The netted radar system(NRS)has been proved to possess unique advantages in anti-jamming and improving target tracking performance.Effective resource management can greatly ensure the combat capability of the NRS.In t...The netted radar system(NRS)has been proved to possess unique advantages in anti-jamming and improving target tracking performance.Effective resource management can greatly ensure the combat capability of the NRS.In this paper,based on the netted collocated multiple input multiple output(CMIMO)radar,an effective joint target assignment and power allocation(JTAPA)strategy for tracking multi-targets under self-defense blanket jamming is proposed.An architecture based on the distributed fusion is used in the radar network to estimate target state parameters.By deriving the predicted conditional Cramer-Rao lower bound(PC-CRLB)based on the obtained state estimation information,the objective function is formulated.To maximize the worst case tracking accuracy,the proposed JTAPA strategy implements an online target assignment and power allocation of all active nodes,subject to some resource constraints.Since the formulated JTAPA is non-convex,we propose an efficient two-step solution strategy.In terms of the simulation results,the proposed algorithm can effectively improve tracking performance in the worst case.展开更多
Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research a...Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research and development of more efficacious and disease-modifying agents for the prevention, treatment and restoration of AD will have tremendous value from both scientific, and economic standpoints. Over the past few years, our series of studies have identified several highly promising anti-AD dimeric leads, with disease-modifying potentials. In this presentation, the latest progress on the neuroprotective and disease modifying effects and the underlying mechanisms of those candidates will be comprehensively illustrated and discussed.展开更多
OBJECTIVE Bisbenzylisoquinoline(BBI)alkaloids have extensive pharmacological functions.The aim of this study was to investigate the mechanisms underlying the antidepressant-like action of 7-O-ethylfangchinoline(YH-200...OBJECTIVE Bisbenzylisoquinoline(BBI)alkaloids have extensive pharmacological functions.The aim of this study was to investigate the mechanisms underlying the antidepressant-like action of 7-O-ethylfangchinoline(YH-200)in mice.METHODS Male ICR mice were used in the forced swimming(FST)and tail suspension tests(TST).RESULTS YH-200(60mg·kg-1,ig)decreased the immobility time in FST and TST,and prolonged the latency to immobility in FST.YH-200 revealed more potent anti-immobility activity than its BBI derivative tetrandrine.In addition,the pretreatment of mice with prazosin(1mg·kg-1,ip,anα1-adrenoceptor antagonist),propranolol(2 mg·kg-1,ip,a nonselectiveβ-adrenoceptor antagonist),SCH23390(0.05mg·kg-1,ip,a dopamine D1/D5 receptor antagonist),haloperidol(0.2mg·kg-1,ip,a dopamine D2/D3 receptor antagonist)and NBQX(10mg·kg-1,ip,an AMPA receptor antagonist)prevented the antidepressant-like effect of YH-200(60mg·kg-1,ig)in FST.Besides that,the pretreatment of mice with yohimbine(1mg·kg-1,ip,an α2 adrenoceptor antagonist)augmented the antidepressant-like effect of YH-200(30mg·kg-1,ig)in FST.After 14 dadministration,YH-200(30 and 60mg·kg-1,ig)did not develop drug resistance,but the potency was strengthened,meanwhile,it did not influence the changes in mice body weight.CONCLUSION YH-200 may possess the therapeutic potential for the treatment of depression via the multi-targets including the noradrenergic(α1,α2 and β-adrenoceptors),dopaminergic(D1/D5 and D2/D3receptors)and AMPAergic systems.展开更多
This paper presents a newmulti-targets inverse synthetic aperture radar (ISAR) imaging approach via the image segmentation processing. This method can separate multi-targets with similar velocities,and there is no str...This paper presents a newmulti-targets inverse synthetic aperture radar (ISAR) imaging approach via the image segmentation processing. This method can separate multi-targets with similar velocities,and there is no strict limit on the rotational state of the targets. Firstly,the motion compensation for the completely multi-targets echo is carried out and the coarse image can be achieved with the Range-Doppler (RD) technique. Then a series of image processing methods and image segmentation processing are used to separate the echo data of each mono-target. At last,the image with high quality of each target can be achieved with the RD technique and the Range-Instantaneous-Doppler (RID) technique. ISAR imaging results of simulated and measured data validate the validity of the proposed approach.展开更多
<div style="text-align:justify;"> STMV beamforming algorithm needs inversion operation of matrix, and its engineering application is limited due to its huge computational cost. This paper proposed bloc...<div style="text-align:justify;"> STMV beamforming algorithm needs inversion operation of matrix, and its engineering application is limited due to its huge computational cost. This paper proposed block iterative STMV algorithm based on one-phase regressive filter, matrix inversion lemma and inversion of block matrix. The computational cost is reduced approximately as 1/4 M times as original algorithm when array number is M. The simulation results show that this algorithm maintains high azimuth resolution and good performance of detecting multi-targets. Within 1 - 2 dB directional index and higher azimuth discrimination of block iterative STMV algorithm are achieved than STMV algorithm for sea trial data processing. And its good robustness lays the foundation of its engineering application. </div>展开更多
The escalating severity of Bombyx mori nuclear polyhedrosis virus(BmNPV)infections poses significant challenges to the silkworm industry,especially when massive production shifts occur from the eastern regions to west...The escalating severity of Bombyx mori nuclear polyhedrosis virus(BmNPV)infections poses significant challenges to the silkworm industry,especially when massive production shifts occur from the eastern regions to western regions with lower labor costs.Education and experience levels are different and disease control is badly needed.To solve the problems,we have developed an innovative CRISPR/Cas9 system specifically targeting BmNPV to enhance viral resistance.For the system,we selected BmNPV genes linked to virus replication and proliferation as targets,designing 2 sites for each gene.Mutating the target sequence renders the system incapable of efficiently cleaving the virus genome,hence decreasing cleavage efficiency.We conducted a search for“NGG”or“CCN”target sequences in the BmNPV genome,excluding non-recurring and potential targets in the B.mori genome.We successfully identified 2 distinct target sequences in the BmNPV genome—one being repeated 12 times and the other three times.These sequences lead to fragmentation of virus genome into multiple large segments that are difficult to repair.Transgenic silkworms demonstrate robust resistance to viruses,significantly boosting their survival rates compared with wild-type silkworms under various virus infection concentrations.Our system efficiently targets dozens of viral genomes with just 2 sequences,minimizing transposable elements while ensuring cutting effectiveness.This marks a pioneering advancement by using repetitive elements within the virus genome for targeted CRISPR cleavage,aiming for antiviral effects through genome fragmentation rather than disrupting essential viral genes.Our research introduces innovative concepts to CRISPR antiviral investigations and shows promise for the practical application of gene editing in industrial silkworm strains.展开更多
After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the tim...After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the timing of interventions,combined with the limitations of current methods.To address these challenges,various techniques have been developed to aid in the repair and reconstruction of neural circuits at different stages of injury.Notably,neuromodulation has garnered considerable attention for its potential to enhance nerve regeneration,provide neuroprotection,restore neurons,and regulate the neural reorganization of circuits within the cerebral cortex and corticospinal tract.To improve the effectiveness of these interventions,the implementation of multitarget early interventional neuromodulation strategies,such as electrical and magnetic stimulation,is recommended to enhance functional recovery across different phases of nerve injury.This review concisely outlines the challenges encountered following spinal cord injury,synthesizes existing neurostimulation techniques while emphasizing neuroprotection,repair,and regeneration of impaired connections,and advocates for multi-targeted,task-oriented,and timely interventions.展开更多
The multi-target assignment(MTA)problem,a crucial challenge in command control,mission planning,and a fundamental research focus in military operations,has garnered significant attention over the years.Extensively stu...The multi-target assignment(MTA)problem,a crucial challenge in command control,mission planning,and a fundamental research focus in military operations,has garnered significant attention over the years.Extensively studied across various domains such as land,sea,air,space,and electronics,the MTA problem has led to the emergence of numerous models and algorithms.To delve deeper into this field,this paper starts by conducting a bibliometric analysis on 463 Scopus database papers using CiteSpace software.The analysis includes examining keyword clustering,co-occurrence,and burst,with visual representations of the results.Following this,the paper provides an overview of current classification and modeling techniques for addressing the MTA problem,distinguishing between static multi-target assignment(SMTA)and dynamic multi-target assignment(DMTA).Subsequently,existing solution algorithms for the MTA problem are reviewed,generally falling into three categories:exact algorithms,heuristic algorithms,and machine learning algorithms.Finally,a development framework is proposed based on the"HIGH"model(high-speed,integrated,great,harmonious)to guide future research and intelligent weapon system development concerning the MTA problem.This framework emphasizes application scenarios,modeling mechanisms,solution algorithms,and system efficiency to offer a roadmap for future exploration in this area.展开更多
Integrated Sensing and Communication(ISAC)is envisioned as a promising technology for Sixth-Generation(6G)wireless communications,which enables simultaneous high-rate communication and high-precision target localizati...Integrated Sensing and Communication(ISAC)is envisioned as a promising technology for Sixth-Generation(6G)wireless communications,which enables simultaneous high-rate communication and high-precision target localization.Compared to independent sensing and communication modules,dual-function ISAC could leverage the strengths of both communication and sensing in order to achieve cooperative gains.When considering the communication core network,ISAC system facilitates multiple communication devices to collaborate for networked sensing.This paper investigates such kind of cooperative ISAC systems with distributed transmitters and receivers to support non-connected and multi-target localization.Specifically,we introduce a Time of Arrival(TOA)based multi-target localization scheme,which leverages the bi-static range measurements between the transmitter,target,and receiver channels in order to achieve elliptical localization.To obtain the low-complexity localization,a two-stage search-refine localization methodology is proposed.In the first stage,we propose a Successive Greedy Grid-Search(SGGS)algorithm and a Successive-Cancellation-List Grid-Search(SCLGS)algorithm to address the Measurement-to-Target Association(MTA)problem with relatively low computational complexity.In the second stage,a linear approximation refinement algorithm is derived to facilitate high-precision localization.Simulation results are presented to validate the effectiveness and superiority of our proposed multi-target localization method.展开更多
Response prediction is a fundamental yet challenging task in aeronautical engineering,requiring an accurate selection of sensor positions correlated with the target responses to achieve precise predictions. Unfortunat...Response prediction is a fundamental yet challenging task in aeronautical engineering,requiring an accurate selection of sensor positions correlated with the target responses to achieve precise predictions. Unfortunately, in large-scale structures, the rigorous selection of reliable sensor candidates for multi-target responses remains largely unexplored. In this paper, we propose a flexible and generalized framework for selecting the most relevant sensors to the multi-target response and predicting the target response, referred to as the Fast-aware Multi-Target Response Prediction(FMTRP) approach in the spirit of divide-and-conquer. Specifically, first, a multi-task learning module is designed to predict multi-point response tasks at the same time. Simultaneously, we meticulously devise adaptive mechanisms to facilitate loss-term reweighting and encourage prioritization of challenging tasks in multiple prediction tasks. Second, to ensure ease of interpretation,we introduce a hybrid penalty to select sensors at the group-sparsity, individual-sparsity and element-sparsity levels. Finally, due to the substantial number of candidate sensors posing a significant computational burden, we develop a more efficient search strategy and support computation to make the proposed approach applicable in practice, leading to substantial runtime improvements. Extensive experiments on aircraft standard model response datasets and large airliner test flight datasets validate the effectiveness of the proposed approach in identifying sensor locations and simultaneously predicting responses at multiple points. Compared to state-of-the-art methods,the proposed approach achieves an accuracy of over 99% in sinusoidal excitation and exhibits the shortest runtime(3.514 s).展开更多
The more information obtained about the driving environment,the more ensures driving safety.Due to the complex driving environment of farmland roads,targets beside the road sometimes have an important impact on drivin...The more information obtained about the driving environment,the more ensures driving safety.Due to the complex driving environment of farmland roads,targets beside the road sometimes have an important impact on driving safety.To achieve this goal,a novel real-time detection and prediction algorithm of targets was proposed.The whole image was divided into four parts by RCM:driving region,crossroad region,roadside region,and the other region.In addition,a safety policy for every part was enforced by the algorithm,which was based mainly on the combination of the YOLACT and GPM.On this basis,a self-collected data set of 5000 test samples is used for testing.The detection accuracy of the algorithm in the data set could reach up to 90%,and the processing speed to 30.4 fps.In addition,experiments were carried out on actual farmland roads,and the results showed that the proposed algorithm was able to detect,track,and predict targets on the farmland road,and alarm to driver in time before the targets rush into the road.This study provides an important reference for the safe driving of agricultural vehicles.展开更多
Aiming at the problems of low efficiency,poor anti-noise and robustness of transfer learning model in intelligent fault diagnosis of rotating machinery,a new method of intelligent fault diagnosis of rotating machinery...Aiming at the problems of low efficiency,poor anti-noise and robustness of transfer learning model in intelligent fault diagnosis of rotating machinery,a new method of intelligent fault diagnosis of rotating machinery based on single source and multi-target domain adversarial network model(WDMACN)and Gram Angle Product field(GAPF)was proposed.Firstly,the original one-dimensional vibration signal is preprocessed using GAPF to generate the image data including all time series.Secondly,the residual network is used to extract data features,and the features of the target domain without labels are pseudo-labeled,and the transferable features among the feature extractors are shared through the depth parameter,and the feature extractors of the multi-target domain are updated anatomically to generate the features that the discriminator cannot distinguish.The modelt through adversarial domain adaptation,thus achieving fault classification.Finally,a large number of validations were carried out on the bearing data set of Case Western Reserve University(CWRU)and the gear data.The results show that the proposed method can greatly improve the diagnostic efficiency of the model,and has good noise resistance and generalization.展开更多
With the great development of Multi-Target Tracking(MTT)technologies,many MTT algorithms have been proposed with their own advantages and disadvantages.Due to the fact that requirements to MTT algorithms vary from the...With the great development of Multi-Target Tracking(MTT)technologies,many MTT algorithms have been proposed with their own advantages and disadvantages.Due to the fact that requirements to MTT algorithms vary from the application scenarios,performance evaluation is significant to select an appropriate MTT algorithm for the specific application scenario.In this paper,we propose a performance evaluation method on the sets of trajectories with temporal dimension specifics to compare the estimated trajectories with the true trajectories.The proposed method evaluates the estimate results of an MTT algorithm in terms of tracking accuracy,continuity and clarity.Furthermore,its computation is based on a multi-dimensional assignment problem,which is formulated as a computable form using linear programming.To enhance the influence of recent estimated states of the trajectories in the evaluation,an attention function is used to reweight the trajectory errors at different time steps.Finally,simulation results show that the proposed performance evaluation method is able to evaluate many aspects of the MTT algorithms.These evaluations are worthy for selecting suitable MTT algorithms in different application scenarios.展开更多
Background:Choerospondias axillaris(CA)is a traditional Mongolian medicine that has been proven to have a good therapeutic effect on cerebrovascular disease.Cerebral Ischemia(CI)is a severe and life-threatening cerebr...Background:Choerospondias axillaris(CA)is a traditional Mongolian medicine that has been proven to have a good therapeutic effect on cerebrovascular disease.Cerebral Ischemia(CI)is a severe and life-threatening cerebrovascular disease.However,the specific mechanism of action of CA in the treatment of CI is still unclear.Methods:In this study,the related targets and pathways of CA in the treatment of CI were first predicted by system pharmacology and then verified by relevant experiments.Results:The results showed that 12 active ingredients and 208 targets were selected.Further validation through protein-protein interaction(PPI)network analysis and active ingredients-target-pathway(A-T-P)network analysis has confirmed the pivotal roles of the main bioactive constituents,including quercetin,kaempferol,naringin,β-sitosterol,and gallic acid.These components exert their anti-ischemic effects by modulating key targets such as IL6,TNF,MAPK3,and CASP3,thereby regulating the PI3K-Akt,HIF-1,and MAPK signaling pathways,which are integral to processes like inflammation,apoptosis,and oxidative stress.More importantly,through experimental verification,this study confirmed our prediction that CAE significantly reduced neurological function scores,infarct volume,and the percentage of apoptosis neurons.Conclusion:This indicates that CA acts on CI through multi-target synergistic mechanism,and this study provides theoretical basis for the clinical application of CA.展开更多
The frequency-modulated continuous wave (FMCW) radar, known for its high range resolution, has garnered significant attention in the field of non-contact vital sign monitoring. However, accurately locating multiple ta...The frequency-modulated continuous wave (FMCW) radar, known for its high range resolution, has garnered significant attention in the field of non-contact vital sign monitoring. However, accurately locating multiple targets and separating their vital sign signals remains a challenging research topic. This paper proposes a scene-differentiated method for multi-target localization and vital sign monitoring. The approach identifies the relative positions of multiple targets using Range FFT and determines the directions of targets via the multiple signal classification (MUSIC) algorithm. Phase signals within the range bins corresponding to the targets are separated using bandpass filtering. If multiple targets reside in the same range bin, the variational mode decomposition (VMD) algorithm is employed to decompose their breathing or heartbeat signals. Experimental results demonstrate that the proposed method accurately localizes targets. When multiple targets occupy the same range bin, the mean absolute error (MAE) for respiratory signals is 3 bpm, and the MAE for heartbeat signals is 5 bpm.展开更多
A definition of self-determined priority is used in airfight decision firstly. A scheme of grouping the whole fighters is introduced, and the principle of target assignment and fire control is designed. Based on the ...A definition of self-determined priority is used in airfight decision firstly. A scheme of grouping the whole fighters is introduced, and the principle of target assignment and fire control is designed. Based on the neutral network, the decision algorithm is derived and the whole coordinated decision system is simulated. Secondly an algorithm for missile-attacking area is described and its calculational result is obtained under initial conditions. Then the attacking of missile is realized by the proportion guidance. Finally, a multi-target attack system. The system includes airfight decision, estimation of missile attack area and calculation of missile attack procedure. A digital simulation demonstrates that the airfight decision algorithm is correct. The methods have important reference values for the study of fire control system of the fourth generation fighter.展开更多
The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays a...The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.展开更多
Alzheimer’s disease(AD)poses one of the most urgent medical challenges in the 21st century as it affects millions of people.Unfortunately,the etiopathogenesis of AD is not yet fully understood and the current pharmac...Alzheimer’s disease(AD)poses one of the most urgent medical challenges in the 21st century as it affects millions of people.Unfortunately,the etiopathogenesis of AD is not yet fully understood and the current pharmacotherapy options are somewhat limited.Here,we report a novel inhibitor,Compound 44,for targeting cholinesterases,amyloid-β(Aβ)aggregation,and glycogen synthase kinase 3β(GSK-3β)simultaneously with the aim of achieving symptomatic relief and disease modification in AD therapy.We found that Compound 44 had good inhibitory effects on all intended targets with IC_(50)s of submicromolar or better,significant neuroprotective effects in cell models,and beneficial improvement of cognitive deficits in the triple transgenic AD(3×Tg AD)mouse model.Moreover,we showed that Compound 44 acts as an autophagy regulator by inducing nuclear translocation of transcription factor EB through GSK-3βinhibition,enhancing the biogenesis of lysosomes and elevating autophagic flux,thus ameliorating the amyloid burden and tauopathy,as well as mitigating the disease phenotype.Our results suggest that triple-target inhibition via Compound 44 could be a promising strategy that may lead to the development of effective therapeutic approaches for AD.展开更多
We are deeply interested in the recent findings onβ-arrestin 2.Liu et al demonstrated thatβ-arrestin 2 knockout provides significant protection in diabetic nephropathy,underscoring its potential as a promising thera...We are deeply interested in the recent findings onβ-arrestin 2.Liu et al demonstrated thatβ-arrestin 2 knockout provides significant protection in diabetic nephropathy,underscoring its potential as a promising therapeutic target for diabetic nephropathy treatment.Furthermore,the role ofβ-arrestin 2 in metabolic regulation is equally critical,particularly in insulin signaling,hepatic glucose production,and adipose tissue function.Althoughβ-arrestin 2 plays a distinct role in metabolism and kidney protection,its tissue-specific regulation opens up valuable avenues for developing targeted therapeutic strategies centered onβ-arrestin 2.展开更多
Cancer is a complex disease associated with multiple gene mutations and malignant phenotypes,and multi-target drugs provide a promising therapy idea for the treatment of cancer.Natural products with abundant chemical ...Cancer is a complex disease associated with multiple gene mutations and malignant phenotypes,and multi-target drugs provide a promising therapy idea for the treatment of cancer.Natural products with abundant chemical structure types and rich pharmacological characteristics could be ideal sources for screening multi-target antineoplastic drugs.In this paper,50 tumor-related targets were collected by searching the Therapeutic Target Database and Thomson Reuters Integrity database,and a multi-target anti-cancer prediction system based on mt-QSAR models was constructed by using naïve Bayesian and recursive partitioning algorithm for the first time.Through the multi-target anti-cancer prediction system,some dominant fragments that act on multiple tumor-related targets were analyzed,which could be helpful in designing multi-target anti-cancer drugs.Anti-cancer traditional Chinese medicine(TCM)and its natural products were collected to form a TCM formula-based natural products library,and the potential targets of the natural products in the library were predicted by multi-target anti-cancer prediction system.As a result,alkaloids,flavonoids and terpenoids were predicted to act on multiple tumor-related targets.The predicted targets of some representative compounds were verified according to literature review and most of the selected natural compounds were found to exert certain anti-cancer activity in vitro biological experiments.In conclusion,the multi-target anti-cancer prediction system is very effective and reliable,and it could be further used for elucidating the functional mechanism of anti-cancer TCM formula and screening for multi-target anti-cancer drugs.The anti-cancer natural compounds found in this paper will lay important information for further study.展开更多
基金National Natural Science Foundation of China(Grant No.62001506)to provide fund for conducting experiments。
文摘The netted radar system(NRS)has been proved to possess unique advantages in anti-jamming and improving target tracking performance.Effective resource management can greatly ensure the combat capability of the NRS.In this paper,based on the netted collocated multiple input multiple output(CMIMO)radar,an effective joint target assignment and power allocation(JTAPA)strategy for tracking multi-targets under self-defense blanket jamming is proposed.An architecture based on the distributed fusion is used in the radar network to estimate target state parameters.By deriving the predicted conditional Cramer-Rao lower bound(PC-CRLB)based on the obtained state estimation information,the objective function is formulated.To maximize the worst case tracking accuracy,the proposed JTAPA strategy implements an online target assignment and power allocation of all active nodes,subject to some resource constraints.Since the formulated JTAPA is non-convex,we propose an efficient two-step solution strategy.In terms of the simulation results,the proposed algorithm can effectively improve tracking performance in the worst case.
基金Poly U(G-YBGQ G-SB81+3 种基金 G-YZ95)the Research Grant Council of Hong Kong(15101014)ITSP-Guangdong-Hong Kong Technology Cooperation Funding Scheme(GHP/012/16GD)Shenzhen Basic Research Program(JCYJ20160331141459373)
文摘Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research and development of more efficacious and disease-modifying agents for the prevention, treatment and restoration of AD will have tremendous value from both scientific, and economic standpoints. Over the past few years, our series of studies have identified several highly promising anti-AD dimeric leads, with disease-modifying potentials. In this presentation, the latest progress on the neuroprotective and disease modifying effects and the underlying mechanisms of those candidates will be comprehensively illustrated and discussed.
基金The project supported by National Natural Science Foundation of China(81173031,81202511 and81302746)
文摘OBJECTIVE Bisbenzylisoquinoline(BBI)alkaloids have extensive pharmacological functions.The aim of this study was to investigate the mechanisms underlying the antidepressant-like action of 7-O-ethylfangchinoline(YH-200)in mice.METHODS Male ICR mice were used in the forced swimming(FST)and tail suspension tests(TST).RESULTS YH-200(60mg·kg-1,ig)decreased the immobility time in FST and TST,and prolonged the latency to immobility in FST.YH-200 revealed more potent anti-immobility activity than its BBI derivative tetrandrine.In addition,the pretreatment of mice with prazosin(1mg·kg-1,ip,anα1-adrenoceptor antagonist),propranolol(2 mg·kg-1,ip,a nonselectiveβ-adrenoceptor antagonist),SCH23390(0.05mg·kg-1,ip,a dopamine D1/D5 receptor antagonist),haloperidol(0.2mg·kg-1,ip,a dopamine D2/D3 receptor antagonist)and NBQX(10mg·kg-1,ip,an AMPA receptor antagonist)prevented the antidepressant-like effect of YH-200(60mg·kg-1,ig)in FST.Besides that,the pretreatment of mice with yohimbine(1mg·kg-1,ip,an α2 adrenoceptor antagonist)augmented the antidepressant-like effect of YH-200(30mg·kg-1,ig)in FST.After 14 dadministration,YH-200(30 and 60mg·kg-1,ig)did not develop drug resistance,but the potency was strengthened,meanwhile,it did not influence the changes in mice body weight.CONCLUSION YH-200 may possess the therapeutic potential for the treatment of depression via the multi-targets including the noradrenergic(α1,α2 and β-adrenoceptors),dopaminergic(D1/D5 and D2/D3receptors)and AMPAergic systems.
基金Sponsored by the National Natural Science Foundation of China(Grant No.61622107)
文摘This paper presents a newmulti-targets inverse synthetic aperture radar (ISAR) imaging approach via the image segmentation processing. This method can separate multi-targets with similar velocities,and there is no strict limit on the rotational state of the targets. Firstly,the motion compensation for the completely multi-targets echo is carried out and the coarse image can be achieved with the Range-Doppler (RD) technique. Then a series of image processing methods and image segmentation processing are used to separate the echo data of each mono-target. At last,the image with high quality of each target can be achieved with the RD technique and the Range-Instantaneous-Doppler (RID) technique. ISAR imaging results of simulated and measured data validate the validity of the proposed approach.
文摘<div style="text-align:justify;"> STMV beamforming algorithm needs inversion operation of matrix, and its engineering application is limited due to its huge computational cost. This paper proposed block iterative STMV algorithm based on one-phase regressive filter, matrix inversion lemma and inversion of block matrix. The computational cost is reduced approximately as 1/4 M times as original algorithm when array number is M. The simulation results show that this algorithm maintains high azimuth resolution and good performance of detecting multi-targets. Within 1 - 2 dB directional index and higher azimuth discrimination of block iterative STMV algorithm are achieved than STMV algorithm for sea trial data processing. And its good robustness lays the foundation of its engineering application. </div>
基金supported by the National Natural Science Foundation Innovation Group Project(32021001)the National Natural Science Foundation of China(32100381 and 31830093)。
文摘The escalating severity of Bombyx mori nuclear polyhedrosis virus(BmNPV)infections poses significant challenges to the silkworm industry,especially when massive production shifts occur from the eastern regions to western regions with lower labor costs.Education and experience levels are different and disease control is badly needed.To solve the problems,we have developed an innovative CRISPR/Cas9 system specifically targeting BmNPV to enhance viral resistance.For the system,we selected BmNPV genes linked to virus replication and proliferation as targets,designing 2 sites for each gene.Mutating the target sequence renders the system incapable of efficiently cleaving the virus genome,hence decreasing cleavage efficiency.We conducted a search for“NGG”or“CCN”target sequences in the BmNPV genome,excluding non-recurring and potential targets in the B.mori genome.We successfully identified 2 distinct target sequences in the BmNPV genome—one being repeated 12 times and the other three times.These sequences lead to fragmentation of virus genome into multiple large segments that are difficult to repair.Transgenic silkworms demonstrate robust resistance to viruses,significantly boosting their survival rates compared with wild-type silkworms under various virus infection concentrations.Our system efficiently targets dozens of viral genomes with just 2 sequences,minimizing transposable elements while ensuring cutting effectiveness.This marks a pioneering advancement by using repetitive elements within the virus genome for targeted CRISPR cleavage,aiming for antiviral effects through genome fragmentation rather than disrupting essential viral genes.Our research introduces innovative concepts to CRISPR antiviral investigations and shows promise for the practical application of gene editing in industrial silkworm strains.
基金supported by the National Key Research and Development Program of China,No.2023YFC3603705(to DX)the National Natural Science Foundation of China,No.82302866(to YZ).
文摘After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the timing of interventions,combined with the limitations of current methods.To address these challenges,various techniques have been developed to aid in the repair and reconstruction of neural circuits at different stages of injury.Notably,neuromodulation has garnered considerable attention for its potential to enhance nerve regeneration,provide neuroprotection,restore neurons,and regulate the neural reorganization of circuits within the cerebral cortex and corticospinal tract.To improve the effectiveness of these interventions,the implementation of multitarget early interventional neuromodulation strategies,such as electrical and magnetic stimulation,is recommended to enhance functional recovery across different phases of nerve injury.This review concisely outlines the challenges encountered following spinal cord injury,synthesizes existing neurostimulation techniques while emphasizing neuroprotection,repair,and regeneration of impaired connections,and advocates for multi-targeted,task-oriented,and timely interventions.
基金the financial support provided by the National Natural Science Foundation of China(NSFC)(Grant No.62173274)the National Key R&D Program of China(Grant No.2019YFA0405300)+4 种基金the Natural Science Foundation of Hunan Province of China(Grant No.2021JJ10045)the Practice and Innovation Funds for Graduate Students of Northwestern Polytechnical University(Grant No.PF2023046)the Open Research Subject of State Key Laboratory of Intelligent Game(Grant No.ZBKF-24-01)the Postdoctoral Fellowship Program of CPSF(No.GZB20240989)the China Postdoctoral Science Foundation(Grant No.2024M754304)。
文摘The multi-target assignment(MTA)problem,a crucial challenge in command control,mission planning,and a fundamental research focus in military operations,has garnered significant attention over the years.Extensively studied across various domains such as land,sea,air,space,and electronics,the MTA problem has led to the emergence of numerous models and algorithms.To delve deeper into this field,this paper starts by conducting a bibliometric analysis on 463 Scopus database papers using CiteSpace software.The analysis includes examining keyword clustering,co-occurrence,and burst,with visual representations of the results.Following this,the paper provides an overview of current classification and modeling techniques for addressing the MTA problem,distinguishing between static multi-target assignment(SMTA)and dynamic multi-target assignment(DMTA).Subsequently,existing solution algorithms for the MTA problem are reviewed,generally falling into three categories:exact algorithms,heuristic algorithms,and machine learning algorithms.Finally,a development framework is proposed based on the"HIGH"model(high-speed,integrated,great,harmonious)to guide future research and intelligent weapon system development concerning the MTA problem.This framework emphasizes application scenarios,modeling mechanisms,solution algorithms,and system efficiency to offer a roadmap for future exploration in this area.
文摘Integrated Sensing and Communication(ISAC)is envisioned as a promising technology for Sixth-Generation(6G)wireless communications,which enables simultaneous high-rate communication and high-precision target localization.Compared to independent sensing and communication modules,dual-function ISAC could leverage the strengths of both communication and sensing in order to achieve cooperative gains.When considering the communication core network,ISAC system facilitates multiple communication devices to collaborate for networked sensing.This paper investigates such kind of cooperative ISAC systems with distributed transmitters and receivers to support non-connected and multi-target localization.Specifically,we introduce a Time of Arrival(TOA)based multi-target localization scheme,which leverages the bi-static range measurements between the transmitter,target,and receiver channels in order to achieve elliptical localization.To obtain the low-complexity localization,a two-stage search-refine localization methodology is proposed.In the first stage,we propose a Successive Greedy Grid-Search(SGGS)algorithm and a Successive-Cancellation-List Grid-Search(SCLGS)algorithm to address the Measurement-to-Target Association(MTA)problem with relatively low computational complexity.In the second stage,a linear approximation refinement algorithm is derived to facilitate high-precision localization.Simulation results are presented to validate the effectiveness and superiority of our proposed multi-target localization method.
基金sponsored by the Innovation Foundation for National Natural Science Foundation of China(No.11872312)。
文摘Response prediction is a fundamental yet challenging task in aeronautical engineering,requiring an accurate selection of sensor positions correlated with the target responses to achieve precise predictions. Unfortunately, in large-scale structures, the rigorous selection of reliable sensor candidates for multi-target responses remains largely unexplored. In this paper, we propose a flexible and generalized framework for selecting the most relevant sensors to the multi-target response and predicting the target response, referred to as the Fast-aware Multi-Target Response Prediction(FMTRP) approach in the spirit of divide-and-conquer. Specifically, first, a multi-task learning module is designed to predict multi-point response tasks at the same time. Simultaneously, we meticulously devise adaptive mechanisms to facilitate loss-term reweighting and encourage prioritization of challenging tasks in multiple prediction tasks. Second, to ensure ease of interpretation,we introduce a hybrid penalty to select sensors at the group-sparsity, individual-sparsity and element-sparsity levels. Finally, due to the substantial number of candidate sensors posing a significant computational burden, we develop a more efficient search strategy and support computation to make the proposed approach applicable in practice, leading to substantial runtime improvements. Extensive experiments on aircraft standard model response datasets and large airliner test flight datasets validate the effectiveness of the proposed approach in identifying sensor locations and simultaneously predicting responses at multiple points. Compared to state-of-the-art methods,the proposed approach achieves an accuracy of over 99% in sinusoidal excitation and exhibits the shortest runtime(3.514 s).
基金supported by Beijing Jiaotong University(C18A800090)China North Vehicle Research Institute.All the support from the above organizations is gratefully acknowledged.
文摘The more information obtained about the driving environment,the more ensures driving safety.Due to the complex driving environment of farmland roads,targets beside the road sometimes have an important impact on driving safety.To achieve this goal,a novel real-time detection and prediction algorithm of targets was proposed.The whole image was divided into four parts by RCM:driving region,crossroad region,roadside region,and the other region.In addition,a safety policy for every part was enforced by the algorithm,which was based mainly on the combination of the YOLACT and GPM.On this basis,a self-collected data set of 5000 test samples is used for testing.The detection accuracy of the algorithm in the data set could reach up to 90%,and the processing speed to 30.4 fps.In addition,experiments were carried out on actual farmland roads,and the results showed that the proposed algorithm was able to detect,track,and predict targets on the farmland road,and alarm to driver in time before the targets rush into the road.This study provides an important reference for the safe driving of agricultural vehicles.
基金Shaanxi Province key Research and Development Plan-Listed project(2022-JBGS-07)。
文摘Aiming at the problems of low efficiency,poor anti-noise and robustness of transfer learning model in intelligent fault diagnosis of rotating machinery,a new method of intelligent fault diagnosis of rotating machinery based on single source and multi-target domain adversarial network model(WDMACN)and Gram Angle Product field(GAPF)was proposed.Firstly,the original one-dimensional vibration signal is preprocessed using GAPF to generate the image data including all time series.Secondly,the residual network is used to extract data features,and the features of the target domain without labels are pseudo-labeled,and the transferable features among the feature extractors are shared through the depth parameter,and the feature extractors of the multi-target domain are updated anatomically to generate the features that the discriminator cannot distinguish.The modelt through adversarial domain adaptation,thus achieving fault classification.Finally,a large number of validations were carried out on the bearing data set of Case Western Reserve University(CWRU)and the gear data.The results show that the proposed method can greatly improve the diagnostic efficiency of the model,and has good noise resistance and generalization.
基金supported by the National Natural Science Foundation of China(No.62276204,No.62306222)the Natural Science Basic Research Program of Shaanxi,China(No.2023-JC-QN-0710)。
文摘With the great development of Multi-Target Tracking(MTT)technologies,many MTT algorithms have been proposed with their own advantages and disadvantages.Due to the fact that requirements to MTT algorithms vary from the application scenarios,performance evaluation is significant to select an appropriate MTT algorithm for the specific application scenario.In this paper,we propose a performance evaluation method on the sets of trajectories with temporal dimension specifics to compare the estimated trajectories with the true trajectories.The proposed method evaluates the estimate results of an MTT algorithm in terms of tracking accuracy,continuity and clarity.Furthermore,its computation is based on a multi-dimensional assignment problem,which is formulated as a computable form using linear programming.To enhance the influence of recent estimated states of the trajectories in the evaluation,an attention function is used to reweight the trajectory errors at different time steps.Finally,simulation results show that the proposed performance evaluation method is able to evaluate many aspects of the MTT algorithms.These evaluations are worthy for selecting suitable MTT algorithms in different application scenarios.
基金supported by the National Natural Science Foundation of China,specifically through grants(No.8227431382074321).
文摘Background:Choerospondias axillaris(CA)is a traditional Mongolian medicine that has been proven to have a good therapeutic effect on cerebrovascular disease.Cerebral Ischemia(CI)is a severe and life-threatening cerebrovascular disease.However,the specific mechanism of action of CA in the treatment of CI is still unclear.Methods:In this study,the related targets and pathways of CA in the treatment of CI were first predicted by system pharmacology and then verified by relevant experiments.Results:The results showed that 12 active ingredients and 208 targets were selected.Further validation through protein-protein interaction(PPI)network analysis and active ingredients-target-pathway(A-T-P)network analysis has confirmed the pivotal roles of the main bioactive constituents,including quercetin,kaempferol,naringin,β-sitosterol,and gallic acid.These components exert their anti-ischemic effects by modulating key targets such as IL6,TNF,MAPK3,and CASP3,thereby regulating the PI3K-Akt,HIF-1,and MAPK signaling pathways,which are integral to processes like inflammation,apoptosis,and oxidative stress.More importantly,through experimental verification,this study confirmed our prediction that CAE significantly reduced neurological function scores,infarct volume,and the percentage of apoptosis neurons.Conclusion:This indicates that CA acts on CI through multi-target synergistic mechanism,and this study provides theoretical basis for the clinical application of CA.
文摘The frequency-modulated continuous wave (FMCW) radar, known for its high range resolution, has garnered significant attention in the field of non-contact vital sign monitoring. However, accurately locating multiple targets and separating their vital sign signals remains a challenging research topic. This paper proposes a scene-differentiated method for multi-target localization and vital sign monitoring. The approach identifies the relative positions of multiple targets using Range FFT and determines the directions of targets via the multiple signal classification (MUSIC) algorithm. Phase signals within the range bins corresponding to the targets are separated using bandpass filtering. If multiple targets reside in the same range bin, the variational mode decomposition (VMD) algorithm is employed to decompose their breathing or heartbeat signals. Experimental results demonstrate that the proposed method accurately localizes targets. When multiple targets occupy the same range bin, the mean absolute error (MAE) for respiratory signals is 3 bpm, and the MAE for heartbeat signals is 5 bpm.
文摘A definition of self-determined priority is used in airfight decision firstly. A scheme of grouping the whole fighters is introduced, and the principle of target assignment and fire control is designed. Based on the neutral network, the decision algorithm is derived and the whole coordinated decision system is simulated. Secondly an algorithm for missile-attacking area is described and its calculational result is obtained under initial conditions. Then the attacking of missile is realized by the proportion guidance. Finally, a multi-target attack system. The system includes airfight decision, estimation of missile attack area and calculation of missile attack procedure. A digital simulation demonstrates that the airfight decision algorithm is correct. The methods have important reference values for the study of fire control system of the fourth generation fighter.
文摘The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.
基金supported by the Science and Technology Development Fund,Macao SAR(File no.0062/2021/A)the University of Macao(MYRG2022-00171-FHS).
文摘Alzheimer’s disease(AD)poses one of the most urgent medical challenges in the 21st century as it affects millions of people.Unfortunately,the etiopathogenesis of AD is not yet fully understood and the current pharmacotherapy options are somewhat limited.Here,we report a novel inhibitor,Compound 44,for targeting cholinesterases,amyloid-β(Aβ)aggregation,and glycogen synthase kinase 3β(GSK-3β)simultaneously with the aim of achieving symptomatic relief and disease modification in AD therapy.We found that Compound 44 had good inhibitory effects on all intended targets with IC_(50)s of submicromolar or better,significant neuroprotective effects in cell models,and beneficial improvement of cognitive deficits in the triple transgenic AD(3×Tg AD)mouse model.Moreover,we showed that Compound 44 acts as an autophagy regulator by inducing nuclear translocation of transcription factor EB through GSK-3βinhibition,enhancing the biogenesis of lysosomes and elevating autophagic flux,thus ameliorating the amyloid burden and tauopathy,as well as mitigating the disease phenotype.Our results suggest that triple-target inhibition via Compound 44 could be a promising strategy that may lead to the development of effective therapeutic approaches for AD.
基金Supported by National Natural Science Foundation of China,No.82471616,No.82170418,and No.82271618Natural Science Foundation of Hubei Province,No.2022CFA015+2 种基金Central Guiding Local Science and Technology Development Project,No.2022BGE237Key Research and Development Program of Hubei Province,No.2022BCE001,and No.2023BCB139Hubei Provincial Health Commission Project,No.WJ2023M151。
文摘We are deeply interested in the recent findings onβ-arrestin 2.Liu et al demonstrated thatβ-arrestin 2 knockout provides significant protection in diabetic nephropathy,underscoring its potential as a promising therapeutic target for diabetic nephropathy treatment.Furthermore,the role ofβ-arrestin 2 in metabolic regulation is equally critical,particularly in insulin signaling,hepatic glucose production,and adipose tissue function.Althoughβ-arrestin 2 plays a distinct role in metabolism and kidney protection,its tissue-specific regulation opens up valuable avenues for developing targeted therapeutic strategies centered onβ-arrestin 2.
基金supported by the National Great Science Technology Projects(2018ZX09711001-003-002,2018ZX09711001-012)the National Natural Science Foundation of China(No.81673480)+2 种基金the Beijing National Science Foundation(7192134)CAMS Initiative for Innovative Medicine(CAMS-IZM)(2016-IZM-3-007)CAMS Major collaborative innovation fund for major frontier research(2020-I2M-1-003).
文摘Cancer is a complex disease associated with multiple gene mutations and malignant phenotypes,and multi-target drugs provide a promising therapy idea for the treatment of cancer.Natural products with abundant chemical structure types and rich pharmacological characteristics could be ideal sources for screening multi-target antineoplastic drugs.In this paper,50 tumor-related targets were collected by searching the Therapeutic Target Database and Thomson Reuters Integrity database,and a multi-target anti-cancer prediction system based on mt-QSAR models was constructed by using naïve Bayesian and recursive partitioning algorithm for the first time.Through the multi-target anti-cancer prediction system,some dominant fragments that act on multiple tumor-related targets were analyzed,which could be helpful in designing multi-target anti-cancer drugs.Anti-cancer traditional Chinese medicine(TCM)and its natural products were collected to form a TCM formula-based natural products library,and the potential targets of the natural products in the library were predicted by multi-target anti-cancer prediction system.As a result,alkaloids,flavonoids and terpenoids were predicted to act on multiple tumor-related targets.The predicted targets of some representative compounds were verified according to literature review and most of the selected natural compounds were found to exert certain anti-cancer activity in vitro biological experiments.In conclusion,the multi-target anti-cancer prediction system is very effective and reliable,and it could be further used for elucidating the functional mechanism of anti-cancer TCM formula and screening for multi-target anti-cancer drugs.The anti-cancer natural compounds found in this paper will lay important information for further study.
