Multi-channel cylindrical applicators for high dose-rate (HDR) brachytherapy are utilized mainly for special gynecology cases often involving image-guidance high dose-rate (IG-HDR or IGBT) brachytherapy. In these case...Multi-channel cylindrical applicators for high dose-rate (HDR) brachytherapy are utilized mainly for special gynecology cases often involving image-guidance high dose-rate (IG-HDR or IGBT) brachytherapy. In these cases, doses are prescribed to partial vaginal wall/depth where the disease is indicated by an MRI study scanned on the same day. These novel IG-HDR procedures are logistical challenges comparing to typical HDR out-patient treatments due to the complexity of planning for asymmetrical prescriptions as well as the extension of the whole procedure. Indeed the main advantages of HDR over LDR brachytherapy would be significantly weaken unless the IG-HDR procedures become more efficient in time, thus timely treatment planning becomes crucial. Based on our clinical experience, we propose the pseudo central-catheter method to reduce errors, to minimize uncertainty and to ensure efficiency. In this method, the central hollow path of the multi-channel cylindrical applicator is digitized into a pseudo catheter similar to other active catheters, and the asymmetrical prescription points could be generated corresponding to the pseudo dwelling points in the pseudo central-catheter. The pseudo dwelling points are later deleted after generating the prescription point arrays. This method is robust with minimal chance of errors or uncertainties, and demonstrates high efficiency with much less chance of uncertainty, which is significant for IG-HDR brachytherapy procedures utilizing multi-channel applicators.展开更多
Stress concentrations about thin cylindrical shells with small openings are reconsidered front a nerv angle. There is a sort of special internal relation between theoretical solutions about cylindrical shells,vith lar...Stress concentrations about thin cylindrical shells with small openings are reconsidered front a nerv angle. There is a sort of special internal relation between theoretical solutions about cylindrical shells,vith large openings and one,with small openings. Using this relation, the extent of applying the theory about small openings to engineering practice is estimated again, thus an idea of how to use this theory and a nerv appraisal of the application of theoretical solutions about cylindrical shells with small openings to engineering practice are given.展开更多
Seismic forward-prospecting in tunnels is an important step to ensure excavation safety. Nowadays, most advanced imaging techniques in seismic exploration involve calculating the solution of elastic wave equation in a...Seismic forward-prospecting in tunnels is an important step to ensure excavation safety. Nowadays, most advanced imaging techniques in seismic exploration involve calculating the solution of elastic wave equation in a certain coordinate system. However, considering the cylindrical geometry of common tunnel body, Cartesian coordinate system seemingly has limited applicability in tunnel seismic forwardprospecting. To accurately simulate the seismic signal received in tunnels, previous imaging method using decoupled non-conversion elastic wave equation is extended from Cartesian coordinates to cylindrical coordinates. The proposed method preserves the general finite-difference time-domain(FDTD)scheme in Cartesian coordinates, except for a novel wavefield calculation strategy addressing the singularity issue inherited at the cylindrical axis. Moreover, the procedure of cylindrical elastic reverse time migration(CERTM) in tunnels is introduced based on the decoupled non-conversion elastic wavefield. Its imaging effect is further validated via numerical experiments on typical tunnel models. As indicated in the synthetic examples, both the PP-and SS-images could clearly show the geological structure in front of the tunnel face without obvious crosstalk artifacts. Migration imaging using PP-waves can present satisfactory results with higher resolution information supplemented by the SS-images. The potential of applying the proposed method in real-world cases is demonstrated in a water diversion tunnel. In the end, we share our insights regarding the singularity treatment and further improvement of the proposed method.展开更多
Background: There are only very few reports on clinical outcomes using multi-channel applicators (MCA) for patients with endometrial cancer (EC) in China. We aimed to evaluate the clinical experience of treating inter...Background: There are only very few reports on clinical outcomes using multi-channel applicators (MCA) for patients with endometrial cancer (EC) in China. We aimed to evaluate the clinical experience of treating intermediate-risk (IR) to high-risk (HR) stage I EC using in-house made multi-channel applicators (IH-MCA) in a single institution. Methods: Three hundred and ninety patients with stage I IR to HR EC were treated with hysterectomy and adjuvant radiotherapy from 2003 to 2015. All patients received post-operative vaginal cuff brachytherapy (VBT) alone or as a boost after external beam radiotherapy (EBRT). The prescriptions were 500 cGy per fraction for a total of 5 to 6 fractions with brachytherapy alone or 400 to 600 cGy per fraction for 2 to 3 fractions if it was combined with EBRT. Two types of applicators including a traditional rigid IH-MCA and a recent model custom-made with 3 dimension printing technology were used for treatment. The Kaplan-Meier method was used to calculate survival rate. Results: Follow-up rate was 92.8% and the median follow-up time was 48 months (range 4–172 months). The 5-year overall survival (OS), progression-free survival, local recurrence, and distant metastasis rates for all patients were 96.3%, 92.1%, 2.9%, and 4.8% respectively. Two patients had isolated relapse in vagina outside the irradiated volume. The univariate and multivariate analysis showed that age and grade were the prognostic factors correlated with OS (hazard ratio: 0.368, 95% confidence interval [CI]: 0.131–1.035, P = 0.048;hazard ratio: 0.576, 95% CI: 0.347–0.958, P = 0.026,). Conclusions: For patients with IR to HR stage I EC, adjuvant VBT alone or in combination with EBRT using IH-MCA led to excellent survival and recurrence rates. Age and grade were the prognostic factors correlated with OS.展开更多
文摘Multi-channel cylindrical applicators for high dose-rate (HDR) brachytherapy are utilized mainly for special gynecology cases often involving image-guidance high dose-rate (IG-HDR or IGBT) brachytherapy. In these cases, doses are prescribed to partial vaginal wall/depth where the disease is indicated by an MRI study scanned on the same day. These novel IG-HDR procedures are logistical challenges comparing to typical HDR out-patient treatments due to the complexity of planning for asymmetrical prescriptions as well as the extension of the whole procedure. Indeed the main advantages of HDR over LDR brachytherapy would be significantly weaken unless the IG-HDR procedures become more efficient in time, thus timely treatment planning becomes crucial. Based on our clinical experience, we propose the pseudo central-catheter method to reduce errors, to minimize uncertainty and to ensure efficiency. In this method, the central hollow path of the multi-channel cylindrical applicator is digitized into a pseudo catheter similar to other active catheters, and the asymmetrical prescription points could be generated corresponding to the pseudo dwelling points in the pseudo central-catheter. The pseudo dwelling points are later deleted after generating the prescription point arrays. This method is robust with minimal chance of errors or uncertainties, and demonstrates high efficiency with much less chance of uncertainty, which is significant for IG-HDR brachytherapy procedures utilizing multi-channel applicators.
文摘Stress concentrations about thin cylindrical shells with small openings are reconsidered front a nerv angle. There is a sort of special internal relation between theoretical solutions about cylindrical shells,vith large openings and one,with small openings. Using this relation, the extent of applying the theory about small openings to engineering practice is estimated again, thus an idea of how to use this theory and a nerv appraisal of the application of theoretical solutions about cylindrical shells with small openings to engineering practice are given.
基金funded by the National Natural Science Foundation of China (Grant Nos. 52021005 and 51739007)the Key Research and Development Plan of Shandong Province (Grant No. 2020ZLYS01)。
文摘Seismic forward-prospecting in tunnels is an important step to ensure excavation safety. Nowadays, most advanced imaging techniques in seismic exploration involve calculating the solution of elastic wave equation in a certain coordinate system. However, considering the cylindrical geometry of common tunnel body, Cartesian coordinate system seemingly has limited applicability in tunnel seismic forwardprospecting. To accurately simulate the seismic signal received in tunnels, previous imaging method using decoupled non-conversion elastic wave equation is extended from Cartesian coordinates to cylindrical coordinates. The proposed method preserves the general finite-difference time-domain(FDTD)scheme in Cartesian coordinates, except for a novel wavefield calculation strategy addressing the singularity issue inherited at the cylindrical axis. Moreover, the procedure of cylindrical elastic reverse time migration(CERTM) in tunnels is introduced based on the decoupled non-conversion elastic wavefield. Its imaging effect is further validated via numerical experiments on typical tunnel models. As indicated in the synthetic examples, both the PP-and SS-images could clearly show the geological structure in front of the tunnel face without obvious crosstalk artifacts. Migration imaging using PP-waves can present satisfactory results with higher resolution information supplemented by the SS-images. The potential of applying the proposed method in real-world cases is demonstrated in a water diversion tunnel. In the end, we share our insights regarding the singularity treatment and further improvement of the proposed method.
基金This study was supported by the grant from the Ministry of Science and Technology of China(No.2016YFC0105207).
文摘Background: There are only very few reports on clinical outcomes using multi-channel applicators (MCA) for patients with endometrial cancer (EC) in China. We aimed to evaluate the clinical experience of treating intermediate-risk (IR) to high-risk (HR) stage I EC using in-house made multi-channel applicators (IH-MCA) in a single institution. Methods: Three hundred and ninety patients with stage I IR to HR EC were treated with hysterectomy and adjuvant radiotherapy from 2003 to 2015. All patients received post-operative vaginal cuff brachytherapy (VBT) alone or as a boost after external beam radiotherapy (EBRT). The prescriptions were 500 cGy per fraction for a total of 5 to 6 fractions with brachytherapy alone or 400 to 600 cGy per fraction for 2 to 3 fractions if it was combined with EBRT. Two types of applicators including a traditional rigid IH-MCA and a recent model custom-made with 3 dimension printing technology were used for treatment. The Kaplan-Meier method was used to calculate survival rate. Results: Follow-up rate was 92.8% and the median follow-up time was 48 months (range 4–172 months). The 5-year overall survival (OS), progression-free survival, local recurrence, and distant metastasis rates for all patients were 96.3%, 92.1%, 2.9%, and 4.8% respectively. Two patients had isolated relapse in vagina outside the irradiated volume. The univariate and multivariate analysis showed that age and grade were the prognostic factors correlated with OS (hazard ratio: 0.368, 95% confidence interval [CI]: 0.131–1.035, P = 0.048;hazard ratio: 0.576, 95% CI: 0.347–0.958, P = 0.026,). Conclusions: For patients with IR to HR stage I EC, adjuvant VBT alone or in combination with EBRT using IH-MCA led to excellent survival and recurrence rates. Age and grade were the prognostic factors correlated with OS.
