindering grain growth and effectively refining the grains.After incorporating the Er-TiB_(2)dual-phase nano-reinforcing phases,the tensile strength and elongation at break of the LPBF-deposited samples reach 550 MPa and 18.7%,which are 13.4%and 26.4%higher than those of the matrix material,respectively. 展开更多
关键词 Al-Mn-Mg-Sc-Zr alloy laser powder bed fusion nano-reinforcing phase synergistic enhancement
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Bearing Fault Diagnosis Based on Multimodal Fusion GRU and Swin-Transformer
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作者 Yingyong Zou Yu Zhang +2 位作者 Long Li Tao Liu Xingkui Zhang 《Computers, Materials & Continua》 2026年第1期1587-1610,共24页
Fault diagnosis of rolling bearings is crucial for ensuring the stable operation of mechanical equipment and production safety in industrial environments.However,due to the nonlinearity and non-stationarity of collect... Fault diagnosis of rolling bearings is crucial for ensuring the stable operation of mechanical equipment and production safety in industrial environments.However,due to the nonlinearity and non-stationarity of collected vibration signals,single-modal methods struggle to capture fault features fully.This paper proposes a rolling bearing fault diagnosis method based on multi-modal information fusion.The method first employs the Hippopotamus Optimization Algorithm(HO)to optimize the number of modes in Variational Mode Decomposition(VMD)to achieve optimal modal decomposition performance.It combines Convolutional Neural Networks(CNN)and Gated Recurrent Units(GRU)to extract temporal features from one-dimensional time-series signals.Meanwhile,the Markovian Transition Field(MTF)is used to transform one-dimensional signals into two-dimensional images for spatial feature mining.Through visualization techniques,the effectiveness of generated images from different parameter combinations is compared to determine the optimal parameter configuration.A multi-modal network(GSTCN)is constructed by integrating Swin-Transformer and the Convolutional Block Attention Module(CBAM),where the attention module is utilized to enhance fault features.Finally,the fault features extracted from different modalities are deeply fused and fed into a fully connected layer to complete fault classification.Experimental results show that the GSTCN model achieves an average diagnostic accuracy of 99.5%across three datasets,significantly outperforming existing comparison methods.This demonstrates that the proposed model has high diagnostic precision and good generalization ability,providing an efficient and reliable solution for rolling bearing fault diagnosis. 展开更多
关键词 MULTI-MODAL GRU swin-transformer CBAM CNN feature fusion
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Trajectory and influencing factors of changes in anxiety and depression in elderly patients after lumbar interbody fusion
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作者 Xiao-Feng Liu Yan-Hua Wu +4 位作者 Guang-Xi Huang Bin Yu Hui-Juan Xu Meng-Hua Qiu Lin Kang 《World Journal of Psychiatry》 2026年第1期312-321,共10页
BACKGROUND Lumbar interbody fusion(LIF)is the primary treatment for lumbar degenerative diseases.Elderly patients are prone to anxiety and depression after undergoing surgery,which affects their postoperative recovery... BACKGROUND Lumbar interbody fusion(LIF)is the primary treatment for lumbar degenerative diseases.Elderly patients are prone to anxiety and depression after undergoing surgery,which affects their postoperative recovery speed and quality of life.Effective prevention of anxiety and depression in elderly patients has become an urgent problem.AIM To investigate the trajectory of anxiety and depression levels in elderly patients after LIF,and the influencing factors.METHODS Random sampling was used to select 239 elderly patients who underwent LIF from January 2020 to December 2024 in Shenzhen Pingle Orthopedic Hospital.General information and surgery-related indices were recorded,and participants completed measures of psychological status,lumbar spine dysfunction,and quality of life.A latent class growth model was used to analyze the post-LIF trajectory of anxiety and depression levels,and unordered multi-categorical logistic regression was used to analyze the influencing factors.RESULTS Three trajectories of change in anxiety level were identified:Increasing anxiety(n=26,10.88%),decreasing anxiety(n=27,11.30%),and stable anxiety(n=186,77.82%).Likewise,three trajectories of change in depression level were identified:Increasing depression(n=30,12.55%),decreasing depression(n=26,10.88%),and stable depression(n=183,76.57%).Regression analysis showed that having no partner,female sex,elevated Oswestry dysfunction index(ODI)scores,and reduced 36-Item Short Form Health Survey scores all contributed to increased anxiety levels,whereas female sex,postoperative opioid use,and elevated ODI scores all contributed to increased depression levels.CONCLUSION During clinical observation,combining factors to predict anxiety and depression in post-LIF elderly patients enables timely intervention,quickens recovery,and enhances quality of life. 展开更多
关键词 Lumbar interbody fusion Elderly patients ANXIETY DEPRESSION Trajectory of change Influencing factors
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Cephalomedullary fusion nails for treatment of infected stemmed revision total knee arthroplasty:Four case reports
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作者 Gregory M Georgiadis Isaac A Arefi +3 位作者 Summer M Drees Ajay Nair Drew Wagner Austin C Lawrence 《World Journal of Orthopedics》 2026年第1期189-196,共8页
BACKGROUND Salvage of the infected long stem revision total knee arthroplasty is challenging due to the presence of well-fixed ingrown or cemented stems.Reconstructive options are limited.Above knee amputation(AKA)is ... BACKGROUND Salvage of the infected long stem revision total knee arthroplasty is challenging due to the presence of well-fixed ingrown or cemented stems.Reconstructive options are limited.Above knee amputation(AKA)is often recommended.We present a surgical technique that was successfully used on four such patients to convert them to a knee fusion(KF)using a cephalomedullary nail.CASE SUMMARY Four patients with infected long stem revision knee replacements that refused AKA had a single stage removal of their infected revision total knee followed by a KF.They were all treated with a statically locked antegrade cephalomedullary fusion nail,augmented with antibiotic impregnated bone cement.All patients had successful limb salvage and were ambulatory with assistive devices at the time of last follow-up.All were infection free at an average follow-up of 25.5 months(range 16-31).CONCLUSION Single stage cephalomedullary nailing can result in a successful KF in patients with infected long stem revision total knees. 展开更多
关键词 Knee fusion Knee arthrodesis Intramedullary nail Cephalomedullary nail Total knee infection Case report
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Identification of small impact craters in Chang’e-4 landing areas using a new multi-scale fusion crater detection algorithm
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作者 FangChao Liu HuiWen Liu +7 位作者 Li Zhang Jian Chen DiJun Guo Bo Li ChangQing Liu ZongCheng Ling Ying-Bo Lu JunSheng Yao 《Earth and Planetary Physics》 2026年第1期92-104,共13页
Impact craters are important for understanding the evolution of lunar geologic and surface erosion rates,among other functions.However,the morphological characteristics of these micro impact craters are not obvious an... Impact craters are important for understanding the evolution of lunar geologic and surface erosion rates,among other functions.However,the morphological characteristics of these micro impact craters are not obvious and they are numerous,resulting in low detection accuracy by deep learning models.Therefore,we proposed a new multi-scale fusion crater detection algorithm(MSF-CDA)based on the YOLO11 to improve the accuracy of lunar impact crater detection,especially for small craters with a diameter of<1 km.Using the images taken by the LROC(Lunar Reconnaissance Orbiter Camera)at the Chang’e-4(CE-4)landing area,we constructed three separate datasets for craters with diameters of 0-70 m,70-140 m,and>140 m.We then trained three submodels separately with these three datasets.Additionally,we designed a slicing-amplifying-slicing strategy to enhance the ability to extract features from small craters.To handle redundant predictions,we proposed a new Non-Maximum Suppression with Area Filtering method to fuse the results in overlapping targets within the multi-scale submodels.Finally,our new MSF-CDA method achieved high detection performance,with the Precision,Recall,and F1 score having values of 0.991,0.987,and 0.989,respectively,perfectly addressing the problems induced by the lesser features and sample imbalance of small craters.Our MSF-CDA can provide strong data support for more in-depth study of the geological evolution of the lunar surface and finer geological age estimations.This strategy can also be used to detect other small objects with lesser features and sample imbalance problems.We detected approximately 500,000 impact craters in an area of approximately 214 km2 around the CE-4 landing area.By statistically analyzing the new data,we updated the distribution function of the number and diameter of impact craters.Finally,we identified the most suitable lighting conditions for detecting impact crater targets by analyzing the effect of different lighting conditions on the detection accuracy. 展开更多
关键词 impact craters Chang’e-4 landing area multi-scale automatic detection YOLO11 fusion algorithm
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基于UPLC-Orbitrap Fusion Lumos Tribrid-MS、网络药理学与实验验证的正骨紫金丸活性成分及作用机制研究
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作者 冯志毅 孙淑仃 +3 位作者 郑历史 孙琪 刘泽 冯素香 《中国现代应用药学》 北大核心 2025年第21期3704-3716,共13页
目的基于UPLC-Orbitrap Fusion Lumos Tribrid-MS联合网络药理学与实验验证预测正骨紫金丸活血化瘀的活性成分及其作用机制。方法首先,采用UPLC-Orbitrap Fusion Lumos Tribrid-MS快速表征正骨紫金丸中的化学成分;其次,通过网络药理学... 目的基于UPLC-Orbitrap Fusion Lumos Tribrid-MS联合网络药理学与实验验证预测正骨紫金丸活血化瘀的活性成分及其作用机制。方法首先,采用UPLC-Orbitrap Fusion Lumos Tribrid-MS快速表征正骨紫金丸中的化学成分;其次,通过网络药理学的研究方法构建“药物-成分-靶点”网络,获取关键靶点及主要活性成分,结合String平台与CytoScape软件构建蛋白质-蛋白质相互作用(protein-protein interaction,PPI)网络,通过MateScape数据库富集分析通路,利用DiscoVery Studio 4.5软件进行分子对接验证;最后,建立急性软组织损伤动物模型,以急性软组织损伤评分与全血黏度为药效学指标开展药效学研究。结果正骨紫金丸中共鉴定出包括黄酮类、生物碱类、有机酸类和香豆素类等化合物67个,其中大黄素、藁本内酯、肉桂酸、水杨酸、芦荟大黄素可能为正骨紫金丸活血化瘀的主要活性成分。PPI网络拓扑分析得到TNF、ALB、AKT1等26个核心靶点,KEGG富集分析表明正骨紫金丸主要通过调控TNF、PI3K-Akt、NF-κB等信号通路发挥活血化瘀作用,分子对接结果显示正骨紫金丸主要活性成分与关键靶点结合良好,药效学结果表明正骨紫金丸可显著降低急性软组织损伤大鼠的全血黏度。结论本研究明确了正骨紫金丸活血化瘀的活性成分和作用机制,同时表明其可能通过作用于多靶点、多通路整体调节,共同发挥活血化瘀作用,为其后续深入研究提供参考。 展开更多
关键词 正骨紫金丸 UPLC-Orbitrap fusion Lumos Tribrid-MS 成分分析 网络药理学 活血化瘀
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基于Clickteam Fusion的HDB3/AMI编译码实验教学软件设计
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作者 张春光 《电脑编程技巧与维护》 2025年第1期31-34,共4页
论文阐述了一种利用Clickteam Fusion引擎进行HDB3/AMI编译码实验仿真的编程方法。利用计算机技术开发的该仿真实验富有一定的真实感,可直接在计算机上模拟操作。通过学生自主操作,使其掌握光纤实验基本原理,记忆并理解相关操作知识,有... 论文阐述了一种利用Clickteam Fusion引擎进行HDB3/AMI编译码实验仿真的编程方法。利用计算机技术开发的该仿真实验富有一定的真实感,可直接在计算机上模拟操作。通过学生自主操作,使其掌握光纤实验基本原理,记忆并理解相关操作知识,有效提高实验学习效率。 展开更多
关键词 HDB3/AMI编译码实验 仿真 Clickteam fusion引擎
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基于UPLC-Orbitrap Fusion Lumos Tribrid-MS的女贞子不同炮制品血中移行成分分析
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作者 夏仪 孙淑仃 +3 位作者 郑历史 赵迪 李焕茹 冯素香 《中药材》 北大核心 2025年第3期606-615,共10页
目的:研究大鼠灌胃给药醋蒸女贞子、盐蒸女贞子、清蒸女贞子后血清中的移行成分并对其进行对比分析。方法:采用UPLC-Orbitrap Fusion Lumos Tribrid-MS技术,结合Xcalibur和Compound Discoverer软件,根据保留时间、精确分子量、二级碎片... 目的:研究大鼠灌胃给药醋蒸女贞子、盐蒸女贞子、清蒸女贞子后血清中的移行成分并对其进行对比分析。方法:采用UPLC-Orbitrap Fusion Lumos Tribrid-MS技术,结合Xcalibur和Compound Discoverer软件,根据保留时间、精确分子量、二级碎片信息及文献报道,鉴定女贞子不同炮制品的入血成分。基于主成分分析(PCA)和正交偏最小二乘判别分析(OPLS-DA)筛选女贞子不同炮制品含药血清的差异性成分。结果:共鉴定出95个入血成分,其中共有成分89个,醋蒸女贞子特有成分2个、盐蒸女贞子特有成分3个、清蒸女贞子特有成分1个。入血成分包含61个原型成分和34个代谢产物,原型成分主要包括苯乙醇类、环烯醚萜苷类、黄酮类化合物,代谢产物主要涉及羟基化、葡萄糖醛酸化、硫酸酯化反应等。PCA、OPLS-DA结果表明女贞子不同炮制品血中移行成分存在明显差异,OPLS-DA筛选出27个差异性成分。结论:该研究初步阐明了醋蒸女贞子、盐蒸女贞子、清蒸女贞子在大鼠血清中移行成分的差异,为进一步明确女贞子不同炮制品的药效物质基础提供了依据。 展开更多
关键词 女贞子 炮制 血清药物化学 UPLC-Orbitrap fusion Lumos Tribrid-MS 多元统计分析
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Hot Isostatic Pressing for Enhancing Mechanical Properties of Mo Alloys Prepared by Laser Powder Bed Fusion 被引量:1
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作者 Liang Xunwen Fu Zhongxue +3 位作者 Zhang Shiming Che Yusi Cheng Pengming Wang Pei 《稀有金属材料与工程》 北大核心 2025年第3期587-592,共6页
To enhance the mechanical properties of Mo alloys prepared through laser powder bed fusion(LPBF),a hot isostatic pressing(HIP)treatment was used.Results show that following HIP treatment,the porosity decreases from 0.... To enhance the mechanical properties of Mo alloys prepared through laser powder bed fusion(LPBF),a hot isostatic pressing(HIP)treatment was used.Results show that following HIP treatment,the porosity decreases from 0.27%to 0.22%,enabling the elements Mo and Ti to diffuse fully and to distribute more uniformly,and to forming a substantial number of low-angle grain boundaries.The tensile strength soars from 286±32 MPa to 598±22 MPa,while the elongation increases from 0.08%±0.02%to 0.18%±0.02%,without notable alterations in grain morphology during the tensile deformation.HIP treatment eliminates the molten pool boundaries,which are the primary source for premature failure in LPBFed Mo alloys.Consequently,HIP treatment emerges as a novel and effective approach for strengthening the mechanical properties of LPBFed Mo alloys,offering a fresh perspective on producing high-performance Mo-based alloys. 展开更多
关键词 Mo alloys hot isostatic pressing laser powder bed fusion mechanical properties
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TGNet:Intelligent Identification of Thunderstorm Wind Gusts Using Multimodal Fusion 被引量:3
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作者 Xiaowen ZHANG Yongguang ZHENG +3 位作者 Hengde ZHANG Jie SHENG Bingjian LU Shuo FENG 《Advances in Atmospheric Sciences》 2025年第1期146-164,共19页
Thunderstorm wind gusts are small in scale,typically occurring within a range of a few kilometers.It is extremely challenging to monitor and forecast thunderstorm wind gusts using only automatic weather stations.There... Thunderstorm wind gusts are small in scale,typically occurring within a range of a few kilometers.It is extremely challenging to monitor and forecast thunderstorm wind gusts using only automatic weather stations.Therefore,it is necessary to establish thunderstorm wind gust identification techniques based on multisource high-resolution observations.This paper introduces a new algorithm,called thunderstorm wind gust identification network(TGNet).It leverages multimodal feature fusion to fuse the temporal and spatial features of thunderstorm wind gust events.The shapelet transform is first used to extract the temporal features of wind speeds from automatic weather stations,which is aimed at distinguishing thunderstorm wind gusts from those caused by synoptic-scale systems or typhoons.Then,the encoder,structured upon the U-shaped network(U-Net)and incorporating recurrent residual convolutional blocks(R2U-Net),is employed to extract the corresponding spatial convective characteristics of satellite,radar,and lightning observations.Finally,by using the multimodal deep fusion module based on multi-head cross-attention,the temporal features of wind speed at each automatic weather station are incorporated into the spatial features to obtain 10-minutely classification of thunderstorm wind gusts.TGNet products have high accuracy,with a critical success index reaching 0.77.Compared with those of U-Net and R2U-Net,the false alarm rate of TGNet products decreases by 31.28%and 24.15%,respectively.The new algorithm provides grid products of thunderstorm wind gusts with a spatial resolution of 0.01°,updated every 10minutes.The results are finer and more accurate,thereby helping to improve the accuracy of operational warnings for thunderstorm wind gusts. 展开更多
关键词 thunderstorm wind gusts shapelet transform multimodal deep feature fusion
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Correction:A Lightweight Approach for Skin Lesion Detection through Optimal Features Fusion
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作者 Khadija Manzoor Fiaz Majeed +5 位作者 Ansar Siddique Talha Meraj Hafiz Tayyab Rauf Mohammed A.El-Meligy Mohamed Sharaf Abd Elatty E.Abd Elgawad 《Computers, Materials & Continua》 SCIE EI 2025年第1期1459-1459,共1页
In the article“A Lightweight Approach for Skin Lesion Detection through Optimal Features Fusion”by Khadija Manzoor,Fiaz Majeed,Ansar Siddique,Talha Meraj,Hafiz Tayyab Rauf,Mohammed A.El-Meligy,Mohamed Sharaf,Abd Ela... In the article“A Lightweight Approach for Skin Lesion Detection through Optimal Features Fusion”by Khadija Manzoor,Fiaz Majeed,Ansar Siddique,Talha Meraj,Hafiz Tayyab Rauf,Mohammed A.El-Meligy,Mohamed Sharaf,Abd Elatty E.Abd Elgawad Computers,Materials&Continua,2022,Vol.70,No.1,pp.1617–1630.DOI:10.32604/cmc.2022.018621,URL:https://www.techscience.com/cmc/v70n1/44361,there was an error regarding the affiliation for the author Hafiz Tayyab Rauf.Instead of“Centre for Smart Systems,AI and Cybersecurity,Staffordshire University,Stoke-on-Trent,UK”,the affiliation should be“Independent Researcher,Bradford,BD80HS,UK”. 展开更多
关键词 fusion SKIN FEATURE
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Factors affecting outcomes of indirect decompression after oblique and lateral lumbar interbody fusions 被引量:1
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作者 Kyle M M Behrens Hossein Elgafy 《World Journal of Orthopedics》 2025年第3期1-6,共6页
In this editorial,the authors of this paper comment on the article by Bokov et al published in the recent issue of World Journal of Orthopedics.We reviewed a general overview of oblique lumbar interbody fusions(OLIF)a... In this editorial,the authors of this paper comment on the article by Bokov et al published in the recent issue of World Journal of Orthopedics.We reviewed a general overview of oblique lumbar interbody fusions(OLIF)and lateral lumbar interbody fusions(LLIF),their indications and complications as an increasingly popular minimally invasive technique to address several lumbar pathologies.This editorial thoroughly discusses and reviews the literature regarding factors affecting outcomes of indirect decompression utilized through OLIF and LLIF procedures.Several parameters play a critical role in patient outcomes including restoration of disc height,foraminal height,central canal squared,and foraminal area.The indirect decompression allows for unbuckling of the ligamentum flavum which can significantly decompress the neural elements as well as aid in reduction of spondylolisthesis.However,the authors further highlight the limitations of indirect decompression and factors that may predict unsuccessful outcomes including bony foraminal stenosis,severe central canal stenosis,and osteoporosis.As a result,failure of indirect decompression can lead to persistent pain,radiculopathy and unsatisfied patients.Spinal surgeons may be left to reimage patients and consider additional procedures with direct decompression. 展开更多
关键词 Interbody fusion Indirect decompression Spinal stenosis Foraminal stenosis LUMBAR
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Multifactorial impacts of B-doping on Fe_(81)Ga_(19) alloys prepared by laser-beam powder bed fusion:Microstructure,magnetostriction,and osteogenesis 被引量:1
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作者 Chengde Gao Liyuan Wang +2 位作者 Youwen Deng Shuping Peng Cijun Shuai 《Journal of Materials Science & Technology》 2025年第2期14-26,共13页
Magnetostrictive Fe-Ga alloys have captivated substantial focus in biomedical applications because of their exceptional transition efficiency and favorable cytocompatibility.Nevertheless,Fe-Ga alloys always exhibit fr... Magnetostrictive Fe-Ga alloys have captivated substantial focus in biomedical applications because of their exceptional transition efficiency and favorable cytocompatibility.Nevertheless,Fe-Ga alloys always exhibit frustrating magnetostriction coefficients when presented in bulk dimensions.It is well-established that the magnetostrictive performance of Fe-Ga alloys is intimately linked to their phase and crystal structures.In this study,various concentrations of boron(B)were doped into Fe_(81)Ga_(19) alloys via the laser-beam powder bed fusion(LPBF)technique to tailor the crystal and phase structures,thereby improving the magnetostrictive performance.The results revealed the capacity for quick solidification of the LPBF process in expediting the solid solution of B element,which increased both lattice distortion and dislocations within the Fe-Ga matrix.These factors contributed to an elevation in the density of the modified-D0_(3) phase structure.Moreover,the prepared Fe-Ga-B alloys also exhibited a(001)preferred grain orientation caused by the high thermal gradients during the LPBF process.As a result,a maximum magnetostriction coefficient of 105 ppm was achieved in the(Fe_(81)Ga_(19))_(98.5)B_(1.5) alloy.In alternating magnetic fields,all the LPBF-prepared alloys showed good dynamic magnetostriction response without visible hysteresis,while the(Fe_(81)Ga_(19))_(98.5)B_(1.5) alloy presented a notable enhancement of~30%in magnetostriction coefficient when compared with the Fe_(81)Ga_(19) alloy.Moreover.the(Fe_(81)Ga_(19))_(98.5)B_(1.5) alloy exhibited favorable biocompatibility and osteogenesis,as confirmed by increased alkaline phosphatase(ALP)activity and the formation of mineralized nodules.These findings suggest that the B-doped Fe-Ga alloys combined with the LPBF technique hold promise for the development of bulk magnetostrictive alloys that are applicable for bone repair applications. 展开更多
关键词 Fe-Ga alloys Laser-beam powder bed fusion Boron doping MAGNETOSTRICTION CYTOCOMPATIBILITY
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MolP-PC:a multi-view fusion and multi-task learning framework for drug ADMET property prediction 被引量:1
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作者 Sishu Li Jing Fan +2 位作者 Haiyang He Ruifeng Zhou Jun Liao 《Chinese Journal of Natural Medicines》 2025年第11期1293-1300,共8页
The accurate prediction of drug absorption,distribution,metabolism,excretion,and toxicity(ADMET)properties represents a crucial step in early drug development for reducing failure risk.Current deep learning approaches... The accurate prediction of drug absorption,distribution,metabolism,excretion,and toxicity(ADMET)properties represents a crucial step in early drug development for reducing failure risk.Current deep learning approaches face challenges with data sparsity and information loss due to single-molecule representation limitations and isolated predictive tasks.This research proposes molecular properties prediction with parallel-view and collaborative learning(MolP-PC),a multi-view fusion and multi-task deep learning framework that integrates 1D molecular fingerprints(MFs),2D molecular graphs,and 3D geometric representations,incorporating an attention-gated fusion mechanism and multi-task adaptive learning strategy for precise ADMET property predictions.Experimental results demonstrate that MolP-PC achieves optimal performance in 27 of 54 tasks,with its multi-task learning(MTL)mechanism significantly enhancing predictive performance on small-scale datasets and surpassing single-task models in 41 of 54 tasks.Additional ablation studies and interpretability analyses confirm the significance of multi-view fusion in capturing multi-dimensional molecular information and enhancing model generalization.A case study examining the anticancer compound Oroxylin A demonstrates MolP-PC’s effective generalization in predicting key pharmacokinetic parameters such as half-life(T0.5)and clearance(CL),indicating its practical utility in drug modeling.However,the model exhibits a tendency to underestimate volume of distribution(VD),indicating potential for improvement in analyzing compounds with high tissue distribution.This study presents an efficient and interpretable approach for ADMET property prediction,establishing a novel framework for molecular optimization and risk assessment in drug development. 展开更多
关键词 Molecular ADMET prediction Multi-view fusion Attention mechanism Multi-task deep learning
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Design Discussion of a Wireless Fire Alarm System Based on Data Fusion Technology 被引量:1
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作者 Qun Wu Jinyang Wu 《Journal of Electronic Research and Application》 2025年第2期58-64,共7页
This article explores the design of a wireless fire alarm system supported by advanced data fusion technology.It includes discussions on the basic design ideas of the wireless fire alarm system,hardware design analysi... This article explores the design of a wireless fire alarm system supported by advanced data fusion technology.It includes discussions on the basic design ideas of the wireless fire alarm system,hardware design analysis,software design analysis,and simulation analysis,all supported by data fusion technology.Hopefully,this analysis can provide some reference for the rational application of data fusion technology to meet the actual design and application requirements of the system. 展开更多
关键词 Data fusion technology Fire alarm system Wireless alarm Hardware design Software design
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Achieving high strength and ductility in laser powder bed fusion-manufactured pure titanium through the addition of carbon nanotubes 被引量:1
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作者 Li Ma Chang-Shun Wang +3 位作者 Ye Ma Jae-Hyuk Kim Cheng-Lin Li Jae-Keun Hong 《Rare Metals》 2025年第6期4149-4161,共13页
The features of additive manufacturing(AM)have made commercially pure titanium(CP-Ti)an attractive candidate material for biomedical implants.However,achieving high strength and ductility is challenging because of the... The features of additive manufacturing(AM)have made commercially pure titanium(CP-Ti)an attractive candidate material for biomedical implants.However,achieving high strength and ductility is challenging because of the columnar structures and fine martensite formation.This study investigated the effect of carbon nanotubes(CNTs)addition on the microstructure and mechanical properties of grade 1 CP-Ti(Gr-1)during the laser powder bed fusion(L-PBF)process.A minute amount of 0.2%mass fraction(wt%)CNTs addition resulted in a high yield strength of approximately 700 MPa and exceptional ductility of 25.7%.Therein,a portion of the CNTs dissolved in the matrix as solute atoms,contributing to solution strengthening,while others were transformed into Ti C_(x)through an in situ reaction with the Ti matrix.Furthermore,the addition of CNTs resulted in the formation of a larger fraction of equiaxed grains and increased the activity of basal and prismatic slip systems.Hence,Gr-1 with CNTs exhibited significantly increased ductility while maintaining a high strength comparable to that of Gr-1 without CNTs.The insights gained from this study provide a novel approach for designing strong and ductile Ti alloys for AM. 展开更多
关键词 Pure titanium Laser powder bed fusion Carbon nanotubes High strength-ductility
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Densification,microstructure,mechanical properties,and thermal stability of high-strength Ti-modified Al-Si-Mg-Zr aluminum alloy fabricated by laser-powder bed fusion 被引量:1
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作者 Yaoxiang Geng Zhifa Shan +2 位作者 Jiaming Zhang Tianshuo Wei Zhijie Zhang 《International Journal of Minerals,Metallurgy and Materials》 2025年第10期2547-2559,共13页
Micrometer-sized,irregularly shaped Ti particles(0.5wt%and 1.0wt%)were mixed with an Al-Si-Mg-Zr matrix powder,and a novel Ti-modified Al-Si-Mg-Zr aluminum alloy was subsequently fabricated via laser-powder bed fusion... Micrometer-sized,irregularly shaped Ti particles(0.5wt%and 1.0wt%)were mixed with an Al-Si-Mg-Zr matrix powder,and a novel Ti-modified Al-Si-Mg-Zr aluminum alloy was subsequently fabricated via laser-powder bed fusion(L-PBF).The results demonstrated that the introduction of Ti particles promoted the formation of near-fully equiaxed grains in the alloy owing to the strong grain refinement of the primary(Al,Si)3(Ti,Zr)nanoparticles.Furthermore,the presence of(Al,Si)3(Ti,Zr)nanoparticles inhibited the decomposition of Si-rich cell boundaries and the precipitation of Si nanoparticles in theα-Al cells.The ultimate tensile strength(UTS),yield strength(YS),and elongation of the asbuilt 0.5wt%Ti(0.5Ti)alloy were(468±11),(350±1)MPa,and(10.0±1.4)%,respectively,which are comparable to those of the L-PBF Al-Si-Mg-Zr matrix alloy and significantly higher than those of traditional L-PBF Al-Si-Mg alloys.After direct aging treatment at 150°C,the precipitation of secondary nanoparticles notably enhanced the strength of the 0.5Ti alloy.Specifically,the 0.5Ti alloy achieved a maximum UTS of(479±11)MPa and YS of(376±10)MPa.At 250°C,the YS of the L-PBF Ti/Al-Si-Mg-Zr alloy was higher than that of the L-PBF Al-Si-Mg-Zr matrix alloy due to the retention of Si-rich cell boundaries,indicating a higher thermal stability.As the aging temperature was increased to 300°C,the dissolution of Si-rich cell boundaries,desolvation of solid-solution elements,and coarsening of nanoprecipitates led to a decrease in the UTS and YS of the alloy to below 300 and 200 MPa,respectively.However,the elongation increased significantly. 展开更多
关键词 laser-powder bed fusion Ti-modified Al-Si-Mg-Zr alloy MICROSTRUCTURE mechanical property thermal stability
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Anisotropy Evolution of Tensile Properties in Laser Powder Bed Fusion-Fabricated Inconel 625 Alloy at High Temperature 被引量:1
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作者 Jiaqing Liu Libo Zhou +5 位作者 Zeai Peng Boyi Chen Yijie Tan Jian Chen Weiying Huang Cong Li 《Acta Metallurgica Sinica(English Letters)》 2025年第4期555-569,共15页
This work investigated the anisotropy tensile properties of Inconel 625 alloy fabricated by laser powder bed fusion (LPBF) under various tests temperature, focusing the anisotropy evolution during the high temperature... This work investigated the anisotropy tensile properties of Inconel 625 alloy fabricated by laser powder bed fusion (LPBF) under various tests temperature, focusing the anisotropy evolution during the high temperature. The microstructure contained columnar grains with (111) texture in the vertical plane (90° sample), while a large equiaxed grain with (100) texture was produced in the horizontal plane (0° sample). As for 45° sample, a large number of equiaxed grains and a few columnar grains with (111) texture can be observed. The sample produced at a 0° orientation demonstrates the highest tensile strength, whereas the 90° sample exhibits the greatest elongation. Conversely, the 45° sample displays the least favorable overall performance. As the tests temperature increased from room temperature to 600℃, the anisotropy rate of ultimate tensile strength, yield strength and ductility between 0° and 45° samples, decreased from 8.98 to 6.96%, 2.36 to 1.28%, 19.93 to 12.23%, as well as between 0° and 90° samples decreased from 4.87 to 4.03%, 11.88 to 7.21% and 14.11 to 6.89%, respectively, because of the recovery of oriented columnar grains. 展开更多
关键词 Laser powder bed fusion Inconel 625 alloy Anisotropy evolution High temperature
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Achieving balanced mechanical properties in laser powder bed fusion processed Inconel 718 superalloy through a simplified heat treatment process 被引量:1
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作者 Ziyi Ding Kesong Miao +5 位作者 Qi Chao Xinliang Xie Xia Ji Hao Wu Xiaojun Wang Guohua Fan 《Journal of Materials Science & Technology》 2025年第15期54-70,共17页
Laser additively manufactured(LAM)Ni-based superalloys commonly exhibit low strength and high residual stress in the as-built state,requiring post-heat treatment to improve mechanical properties.We propose a modified ... Laser additively manufactured(LAM)Ni-based superalloys commonly exhibit low strength and high residual stress in the as-built state,requiring post-heat treatment to improve mechanical properties.We propose a modified heat treatment(MHT)process that only involves a single-step aging at 650℃ for 4 h to achieve high strength,high ductility,and low residual stress simultaneously in a laser powder bed fusion(LPBF)-processed Inconel 718(IN718)alloy.The MHT treated alloy exhibits comparable tensile strength(1368 MPa)to the conventional solution plus two-step aging(SA)treated alloy(1398 MPa),while the tensile elongation(∼21.7%for MHT treated alloy and 13.4%for SA treated alloy)is 60%higher and the residual stress(∼195 MPa)is 20%lower than the SA treated alloy.The balanced high performance of the MHT IN718 alloy was mainly attributed to the precipitation of abundantγ’’phase with a size of∼5 nm,while the original nano-sized Laves precipitates and dislocation cells were mostly retained.The finer size and higher fraction ofγ”of the MHT sample mainly result from the dislocation structure and compositional variations in the as-built IN718,which promotes precipitation during aging.The retention of Laves phase,and cellular dislocation network in the MHT alloy also contributes to work hardening during tension and suspends the occurrence of necking.This study unveils a unique strengthening and toughening mechanism in the Ni-based superalloy produced by LAM with the presence of abundant Laves precipitates and provides a simple,low energy-consumption and cost-effective heat treatment route for achieving desirable mechanical properties. 展开更多
关键词 Inconel 718 Laser powder bed fusion Heat treatment Strengthening mechanism Deformation behavior
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