The naturally fermented Inner Mongolian cheese’s flavor and nutritional value make it a popular choice among customers.In this work,to create multi-functional peptides that have taste and biological activity,peptidom...The naturally fermented Inner Mongolian cheese’s flavor and nutritional value make it a popular choice among customers.In this work,to create multi-functional peptides that have taste and biological activity,peptidomics and bioinformatics were used to screen flavor peptides from Inner Mongolian cheese and further assess their antioxidant and angiotensin I-converting enzyme(ACE)inhibitory properties.According to sensory data,YH8 and IL7 had detectable bitter tastes with low thresholds of 0.03 and 0.06 mmol/L,respectively.With an umami threshold range of 0.24‒0.81 mmol/L,VQ6,FK13,HP13 and QT14 exhibited a range of flavors dominated by umami,including sweet,bitter,salty,sour and kokumi.Antioxidant activity wise,YH8,VQ6,HP13 and QT14 were well represented.The above-mentioned peptides all had some ACE inhibitory effect.The bitter peptide IL7(IC_(50)=0.08 mmol/L)had the highest level of ACE inhibitory activity,followed by YH8(IC_(50)=0.33 mmol/L).These multi-functional peptides,which have been assessed for bioactive and taste features in Inner Mongolian cheese,may have positive impacts on health and harmonize the cheese’s overall flavor.These results suggest that some flavor peptides produced in fermented foods might be with bioactivities while providing a basis for the exploration and application of multi-functional peptides.展开更多
Figure 6(a)in the paper[Chin.Phys.B 33074203(2024)]was incorrect due to editorial oversight.The correct figure is provided.This modification does not affect the result presented in the paper.
Photonic spin Hall effect(PSHE), as a novel physical effect in light–matter interaction, provides an effective metrological method for characterizing the tiny variation in refractive index(RI). In this work, we propo...Photonic spin Hall effect(PSHE), as a novel physical effect in light–matter interaction, provides an effective metrological method for characterizing the tiny variation in refractive index(RI). In this work, we propose a multi-functional PSHE sensor based on VO_(2), a material that can reveal the phase transition behavior. By applying thermal control, the mutual transformation into different phase states of VO_(2) can be realized, which contributes to the flexible switching between multiple RI sensing tasks. When VO_(2) is insulating, the ultrasensitive detection of glucose concentrations in human blood is achieved. When VO_(2) is in a mixed phase, the structure can be designed to distinguish between the normal cells and cancer cells through no-label and real-time monitoring. When VO_(2) is metallic, the proposed PSHE sensor can act as an RI indicator for gas analytes. Compared with other multi-functional sensing devices with the complex structures, our design consists of only one analyte and two VO_(2) layers, which is very simple and elegant. Therefore, the proposed VO_(2)-based PSHE sensor has outstanding advantages such as small size, high sensitivity, no-label, and real-time detection, providing a new approach for investigating tunable multi-functional sensors.展开更多
Multi-functional Al-matrix composites with high volume fraction （55%-57%） of SiC particles are produced with the new pressureless infiltration fabrication technology. X-ray detection and microscopic observation disp...Multi-functional Al-matrix composites with high volume fraction （55%-57%） of SiC particles are produced with the new pressureless infiltration fabrication technology. X-ray detection and microscopic observation display the composites which are macroscopically homogeneous without porosity. The investigation further reveals that the SiC/Al composites possess low density （2.94 g/cm^3）, high elastic modulus （220 GPa）, prominent thermal management function as a result of low coefficient of thermal expansion （8 × 10^4 K^-1） and high thermal conductivity （235 W/（m.K）） as well as unique preventability of resonance vibration. By adopting a series of developed techniques, the multi-functional SiC/Al composites have managed to be made into near-net-shape parts. Many kinds of precision components of space-based optomechanical structures and airborne optoelectronic platform have been turned out. Of them, several typical products are being under test in practices.展开更多
In order to provide reliable data for the dynamic design or modification of a tool machine,the dynamic character- istics of the headstock,which is the main component to bear moment,must be obtained precisely.In the pa...In order to provide reliable data for the dynamic design or modification of a tool machine,the dynamic character- istics of the headstock,which is the main component to bear moment,must be obtained precisely.In the paper,the method based on the combination of calculation mode and experiment mode is proposed to analyze the dynamic characteristics of the headstock.The modal parameters and the mode shapes are calculated by ANSYS7.1 software.According to the FEM calculating results,the ex- periment parameters can be selected correctly.The modal parameters of the headstock have to be calculated and identified precisely. On the basis of these modal parameters,the faults of the headstock are shown and its weak points of design are illustrated.A con- clusion is drawn that some reasonable reinforce positions could greatly improve the dynamic characteristics of the system and this ap- proach is proved to be precise and reliable.展开更多
The current research of reliability allocation of CNC lathes always treat CNC lathes as independent series systems. However, CNC lathes are complex systems in the actual situation. Failure correlation is rarely consid...The current research of reliability allocation of CNC lathes always treat CNC lathes as independent series systems. However, CNC lathes are complex systems in the actual situation. Failure correlation is rarely considered when reliabil?ity allocation is conducted. In this paper, drawbacks of reliability model based on failure independence assumption are illustrated, after which, reliability model of CNC lathes considering failure correlation of subsystems is established based on Copula theory, which is an improvement of traditional reliability model of series systems. As the failure time of CNC lathes often obeys Weibull or exponential distribution, Gumbel Copula is selected to build correlation model. After that, a reliability allocation method considering failure correlation is analyzed based on the model established before. Reliability goal is set first and then failure rates are allocated to subsystems according to the allocation vector through solving the correlation model. Reliability allocation is conducted for t = 1. A real case of a CNC lathe and a numerical case are presented together to illustrate the advantages of the reliability model established consider?ing failure correlation and the corresponding allocation method. It shows that the model accords to facts and real working condition more, and failure rates allocated to all the subsystems are increased to some extent. This research proposes a reliability allocation method which takes failure correlation among subsystems of CNC lathes into consid?eration, and costs for design and manufacture could be decreased.展开更多
Metal-organic frameworks（MOFs） are a unique class of porous crystalline materials that have shown promise for a wide range of applications. MOFs have been explored as a new type of heterogeneous catalytic materials,...Metal-organic frameworks（MOFs） are a unique class of porous crystalline materials that have shown promise for a wide range of applications. MOFs have been explored as a new type of heterogeneous catalytic materials, because of their high surface area, uniform and tunable pores, facile functionalization and incorporation of catalytic active sites. The use of multi-functional sites MOF materials as catalysts for synergistic catalysis and tandem reactions has attracted increasing attention. In this review, we aim to introduce the construction of bi-or multi-functional MOF catalysts with cooperative or cascade functions via post-synthetic modification（PSM）.展开更多
Based on the mechanism of chip breaking and the principle of semi-solid thixomolding, the lathe process of AZ91D magnesium alloys chips used in semi-solid thixotropic injection molding process was studied. With three ...Based on the mechanism of chip breaking and the principle of semi-solid thixomolding, the lathe process of AZ91D magnesium alloys chips used in semi-solid thixotropic injection molding process was studied. With three kinds of turning tools, such as 31303C5, 31003C and 31303C, different chips were gotten. And by one tool with different lathe parameters, different chips were gotten. The results show that, under the needed condition of the thixotropic injection molding machine, the ideal chips are gotten and the size of magnesium alloy chips must be about 35mm, and the turning tool is chosen, whose chip breaker groove is narrower and the depth of cutting is more than 3mm as well as the amount of feed is larger than 0.3mm. The deformation occurs on the microstructure of the chips, and the residual stress is important to the later microstructure of semi-solid state in injection molding.展开更多
This paper introduces a system of computer aided assembly process planning for spindle box of NC lathe. The method of describing assembly information and generating assembly process drawing is presented. The principle...This paper introduces a system of computer aided assembly process planning for spindle box of NC lathe. The method of describing assembly information and generating assembly process drawing is presented. The principles of decision for assembly sequence ar展开更多
According to the reliable data of sixteen CNC lathes, each reliable index of the serial CNC lathes is evaluated before tackling and after tackling. According to the failure analysis, reliable improvement measures of t...According to the reliable data of sixteen CNC lathes, each reliable index of the serial CNC lathes is evaluated before tackling and after tackling. According to the failure analysis, reliable improvement measures of the serial CNC lathes are put forward.展开更多
Reliability allocation of computerized numerical controlled（CNC）lathes is very important in industry.Traditional allocation methods only focus on high-failure rate components rather than moderate failure rate compon...Reliability allocation of computerized numerical controlled（CNC）lathes is very important in industry.Traditional allocation methods only focus on high-failure rate components rather than moderate failure rate components,which is not applicable in some conditions.Aiming at solving the problem of CNC lathes reliability allocating,a comprehensive reliability allocation method based on cubic transformed functions of failure modes and effects analysis（FMEA）is presented.Firstly,conventional reliability allocation methods are introduced.Then the limitations of direct combination of comprehensive allocation method with the exponential transformed FMEA method are investigated.Subsequently,a cubic transformed function is established in order to overcome these limitations.Properties of the new transformed functions are discussed by considering the failure severity and the failure occurrence.Designers can choose appropriate transform amplitudes according to their requirements.Finally,a CNC lathe and a spindle system are used as an example to verify the new allocation method.Seven criteria are considered to compare the results of the new method with traditional methods.The allocation results indicate that the new method is more flexible than traditional methods.By employing the new cubic transformed function,the method covers a wider range of problems in CNC reliability allocation without losing the advantages of traditional methods.展开更多
To fulfill the demands for higher quality,efficiency and flexibility in aviation industry,a multi-functional end effector is designed to automate the drilling and riveting processes in assembling carbon fiber reinforc...To fulfill the demands for higher quality,efficiency and flexibility in aviation industry,a multi-functional end effector is designed to automate the drilling and riveting processes in assembling carbon fiber reinforced polymer(CFRP)and aluminum components for a robotic aircraft assembly system.To meet the specific functional requirements for blind rivet installation on CFRP and aluminum materials,additional modules are incorporated on the end effector aside of the basic processing modules for drilling.And all of these processing modules allow for a onestep-drilling-countersinking process,hole inspection,automatic rivet feed,rivet geometry check,sealant application,rivet insertion and installation.Besides,to guarantee the better quality of the hole drilled and joints riveted,several online detection and adjustment measures are applied to this end effector,including the reference detection and perpendicular calibration,which could effectively ensure the positioning precision and perpendicular accuracy as demanded.Finally,the test result shows that this end effector is capable of producing each hole to a positioning precision within ±0.5 mm,aperpendicular accuracy within 0.3°,a diameter tolerance of H8,and a countersink depth tolerance of±0.01 mm.Moreover,it could drill and rivet up to three joints per minute,with acceptable shearing and tensile strength.展开更多
Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmo...Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmoplasia causes a hypoxic microenvironment in pancreatic cancer.In this study,a novel FR-directed,macropinocytosis-enhanced,and highly cytotoxic bioconjugate folate(F)-human serum albumin(HSA)-apoprotein of lidamycin(LDP)-active enediyne(AE)derived from lidamycin was designed and prepared.F-HSA-LDP-AE consisted of four moieties:F,HSA,LDP,and AE.F-HSA-LDP presented high binding efficiency with the FR and pancreatic cancer cells.Its uptake in wild-type cells was more extensive than in K-Ras mutant-type cells.By in vivo optical imaging,F-HSA-LDP displayed prominent tumor-specific biodistribution in pancreatic cancer xenograft-bearing mice,showing clear and lasting tumor localization for 360 h.In the MTT assay,F-HSA-LDP-AE demonstrated potent cytotoxicity in three types of pancreatic cancer cell lines.It also induced apoptosis and caused G2/M cell cycle arrest.F-HSALDP-AE markedly suppressed the tumor growth of AsPc-1 pancreatic cancer xenografts in athymic mice.At well-tolerated doses of 0.5 and 1 mg/kg,(i.v.,twice),the inhibition rates were 91.2%and 94.8%,respectively(P<0.01).The results of this study indicate that the F-HSA-LDP multi-functional bioconjugate might be effective for treating K-Ras mutant pancreatic cancer.展开更多
Making an analysis for vibration modal and frequency response of the lathe spindle,respectively by using finite element method based on ANSYS and experiment of CA6140 type lathe in machining,and the calculation result...Making an analysis for vibration modal and frequency response of the lathe spindle,respectively by using finite element method based on ANSYS and experiment of CA6140 type lathe in machining,and the calculation results are compared and analyzed,which verified the accuracy of ANSYS method. Numerical simulation and experimental results show that: Spindle in the first order and fifth order are prone to resonance,but did not reach resonance,the low order natural frequency have more effect than the high order natural frequency of the spindle vibration; by the experiments can conclude that the maximum vibration of the main shaft in the working state is mainly concentrated in the vicinity of its two ends,therefore,the improved bearing is an important way to reduce the vibration of the main shaft and ensure the machining accuracy,and the research results can provide a theoretical reference for the structural optimization design of the lathe.展开更多
The lathes are basic machine tools for manufacturing cylindrical parts. In recent years, the DLseries computer numerical control(CNC) heavy-duty horizontal lathes(HDHLs) have been widely used in the transportation, en...The lathes are basic machine tools for manufacturing cylindrical parts. In recent years, the DLseries computer numerical control(CNC) heavy-duty horizontal lathes(HDHLs) have been widely used in the transportation, energy and aviation industries. High availability of the CNC heavy-duty lathes is demanded to guarantee the efficiency and benefit of these manufacturing industries. As one of the key subsystems of the HDHLs, the feeding control system is studied in this paper on reliability modeling and reliability analysis. The fault tree analysis(FTA) method is used for reliability modelling of the feeding control system. Considering the multiple common cause failure groups(CCFGs) existing in the system, a modified beta factor parametric model is introduced to model the common cause failure(CCF) in system. The reliability of feeding control system is then obtained and the effect of CCF on the reliability of the whole system is studied as well.展开更多
For virtually realizing the graphic realism display of DXF machine parts, in AutoCAD2007 graphic drawing environment, an interactive experimental method was taken to realize the display of graphic in DXF, which was ta...For virtually realizing the graphic realism display of DXF machine parts, in AutoCAD2007 graphic drawing environment, an interactive experimental method was taken to realize the display of graphic in DXF, which was taken as the data-exchanged interface and source. Based on depth analysis of DXF data structure, take one drawing of DXF lathe turning rotational part asthe test piece. By VC＋＋6.0 programming, part＇s geometry information could be obtained. Through data processing, 3D data of the test piece could be generated, which is based on 2D data of DXF test piece. Then, OpenGL graphic processing technologies （light, material, texture, map, et al.） were applied on the 3D display of test piece from DXF files or program modules. Finally based on the test report, results of the system functions were shared to prove the realization of system design, and the feasibility of algorithms used. In the developed software, Machine Designers could get a full view of machine parts, and do some proper modifications. The study content and results of our work have some theory and practical significance on the application of program design in the practical projects.展开更多
According to the technique requests of the brake caliper in the process of production, a special fixture of float brake caliper has been developed based on 3 D design in this paper. The development process and verifie...According to the technique requests of the brake caliper in the process of production, a special fixture of float brake caliper has been developed based on 3 D design in this paper. The development process and verified data from 3D modeling and kinematics simulation for this special fixture show that this 3D-designed process can conveniently forecast the assembly interference of the fixture and accurately add the mass of lead brick before the prototype is made. In this way the flutter caused by the unbalanced lathe fixture can be eliminated and the precision of run-out tolerance in cylinder hole compared with machine tool spindle can be improved, thus the processing quality of the cylinder hole in a brake caliper can be greatly guaranteed.展开更多
In order to meet increasing demand for higher productivity and flexibility, recently many kinds of multi-functional machine tools, which are capable of multiple machining functions or different kinds of machining proc...In order to meet increasing demand for higher productivity and flexibility, recently many kinds of multi-functional machine tools, which are capable of multiple machining functions or different kinds of machining processes on one machine, have been developed and widely used in manufacturing industries. In this study, a multi-functional turning lathe, which has two spindles and two turrets so that multiple turning operations and various machining processes could be performed simultaneously, has been developed. Furthermore, the equations of correlation between whole responses and cross responses of the two spindles have been derived to examine to what extent the two spindles affect each other’s vibrations.展开更多
An importance analysis model for computer numerical control（CNC）lathe subsystems was proposed.The model was based on technique for order preference by similarity to an ideal solution（TOPSIS）and considered the stru...An importance analysis model for computer numerical control（CNC）lathe subsystems was proposed.The model was based on technique for order preference by similarity to an ideal solution（TOPSIS）and considered the structure correlation between subsystems and the complete machine,the fault correlation of each subsystem and so on.The model can obtain a comprehensive sequencing of subsystems based on their importance to the complete machine.It lays a theoretical foundation for reliability allocation.展开更多
基金supported by the central government and guides local funds for science and technology development(2022ZY0109).
文摘The naturally fermented Inner Mongolian cheese’s flavor and nutritional value make it a popular choice among customers.In this work,to create multi-functional peptides that have taste and biological activity,peptidomics and bioinformatics were used to screen flavor peptides from Inner Mongolian cheese and further assess their antioxidant and angiotensin I-converting enzyme(ACE)inhibitory properties.According to sensory data,YH8 and IL7 had detectable bitter tastes with low thresholds of 0.03 and 0.06 mmol/L,respectively.With an umami threshold range of 0.24‒0.81 mmol/L,VQ6,FK13,HP13 and QT14 exhibited a range of flavors dominated by umami,including sweet,bitter,salty,sour and kokumi.Antioxidant activity wise,YH8,VQ6,HP13 and QT14 were well represented.The above-mentioned peptides all had some ACE inhibitory effect.The bitter peptide IL7(IC_(50)=0.08 mmol/L)had the highest level of ACE inhibitory activity,followed by YH8(IC_(50)=0.33 mmol/L).These multi-functional peptides,which have been assessed for bioactive and taste features in Inner Mongolian cheese,may have positive impacts on health and harmonize the cheese’s overall flavor.These results suggest that some flavor peptides produced in fermented foods might be with bioactivities while providing a basis for the exploration and application of multi-functional peptides.
文摘Figure 6(a)in the paper[Chin.Phys.B 33074203(2024)]was incorrect due to editorial oversight.The correct figure is provided.This modification does not affect the result presented in the paper.
基金Project supported by the National Natural Science Foundation of China(Grant No.NSFC 12175107)the Natural Science Foundation of Nanjing Vocational University of Industry Technology,China(Grant No.YK22-02-08)+3 种基金the Qing Lan Project of Jiangsu Province,Chinathe Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(Grant No.KYCX23_0964)the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20230347)the Fund from the Research Center of Industrial Perception and Intelligent Manufacturing Equipment Engineering of Jiangsu Province,China(Grant No.ZK21-05-09)。
文摘Photonic spin Hall effect(PSHE), as a novel physical effect in light–matter interaction, provides an effective metrological method for characterizing the tiny variation in refractive index(RI). In this work, we propose a multi-functional PSHE sensor based on VO_(2), a material that can reveal the phase transition behavior. By applying thermal control, the mutual transformation into different phase states of VO_(2) can be realized, which contributes to the flexible switching between multiple RI sensing tasks. When VO_(2) is insulating, the ultrasensitive detection of glucose concentrations in human blood is achieved. When VO_(2) is in a mixed phase, the structure can be designed to distinguish between the normal cells and cancer cells through no-label and real-time monitoring. When VO_(2) is metallic, the proposed PSHE sensor can act as an RI indicator for gas analytes. Compared with other multi-functional sensing devices with the complex structures, our design consists of only one analyte and two VO_(2) layers, which is very simple and elegant. Therefore, the proposed VO_(2)-based PSHE sensor has outstanding advantages such as small size, high sensitivity, no-label, and real-time detection, providing a new approach for investigating tunable multi-functional sensors.
基金Foundation items： High-technology Research and Development Programme of China （2007AA03Z544） Aeronautical Science Foundation of China （20075221001）
文摘Multi-functional Al-matrix composites with high volume fraction （55%-57%） of SiC particles are produced with the new pressureless infiltration fabrication technology. X-ray detection and microscopic observation display the composites which are macroscopically homogeneous without porosity. The investigation further reveals that the SiC/Al composites possess low density （2.94 g/cm^3）, high elastic modulus （220 GPa）, prominent thermal management function as a result of low coefficient of thermal expansion （8 × 10^4 K^-1） and high thermal conductivity （235 W/（m.K）） as well as unique preventability of resonance vibration. By adopting a series of developed techniques, the multi-functional SiC/Al composites have managed to be made into near-net-shape parts. Many kinds of precision components of space-based optomechanical structures and airborne optoelectronic platform have been turned out. Of them, several typical products are being under test in practices.
基金The financial support for this research is provided by the Natural Science foundation of China(No.50475117)Youth Natural Science Fund of Shanxi(No.20011021)
文摘In order to provide reliable data for the dynamic design or modification of a tool machine,the dynamic character- istics of the headstock,which is the main component to bear moment,must be obtained precisely.In the paper,the method based on the combination of calculation mode and experiment mode is proposed to analyze the dynamic characteristics of the headstock.The modal parameters and the mode shapes are calculated by ANSYS7.1 software.According to the FEM calculating results,the ex- periment parameters can be selected correctly.The modal parameters of the headstock have to be calculated and identified precisely. On the basis of these modal parameters,the faults of the headstock are shown and its weak points of design are illustrated.A con- clusion is drawn that some reasonable reinforce positions could greatly improve the dynamic characteristics of the system and this ap- proach is proved to be precise and reliable.
基金National Natural Science Foundation of China(Grant Nos.51135003,U1234208)National Basic Research Program of China(973 Program,Grant No.2014CB046303)+3 种基金High-class CNC Machine Tools and Basic Manufacturing Equipment of Important National Science and Technology Specific Projects(Grant No.2013ZX04011-011)National Key Laboratory of Mechanical System and Vibration Project(Grant No.MSV201402)Scientific Research Business Fund of Central Colleges and Universities(Grant No.N150304006)Excellent Talents Support Program for Colleges and Universities in Liaoning Province of China(Grant No.LJQ2014030)
文摘The current research of reliability allocation of CNC lathes always treat CNC lathes as independent series systems. However, CNC lathes are complex systems in the actual situation. Failure correlation is rarely considered when reliabil?ity allocation is conducted. In this paper, drawbacks of reliability model based on failure independence assumption are illustrated, after which, reliability model of CNC lathes considering failure correlation of subsystems is established based on Copula theory, which is an improvement of traditional reliability model of series systems. As the failure time of CNC lathes often obeys Weibull or exponential distribution, Gumbel Copula is selected to build correlation model. After that, a reliability allocation method considering failure correlation is analyzed based on the model established before. Reliability goal is set first and then failure rates are allocated to subsystems according to the allocation vector through solving the correlation model. Reliability allocation is conducted for t = 1. A real case of a CNC lathe and a numerical case are presented together to illustrate the advantages of the reliability model established consider?ing failure correlation and the corresponding allocation method. It shows that the model accords to facts and real working condition more, and failure rates allocated to all the subsystems are increased to some extent. This research proposes a reliability allocation method which takes failure correlation among subsystems of CNC lathes into consid?eration, and costs for design and manufacture could be decreased.
基金supported by the National Natural Science Foundation of China (Nos. 21371069 and 21621001)
文摘Metal-organic frameworks（MOFs） are a unique class of porous crystalline materials that have shown promise for a wide range of applications. MOFs have been explored as a new type of heterogeneous catalytic materials, because of their high surface area, uniform and tunable pores, facile functionalization and incorporation of catalytic active sites. The use of multi-functional sites MOF materials as catalysts for synergistic catalysis and tandem reactions has attracted increasing attention. In this review, we aim to introduce the construction of bi-or multi-functional MOF catalysts with cooperative or cascade functions via post-synthetic modification（PSM）.
文摘Based on the mechanism of chip breaking and the principle of semi-solid thixomolding, the lathe process of AZ91D magnesium alloys chips used in semi-solid thixotropic injection molding process was studied. With three kinds of turning tools, such as 31303C5, 31003C and 31303C, different chips were gotten. And by one tool with different lathe parameters, different chips were gotten. The results show that, under the needed condition of the thixotropic injection molding machine, the ideal chips are gotten and the size of magnesium alloy chips must be about 35mm, and the turning tool is chosen, whose chip breaker groove is narrower and the depth of cutting is more than 3mm as well as the amount of feed is larger than 0.3mm. The deformation occurs on the microstructure of the chips, and the residual stress is important to the later microstructure of semi-solid state in injection molding.
文摘This paper introduces a system of computer aided assembly process planning for spindle box of NC lathe. The method of describing assembly information and generating assembly process drawing is presented. The principles of decision for assembly sequence ar
文摘According to the reliable data of sixteen CNC lathes, each reliable index of the serial CNC lathes is evaluated before tackling and after tackling. According to the failure analysis, reliable improvement measures of the serial CNC lathes are put forward.
基金Supported by National Natural Science Foundation of China(Grant Nos.51135003,51205050,U1234208)Key National Science & Technology Special Project on"High-Grade CNC Machine Tools and Basic Manufacturing Equipments"(Grant No.2013ZX04011011)+1 种基金Research Fund for the Doctoral Program of Higher Education of China(Grant No.20110042120020)Fundamental Research Funds for the Central
文摘Reliability allocation of computerized numerical controlled（CNC）lathes is very important in industry.Traditional allocation methods only focus on high-failure rate components rather than moderate failure rate components,which is not applicable in some conditions.Aiming at solving the problem of CNC lathes reliability allocating,a comprehensive reliability allocation method based on cubic transformed functions of failure modes and effects analysis（FMEA）is presented.Firstly,conventional reliability allocation methods are introduced.Then the limitations of direct combination of comprehensive allocation method with the exponential transformed FMEA method are investigated.Subsequently,a cubic transformed function is established in order to overcome these limitations.Properties of the new transformed functions are discussed by considering the failure severity and the failure occurrence.Designers can choose appropriate transform amplitudes according to their requirements.Finally,a CNC lathe and a spindle system are used as an example to verify the new allocation method.Seven criteria are considered to compare the results of the new method with traditional methods.The allocation results indicate that the new method is more flexible than traditional methods.By employing the new cubic transformed function,the method covers a wider range of problems in CNC reliability allocation without losing the advantages of traditional methods.
基金supported by the National Natural Science Foundations of China(Nos.5157051626,51475225)
文摘To fulfill the demands for higher quality,efficiency and flexibility in aviation industry,a multi-functional end effector is designed to automate the drilling and riveting processes in assembling carbon fiber reinforced polymer(CFRP)and aluminum components for a robotic aircraft assembly system.To meet the specific functional requirements for blind rivet installation on CFRP and aluminum materials,additional modules are incorporated on the end effector aside of the basic processing modules for drilling.And all of these processing modules allow for a onestep-drilling-countersinking process,hole inspection,automatic rivet feed,rivet geometry check,sealant application,rivet insertion and installation.Besides,to guarantee the better quality of the hole drilled and joints riveted,several online detection and adjustment measures are applied to this end effector,including the reference detection and perpendicular calibration,which could effectively ensure the positioning precision and perpendicular accuracy as demanded.Finally,the test result shows that this end effector is capable of producing each hole to a positioning precision within ±0.5 mm,aperpendicular accuracy within 0.3°,a diameter tolerance of H8,and a countersink depth tolerance of±0.01 mm.Moreover,it could drill and rivet up to three joints per minute,with acceptable shearing and tensile strength.
基金supported by grants from CAMS Innovation Fund for Medical Sciences(Grant No.:2021-I2M-1-026)Scientific Research Project of Tianjin Education Commission(Grant No.:2020KJ140)Tianjin Health Research Project(Grant No.:KJ20017)。
文摘Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmoplasia causes a hypoxic microenvironment in pancreatic cancer.In this study,a novel FR-directed,macropinocytosis-enhanced,and highly cytotoxic bioconjugate folate(F)-human serum albumin(HSA)-apoprotein of lidamycin(LDP)-active enediyne(AE)derived from lidamycin was designed and prepared.F-HSA-LDP-AE consisted of four moieties:F,HSA,LDP,and AE.F-HSA-LDP presented high binding efficiency with the FR and pancreatic cancer cells.Its uptake in wild-type cells was more extensive than in K-Ras mutant-type cells.By in vivo optical imaging,F-HSA-LDP displayed prominent tumor-specific biodistribution in pancreatic cancer xenograft-bearing mice,showing clear and lasting tumor localization for 360 h.In the MTT assay,F-HSA-LDP-AE demonstrated potent cytotoxicity in three types of pancreatic cancer cell lines.It also induced apoptosis and caused G2/M cell cycle arrest.F-HSALDP-AE markedly suppressed the tumor growth of AsPc-1 pancreatic cancer xenografts in athymic mice.At well-tolerated doses of 0.5 and 1 mg/kg,(i.v.,twice),the inhibition rates were 91.2%and 94.8%,respectively(P<0.01).The results of this study indicate that the F-HSA-LDP multi-functional bioconjugate might be effective for treating K-Ras mutant pancreatic cancer.
基金financially supported by Independent Innovation Research Fund of Wuhan University of Technology(No.2014-ND-B1-09)
文摘Making an analysis for vibration modal and frequency response of the lathe spindle,respectively by using finite element method based on ANSYS and experiment of CA6140 type lathe in machining,and the calculation results are compared and analyzed,which verified the accuracy of ANSYS method. Numerical simulation and experimental results show that: Spindle in the first order and fifth order are prone to resonance,but did not reach resonance,the low order natural frequency have more effect than the high order natural frequency of the spindle vibration; by the experiments can conclude that the maximum vibration of the main shaft in the working state is mainly concentrated in the vicinity of its two ends,therefore,the improved bearing is an important way to reduce the vibration of the main shaft and ensure the machining accuracy,and the research results can provide a theoretical reference for the structural optimization design of the lathe.
基金the National Science and Technology Major Project of China(No.2014ZX04014-011)
文摘The lathes are basic machine tools for manufacturing cylindrical parts. In recent years, the DLseries computer numerical control(CNC) heavy-duty horizontal lathes(HDHLs) have been widely used in the transportation, energy and aviation industries. High availability of the CNC heavy-duty lathes is demanded to guarantee the efficiency and benefit of these manufacturing industries. As one of the key subsystems of the HDHLs, the feeding control system is studied in this paper on reliability modeling and reliability analysis. The fault tree analysis(FTA) method is used for reliability modelling of the feeding control system. Considering the multiple common cause failure groups(CCFGs) existing in the system, a modified beta factor parametric model is introduced to model the common cause failure(CCF) in system. The reliability of feeding control system is then obtained and the effect of CCF on the reliability of the whole system is studied as well.
文摘For virtually realizing the graphic realism display of DXF machine parts, in AutoCAD2007 graphic drawing environment, an interactive experimental method was taken to realize the display of graphic in DXF, which was taken as the data-exchanged interface and source. Based on depth analysis of DXF data structure, take one drawing of DXF lathe turning rotational part asthe test piece. By VC＋＋6.0 programming, part＇s geometry information could be obtained. Through data processing, 3D data of the test piece could be generated, which is based on 2D data of DXF test piece. Then, OpenGL graphic processing technologies （light, material, texture, map, et al.） were applied on the 3D display of test piece from DXF files or program modules. Finally based on the test report, results of the system functions were shared to prove the realization of system design, and the feasibility of algorithms used. In the developed software, Machine Designers could get a full view of machine parts, and do some proper modifications. The study content and results of our work have some theory and practical significance on the application of program design in the practical projects.
文摘According to the technique requests of the brake caliper in the process of production, a special fixture of float brake caliper has been developed based on 3 D design in this paper. The development process and verified data from 3D modeling and kinematics simulation for this special fixture show that this 3D-designed process can conveniently forecast the assembly interference of the fixture and accurately add the mass of lead brick before the prototype is made. In this way the flutter caused by the unbalanced lathe fixture can be eliminated and the precision of run-out tolerance in cylinder hole compared with machine tool spindle can be improved, thus the processing quality of the cylinder hole in a brake caliper can be greatly guaranteed.
文摘In order to meet increasing demand for higher productivity and flexibility, recently many kinds of multi-functional machine tools, which are capable of multiple machining functions or different kinds of machining processes on one machine, have been developed and widely used in manufacturing industries. In this study, a multi-functional turning lathe, which has two spindles and two turrets so that multiple turning operations and various machining processes could be performed simultaneously, has been developed. Furthermore, the equations of correlation between whole responses and cross responses of the two spindles have been derived to examine to what extent the two spindles affect each other’s vibrations.
基金Supported by the Project of Jilin Province(20150101025JC)the National Natural Science Foundation of China(51175222)
文摘An importance analysis model for computer numerical control（CNC）lathe subsystems was proposed.The model was based on technique for order preference by similarity to an ideal solution（TOPSIS）and considered the structure correlation between subsystems and the complete machine,the fault correlation of each subsystem and so on.The model can obtain a comprehensive sequencing of subsystems based on their importance to the complete machine.It lays a theoretical foundation for reliability allocation.
