A new morphinane alkaloid named as mecoquitupline was isolated from Meconopsis quintuplinervia Regel. Its structure was elucidated to be 6-methoxy-17-methyl-2,3-[methylene bis(oxy)]-morphinan-5-en-7-one by spectrosco...A new morphinane alkaloid named as mecoquitupline was isolated from Meconopsis quintuplinervia Regel. Its structure was elucidated to be 6-methoxy-17-methyl-2,3-[methylene bis(oxy)]-morphinan-5-en-7-one by spectroscopic techniques.展开更多
A convergent strategy to the key allylic silyl ether precursor 4 in our synthetic efforts toward morphinan alkaloid is presented. The vital step is the selective 1,2-addition of the organocerium agent of 6 to ketene 5.
Plants, as primary producers, have been playing an indispensable role in other organisms’ survival and the balance of whole ecosystem on Earth. Especially, they provide the main source of energy, food, and medicine f...Plants, as primary producers, have been playing an indispensable role in other organisms’ survival and the balance of whole ecosystem on Earth. Especially, they provide the main source of energy, food, and medicine for human beings, some of which are derived from the primary or secondary metabolites展开更多
目的探讨丙帕他莫和地佐辛用于断指再植术后超前镇痛防治血管危象的临床效果。方法 85例行断指再植术患者根据术后超前镇痛方法的不同分为丙帕他莫组(45例)和地佐辛组(40例),分别给予丙帕他莫、地佐辛静脉自控镇痛(PCIA),比较两组镇痛...目的探讨丙帕他莫和地佐辛用于断指再植术后超前镇痛防治血管危象的临床效果。方法 85例行断指再植术患者根据术后超前镇痛方法的不同分为丙帕他莫组(45例)和地佐辛组(40例),分别给予丙帕他莫、地佐辛静脉自控镇痛(PCIA),比较两组镇痛及镇静效果,血管栓塞、血管危象发生情况及断指再植存活率。结果两组术后3 h视觉模拟疼痛评分(VAS)比较差异无统计学意义(P<0.05),两组术后6、24 h VAS评分有明显升高的趋势,术后48 h VAS评分明显回落(P<0.05),而丙帕他莫组术后6、24、48 h VAS评分均显著低于地佐辛组(P<0.05)。两组术后3 h Ramsay镇静评分分布比较差异有统计学意义(P<0.05),且丙帕他莫组术后48 h内PCI有效次数/实际次数值均显著高于地佐辛组(P<0.05)。丙帕他莫组术后血管栓塞及动脉、静脉血管危象发生率分别为4.44%、6.67%、6.67%,明显低于地佐辛组的20.00%、22.50%、27.50%(P<0.05)。丙帕他莫组断指再植存活率、术后6个月断指再植功能优良率(97.78%、91.11%)明显高于地佐辛组(91.11%、75.00%,P<0.05)。结论与地佐辛相比,丙帕他莫辅助断指再植术术后镇痛,可发挥理想的镇痛镇静效果,提高再植指存活率,并对防治血管危象有显著作用。展开更多
文摘A new morphinane alkaloid named as mecoquitupline was isolated from Meconopsis quintuplinervia Regel. Its structure was elucidated to be 6-methoxy-17-methyl-2,3-[methylene bis(oxy)]-morphinan-5-en-7-one by spectroscopic techniques.
基金the financial support of the NNSFC(No.30271488,20021001,and 203900501).
文摘A convergent strategy to the key allylic silyl ether precursor 4 in our synthetic efforts toward morphinan alkaloid is presented. The vital step is the selective 1,2-addition of the organocerium agent of 6 to ketene 5.
基金funding from the Thousand Youth Talents Program and Institute of Botany,CAS,China
文摘Plants, as primary producers, have been playing an indispensable role in other organisms’ survival and the balance of whole ecosystem on Earth. Especially, they provide the main source of energy, food, and medicine for human beings, some of which are derived from the primary or secondary metabolites
文摘目的探讨丙帕他莫和地佐辛用于断指再植术后超前镇痛防治血管危象的临床效果。方法 85例行断指再植术患者根据术后超前镇痛方法的不同分为丙帕他莫组(45例)和地佐辛组(40例),分别给予丙帕他莫、地佐辛静脉自控镇痛(PCIA),比较两组镇痛及镇静效果,血管栓塞、血管危象发生情况及断指再植存活率。结果两组术后3 h视觉模拟疼痛评分(VAS)比较差异无统计学意义(P<0.05),两组术后6、24 h VAS评分有明显升高的趋势,术后48 h VAS评分明显回落(P<0.05),而丙帕他莫组术后6、24、48 h VAS评分均显著低于地佐辛组(P<0.05)。两组术后3 h Ramsay镇静评分分布比较差异有统计学意义(P<0.05),且丙帕他莫组术后48 h内PCI有效次数/实际次数值均显著高于地佐辛组(P<0.05)。丙帕他莫组术后血管栓塞及动脉、静脉血管危象发生率分别为4.44%、6.67%、6.67%,明显低于地佐辛组的20.00%、22.50%、27.50%(P<0.05)。丙帕他莫组断指再植存活率、术后6个月断指再植功能优良率(97.78%、91.11%)明显高于地佐辛组(91.11%、75.00%,P<0.05)。结论与地佐辛相比,丙帕他莫辅助断指再植术术后镇痛,可发挥理想的镇痛镇静效果,提高再植指存活率,并对防治血管危象有显著作用。
