Objective To explore the characteristics and differencesinChinesemedicine(CM)syndrome elements among patients with different motor subtypes of Parkinson's disease(PD),and the correlations between CM syndrome eleme...Objective To explore the characteristics and differencesinChinesemedicine(CM)syndrome elements among patients with different motor subtypes of Parkinson's disease(PD),and the correlations between CM syndrome elements and the postural instability and gait difficulty(PICD)subtype.Methods Clinical data and CM syndrome elements information were collected from 96 primary PD patients at Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine,over the period from August 2022 to December 2023.The patients were assigned to two groups:PIGD type(43 cases)and non-PIGD type(53 cases).During the research,T-tests,U-tests,X tests,or Fisher's exact tests were used to analyze differences in CM syndrome elements between the groups.Besides,Binary logistic regression was employed to assess the correlations between CM syndrome elements and the PIGD phenotype.Results Compared with the non-PIGD group,individuals with PIGD exhibited a higher prevalence of freezing of gait(FOG)(P<0.001),lower scores on Montreal Cognitive Assessment(MoCA)(P=0.042),and higher levodopa equivalent daily doses(P=0.009).The predominant CM syndrome elements in the PIGD group were Shen deficiency(40/43,93.0%),qi deficiency(35/43,81.4%),Pi deficiency(34/43,79.1%),yin deficiency(29/43,67.4%),and blood deficiency(27/43,62.8%).Compared with the non-PIGD group,the incidence of Shen deficiency(P=0.022),Pi deficiency(P<0.001),qi deficiency(P=0.006),and blood deficiency(P=0.001)was significantly higher in the PIGD group,whereas the incidence of Gan wind was significantly lower(P<0.001).Regression analysis revealed a positive correlation between blood deficiency(OR=5.383,P=0.037)and the PICD subtype,while Gan wind was negatively correlated with it(OR=0.016,P<0.001).Conclusion There are differences in the distribution of CM syndrome elements among different motor subtypes of PD.The PIGD subtype is mainly characterized by deficiencies in Shen,qi,Pi,yin,and blood.Blood deficiency exhibits a positive correlation with the PICD phenotype,whereas Gan wind shows a negative correlation.展开更多
文摘Objective To explore the characteristics and differencesinChinesemedicine(CM)syndrome elements among patients with different motor subtypes of Parkinson's disease(PD),and the correlations between CM syndrome elements and the postural instability and gait difficulty(PICD)subtype.Methods Clinical data and CM syndrome elements information were collected from 96 primary PD patients at Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine,over the period from August 2022 to December 2023.The patients were assigned to two groups:PIGD type(43 cases)and non-PIGD type(53 cases).During the research,T-tests,U-tests,X tests,or Fisher's exact tests were used to analyze differences in CM syndrome elements between the groups.Besides,Binary logistic regression was employed to assess the correlations between CM syndrome elements and the PIGD phenotype.Results Compared with the non-PIGD group,individuals with PIGD exhibited a higher prevalence of freezing of gait(FOG)(P<0.001),lower scores on Montreal Cognitive Assessment(MoCA)(P=0.042),and higher levodopa equivalent daily doses(P=0.009).The predominant CM syndrome elements in the PIGD group were Shen deficiency(40/43,93.0%),qi deficiency(35/43,81.4%),Pi deficiency(34/43,79.1%),yin deficiency(29/43,67.4%),and blood deficiency(27/43,62.8%).Compared with the non-PIGD group,the incidence of Shen deficiency(P=0.022),Pi deficiency(P<0.001),qi deficiency(P=0.006),and blood deficiency(P=0.001)was significantly higher in the PIGD group,whereas the incidence of Gan wind was significantly lower(P<0.001).Regression analysis revealed a positive correlation between blood deficiency(OR=5.383,P=0.037)and the PICD subtype,while Gan wind was negatively correlated with it(OR=0.016,P<0.001).Conclusion There are differences in the distribution of CM syndrome elements among different motor subtypes of PD.The PIGD subtype is mainly characterized by deficiencies in Shen,qi,Pi,yin,and blood.Blood deficiency exhibits a positive correlation with the PICD phenotype,whereas Gan wind shows a negative correlation.
