期刊文献+
共找到546,063篇文章
< 1 2 250 >
每页显示 20 50 100
Cross-Domain Time Synchronization in Software-Defined Time-Sensitive Networking 被引量:1
1
作者 Zhang Xiaodong Shou Guochu +2 位作者 Li Hongxing Liu Yaqiong Hu Yihong 《China Communications》 2025年第9期289-306,共18页
The rise of time-sensitive applications with broad geographical scope drives the development of time-sensitive networking(TSN)from intra-domain to inter-domain to ensure overall end-to-end connectivity requirements in... The rise of time-sensitive applications with broad geographical scope drives the development of time-sensitive networking(TSN)from intra-domain to inter-domain to ensure overall end-to-end connectivity requirements in heterogeneous deployments.When multiple TSN networks interconnect over non-TSN networks,all devices in the network need to be syn-chronized by sharing a uniform time reference.How-ever,most non-TSN networks are best-effort.Path delay asymmetry and random noise accumulation can introduce unpredictable time errors during end-to-end time synchronization.These factors can degrade syn-chronization performance.Therefore,cross-domain time synchronization becomes a challenging issue for multiple TSN networks interconnected by non-TSN networks.This paper presents a cross-domain time synchronization scheme that follows the software-defined TSN(SD-TSN)paradigm.It utilizes a com-bined control plane constructed by a coordinate con-troller and a domain controller for centralized control and management of cross-domain time synchroniza-tion.The general operation flow of the cross-domain time synchronization process is designed.The mecha-nism of cross-domain time synchronization is revealed by introducing a synchronization model and an error compensation method.A TSN cross-domain proto-type testbed is constructed for verification.Results show that the scheme can achieve end-to-end high-precision time synchronization with accuracy and sta-bility. 展开更多
关键词 cross-domain time synchronization de-terministic communications error compensation software-defined networking(SDN) time-sensitive networking(TSN)
在线阅读 下载PDF
Curvularin derivatives from hydrothermal vent sediment fungus Penicillium sp.HL-50 guided by molecular networking and their antiinflammatory activity 被引量:2
2
作者 Chunxue Yu Zixuan Xia +6 位作者 Zhipeng Xu Xiyang Tang Wenjuan Ding Jihua Wei Danmei Tian Bin Wu Jinshan Tang 《Chinese Journal of Natural Medicines》 2025年第1期119-128,共10页
Guided by molecular networking,nine novel curvularin derivatives(1-9)and 16 known analogs(10-25)were isolated from the hydrothermal vent sediment fungus Penicillium sp.HL-50.Notably,compounds 5-7 represented a hybrid ... Guided by molecular networking,nine novel curvularin derivatives(1-9)and 16 known analogs(10-25)were isolated from the hydrothermal vent sediment fungus Penicillium sp.HL-50.Notably,compounds 5-7 represented a hybrid of curvularin and purine.The structures and absolute configurations of compounds 1-9 were elucidated via nuclear magnetic resonance(NMR)spectroscopy,X-ray diffraction,electronic circular dichroism(ECD)calculations,^(13)C NMR calculation,modified Mosher's method,and chemical derivatization.Investigation of anti-inflammatory activities revealed that compounds 7-9,11,12,14,15,and 18 exhibited significant suppressive effects against lipopolysaccharide(LPS)-induced nitric oxide(NO)production in murine macrophage RAW264.7 cells,with IC_(50)values ranging from 0.44 to 4.40μmol·L^(-1).Furthermore,these bioactive compounds were found to suppress the expression of inflammation-related proteins,including inducible NO synthase(i NOS),cyclooxygenase-2(COX-2),NLR family pyrin domain-containing protein 3(NLRP3),and nuclear factor kappa-B(NF-κB).Additional studies demonstrated that the novel compound 7 possessed potent antiinflammatory activity by inhibiting the transcription of inflammation-related genes,downregulating the expression of inflammation-related proteins,and inhibiting the release of inflammatory cytokines,indicating its potential application in the treatment of inflammatory diseases. 展开更多
关键词 Penicillium sp.HL-50 Curvularin derivatives Molecular networking Anti-inflammatory activity
原文传递
Multi-interface engineering of FeS_(2)/C/MoS_(2)with core–shell structure for superior microwave absorption performance
3
作者 Pan-Pan Zhou Cheng-Yao Hu +6 位作者 Shi-Lin Yuan Jian-Cheng Zhao Ya-Wei Kuang Han Gu Yu-Shen Liu Li-Xi Wang Qi-Tu Zhang 《Rare Metals》 2025年第6期4095-4106,共12页
Heterojunction and morphology control assume a significant part in adjusting the intrinsic electromagnetic properties of absorbers to acquire outstanding microwave absorption(MA)performance,but this still faces huge c... Heterojunction and morphology control assume a significant part in adjusting the intrinsic electromagnetic properties of absorbers to acquire outstanding microwave absorption(MA)performance,but this still faces huge challenges.Herein,FeS_(2)/C/MoS_(2)composite with core–shell structure was successfully designed and prepared via a multi-interface engineering.MoS_(2)nanosheets with 1T and 2H phases are coated on the outside of FeS_(2)/C to form a porous interconnected structure that can optimize the impedance matching characteristics and strengthen the interfacial polarization loss capacity.Remarkably,as-fabricated FCM-3 harvests a broad effective absorption bandwidth(EAB)of 5.12 GHz and a minimum reflection loss(RL_(min))value of-45.1 d B.Meanwhile,FCM-3 can accomplish a greatest radar cross section(RCS)reduction value of 18.52 d B m^(2)when the detection angle is 0°.Thus,the convenient computer simulation technology(CST)simulations and encouraging accomplishments provide a novel avenue for the further development of efficient and lightweight MA materials. 展开更多
关键词 MOS2 multi-interface Polarization loss Microwave absorption RCS simulation
原文传递
Multi-Band Integrated Networking for Efficient Spectrum Utilization in 6G 被引量:1
4
作者 Wang Ailing Kong Lei +4 位作者 Liu Jianjun Xia Liang Wang Xiaoqian Wang Qixing Liu Guangyi 《China Communications》 2025年第4期42-54,共13页
The sixth-generation(6G)networks will consist of multiple bands such as low-frequency,midfrequency,millimeter wave,terahertz and other bands to meet various business requirements and networking scenarios.The dynamic c... The sixth-generation(6G)networks will consist of multiple bands such as low-frequency,midfrequency,millimeter wave,terahertz and other bands to meet various business requirements and networking scenarios.The dynamic complementarity of multiple bands are crucial for enhancing the spectrum efficiency,reducing network energy consumption,and ensuring a consistent user experience.This paper investigates the present researches and challenges associated with deployment of multi-band integrated networks in existing infrastructures.Then,an evolutionary path for integrated networking is proposed with the consideration of maturity of emerging technologies and practical network deployment.The proposed design principles for 6G multi-band integrated networking aim to achieve on-demand networking objectives,while the architecture supports full spectrum access and collaboration between high and low frequencies.In addition,the potential key air interface technologies and intelligent technologies for integrated networking are comprehensively discussed.It will be a crucial basis for the subsequent standards promotion of 6G multi-band integrated networking technology. 展开更多
关键词 full spectrum access high and low frequency collaboration multi-band integrated networking 6G spectrum efficiency
在线阅读 下载PDF
Call for Papers─Feature Topic Vol.23,No.1,2026 Space-Terrestrial Integrated 6G Network:Architecture,Networking,and Transmission Technologies
5
《China Communications》 2025年第6期F0003-F0003,共1页
With the large-scale deployment of satellite constellations such as Starlink and the rapid advancement of technologies including artificial intelligence (AI) and non-terrestrial networks (NTNs), the integration of hig... With the large-scale deployment of satellite constellations such as Starlink and the rapid advancement of technologies including artificial intelligence (AI) and non-terrestrial networks (NTNs), the integration of high, medium, and low Earth orbit satellite networks with terrestrial networks has become a critical direction for future communication technologies. The objective is to develop a space-terrestrial integrated 6G network that ensures ubiquitous connectivity and seamless services, facilitating intelligent interconnection and collaborative symbiosis among humans, machines, and objects. This integration has become a central focus of global technological innovation. 展开更多
关键词 communication technologiesthe space terrestrial integrated G network g network satellite constellations terrestrial networks artificial intelligence ai intelligent int satellite networks
在线阅读 下载PDF
Non-Terrestrial Networking for 6G:Evolution,Opportunities,and Future Directions
6
作者 Feng Wang Shengyu Zhang +1 位作者 Huiting Yang Tony Q.S.Quek 《Engineering》 2025年第11期56-68,共13页
From fifth-generation(5G)communication technology onward,non-terrestrial networks(NTNs)have emerged as a key component of future network architectures.Especially through the rise of low-Earth-orbit satellite constella... From fifth-generation(5G)communication technology onward,non-terrestrial networks(NTNs)have emerged as a key component of future network architectures.Especially through the rise of low-Earth-orbit satellite constellations,NTNs enable a space Internet and present a paradigm shift in delivering reliable services to even the most remote regions on Earth.However,the extensive coverage and rapid movement of satellites pose unique challenges in user equipment access and inter-satellite transmission,impacting the quality of service and service continuity.This paper offers an in-depth review of NTN networking technologies in the context of six-generation(6G)mobile networks evolution,focusing on access management,satellite mobility,and hetero-network slicing.Building on this foundation and considering the latest trends in NTN development,we then present innovative perspectives on emerging challenges,including satellite beamforming,handover mechanisms,and service delivery.Lastly,we identify key open research areas and propose future directions to improve NTN performance and accelerate satellite Internet deployment. 展开更多
关键词 Non-terrestrial networks Six-generation mobile networks Satellite networking Access and mobility management Inter-satellite transmission
在线阅读 下载PDF
Theory and Key Technologies in Space Internet Networking
7
作者 Jiangzhou Wang Jiandong Li Di Zhou 《Engineering》 2025年第11期1-2,共2页
The rapid evolution of satellite constellation projects(e.g.,SpaceX)and the standardization of 3rd Generation Partnership Project(3GPP)non-terrestrial networks(NTNs)have positioned satellite Internet networking(SIN)as... The rapid evolution of satellite constellation projects(e.g.,SpaceX)and the standardization of 3rd Generation Partnership Project(3GPP)non-terrestrial networks(NTNs)have positioned satellite Internet networking(SIN)as a cornerstone of future communication systems.The demand for ubiquitous connectivity,resilient infrastructures,and intelligent network services has never been greater,driven by applications ranging from global broadband access to emergency response and space-air-ground integration. 展开更多
关键词 emergency response rd generation partnership project gpp non terrestrial communication systemsthe global broadband access intelligent network services satellite internet networking sin satellite constellation projects egspacex space internet networking
在线阅读 下载PDF
A High Destruction-Resistant Resilient Networking Platform for Air-to-Ground Cooperative Communications
8
作者 Dong Ping Ren Jiaxin +3 位作者 Guo Jiannan Zhang Yuzhen Liu Qianwen Amr Tolba 《China Communications》 2025年第4期27-41,共15页
With the continuous advancement of communication and unmanned aerial vehicle(UAV)technologies,the collaborative operations of diverse platforms,including UAVs and ground vehicles,have been significantly promoted.Howev... With the continuous advancement of communication and unmanned aerial vehicle(UAV)technologies,the collaborative operations of diverse platforms,including UAVs and ground vehicles,have been significantly promoted.However,battlefield uncertainties,such as equipment failures and enemy attacks,can impact these collaborative operations'stability and communication efficiency.To this end,we design a highly destruction-resistant air-ground cooperative resilient networking platform that aims to enhance the robustness of network communications by integrating ground vehicle information for UAV network deployment.It then incorporates the concept of virtual guiding force,enabling the UAV swarm to adaptively configure its network layout based on ground vehicle information,thereby improving network destruction resistance.Simulation results demonstrate that the UAV swarm involved in the proposed platform exhibits balanced flight energy consumption and excellent performance in network destruction resistance. 展开更多
关键词 air-to-ground coordination network destruction resistance SpringBoot UAV
在线阅读 下载PDF
A Hierarchical-Based Sequential Caching Scheme in Named Data Networking
9
作者 Zhang Junmin Jin Jihuan +3 位作者 Hou Rui Dong Mianxiong Kaoru Ota Zeng Deze 《China Communications》 2025年第5期48-60,共13页
Named data networking(NDNs)is an idealized deployment of information-centric networking(ICN)that has attracted attention from scientists and scholars worldwide.A distributed in-network caching scheme can efficiently r... Named data networking(NDNs)is an idealized deployment of information-centric networking(ICN)that has attracted attention from scientists and scholars worldwide.A distributed in-network caching scheme can efficiently realize load balancing.However,such a ubiquitous caching approach may cause problems including duplicate caching and low data diversity,thus reducing the caching efficiency of NDN routers.To mitigate these caching problems and improve the NDN caching efficiency,in this paper,a hierarchical-based sequential caching(HSC)scheme is proposed.In this scheme,the NDN routers in the data transmission path are divided into various levels and data with different request frequencies are cached in distinct router levels.The aim is to cache data with high request frequencies in the router that is closest to the content requester to increase the response probability of the nearby data,improve the data caching efficiency of named data networks,shorten the response time,and reduce cache redundancy.Simulation results show that this scheme can effectively improve the cache hit rate(CHR)and reduce the average request delay(ARD)and average route hop(ARH). 展开更多
关键词 hierarchical router named data networking sequential caching
在线阅读 下载PDF
End-to-End Deterministic Transmission with Bounded Time Error in Time-Sensitive Networking
10
作者 Ma Hao Shou Guochu +3 位作者 Li Hongxing Liu Yaqiong Hu Yihong Chen Li 《China Communications》 2025年第12期30-46,共17页
Time synchronization is a prerequisite for ensuring determinism in time-sensitive networking(TSN).While time synchronization errors cannot be overlooked,pursuing minimal time errors may incur unnecessary costs.Using c... Time synchronization is a prerequisite for ensuring determinism in time-sensitive networking(TSN).While time synchronization errors cannot be overlooked,pursuing minimal time errors may incur unnecessary costs.Using complex network theory,this study proposes a hierarchy for TSN and introduces the concept of bounded time error.A coupling model between traffic scheduling and time synchronization is established,deriving functional relationships among end-to-end delay,delay jitter,gate window,and time error.These relationships illustrate that time errors can trigger jumps in delay and delay jitter.To evaluate different time errors impact on traffic scheduling performance,an end-to-end transmission experiment scheme is designed,along with the construction of a TSN test platform implementing two representative cases.Case A is a closed TSN domain scenario with pure TSN switches emulating closed factory floor network.Case B depicts remote factory interconnection where TSN domains link via non-TSN domains composed of OpenFlow switches.Results from Case A show that delay and delay jitter on a single node are most significantly affected by time errors,up to one gating cycle.End-to-end delay jitter tends to increase with the number of hops.When the ratio of time error bound to window exceeds 10%,the number of schedulable traffic flows decreases rapidly.Case B reveals that when time error is below 1μs,the number of schedulable traffic flows begins to increase significantly,approaching full schedulability at errors below 0.6μs. 展开更多
关键词 bounded time error deterministic communications time synchronization time-sensitive networking traffic scheduling
在线阅读 下载PDF
Deep Learning-Based Natural Language Processing Model and Optical Character Recognition for Detection of Online Grooming on Social Networking Services
11
作者 Sangmin Kim Byeongcheon Lee +2 位作者 Muazzam Maqsood Jihoon Moon Seungmin Rho 《Computer Modeling in Engineering & Sciences》 2025年第5期2079-2108,共30页
The increased accessibility of social networking services(SNSs)has facilitated communication and information sharing among users.However,it has also heightened concerns about digital safety,particularly for children a... The increased accessibility of social networking services(SNSs)has facilitated communication and information sharing among users.However,it has also heightened concerns about digital safety,particularly for children and adolescents who are increasingly exposed to online grooming crimes.Early and accurate identification of grooming conversations is crucial in preventing long-term harm to victims.However,research on grooming detection in South Korea remains limited,as existing models trained primarily on English text and fail to reflect the unique linguistic features of SNS conversations,leading to inaccurate classifications.To address these issues,this study proposes a novel framework that integrates optical character recognition(OCR)technology with KcELECTRA,a deep learning-based natural language processing(NLP)model that shows excellent performance in processing the colloquial Korean language.In the proposed framework,the KcELECTRA model is fine-tuned by an extensive dataset,including Korean social media conversations,Korean ethical verification data from AI-Hub,and Korean hate speech data from Hug-gingFace,to enable more accurate classification of text extracted from social media conversation images.Experimental results show that the proposed framework achieves an accuracy of 0.953,outperforming existing transformer-based models.Furthermore,OCR technology shows high accuracy in extracting text from images,demonstrating that the proposed framework is effective for online grooming detection.The proposed framework is expected to contribute to the more accurate detection of grooming text and the prevention of grooming-related crimes. 展开更多
关键词 Online grooming KcELECTRA natural language processing optical character recognition social networking service text classification
在线阅读 下载PDF
Key technologies for networking in satellite-terrestrial integrated network
12
作者 Haijun ZHANG Sichen LU Xiaoqi ZHANG 《Chinese Journal of Aeronautics》 2025年第9期267-270,共4页
1.Introduction As a key development of the next-generation spatial information infrastructure,1the Satellite-Terrestrial Integrated Network(STIN)has become a strategic priority actively pursued by major spacefaring na... 1.Introduction As a key development of the next-generation spatial information infrastructure,1the Satellite-Terrestrial Integrated Network(STIN)has become a strategic priority actively pursued by major spacefaring nations and regions,including the United States,Europe,China,and Russia.Specifically,Space X’s Starlink project has deployed over 6750 satellites,2while One Web has completed its initial phase of satellite constellation deployment with more than 600 satellites. 展开更多
关键词 satellite terrestrial integrated network satellite constellation starlink project next generation spatial information infrastructure Starlink OneWeb STIN
原文传递
Cytotoxic anthrone–cyclopentenone heterodimers from the fungus Penicillium sp.guided by molecular networking
13
作者 Ruiyun Huo Jiayu Dong +2 位作者 Gaoran Liu Ying Shi Ling Liu 《Chinese Journal of Natural Medicines》 2025年第10期1259-1267,共9页
(±)-Penicithrones A–D(1a/1b–4a/4b),four novel pairs of anthrone–cyclopentenone heterodimers characterized by a distinctive bridged 6/6/6−5 tetracyclic core skeleton,together with three previously identified co... (±)-Penicithrones A–D(1a/1b–4a/4b),four novel pairs of anthrone–cyclopentenone heterodimers characterized by a distinctive bridged 6/6/6−5 tetracyclic core skeleton,together with three previously identified compounds(5–7),were isolated from the crude extract of the mangrove-derived fungus Penicillium sp.,guided by heteronuclear single quantum correlation(HSQC)-based small molecule accurate recognition technology(SMART 2.0)and liquid chromatography-tandem mass spectrometry(LC-MS/MS)-based molecular networking.The structural elucidation of new compounds was accomplished through comprehensive spectroscopic analysis,and their absolute configurations were determined using DP4+^(13)C nuclear magnetic resonance(NMR)calculations and electronic circular dichroism(ECD)calculations.Compounds 1a/1b–4a/4b demonstrated moderate cytotoxicity against three human cancer cell lines HeLa,HCT116 and MCF-7 with half maximal inhibitory concentration(IC50)values ranging from 15.95±1.64 to 28.56±2.59μmol·L–1. 展开更多
关键词 Mangrove-derived fungi Molecular networking HSQC-based SMART Structure elucidation DP4+13C NMR calculation Cytotoxic activity
原文传递
Detecting and Mitigating Distributed Denial of Service Attacks in Software-Defined Networking
14
作者 Abdullah M.Alnajim Faisal Mohammed Alotaibi Sheroz Khan 《Computers, Materials & Continua》 2025年第6期4515-4535,共21页
Distributed denial of service(DDoS)attacks are common network attacks that primarily target Internet of Things(IoT)devices.They are critical for emerging wireless services,especially for applications with limited late... Distributed denial of service(DDoS)attacks are common network attacks that primarily target Internet of Things(IoT)devices.They are critical for emerging wireless services,especially for applications with limited latency.DDoS attacks pose significant risks to entrepreneurial businesses,preventing legitimate customers from accessing their websites.These attacks require intelligent analytics before processing service requests.Distributed denial of service(DDoS)attacks exploit vulnerabilities in IoT devices by launchingmulti-point distributed attacks.These attacks generate massive traffic that overwhelms the victim’s network,disrupting normal operations.The consequences of distributed denial of service(DDoS)attacks are typically more severe in software-defined networks(SDNs)than in traditional networks.The centralised architecture of these networks can exacerbate existing vulnerabilities,as these weaknesses may not be effectively addressed in this model.The preliminary objective for detecting and mitigating distributed denial of service(DDoS)attacks in software-defined networks(SDN)is to monitor traffic patterns and identify anomalies that indicate distributed denial of service(DDoS)attacks.It implements measures to counter the effects ofDDoS attacks,and ensure network reliability and availability by leveraging the flexibility and programmability of SDN to adaptively respond to threats.The authors present a mechanism that leverages the OpenFlow and sFlow protocols to counter the threats posed by DDoS attacks.The results indicate that the proposed model effectively mitigates the negative effects of DDoS attacks in an SDN environment. 展开更多
关键词 Software-defined networking(SDN) distributed denial of service(DDoS)attack sampling Flow(sFlow) OpenFlow OpenDaylight controller
在线阅读 下载PDF
Network perspective on rumination and non-suicidal self-injury among adolescents with depressive disorders
15
作者 Fang-Fang Zhang Rui Guo +3 位作者 Si-Lan Chen Wei Yang Xing-Li Liang Ming-Fang Ma 《World Journal of Psychiatry》 2026年第1期346-355,共10页
BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes tha... BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations. 展开更多
关键词 Depressive disorders Adolescents network analysis RUMINATION Non-suicidal self-injury
暂未订购
Investigating the potential mechanisms of Wenqing Yin against atopic dermatitis based on network pharmacology,experimental pharmacology,and molecular docking
16
作者 Yi Wang Zhen Liu +3 位作者 Si-Man Li Lin Lin Wei Dai Meng-Yue Ren 《Traditional Medicine Research》 2026年第2期1-11,共11页
Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY o... Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses. 展开更多
关键词 Wenqing Yin atopic dermatitis mouse model UPLC-Orbitrap-MS/MS network pharmacology
暂未订购
Combined Fault Tree Analysis and Bayesian Network for Reliability Assessment of Marine Internal Combustion Engine
17
作者 Ivana Jovanović Çağlar Karatuğ +1 位作者 Maja Perčić Nikola Vladimir 《哈尔滨工程大学学报(英文版)》 2026年第1期239-258,共20页
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ... This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels. 展开更多
关键词 Fault tree analysis Bayesian network RELIABILITY REDUNDANCY Internal combustion engine
在线阅读 下载PDF
支持Multi-interface的MVC设计模式研究 被引量:6
18
作者 邓贵仕 易峰 李文立 《计算机应用》 CSCD 北大核心 2002年第6期8-10,共3页
支持多类型用户界面的复杂应用程序架构设计一直是困扰企业的难题 ,文章引入源于Smalltalk的MVC架构设计思想 ,提出了具有经济性、可扩展性、安全性等支持多类型用户界面复杂应用程序的新型MVC设计模式 。
关键词 MVC模型 multi-interface JAVA 设计模式 J2EE 程序架构设计
在线阅读 下载PDF
支持Multi-interface的Java程序MVC设计模式研究 被引量:2
19
作者 邓贵仕 易峰 李文立 《计算机工程与应用》 CSCD 北大核心 2003年第7期126-128,共3页
支持多类型用户界面的复杂应用程序架构设计一直是困扰企业的难题,文章引入源于Smalltalk的MVC架构设计思想,提出了具有经济性、可扩展性、安全性等支持多类型用户界面复杂应用程序的新型MVC设计模式,并分析了工作原理和性能特点。
关键词 用户界面 JAVA语言 程序架构设计 MVC 设计模式 multi-interface 应用程序
在线阅读 下载PDF
Development of geo-electrical meter based on networking 被引量:3
20
作者 王兰炜 赵家骝 《地震学报》 CSCD 北大核心 2008年第5期484-490,共7页
Further development of earthquake equipments is closely associated with that of computer technology. Because Embedded PC104 module has the equivalent functions of PC,it has been widely used in recent years,and can pro... Further development of earthquake equipments is closely associated with that of computer technology. Because Embedded PC104 module has the equivalent functions of PC,it has been widely used in recent years,and can provide a new and flexible hardware design environment,but its applications in observation instruments of earth-quake precursor are rare. The present paper introduces in detail the realization of a networked geo-electrical meter by applying the low price,high reliability embedded PC104 industrial computer. 展开更多
关键词 网络 嵌入式PC104 电阻率仪 数据通信
在线阅读 下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部