General survey ofhypertension has beencarried out in our coun—try for three times.Thelast time was in 1999,with the result showingthat in our country theincidence of hyperten-sion among people over15 years old was11...General survey ofhypertension has beencarried out in our coun—try for three times.Thelast time was in 1999,with the result showingthat in our country theincidence of hyperten-sion among people over15 years old was11.26％.The incidencehas been raised by 25％展开更多
BACKGROUND Castleman's disease(CD)is a lymphoproliferative disorder.TAFRO syndrome is classified as a variant of CD based on its key clinical manifestations of thrombocytopenia,anasarca(generalized edema and pleur...BACKGROUND Castleman's disease(CD)is a lymphoproliferative disorder.TAFRO syndrome is classified as a variant of CD based on its key clinical manifestations of thrombocytopenia,anasarca(generalized edema and pleural effusion),fever(pyrexia),reticulin fibrosis in the bone marrow and the proliferation of megakaryocytes,and organomegaly(such as hepatosplenomegaly and multiple lymphadenopathies);TAFRO syndrome is mainly reported in Japanese patients.To our knowledge,this is the first pediatric case report detailing a CD-associated disorder progressing to cirrhosis.CASE SUMMARY A 10-year old male patient presented with fever and anemia.Six months before hospitalization,he had remarkable abdominal distention.Subsequently,he visited a clinic for a fever that lasted 5 d.The physical findings were marked hepatosplenomegaly and cervical lymphadenopathy.A blood test revealed leukocytosis,microcytic anemia,aspartate aminotransferase-dominant transaminase elevation,high levels of C-reactive protein,polyclonal hypergammaglobulinemia,and high levels of interleukin-6 and vascular endothelial growth factor.Abdominal contrast computed tomography and magnetic resonance imaging suggested cirrhosis,which was confirmed by liver histology.Histological findings in the enlarged hepatic lymph nodes revealed both hyperplasia and atrophy of lymphoid follicles with some vascular hyperplasia and moderate plasmacytosis between the lymphoid follicles,which is compatible with lymph node histology in TAFRO syndrome.Prednisolone was not effective in reducing the patient’s symptoms;therefore,the patient was prescribed tocilizumab.To date,the patient remains free of fever and continues to receive tocilizumab.CONCLUSION We described the clinicopathological features of TAFRO syndrome to highlight the clinical presentation of this rare disease in a pediatric case.展开更多
基于Cell处理器的异构多核架构及软件显式管理的多级存储层次,使其面临编程困难和性能难以有效发挥等问题.现有基于Cell/B.E.的编程模型多侧重于支持类似于流处理的"批量访存"(bulk data transfer)应用,传统非规则访存应用性...基于Cell处理器的异构多核架构及软件显式管理的多级存储层次,使其面临编程困难和性能难以有效发挥等问题.现有基于Cell/B.E.的编程模型多侧重于支持类似于流处理的"批量访存"(bulk data transfer)应用,传统非规则访存应用性能较低.通过扩展Cell/B.E.访存库增强协处理单元的自主作用,以协处理单元为中心建立Cell计算平台上的MPI和弱一致性Pthread分层并行编程运行时支持.分层的运行时支持结构及扩展后的Cell/B.E.访存库使模型具有更好的效率和可扩展性,并且提高了非规则应用的性能;模型中的MPI方便了大量传统并行应用向新架构的移植及开发,而弱一致性Pthread则为MPI提供高效的任务运行时管理支持及为系统级用户提供对架构全面控制的编程接口.实验结果表明,提出的运行时支持技术不仅可适应不同应用的要求,同时借助访存库中的剖分优化机制可有效地挖掘Cell/B.E.架构性能.展开更多
文摘General survey ofhypertension has beencarried out in our coun—try for three times.Thelast time was in 1999,with the result showingthat in our country theincidence of hyperten-sion among people over15 years old was11.26％.The incidencehas been raised by 25％
基金Kazuyuki Yoshizaki,Department of Organic Fine Chemicals,The Institute of Scientific and Industrial Research,Osaka University,Osaka,Japan.Masaru Kojima,Department of Diagnostic Pathology,Dokkyo Medical University School of Medicine,Tochigi,Japan.
文摘BACKGROUND Castleman's disease(CD)is a lymphoproliferative disorder.TAFRO syndrome is classified as a variant of CD based on its key clinical manifestations of thrombocytopenia,anasarca(generalized edema and pleural effusion),fever(pyrexia),reticulin fibrosis in the bone marrow and the proliferation of megakaryocytes,and organomegaly(such as hepatosplenomegaly and multiple lymphadenopathies);TAFRO syndrome is mainly reported in Japanese patients.To our knowledge,this is the first pediatric case report detailing a CD-associated disorder progressing to cirrhosis.CASE SUMMARY A 10-year old male patient presented with fever and anemia.Six months before hospitalization,he had remarkable abdominal distention.Subsequently,he visited a clinic for a fever that lasted 5 d.The physical findings were marked hepatosplenomegaly and cervical lymphadenopathy.A blood test revealed leukocytosis,microcytic anemia,aspartate aminotransferase-dominant transaminase elevation,high levels of C-reactive protein,polyclonal hypergammaglobulinemia,and high levels of interleukin-6 and vascular endothelial growth factor.Abdominal contrast computed tomography and magnetic resonance imaging suggested cirrhosis,which was confirmed by liver histology.Histological findings in the enlarged hepatic lymph nodes revealed both hyperplasia and atrophy of lymphoid follicles with some vascular hyperplasia and moderate plasmacytosis between the lymphoid follicles,which is compatible with lymph node histology in TAFRO syndrome.Prednisolone was not effective in reducing the patient’s symptoms;therefore,the patient was prescribed tocilizumab.To date,the patient remains free of fever and continues to receive tocilizumab.CONCLUSION We described the clinicopathological features of TAFRO syndrome to highlight the clinical presentation of this rare disease in a pediatric case.
文摘基于Cell处理器的异构多核架构及软件显式管理的多级存储层次,使其面临编程困难和性能难以有效发挥等问题.现有基于Cell/B.E.的编程模型多侧重于支持类似于流处理的"批量访存"(bulk data transfer)应用,传统非规则访存应用性能较低.通过扩展Cell/B.E.访存库增强协处理单元的自主作用,以协处理单元为中心建立Cell计算平台上的MPI和弱一致性Pthread分层并行编程运行时支持.分层的运行时支持结构及扩展后的Cell/B.E.访存库使模型具有更好的效率和可扩展性,并且提高了非规则应用的性能;模型中的MPI方便了大量传统并行应用向新架构的移植及开发,而弱一致性Pthread则为MPI提供高效的任务运行时管理支持及为系统级用户提供对架构全面控制的编程接口.实验结果表明,提出的运行时支持技术不仅可适应不同应用的要求,同时借助访存库中的剖分优化机制可有效地挖掘Cell/B.E.架构性能.
