Introduction:This study aims to analyze the clinical characteristics and pathogenic features of Chlamydia pneumoniae pneumonia,providing a scientific basis for the diagnosis and treatment of C.pneumoniae infections.Me...Introduction:This study aims to analyze the clinical characteristics and pathogenic features of Chlamydia pneumoniae pneumonia,providing a scientific basis for the diagnosis and treatment of C.pneumoniae infections.Methods:Clinical data from four patients diagnosed with C.pneumoniae pneumonia in Lishui City,Zhejiang Province,between April and May 2024,were collected to analyze clinical manifestations and pathogenic findings.Multi-locus sequence typing(MLST)analysis of the pathogen was conducted using seven housekeeping genes.Results:All patients exhibited decreased levels of retinol-binding protein and prealbumin,findings not previously reported in earlier studies.Additionally,coinfections were identified in two cases.Analysis of the 16S rRNA and ompA gene sequences indicated a homology of 98%to 100%with known C.pneumoniae strains.To further characterize these strains,sequencing of the seven housekeeping genes confirmed that all cases were infected with the ST16 genotype.Conclusions:C.pneumoniae infections in Lishui City are predominantly caused by the ST16 genotype,highlighting the need for enhanced research into these infections.The decrease in retinol-binding protein and prealbumin levels may serve as auxiliary diagnostic biomarkers in clinical practice.Next-generation sequencing methods demonstrate significant potential for pathogen identification,particularly in diagnosing co-infections.展开更多
基金supported by grants from the Tengfei initiative by the National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(grant number 2024NITFID504)grants from the National Key Research and Development Program of China(grant number 2021YFC2301202)the National Natural Science Foundation of China(grant number 82102390).
文摘Introduction:This study aims to analyze the clinical characteristics and pathogenic features of Chlamydia pneumoniae pneumonia,providing a scientific basis for the diagnosis and treatment of C.pneumoniae infections.Methods:Clinical data from four patients diagnosed with C.pneumoniae pneumonia in Lishui City,Zhejiang Province,between April and May 2024,were collected to analyze clinical manifestations and pathogenic findings.Multi-locus sequence typing(MLST)analysis of the pathogen was conducted using seven housekeeping genes.Results:All patients exhibited decreased levels of retinol-binding protein and prealbumin,findings not previously reported in earlier studies.Additionally,coinfections were identified in two cases.Analysis of the 16S rRNA and ompA gene sequences indicated a homology of 98%to 100%with known C.pneumoniae strains.To further characterize these strains,sequencing of the seven housekeeping genes confirmed that all cases were infected with the ST16 genotype.Conclusions:C.pneumoniae infections in Lishui City are predominantly caused by the ST16 genotype,highlighting the need for enhanced research into these infections.The decrease in retinol-binding protein and prealbumin levels may serve as auxiliary diagnostic biomarkers in clinical practice.Next-generation sequencing methods demonstrate significant potential for pathogen identification,particularly in diagnosing co-infections.
