The purpose of the study is to investigate the age group of children aged 9 years old who have experienced delays in gross motor development. Instrument used in this study is TGMD （test gross motor development）-2, U...The purpose of the study is to investigate the age group of children aged 9 years old who have experienced delays in gross motor development. Instrument used in this study is TGMD （test gross motor development）-2, Ulrich, which was adopted at the international level. Gross motor development data were obtained by video recording （Sony DRC-SR42 with a 40x optical zoom capability, and software Ultimate Studio 14） on locomotors and manipulative skills. A total n = 64 persons, children of 9 years （9.30± 0.43） at Mutiara Perdana Primary School, Bayan Lepas, Penang were involved as the subjects. The result of the study found that children aged 9 years old experienced delays in age equivalent locomotor score （4.61 ± 0.69）, age equivalent manipulative score （5.52 ±0.62） and gross motor development quotient （7.26 ± 2.14）.展开更多
After Enzyme Replacement Therapy (ERT) using recombinant human acid alpha-glucosidase (rhGAA), survival of Infantile Pompe Disease (IPD) patients through the first 18 months of age has been documented and acquisitions...After Enzyme Replacement Therapy (ERT) using recombinant human acid alpha-glucosidase (rhGAA), survival of Infantile Pompe Disease (IPD) patients through the first 18 months of age has been documented and acquisitions of motor development are an important outcome, but description of its course is scarce. Objective: To describe the motor development in an IPD patient and its correlation with clinical conditions during the first 18 months on ERT with rhGAA. Methods: By longitudinal observational study of an IPD case at early stage. Clinical and biochemical characteristics were obtained from patient records. Echocardiogram assessed cardiac indexes and the urinary biomarker—glucose tetrasaccharide (Glc4)—was obtained by HPLC/UV, following sample derivatization with butyl 4-amino benzoate and analysis on a C18 stationary phase column. Motor skills were evaluated with Alberta Infant of Motor Scale (AIMS) and motor delay was considered as motor percentile (p) below 10. Descriptive statistical analysis was carried out and t-test was used to calculate the differences among means, with significance level defined as p value < 0.05. Results: After ERT beginning amelioration of the cardiomyopathy with reduced left ventricle mass index (LVMI) from the 2nd month onwards was observed, but above the upper normal limit for healthy children and CRIM-positive IPD patients. Although GAA antibodies level remained above the recommended titers and fluctuating elevation of Glc4 quantified, motor development analysis showed an ascendant curve expected for age within achievement of independent ambulation. Motor delay after pneumonia and maintenance of hypotonia were noted. Variation of Glc4 appeared long after a transitory intercurrence. Conclusion: In an IPD case, motor development can have normal evolution despite hypotonia. Motor analysis seems to be sensitive to follow-up clinical intercurrences. To elucidate the interaction among prognostic factors and outcomes, further clinical studies need to be conducted.展开更多
Motor development has been extensively studied in human infants and children, with several established scales for the evaluation of motor functions. However, the study of the neuronal mechanisms underlying human motor...Motor development has been extensively studied in human infants and children, with several established scales for the evaluation of motor functions. However, the study of the neuronal mechanisms underlying human motor development is hampered by the lack of good animal models. The common marmoset （Callithrix jacchus）, a small New World monkey, has recently attracted much attention as a potential non- human primate model for understanding human physiology and diseases. However, little is known about its gross motor development. In the present study, we found that marmosets have a critical period for motor development in postnatal weeks 2 to 5, and acquire most of their motor skills by 8 weeks of age. We also developed methods to assess their motor functions, which will be useful for the evaluation of motor performance in marmoset models of human diseases. In addition, we found that marmosets exhibit a ＂head-to-tail＂ sequence of motor development similar to that found in humans, further supporting the notion that they provide a good animal model for studying the neuronal mechanisms underlying human motor development.展开更多
AHEMD-SR(Affordances in the Home Environment for Motor Development-Self Report)was applied to children from 18 to 42 months(N=132),from a coastal municipality of Portugal.The results revealed that the father’s income...AHEMD-SR(Affordances in the Home Environment for Motor Development-Self Report)was applied to children from 18 to 42 months(N=132),from a coastal municipality of Portugal.The results revealed that the father’s income provides more conditions for motor development stimulation,and that a higher number of offspring may result in less conditions for the younger ones.Having a mother,whatever her academic qualifications,is also a factor that promotes better conditions.Thus,in families with fewer resources and more children,it is strategically advisable to technically support the mother.The kindergarten appears to be an equalizer factor for opportunities for access to motor stimulation resources.展开更多
The purpose of this study was to observe record and compare the children＇s of early childhood performance of motor skills of different nationalities from Greece, Albania and Sweden. Additionally to investigate differ...The purpose of this study was to observe record and compare the children＇s of early childhood performance of motor skills of different nationalities from Greece, Albania and Sweden. Additionally to investigate differences in motor performance between boys and girls and between age groups. The survey was conducted in the school years 2013-2014 and 2014-2015, and took place in the flame of the student exchange program ERASMUS internships of Preschool Education, University of loannina. The sample consisted of 369 infants （187 boys, 182 girls） aged 66 ± 7 months. The sample was selected according to the access that the team had in nursery schools of Ioannina （N1 = 133）, in Dervitsani （N2 = 131） Albania and Gothenburg （N2 = 105） of Sweden. The array of 18 different motor activities for children aged 4-6 years old was used to investigate the toddlers＇ degree of movement performance. They were used the manufacturer＇s instructions for the degree of movement performance and classification of the sample in different categories, while a descriptive statistics and analysis of variance （Three Way ANOVA） took place for sex factors, age and region of origin. The results showed that although there were differences in rates distributions and averages, there were no significant differences either between children from the three countries or between boys and girls, however, there were in the age groups with older children who achieved better rates.展开更多
Motor development at late preterm infants has significant importance as it composes the picture of the severe evidences of motor impairments or other developmental difficulties. Early detection is crucial as early int...Motor development at late preterm infants has significant importance as it composes the picture of the severe evidences of motor impairments or other developmental difficulties. Early detection is crucial as early intervention is the unique immediate solution option to catch up the developmental milestones. Method: Α systematic search for scientific articles of the decade 2010-2020 investigating the motor profile of late preterm infants was conducted. Results: The search identified 9 studies, many of which highlighted the risk of motor and developmental delays even at 36 months of age. Conclusions: The stability of motor and developmental delays indicates the need of further investigation at a later age and intervention to avoid possible academic difficulties.展开更多
儿童动作发展是终身体育和健康教育的重要内涵。基于测评体系推广应用的视角,对英国儿童动作发展测评体系(Movement Assessment Battery for Children,MABC)的测量与评价系统、跨文化应用的信效度、优缺点以及应用情况开展研究,旨在促...儿童动作发展是终身体育和健康教育的重要内涵。基于测评体系推广应用的视角,对英国儿童动作发展测评体系(Movement Assessment Battery for Children,MABC)的测量与评价系统、跨文化应用的信效度、优缺点以及应用情况开展研究,旨在促进我国儿童动作发展研究的开展。结果显示:MABC的产生和发展具有特定的学术背景,经过50多年的发展,MABC被广泛应用于儿童动作功能发展障碍预警评估和筛查、基本运动技能以及协调能力的测量与评价当中,原因在于其测量程序的标准化、测量内容的精确性以及常模评价的实用性等。但MABC存在着诸如检测员资质要求高、测试程序烦琐等不足,这需要引起使用者的注意。结合当前MABC的应用情况,从思路和方法上提出了其对我国儿童动作发展研究的启示:加快进行国际先进动作发展测评工具的本土化工作,基于测评研究的视角深化我国儿童动作发展的相关研究,基于学科融合交叉发展视角拓展动作发展研究的内容和方法。展开更多
Developmental plagiocephaly (DP) has been an increasing problem since the successful “back to sleep campaign”. The referrals for DP have increased by >400% during the years 2004 to 2008. Many infants spend less t...Developmental plagiocephaly (DP) has been an increasing problem since the successful “back to sleep campaign”. The referrals for DP have increased by >400% during the years 2004 to 2008. Many infants spend less time in the prone position nowadays and some of the risk factors for DP are as follows: less than 3 times per day for the tummy time, torticollis and slow achievement of motor milestones. There is a need for better information to the parents but also for other strategies to prevent DP. The aim of this study was to investigate the effect of a special pillow and thus to reduce pressure on the infant head. Method: infants aged zero to two months were included in the study. They were randomized to either intervention group or control group. Head shape was investigated on two occasions, on the second occasion motor development, mobility and muscle function of the neck were also investigated. The parents were asked about tummy time and sleep position. All infants were investigated by the same physical therapist, blinded to group belonging. Result: seven infants had CVAI >3.5 on the last assessment, five of these had not used any method to reduce pressure. Fishers exact test showed a tendency where infants with reduced pressure on the head had less DP (P 0.08). Paired t test showed significant decrease in CVAI for the infants who had had reduced pressure on the head (P 0.01). Among these infants the CVAI was zero for 47% in the last assessment. For the infants who had not had a reduction of pressure on the head, there was no indication of a decrease of CVAI (P 0.45), and only 12% of these infants had a CVAI that was zero in the last assessment. Conclusion: this pilot study shows that a specially designed pillow may prevent DP in young infants. However, a larger sample is needed to confirm or disprove this. The study is planned to go on until there are 200 participants.展开更多
Developmental plagiocephaly (DP) has been an increasing problem since the successful “back to sleep campaign”. The referrals for DP have increased by more than 400% during the years 2004 to 2008. Many infants spend ...Developmental plagiocephaly (DP) has been an increasing problem since the successful “back to sleep campaign”. The referrals for DP have increased by more than 400% during the years 2004 to 2008. Many infants spend less time in the prone position nowadays and some of the risk factors for DP are: tummy time less than 3 times per day, torticollis and slow achievement of motor milestones. Improved information for the parents is needed but also other strategies to prevent DP. This study is a continuum of an earlier pilot study;the aim was to investigate the effect of a pillow, designed to reduce pressure on the infant head. Method: Infants aged zero to two months were included in the study. They were randomized to either intervention group or control group. Head shape was investigated on two occasions, on the second occasion motor development, mobility and muscle function of the neck were also investigated. The parents were asked about tummy time and sleep position. All infants were investigated by the same physical therapist, blinded to group belonging. Result: Fishers exact test showed that it was more common with decreased CVAI among infants in the intervention group (P 0.001). Paired t test showed significant decrease in CVAI for the intervention group (P 0.002), but not for the control group (P 0.96). Conclusion: This study shows that a specially designed pillow can decrease DP in young infants.展开更多
Primary impairments of developmental coordination disorder (DCD) include impairments in motor skill, motor learning, and imitation. Such difficulties present challenges for individuals with DCD and may persist into ad...Primary impairments of developmental coordination disorder (DCD) include impairments in motor skill, motor learning, and imitation. Such difficulties present challenges for individuals with DCD and may persist into adulthood, negatively impacting daily life in school, work, and social domains. A better understanding of the neural correlates of motor and imitation impairments in DCD holds the potential for informing development of treatment approaches to address these impairments. Although the disorder is assumed to be of neurological origin, little is known of the brain-based etiology of DCD. In recent years the discovery of a fronto-parietal circuit—known as the mirror neuron system—has enabled researchers to better understand imitation, general motor functions, and aspects of social cognition. Given its involvement in imitation and other motor functions, we propose that dysfunction in the mirror neuron system may underlie the characteristic impairments of DCD. We review literature pertaining to the mirror neuron system and develop a theory of disordered mirror neuron functioning in DCD. Finally, we review the limited neuroimaging literature available on neural correlates of DCD and show that the findings from those investigations are congruent with a mirror neuron system theory of DCD. Future research in this population should be designed to investigate specifically mirror neuron regions in individuals with DCD during skilled motor tasks and imitation in particular.展开更多
Introduction: The MNRI (Masgutova Neurosensorimotor Reflex Integration) method was developed in 1989 in Russia and has spread world-wide to treat individuals with certain types reflex development deficits, behavior di...Introduction: The MNRI (Masgutova Neurosensorimotor Reflex Integration) method was developed in 1989 in Russia and has spread world-wide to treat individuals with certain types reflex development deficits, behavior disorders, disorders of speech or language development, and learning disabilities. MNRI is based on techniques called “repatterning” or remodulation, meaning re-education, recoding the reflex nerve pathways specific for dynamic and postural reflex schemes. Objectives: Repatterning activates the extra pyramidal nervous system responsible for automatic mechanisms and processes, the extension of links between neurons, the growth of neural nets, myelination, and the creation of new nerve routing. This potential result was tested utilizing urinary measurements of the following neurotransmitters: epinephrine, norepinephrine, dopamine, DOPAC, serotonin, 5-HIAA, glycine, taurine, GABA, glutamate, PEA, and histamine. Methods: Neurological impact of the Masgutova Neurosensorimotor Reflex Method on the magnitude of changes in neurotransmitters was assessed by an external controlled and double-blind method using patients from one of the four diagnosis groups: 1) global developmental disorders;2) cerebral palsy, Traumatic Brain Injury (TBI), Acute Brain Injury (ABI), and seizures;3) ADD/ADHD;and 4) anxiety disorders. Results: The post-MNRI results in participants show a tendency for regulation of the above neurotransmitters resulting in their calming down, decrease of hypervigilance, stress resilience increase, improvements in behavioral and emotional regulation, positive emotions, and cognitive processes control. Conclusion: The application of the Masgutova Neurosensorimotor Reflex Method as a therapy modality offers a novelty paradigm for the treatment using neuro- and immune-modulation technologies presenting a non-pharmaceutical approach, based on use of neurosensorimotor reflex circuit concept.展开更多
文摘The purpose of the study is to investigate the age group of children aged 9 years old who have experienced delays in gross motor development. Instrument used in this study is TGMD （test gross motor development）-2, Ulrich, which was adopted at the international level. Gross motor development data were obtained by video recording （Sony DRC-SR42 with a 40x optical zoom capability, and software Ultimate Studio 14） on locomotors and manipulative skills. A total n = 64 persons, children of 9 years （9.30± 0.43） at Mutiara Perdana Primary School, Bayan Lepas, Penang were involved as the subjects. The result of the study found that children aged 9 years old experienced delays in age equivalent locomotor score （4.61 ± 0.69）, age equivalent manipulative score （5.52 ±0.62） and gross motor development quotient （7.26 ± 2.14）.
文摘After Enzyme Replacement Therapy (ERT) using recombinant human acid alpha-glucosidase (rhGAA), survival of Infantile Pompe Disease (IPD) patients through the first 18 months of age has been documented and acquisitions of motor development are an important outcome, but description of its course is scarce. Objective: To describe the motor development in an IPD patient and its correlation with clinical conditions during the first 18 months on ERT with rhGAA. Methods: By longitudinal observational study of an IPD case at early stage. Clinical and biochemical characteristics were obtained from patient records. Echocardiogram assessed cardiac indexes and the urinary biomarker—glucose tetrasaccharide (Glc4)—was obtained by HPLC/UV, following sample derivatization with butyl 4-amino benzoate and analysis on a C18 stationary phase column. Motor skills were evaluated with Alberta Infant of Motor Scale (AIMS) and motor delay was considered as motor percentile (p) below 10. Descriptive statistical analysis was carried out and t-test was used to calculate the differences among means, with significance level defined as p value < 0.05. Results: After ERT beginning amelioration of the cardiomyopathy with reduced left ventricle mass index (LVMI) from the 2nd month onwards was observed, but above the upper normal limit for healthy children and CRIM-positive IPD patients. Although GAA antibodies level remained above the recommended titers and fluctuating elevation of Glc4 quantified, motor development analysis showed an ascendant curve expected for age within achievement of independent ambulation. Motor delay after pneumonia and maintenance of hypotonia were noted. Variation of Glc4 appeared long after a transitory intercurrence. Conclusion: In an IPD case, motor development can have normal evolution despite hypotonia. Motor analysis seems to be sensitive to follow-up clinical intercurrences. To elucidate the interaction among prognostic factors and outcomes, further clinical studies need to be conducted.
基金supported by the Youth Innovation Promotion Association of the Chinese Academy of Sciences and an SA-SIBS scholarship to NGthe MoST 973 Program of China (2011CBA00400)the Strategic Priority Research Program of the CAS (XDB02020100)
文摘Motor development has been extensively studied in human infants and children, with several established scales for the evaluation of motor functions. However, the study of the neuronal mechanisms underlying human motor development is hampered by the lack of good animal models. The common marmoset （Callithrix jacchus）, a small New World monkey, has recently attracted much attention as a potential non- human primate model for understanding human physiology and diseases. However, little is known about its gross motor development. In the present study, we found that marmosets have a critical period for motor development in postnatal weeks 2 to 5, and acquire most of their motor skills by 8 weeks of age. We also developed methods to assess their motor functions, which will be useful for the evaluation of motor performance in marmoset models of human diseases. In addition, we found that marmosets exhibit a ＂head-to-tail＂ sequence of motor development similar to that found in humans, further supporting the notion that they provide a good animal model for studying the neuronal mechanisms underlying human motor development.
基金Funding acknowledgements:This study was partially supported by the Portuguese Foundation for Science and Technology,I.P.under Grant number UIDP/04748/2020。
文摘AHEMD-SR(Affordances in the Home Environment for Motor Development-Self Report)was applied to children from 18 to 42 months(N=132),from a coastal municipality of Portugal.The results revealed that the father’s income provides more conditions for motor development stimulation,and that a higher number of offspring may result in less conditions for the younger ones.Having a mother,whatever her academic qualifications,is also a factor that promotes better conditions.Thus,in families with fewer resources and more children,it is strategically advisable to technically support the mother.The kindergarten appears to be an equalizer factor for opportunities for access to motor stimulation resources.
文摘The purpose of this study was to observe record and compare the children＇s of early childhood performance of motor skills of different nationalities from Greece, Albania and Sweden. Additionally to investigate differences in motor performance between boys and girls and between age groups. The survey was conducted in the school years 2013-2014 and 2014-2015, and took place in the flame of the student exchange program ERASMUS internships of Preschool Education, University of loannina. The sample consisted of 369 infants （187 boys, 182 girls） aged 66 ± 7 months. The sample was selected according to the access that the team had in nursery schools of Ioannina （N1 = 133）, in Dervitsani （N2 = 131） Albania and Gothenburg （N2 = 105） of Sweden. The array of 18 different motor activities for children aged 4-6 years old was used to investigate the toddlers＇ degree of movement performance. They were used the manufacturer＇s instructions for the degree of movement performance and classification of the sample in different categories, while a descriptive statistics and analysis of variance （Three Way ANOVA） took place for sex factors, age and region of origin. The results showed that although there were differences in rates distributions and averages, there were no significant differences either between children from the three countries or between boys and girls, however, there were in the age groups with older children who achieved better rates.
文摘Motor development at late preterm infants has significant importance as it composes the picture of the severe evidences of motor impairments or other developmental difficulties. Early detection is crucial as early intervention is the unique immediate solution option to catch up the developmental milestones. Method: Α systematic search for scientific articles of the decade 2010-2020 investigating the motor profile of late preterm infants was conducted. Results: The search identified 9 studies, many of which highlighted the risk of motor and developmental delays even at 36 months of age. Conclusions: The stability of motor and developmental delays indicates the need of further investigation at a later age and intervention to avoid possible academic difficulties.
文摘儿童动作发展是终身体育和健康教育的重要内涵。基于测评体系推广应用的视角,对英国儿童动作发展测评体系(Movement Assessment Battery for Children,MABC)的测量与评价系统、跨文化应用的信效度、优缺点以及应用情况开展研究,旨在促进我国儿童动作发展研究的开展。结果显示:MABC的产生和发展具有特定的学术背景,经过50多年的发展,MABC被广泛应用于儿童动作功能发展障碍预警评估和筛查、基本运动技能以及协调能力的测量与评价当中,原因在于其测量程序的标准化、测量内容的精确性以及常模评价的实用性等。但MABC存在着诸如检测员资质要求高、测试程序烦琐等不足,这需要引起使用者的注意。结合当前MABC的应用情况,从思路和方法上提出了其对我国儿童动作发展研究的启示:加快进行国际先进动作发展测评工具的本土化工作,基于测评研究的视角深化我国儿童动作发展的相关研究,基于学科融合交叉发展视角拓展动作发展研究的内容和方法。
文摘Developmental plagiocephaly (DP) has been an increasing problem since the successful “back to sleep campaign”. The referrals for DP have increased by >400% during the years 2004 to 2008. Many infants spend less time in the prone position nowadays and some of the risk factors for DP are as follows: less than 3 times per day for the tummy time, torticollis and slow achievement of motor milestones. There is a need for better information to the parents but also for other strategies to prevent DP. The aim of this study was to investigate the effect of a special pillow and thus to reduce pressure on the infant head. Method: infants aged zero to two months were included in the study. They were randomized to either intervention group or control group. Head shape was investigated on two occasions, on the second occasion motor development, mobility and muscle function of the neck were also investigated. The parents were asked about tummy time and sleep position. All infants were investigated by the same physical therapist, blinded to group belonging. Result: seven infants had CVAI >3.5 on the last assessment, five of these had not used any method to reduce pressure. Fishers exact test showed a tendency where infants with reduced pressure on the head had less DP (P 0.08). Paired t test showed significant decrease in CVAI for the infants who had had reduced pressure on the head (P 0.01). Among these infants the CVAI was zero for 47% in the last assessment. For the infants who had not had a reduction of pressure on the head, there was no indication of a decrease of CVAI (P 0.45), and only 12% of these infants had a CVAI that was zero in the last assessment. Conclusion: this pilot study shows that a specially designed pillow may prevent DP in young infants. However, a larger sample is needed to confirm or disprove this. The study is planned to go on until there are 200 participants.
文摘Developmental plagiocephaly (DP) has been an increasing problem since the successful “back to sleep campaign”. The referrals for DP have increased by more than 400% during the years 2004 to 2008. Many infants spend less time in the prone position nowadays and some of the risk factors for DP are: tummy time less than 3 times per day, torticollis and slow achievement of motor milestones. Improved information for the parents is needed but also other strategies to prevent DP. This study is a continuum of an earlier pilot study;the aim was to investigate the effect of a pillow, designed to reduce pressure on the infant head. Method: Infants aged zero to two months were included in the study. They were randomized to either intervention group or control group. Head shape was investigated on two occasions, on the second occasion motor development, mobility and muscle function of the neck were also investigated. The parents were asked about tummy time and sleep position. All infants were investigated by the same physical therapist, blinded to group belonging. Result: Fishers exact test showed that it was more common with decreased CVAI among infants in the intervention group (P 0.001). Paired t test showed significant decrease in CVAI for the intervention group (P 0.002), but not for the control group (P 0.96). Conclusion: This study shows that a specially designed pillow can decrease DP in young infants.
文摘Primary impairments of developmental coordination disorder (DCD) include impairments in motor skill, motor learning, and imitation. Such difficulties present challenges for individuals with DCD and may persist into adulthood, negatively impacting daily life in school, work, and social domains. A better understanding of the neural correlates of motor and imitation impairments in DCD holds the potential for informing development of treatment approaches to address these impairments. Although the disorder is assumed to be of neurological origin, little is known of the brain-based etiology of DCD. In recent years the discovery of a fronto-parietal circuit—known as the mirror neuron system—has enabled researchers to better understand imitation, general motor functions, and aspects of social cognition. Given its involvement in imitation and other motor functions, we propose that dysfunction in the mirror neuron system may underlie the characteristic impairments of DCD. We review literature pertaining to the mirror neuron system and develop a theory of disordered mirror neuron functioning in DCD. Finally, we review the limited neuroimaging literature available on neural correlates of DCD and show that the findings from those investigations are congruent with a mirror neuron system theory of DCD. Future research in this population should be designed to investigate specifically mirror neuron regions in individuals with DCD during skilled motor tasks and imitation in particular.
文摘Introduction: The MNRI (Masgutova Neurosensorimotor Reflex Integration) method was developed in 1989 in Russia and has spread world-wide to treat individuals with certain types reflex development deficits, behavior disorders, disorders of speech or language development, and learning disabilities. MNRI is based on techniques called “repatterning” or remodulation, meaning re-education, recoding the reflex nerve pathways specific for dynamic and postural reflex schemes. Objectives: Repatterning activates the extra pyramidal nervous system responsible for automatic mechanisms and processes, the extension of links between neurons, the growth of neural nets, myelination, and the creation of new nerve routing. This potential result was tested utilizing urinary measurements of the following neurotransmitters: epinephrine, norepinephrine, dopamine, DOPAC, serotonin, 5-HIAA, glycine, taurine, GABA, glutamate, PEA, and histamine. Methods: Neurological impact of the Masgutova Neurosensorimotor Reflex Method on the magnitude of changes in neurotransmitters was assessed by an external controlled and double-blind method using patients from one of the four diagnosis groups: 1) global developmental disorders;2) cerebral palsy, Traumatic Brain Injury (TBI), Acute Brain Injury (ABI), and seizures;3) ADD/ADHD;and 4) anxiety disorders. Results: The post-MNRI results in participants show a tendency for regulation of the above neurotransmitters resulting in their calming down, decrease of hypervigilance, stress resilience increase, improvements in behavioral and emotional regulation, positive emotions, and cognitive processes control. Conclusion: The application of the Masgutova Neurosensorimotor Reflex Method as a therapy modality offers a novelty paradigm for the treatment using neuro- and immune-modulation technologies presenting a non-pharmaceutical approach, based on use of neurosensorimotor reflex circuit concept.
