Moringa oleifera(M.oleifera)Lam.(family Moringaceae)possesses anti-inflammatory,anticancer,anti-diabetic,neuroprotective,and cardioprotective properties.The present review aimed to explore the protective effects of M....Moringa oleifera(M.oleifera)Lam.(family Moringaceae)possesses anti-inflammatory,anticancer,anti-diabetic,neuroprotective,and cardioprotective properties.The present review aimed to explore the protective effects of M.oleifera Lam.against metabolic disorders and to serve as a guide for future research on this medicinal plant.Research data on the anti-diabetic and anti-obesity properties of M.oleifera Lam.were collected from Science Direct,PubMed,Springer,Google Scholar,Web of Science,etc.M.oleifera has a protective effect against metabolic disorders through the modulation of various signaling pathways involved in glucose and lipid metabolism.Specifically,M.oleifera enhances insulin sensitivity by activating insulin receptor phosphorylation and the PI3K/Akt pathway,which promotes glucose uptake by facilitating GLUT-4 translocation to the cell membrane.In addition,it improves energy homeostasis and lipid metabolism by modulating the AMPK pathway.Inhibition of inflammatory biomarkers(nuclear factor kappa B,tumor necrosis factor-α,interleukin-1β,monocyte chemoattractant protein-1)and lipid peroxidation markers(malondialdehyde,F2-isoprostanes),along with enhanced activity of antioxidant enzymes(glutathione peroxidase,glutathione reductase,superoxide dismutase,and catalase),contributes to its anti-diabetic and anti-obesity effects.This review suggests that M.oleifera Lam.modulates key signaling pathways involved in glucose and lipid metabolism and holds promise as a potential therapeutic agent for managing metabolic diseases.展开更多
文摘Moringa oleifera(M.oleifera)Lam.(family Moringaceae)possesses anti-inflammatory,anticancer,anti-diabetic,neuroprotective,and cardioprotective properties.The present review aimed to explore the protective effects of M.oleifera Lam.against metabolic disorders and to serve as a guide for future research on this medicinal plant.Research data on the anti-diabetic and anti-obesity properties of M.oleifera Lam.were collected from Science Direct,PubMed,Springer,Google Scholar,Web of Science,etc.M.oleifera has a protective effect against metabolic disorders through the modulation of various signaling pathways involved in glucose and lipid metabolism.Specifically,M.oleifera enhances insulin sensitivity by activating insulin receptor phosphorylation and the PI3K/Akt pathway,which promotes glucose uptake by facilitating GLUT-4 translocation to the cell membrane.In addition,it improves energy homeostasis and lipid metabolism by modulating the AMPK pathway.Inhibition of inflammatory biomarkers(nuclear factor kappa B,tumor necrosis factor-α,interleukin-1β,monocyte chemoattractant protein-1)and lipid peroxidation markers(malondialdehyde,F2-isoprostanes),along with enhanced activity of antioxidant enzymes(glutathione peroxidase,glutathione reductase,superoxide dismutase,and catalase),contributes to its anti-diabetic and anti-obesity effects.This review suggests that M.oleifera Lam.modulates key signaling pathways involved in glucose and lipid metabolism and holds promise as a potential therapeutic agent for managing metabolic diseases.
