Interpersonal meaning is derived from interpersonal function of language which is one component in the notion of metafunction in Hallidays" s systemic functional grammar.The present study take Katherine Mansfield...Interpersonal meaning is derived from interpersonal function of language which is one component in the notion of metafunction in Hallidays" s systemic functional grammar.The present study take Katherine Mansfield" s A Cup of Tea as an ex ample.Mood system is employed to analyze the subtle relationship between women and men and between women themselves.展开更多
Mood disorders include a set of psychiatric manifestations of increasing prevalence in our society,being mainly represented by major depressive disorder(MDD)and bipolar disorder(BD).The etiopathogenesis of mood disord...Mood disorders include a set of psychiatric manifestations of increasing prevalence in our society,being mainly represented by major depressive disorder(MDD)and bipolar disorder(BD).The etiopathogenesis of mood disorders is extremely complex,with a wide spectrum of biological,psychological,and sociocultural factors being responsible for their appearance and development.In this sense,immune system dysfunction represents a key mechanism in the onset and pathophysiology of mood disorders,worsening mainly the central nervous system(neuroinflammation)and the periphery of the body(systemic inflammation).However,these alterations cannot be understood separately,but as part of a complex picture in which different factors and systems interact with each other.Psychoneuroimmunoendocrinology(PNIE)is the area responsible for studying the relationship between these elements and the impact of mind–body integration,placing the immune system as part of a whole.Thus,the dysfunction of the immune system is capable of influencing and activating different mechanisms that promote disruption of the psyche,damage to the nervous system,alterations to the endocrine and metabolic systems,and disruption of the microbiota and intestinal ecosystem,as well as of other organs and,in turn,all these mechanisms are responsible for inducing and enhancing the immune dysfunction.Similarly,the clinical approach to these patients is usually multidisciplinary,and the therapeutic arsenal includes different pharmacological(for example,antidepressants,antipsychotics,and lithium)and non-pharmacological(i.e.,psychotherapy,lifestyle,and electroconvulsive therapy)treatments.These interventions also modulate the immune system and other elements of the PNIE in these patients,which may be interesting to understand the therapeutic success or failure of these approaches.In this sense,this review aims to delve into the relationship between immune dysfunction and mood disorders and their integration in the complex context of PNIE.Likewise,an attempt will be made to explore the effects on the immune system of different strategies available in the clinical approach to these patients,in order to identify the mechanisms described and their possible uses as biomarkers.展开更多
The recently published article by Gao et al identifies risk factors for anxiety and depression in patients with diabetic retinopathy.We supplement that there is pathophysiological evidence to show a complex and possib...The recently published article by Gao et al identifies risk factors for anxiety and depression in patients with diabetic retinopathy.We supplement that there is pathophysiological evidence to show a complex and possibly bidirectional re-lation between diabetes,diabetic retinopathy,and mood disorders,especially depression.Longitudinal studies may strengthen proof of a causal relationship between these diseases.A better understanding can help in the holistic manage-ment of these patients.展开更多
A comprehensive analysis was performed on 30 healthy female participants to assess the impact of fragranced body washes on mood improvement.The study examined their objective electroencephalographic (EEG) changes and ...A comprehensive analysis was performed on 30 healthy female participants to assess the impact of fragranced body washes on mood improvement.The study examined their objective electroencephalographic (EEG) changes and subjective feedback before and after using the fragranced products.The results showed that both the alpha and theta band activities of the participants increased significantly after using body washes,especially in the occipito-parietal and frontal area of brain,indicating that their brains were at a higher level of stability and relaxation.Meanwhile,in terms of subjective evaluation,the participants’ subjective feelings such as calmness,relaxation,tranquility,and calmness were significantly enhanced.This study has revealed the efficacy of fragranced products in improving mood and is expected to provide support for the development and application of fragranced products.展开更多
BACKGROUND Herbal supplements are increasingly used to manage menopausal symptoms.Physta®is a commercial herbal ingredient containing Eurycoma longifolia standardized water extract,traditionally used for vitality...BACKGROUND Herbal supplements are increasingly used to manage menopausal symptoms.Physta®is a commercial herbal ingredient containing Eurycoma longifolia standardized water extract,traditionally used for vitality.Its adaptogenic and anti-inflammatory properties promote hormonal balance,physical function,and sexual health,supporting its potential benefits for menopausal health.AIM To investigate Physta®’s role in improving menopausal quality of life,mood states,and overall safety profile compared with placebo.METHODS In this 12-week,randomized,double-blind,placebo-controlled trial,138 females aged 40-55 with menopausal symptoms were randomly assigned to receive Physta®50 mg,Physta®100 mg,or placebo.MENQOL and POMS were assessed at baseline,week 6,and week 12.Safety outcomes were evaluated through biochemical tests,vital signs,and female reproductive hormonal profile.RESULTS Physta®100 mg significantly reduced total MENQOL scores by 33.9%from baseline to week 12(P=0.049)with notable improvements in the physical(-36.4%,P=0.046)and sexual(-36.3%,P=0.043)domains.Total mood disturbance also declined more in the Physta®100 mg group(-38.6%)compared with placebo(-30.1%),although not statistically significant.No significant changes were observed in the vital signs and biochemical parameters,indicating the safety and tolerability of Physta®.No significant alterations were found in the female reproductive hormone profile,supporting its hormonal neutrality.CONCLUSION Physta®100 mg improved menopausal quality of life and mood without adverse effects,supporting its potential as a safe herbal therapy.Further studies with higher doses and longer durations are needed.展开更多
BACKGROUND Depression is one of the most common mental disorders,with high rates of disability,particularly among women.AIM To explore the effects of suggestion therapy on anxiety,mood,and sleep-quality in middle-aged...BACKGROUND Depression is one of the most common mental disorders,with high rates of disability,particularly among women.AIM To explore the effects of suggestion therapy on anxiety,mood,and sleep-quality in middle-aged women with depression treated with escitalopram.METHODS Overall,102 female patients with depression aged 35-49 years were divided into control and experimental groups.The control group received oral escitalopram therapy,starting at a dose of 5 mg/day,which was gradually increased to 10-20 mg/day after 1 week for a total of 8 weeks.The experimental group received the suggested therapy based on the control group.The Self-Rating Depression Scale(SDS),Self-Rating Anxiety Scale(SAS),Profile of Mood States-Short Form,and Pittsburgh Sleep Quality Index(PSQI)were used to assess depression,anxiety,mood status,and sleep quality.RESULTS Before treatment,there were no significant differences in the SDS,SAS,Profile of Mood States,and PSQI scores between the two groups(P>0.05).After treatment,compared to the control group and baseline,the SDS,SAS,tension-anxiety,depression-dejection,and confusion-bewilderment scores in the experimental group significantly decreased(P<0.05),whereas sleep efficiency,sleep disturbance,hypnotics,and PSQI scores significantly increased(P<0.05).CONCLUSION Suggestion therapy combined with escitalopram treatment can reduce the severity of depression and anxiety,change mood status,and improve sleep quality in middle-aged women with depression.展开更多
BACKGROUND Abdominal postoperative patients are susceptible to postoperative depression resulting from pain and stress,which can hinder their rehabilitation.Acupuncture has shown potential to relieve this condition.AI...BACKGROUND Abdominal postoperative patients are susceptible to postoperative depression resulting from pain and stress,which can hinder their rehabilitation.Acupuncture has shown potential to relieve this condition.AIM To analyze the mechanism by which acupuncture relieves postoperative depression in patients post-abdominal surgery.METHODS Abdominal postoperative patients with depression between January 2015 and December 2023 at the First Affiliated Hospital of Heilongjiang University of Chinese Medicine were enrolled.Patients were divided into two groups using the random throwing method:Observation(250 cases,fluoxetine hydrochloride+acupuncture treatment)and control(250 cases,fluoxetine hydrochloride treatment).Changes in negative emotions Hamilton Depression Scale 24,serum inflammatory factors[tumor necrosis factorα,interleukin(IL)-1β,IL-6],miR-155 expression levels,and BDNF levels were assessed.RESULTS Significant improvements were observed in the observation group compared to the control group in all assessed parameters after six weeks(P<0.05).This suggests that the combination of fluoxetine hydrochloride and acupuncture may be more effective in managing postoperative depression than medication alone.CONCLUSION Acupuncture complies with the principle of traditional Chinese medicine syndrome differentiation and ensures the pertinence and effectiveness of treatment.In addition,it not only actively improves depressive symptoms but also effectively regulates the serum level of inflammatory factors.展开更多
BACKGROUND The participation of caregivers,who play a crucial role in the recovery of patients with gastrointestinal tumors,in family nutrition support decisions can help tailor nutrition plans to meet the specific ne...BACKGROUND The participation of caregivers,who play a crucial role in the recovery of patients with gastrointestinal tumors,in family nutrition support decisions can help tailor nutrition plans to meet the specific needs and lifestyle habits of the patient,thereby enhancing the effectiveness of nutritional intake.AIM To assess the impact of caregiver-shared decision-making in family nutritional support with mindfulness-based behavioral therapy on the risk of malnutrition and mood states in patients with gastrointestinal tumors.METHODS Patients with gastrointestinal tumors(n=118)treated at the Jiangnan University Affiliated Hospital between December 2021 and March 2024 were assigned to the observation(n=59)and control(n=59)groups using the random number table method.In addition to the standard treatment and basic nursing measures im-plemented in the control group,the integrated approach was implemented in the observation group.The nutritional and mood state indicators,compliance,and satisfaction before and 6 months after implementing the intervention were com-pared between the groups.RESULTS The body mass index,serum albumin levels,and transferrin levels,as well as the scores for all seven dimensions of the Profile of Mood States questionnaire,in the observation were higher than those in the control group after the 6-month follow-up period(P<0.05).However,the Nutrition Risk Screening 2002 and Mindful Attention Awareness Scale scores were lower than those in the control group(P<0.05).The compliance and satisfaction rates were 94.92%and 98.31%,respectively,which were higher than those of the control group(79.66%and 88.14%,respectively;P<0.05).CONCLUSION The implementation of the integrated approach significantly reduced the risk of malnutrition and improved mood states in patients with gastrointestinal tumors.Moreover,the compliance and satisfaction rates were higher.展开更多
BACKGROUND The central link between septic shock and acute skin failure(ASF)is the inflammatory response,which occurs throughout disease progression and can lead to systemic inflammatory response syndrome.Patients oft...BACKGROUND The central link between septic shock and acute skin failure(ASF)is the inflammatory response,which occurs throughout disease progression and can lead to systemic inflammatory response syndrome.Patients often experience bad moods,sleep disorders,and other health issues.Despite recognizing these factors,no studies have examined the correlation between inflammatory factors,lactic acid levels,ASF,mood disturbances,and sleep quality in critically ill patients.We hypothesize that higher levels of inflammatory factors and lactic acid are associated with more severe ASF and poorer mood and sleep quality,which may inform clinical treatment for septic shock and ASF.AIM To explore the relationship between inflammatory factors,lactic acid levels,the severity of ASF,bad mood,and sleep quality.METHODS The retrospective study included 150 patients with septic shock from the Second Hospital of Dalian Medical University,categorized into ASF(n=35)or non-ASF groups(n=115).We compared the peripheral blood inflammatory factors,including tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),lactic acid levels,skin mottling score(SMS),modified early warning score(MEWS),self-rating depression scale(SDS),self-rating anxiety scale(SAS),and Pittsburgh sleep quality index(PSQI)scores.Pearson correlation analysis assessed relationships among these variables.RESULTS The ASF group had significantly higher levels of CRP(19.60±4.10 vs 15.30±2.96 mg/mL),IL-6(298.65±48.65 vs 268.66±33.66 pg/L),procalcitonin,lactic acid(8.42±2.32 vs 5.70±1.27 mmol/L),SMS[0(0,1)vs 3(2,3)],MEWS(9.34±1.92 vs 6.48±1.96),SAS(61.63±12.03 vs 53.71±12.48),SDS(60.17±12.64 vs 52.27±12.64),and PSQI scores(14.23±3.94 vs 8.69±2.46)compared with the non-ASF group(all P<0.001).Pearson correlation analysis revealed that IL-6,CRP,TNF-α,and lactic acid were positively correlated with SMS,MEWS,SAS,SDS,and PSQI scores(P<0.05).CONCLUSION Peripheral blood levels of IL-6,CRP,TNF-α,and lactic acid correlate positively with SMS,MEWS,SAS,SDS,and PSQI in critically ill patients with ASF.展开更多
Events in the first few days of September have confirmed what was already in motion.A new rhythm in world affairs is emerging.In Tianjin,a metropolis in north China,Chinese President Xi Jinping launched the Global Gov...Events in the first few days of September have confirmed what was already in motion.A new rhythm in world affairs is emerging.In Tianjin,a metropolis in north China,Chinese President Xi Jinping launched the Global Governance Initiative(GGI)at the Shanghai Cooperation Organisation(SCO)Summit.In Beijing,China’s capital,President Xi reviewed troops during a military parade to mark the 80th Anniversary of the Victory in the Chinese People’s War of Resistance Against Japanese Aggression and the World Anti-Fascist War.展开更多
The aim of this study was to investigate changes in autonomic nervous system (ANS) activity and mood caused by Mindfulness Art Therapy Short version (MATS). The participants were 20 Japanese college students who were ...The aim of this study was to investigate changes in autonomic nervous system (ANS) activity and mood caused by Mindfulness Art Therapy Short version (MATS). The participants were 20 Japanese college students who were separated into high and low risk groups based on the median score of the General Health Questionnaire (GHQ). MATS consisted of mindfulness exercise and making of art in one session. ANS activity (TP: total energy, LF/HF: sympathetic nervous, HF: parasympathetic nervous system, LF: both sympathetic and parasympathetic) and mood (TA: tension arousal, EA: energy arousal) were measured psychologically before and after MATS. In the high risk group, TP significantly decreased and LF, HF, and LF/HF did not change significantly;while TA significantly decreased and EA significantly increased. In the low risk group, TP and LF significantly increased and HF and LF/HF did not change significantly;while TA significantly decreased and EA showed a non-significant increase. These results suggest that MATS affects the ANS differently for participants with different states of mental health, and particularly promotes activity in low-risk participants. Psychologically, MATS decreased tension or anxiety and increased energy. These findings justify further use of this therapy.展开更多
Menopausal syndrome is a common disease of clinical women,which refers to a series of physical and mental symptoms caused by the fluctuation or reduction of sex hormones before and after menopause.Many of these patien...Menopausal syndrome is a common disease of clinical women,which refers to a series of physical and mental symptoms caused by the fluctuation or reduction of sex hormones before and after menopause.Many of these patients have sleep and mood abnormalities that affect their health and quality of life.At present,the understanding of it is gradually improving.This paper mainly analyzes its back-ground and current treatment.展开更多
BACKGROUND Hormone replacement therapy is an effective treatment strategy for the management of symptoms in naturally menopausal women.However,some patients report experiencing adverse effects.AIM To analyze the effec...BACKGROUND Hormone replacement therapy is an effective treatment strategy for the management of symptoms in naturally menopausal women.However,some patients report experiencing adverse effects.AIM To analyze the effects of hormone replacement therapy in menopausal female patients.METHODS A total of 152 menopausal female patients admitted to the Gynecology Department of the Ganzhou Maternal and Child Health Hospital between January 2021 and December 2023 were divided into the observation group(n=76,conventional treatment+hormone replacement therapy)and the control group(n=76,conventional treatment only)via random casting.The improvement observed in the following items were compared between the groups:Kupperman menopausal index(KMI),emotional state[The Positive and Negative Affect Scale(PANAS)],sleep quality[Self-Rating Scale of Sleep(SRSS)],treatment effectiveness,and treatment safety.RESULTS The modified KMI and SRSS scores of the observation group were lower than those of the control group after three rounds of treatment.The improvement in the PANAS score observed in the observation group was greater than that observed in the control group(P<0.05).The total treatment effectivity rate in the observation group was higher than that in the control group(86.84%vs 96.05%,χ2=4.121,P=0.042).The incidence rate of adverse reactions in the two groups was comparable(6.58%vs 9.21%,χ2=0.361,P=0.547).CONCLUSION Hormone replacement therapy effectively improved the clinical symptoms,actively channeled negative emotions,and improved the quality of sleep in menopausal patients,indicating its effectiveness and safety.展开更多
Marked alterations in the normal female hormonal milieu in the perimenopausal period significantly affect women’s health,leading to decreased well-being,psychological distress,and impaired quality of life.Common meno...Marked alterations in the normal female hormonal milieu in the perimenopausal period significantly affect women’s health,leading to decreased well-being,psychological distress,and impaired quality of life.Common menopausal symp-toms include hot flashes,sleep and mood changes,fatigue,weight gain,and urogenital disturbances.Clinicians often neglect mood swings and disrupted sleep,although those can significantly limit the productivity of women and impair their cognitive function and mental health.Evidence-based management should include a personalized,holistic approach to alleviate symptoms and careful consideration of the risks vs benefits of hormone replacement therapy(HRT),with due consideration of personal preferences.A research paper in the recent issue of the World Journal of Psychiatry by Liu et al investigated the role of HRT in altering mood changes and impaired sleep quality in menopausal women,which helps us to understand the benefits of this treatment approach.展开更多
Available evidence points to a possible role of the renin-angiotensin system(RAS)in the pathophysiology of mood disorders and suicide.We carried out a critical analysis of literature data regarding this role,with a fo...Available evidence points to a possible role of the renin-angiotensin system(RAS)in the pathophysiology of mood disorders and suicide.We carried out a critical analysis of literature data regarding this role,with a focus on the proposed association between RAS dysfunction and suicidal behavior.Epidemiological,genetic,and biochemical findings are described,and the pathophysiological hypothesis aiming at explaining the possible relationship between RAS and suicide are discussed.Available findings do support the involvement of the RAS in the neurobiology of suicide,although the exact mechanisms underlying this involvement are still unknown.展开更多
BACKGROUND Nowadays there is an increasing use of transcranial magnetic stimulation(TMS)both in neurological and psychiatric fields.After Food and Drug Administration approval of TMS for the therapy of treatment-resis...BACKGROUND Nowadays there is an increasing use of transcranial magnetic stimulation(TMS)both in neurological and psychiatric fields.After Food and Drug Administration approval of TMS for the therapy of treatment-resistant depression,TMS has been widely used in the context of mood disorders(MD).However,growing reports regarding the possibility of developing hypomanic/manic switch(HMS)have generated concern regarding its use in MDs.AIM To investigate the actual risk of developing HMS due to TMS in the treatment of MD.METHODS We led our research on PubMed,Scopus and Web of Science on March 22,2020,in accordance to the PRISMA guidelines for systematic review.Only double blind/single blind studies,written in English and focused on the TMS treatment of MD,were included.A meta-analysis of repetitive TMS protocol studies including HMS was conducted using RevMan 5.4 software.The assessment of Risk of Bias was done using Cochrane risk of bias tool.This protocol was registered on PROSPERO with the CRD42020175811 code.RESULTS Twenty-five studies were included in our meta-analysis:Twenty-one double blind randomized controlled trials(RCT)and four single blind-RCT(no.of subjects involved in active stimulation=576;no.of subjects involved in sham protocol=487).The most frequently treated pathology was major depressive episode/major depressive disorder,followed by resistant depression,bipolar depression and other MD.The majority of the studies used a repetitive TMS protocol,and the left dorsolateral prefrontal cortex was the main target area.Side effects were reported in eight studies and HMS(described as greater energy,insomnia,irritability,anxiety,suicidal attempt)in four studies.When comparing active TMS vs sham treatment,the risk of developing HMS was not significantly different between conditions.CONCLUSION Applying the most usual protocols and the appropriate precautionary measures,TMS seems not to be related to HMS development.展开更多
The aim of this study was to investigate changes in the Autonomic Nervous System (ANS) and moods before and after participation in a Mindfulness Art Therapy Short version (MATS). The study design was non-randomized co...The aim of this study was to investigate changes in the Autonomic Nervous System (ANS) and moods before and after participation in a Mindfulness Art Therapy Short version (MATS). The study design was non-randomized controlled trial in intervention study. Participants were 10 Japanese patients with advanced cancer. They received the MATS in one session, which consisted of mindfulness practices and making arts. Their Autonomic Nervous System (sympathetic nervous, parasympathetic nervous) physiologically and mood (Tense Arousal: TA, Energetic Arousal: EA) psychologically were measured before and after the MATS. The results showed that the level of parasympathetic nervous system decreased and that the sympathetic nervous system increased in small effect size. The TA decreased in a large effect size and EA increased in a middle effect size. These results suggested that the MATS might activate physiologically, alleviate tension and increase energy psychologically.展开更多
OBJECTIVE:To systematically evaluate the efficacy and safety of acupuncture(AM)in the treatment of pregnancyrelated symptoms such as acute vomiting during pregnancy.METHODS:We comprehensively searched the available li...OBJECTIVE:To systematically evaluate the efficacy and safety of acupuncture(AM)in the treatment of pregnancyrelated symptoms such as acute vomiting during pregnancy.METHODS:We comprehensively searched the available literature up to November 2021,including Pub Med,Embase,Cochrane Library,Chinese Biomedical Literature Database,and China National Knowledge Infrastructure Database,for randomized controlled trials(RCTs)on AM for the treatment of severe vomiting,insomnia,pharyngeal and pelvic pain,mood abnormalities,and dyspepsia during pregnancy.RESULTS:Sixteen RCTs with a cumulative sample size of 1178 cases were included.Of these,964 patients were included in the Meta-analysis.The Meta-analysis results showed that AM was more efficient than Western medicine in treating discomfort during pregnancy[odds ratio(OR)=1.19,95%confidence interval(CI)(1.11,1.28),P<0.01].AM was better than the control group in improving the visual analog scale scores[standard mean difference(SMD)=0.62,95%CI(0.53,0.71),P<0.01].AM was superior to the control group in improving Numerical Rating Scale(NRS)symptom scores[OR=7.31,95%CI(3.36,15.94),P<0.01].There was no significant difference in adverse effects between the AM and sham-AM groups and the analgesic drug group[OR=0.70,95%CI(0.39,1.28),P=0.25],but the treatment and control groups had mild adverse effects with a low incidence.CONCLUSIONS:AM is more effective than other treatments or pharmacotherapy alone in the treatment of pregnancy-related symptoms,and is relatively safe.However,the quality of the included trials was rather poor,and high-quality studies are required to confirm our findings.展开更多
Noise is one of the environmental factors with mental and physical effects.The workload is also the multiple mental and physical demands of the task.Therefore,his study investigated the relationship between noise expo...Noise is one of the environmental factors with mental and physical effects.The workload is also the multiple mental and physical demands of the task.Therefore,his study investigated the relationship between noise exposure and mood states at different levels of workload.The study recruited 50 workers from the manufacturing sector(blue-collar workers)as the exposed group and 50 workers from the office sector(white-collar workers)as the control group.Their occupational noise exposure was measured by dosimetry.The Stress-Arousal Checklist(SACL)and the NASA Task Load Index(NASA-TLX)were used to measure mood and workload,respectively.The equivalent noise exposure level of the exposed group at high and very high workload levels was 85 and 87 dBA,respectively.The mean mood score of the exposed group was 76 at very high workload.The correlation coefficient between noise exposure level and mood state based on workload levels ranged from 0.3 at medium workload to 0.57 at very high workload.Noise exposure at high workload levels can increase its adverse effects,so controlling and optimizing the multiple demands of the task in the workplace can be used as a privative measure to reduce the adverse effects of noise.展开更多
Few studies have examined the impacts of color stimuli on perioperative mood and quality of recovery;thus, this randomized controlled trial aimed to assess impacts of vividly colored accessories on mood and quality of...Few studies have examined the impacts of color stimuli on perioperative mood and quality of recovery;thus, this randomized controlled trial aimed to assess impacts of vividly colored accessories on mood and quality of recovery after breast surgery. This single-center, single-blind randomized controlled trial included 36 participants (all aged ≥ 20 years) who were randomized into intervention (n = 19) and control groups (n = 17). The intervention group received vividly colored accessories. The primary and secondary study outcomes were patient mood, evaluated using a two-dimensional mood scale, and postoperative recovery, evaluated using Quality of Recovery-15, which were assessed on postoperative day 3. There were no statistical intergroup differences in the scores of the Two-Dimensional Mood Scale (11.2 [intervention group] vs. 10.4 [control group], P = 0.75) and Quality of Recovery-15 (126.8 [intervention group] vs. 129.3 [control group], P = 0.73). Thus, the use of vividly colored accessories by patients undergoing breast surgery was not found to affect patients’ mood and quality of recovery.展开更多
文摘Interpersonal meaning is derived from interpersonal function of language which is one component in the notion of metafunction in Hallidays" s systemic functional grammar.The present study take Katherine Mansfield" s A Cup of Tea as an ex ample.Mood system is employed to analyze the subtle relationship between women and men and between women themselves.
基金supported by the Instituto de Salud Carlos III(EstataldeI+D+I2020-2027)co-financed by the European Development Regional Fund“A way to achieve Europe”P2022/BMD-7321(Comunidad de Madrid)and ProACapital,Halekulani S.L.and MJR.
文摘Mood disorders include a set of psychiatric manifestations of increasing prevalence in our society,being mainly represented by major depressive disorder(MDD)and bipolar disorder(BD).The etiopathogenesis of mood disorders is extremely complex,with a wide spectrum of biological,psychological,and sociocultural factors being responsible for their appearance and development.In this sense,immune system dysfunction represents a key mechanism in the onset and pathophysiology of mood disorders,worsening mainly the central nervous system(neuroinflammation)and the periphery of the body(systemic inflammation).However,these alterations cannot be understood separately,but as part of a complex picture in which different factors and systems interact with each other.Psychoneuroimmunoendocrinology(PNIE)is the area responsible for studying the relationship between these elements and the impact of mind–body integration,placing the immune system as part of a whole.Thus,the dysfunction of the immune system is capable of influencing and activating different mechanisms that promote disruption of the psyche,damage to the nervous system,alterations to the endocrine and metabolic systems,and disruption of the microbiota and intestinal ecosystem,as well as of other organs and,in turn,all these mechanisms are responsible for inducing and enhancing the immune dysfunction.Similarly,the clinical approach to these patients is usually multidisciplinary,and the therapeutic arsenal includes different pharmacological(for example,antidepressants,antipsychotics,and lithium)and non-pharmacological(i.e.,psychotherapy,lifestyle,and electroconvulsive therapy)treatments.These interventions also modulate the immune system and other elements of the PNIE in these patients,which may be interesting to understand the therapeutic success or failure of these approaches.In this sense,this review aims to delve into the relationship between immune dysfunction and mood disorders and their integration in the complex context of PNIE.Likewise,an attempt will be made to explore the effects on the immune system of different strategies available in the clinical approach to these patients,in order to identify the mechanisms described and their possible uses as biomarkers.
文摘The recently published article by Gao et al identifies risk factors for anxiety and depression in patients with diabetic retinopathy.We supplement that there is pathophysiological evidence to show a complex and possibly bidirectional re-lation between diabetes,diabetic retinopathy,and mood disorders,especially depression.Longitudinal studies may strengthen proof of a causal relationship between these diseases.A better understanding can help in the holistic manage-ment of these patients.
文摘A comprehensive analysis was performed on 30 healthy female participants to assess the impact of fragranced body washes on mood improvement.The study examined their objective electroencephalographic (EEG) changes and subjective feedback before and after using the fragranced products.The results showed that both the alpha and theta band activities of the participants increased significantly after using body washes,especially in the occipito-parietal and frontal area of brain,indicating that their brains were at a higher level of stability and relaxation.Meanwhile,in terms of subjective evaluation,the participants’ subjective feelings such as calmness,relaxation,tranquility,and calmness were significantly enhanced.This study has revealed the efficacy of fragranced products in improving mood and is expected to provide support for the development and application of fragranced products.
基金Supported by Biotropics Malaysia Berhad,Malaysia,NN-2021-016.
文摘BACKGROUND Herbal supplements are increasingly used to manage menopausal symptoms.Physta®is a commercial herbal ingredient containing Eurycoma longifolia standardized water extract,traditionally used for vitality.Its adaptogenic and anti-inflammatory properties promote hormonal balance,physical function,and sexual health,supporting its potential benefits for menopausal health.AIM To investigate Physta®’s role in improving menopausal quality of life,mood states,and overall safety profile compared with placebo.METHODS In this 12-week,randomized,double-blind,placebo-controlled trial,138 females aged 40-55 with menopausal symptoms were randomly assigned to receive Physta®50 mg,Physta®100 mg,or placebo.MENQOL and POMS were assessed at baseline,week 6,and week 12.Safety outcomes were evaluated through biochemical tests,vital signs,and female reproductive hormonal profile.RESULTS Physta®100 mg significantly reduced total MENQOL scores by 33.9%from baseline to week 12(P=0.049)with notable improvements in the physical(-36.4%,P=0.046)and sexual(-36.3%,P=0.043)domains.Total mood disturbance also declined more in the Physta®100 mg group(-38.6%)compared with placebo(-30.1%),although not statistically significant.No significant changes were observed in the vital signs and biochemical parameters,indicating the safety and tolerability of Physta®.No significant alterations were found in the female reproductive hormone profile,supporting its hormonal neutrality.CONCLUSION Physta®100 mg improved menopausal quality of life and mood without adverse effects,supporting its potential as a safe herbal therapy.Further studies with higher doses and longer durations are needed.
文摘BACKGROUND Depression is one of the most common mental disorders,with high rates of disability,particularly among women.AIM To explore the effects of suggestion therapy on anxiety,mood,and sleep-quality in middle-aged women with depression treated with escitalopram.METHODS Overall,102 female patients with depression aged 35-49 years were divided into control and experimental groups.The control group received oral escitalopram therapy,starting at a dose of 5 mg/day,which was gradually increased to 10-20 mg/day after 1 week for a total of 8 weeks.The experimental group received the suggested therapy based on the control group.The Self-Rating Depression Scale(SDS),Self-Rating Anxiety Scale(SAS),Profile of Mood States-Short Form,and Pittsburgh Sleep Quality Index(PSQI)were used to assess depression,anxiety,mood status,and sleep quality.RESULTS Before treatment,there were no significant differences in the SDS,SAS,Profile of Mood States,and PSQI scores between the two groups(P>0.05).After treatment,compared to the control group and baseline,the SDS,SAS,tension-anxiety,depression-dejection,and confusion-bewilderment scores in the experimental group significantly decreased(P<0.05),whereas sleep efficiency,sleep disturbance,hypnotics,and PSQI scores significantly increased(P<0.05).CONCLUSION Suggestion therapy combined with escitalopram treatment can reduce the severity of depression and anxiety,change mood status,and improve sleep quality in middle-aged women with depression.
文摘BACKGROUND Abdominal postoperative patients are susceptible to postoperative depression resulting from pain and stress,which can hinder their rehabilitation.Acupuncture has shown potential to relieve this condition.AIM To analyze the mechanism by which acupuncture relieves postoperative depression in patients post-abdominal surgery.METHODS Abdominal postoperative patients with depression between January 2015 and December 2023 at the First Affiliated Hospital of Heilongjiang University of Chinese Medicine were enrolled.Patients were divided into two groups using the random throwing method:Observation(250 cases,fluoxetine hydrochloride+acupuncture treatment)and control(250 cases,fluoxetine hydrochloride treatment).Changes in negative emotions Hamilton Depression Scale 24,serum inflammatory factors[tumor necrosis factorα,interleukin(IL)-1β,IL-6],miR-155 expression levels,and BDNF levels were assessed.RESULTS Significant improvements were observed in the observation group compared to the control group in all assessed parameters after six weeks(P<0.05).This suggests that the combination of fluoxetine hydrochloride and acupuncture may be more effective in managing postoperative depression than medication alone.CONCLUSION Acupuncture complies with the principle of traditional Chinese medicine syndrome differentiation and ensures the pertinence and effectiveness of treatment.In addition,it not only actively improves depressive symptoms but also effectively regulates the serum level of inflammatory factors.
文摘BACKGROUND The participation of caregivers,who play a crucial role in the recovery of patients with gastrointestinal tumors,in family nutrition support decisions can help tailor nutrition plans to meet the specific needs and lifestyle habits of the patient,thereby enhancing the effectiveness of nutritional intake.AIM To assess the impact of caregiver-shared decision-making in family nutritional support with mindfulness-based behavioral therapy on the risk of malnutrition and mood states in patients with gastrointestinal tumors.METHODS Patients with gastrointestinal tumors(n=118)treated at the Jiangnan University Affiliated Hospital between December 2021 and March 2024 were assigned to the observation(n=59)and control(n=59)groups using the random number table method.In addition to the standard treatment and basic nursing measures im-plemented in the control group,the integrated approach was implemented in the observation group.The nutritional and mood state indicators,compliance,and satisfaction before and 6 months after implementing the intervention were com-pared between the groups.RESULTS The body mass index,serum albumin levels,and transferrin levels,as well as the scores for all seven dimensions of the Profile of Mood States questionnaire,in the observation were higher than those in the control group after the 6-month follow-up period(P<0.05).However,the Nutrition Risk Screening 2002 and Mindful Attention Awareness Scale scores were lower than those in the control group(P<0.05).The compliance and satisfaction rates were 94.92%and 98.31%,respectively,which were higher than those of the control group(79.66%and 88.14%,respectively;P<0.05).CONCLUSION The implementation of the integrated approach significantly reduced the risk of malnutrition and improved mood states in patients with gastrointestinal tumors.Moreover,the compliance and satisfaction rates were higher.
文摘BACKGROUND The central link between septic shock and acute skin failure(ASF)is the inflammatory response,which occurs throughout disease progression and can lead to systemic inflammatory response syndrome.Patients often experience bad moods,sleep disorders,and other health issues.Despite recognizing these factors,no studies have examined the correlation between inflammatory factors,lactic acid levels,ASF,mood disturbances,and sleep quality in critically ill patients.We hypothesize that higher levels of inflammatory factors and lactic acid are associated with more severe ASF and poorer mood and sleep quality,which may inform clinical treatment for septic shock and ASF.AIM To explore the relationship between inflammatory factors,lactic acid levels,the severity of ASF,bad mood,and sleep quality.METHODS The retrospective study included 150 patients with septic shock from the Second Hospital of Dalian Medical University,categorized into ASF(n=35)or non-ASF groups(n=115).We compared the peripheral blood inflammatory factors,including tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),lactic acid levels,skin mottling score(SMS),modified early warning score(MEWS),self-rating depression scale(SDS),self-rating anxiety scale(SAS),and Pittsburgh sleep quality index(PSQI)scores.Pearson correlation analysis assessed relationships among these variables.RESULTS The ASF group had significantly higher levels of CRP(19.60±4.10 vs 15.30±2.96 mg/mL),IL-6(298.65±48.65 vs 268.66±33.66 pg/L),procalcitonin,lactic acid(8.42±2.32 vs 5.70±1.27 mmol/L),SMS[0(0,1)vs 3(2,3)],MEWS(9.34±1.92 vs 6.48±1.96),SAS(61.63±12.03 vs 53.71±12.48),SDS(60.17±12.64 vs 52.27±12.64),and PSQI scores(14.23±3.94 vs 8.69±2.46)compared with the non-ASF group(all P<0.001).Pearson correlation analysis revealed that IL-6,CRP,TNF-α,and lactic acid were positively correlated with SMS,MEWS,SAS,SDS,and PSQI scores(P<0.05).CONCLUSION Peripheral blood levels of IL-6,CRP,TNF-α,and lactic acid correlate positively with SMS,MEWS,SAS,SDS,and PSQI in critically ill patients with ASF.
文摘Events in the first few days of September have confirmed what was already in motion.A new rhythm in world affairs is emerging.In Tianjin,a metropolis in north China,Chinese President Xi Jinping launched the Global Governance Initiative(GGI)at the Shanghai Cooperation Organisation(SCO)Summit.In Beijing,China’s capital,President Xi reviewed troops during a military parade to mark the 80th Anniversary of the Victory in the Chinese People’s War of Resistance Against Japanese Aggression and the World Anti-Fascist War.
文摘The aim of this study was to investigate changes in autonomic nervous system (ANS) activity and mood caused by Mindfulness Art Therapy Short version (MATS). The participants were 20 Japanese college students who were separated into high and low risk groups based on the median score of the General Health Questionnaire (GHQ). MATS consisted of mindfulness exercise and making of art in one session. ANS activity (TP: total energy, LF/HF: sympathetic nervous, HF: parasympathetic nervous system, LF: both sympathetic and parasympathetic) and mood (TA: tension arousal, EA: energy arousal) were measured psychologically before and after MATS. In the high risk group, TP significantly decreased and LF, HF, and LF/HF did not change significantly;while TA significantly decreased and EA significantly increased. In the low risk group, TP and LF significantly increased and HF and LF/HF did not change significantly;while TA significantly decreased and EA showed a non-significant increase. These results suggest that MATS affects the ANS differently for participants with different states of mental health, and particularly promotes activity in low-risk participants. Psychologically, MATS decreased tension or anxiety and increased energy. These findings justify further use of this therapy.
基金Research Project of Nantong Health and Health Commission,No.MS2023041,No.MA2019003,and No.MA2021017Science and Technology Program of Nantong City,No.Key03,and No.JCZ2022040and Kangda College of Nanjing Medical University,No.KD2021JYYJYB025,No.KD2022KYJJZD019,and No.KD2022KYJJZD022.
文摘Menopausal syndrome is a common disease of clinical women,which refers to a series of physical and mental symptoms caused by the fluctuation or reduction of sex hormones before and after menopause.Many of these patients have sleep and mood abnormalities that affect their health and quality of life.At present,the understanding of it is gradually improving.This paper mainly analyzes its back-ground and current treatment.
文摘BACKGROUND Hormone replacement therapy is an effective treatment strategy for the management of symptoms in naturally menopausal women.However,some patients report experiencing adverse effects.AIM To analyze the effects of hormone replacement therapy in menopausal female patients.METHODS A total of 152 menopausal female patients admitted to the Gynecology Department of the Ganzhou Maternal and Child Health Hospital between January 2021 and December 2023 were divided into the observation group(n=76,conventional treatment+hormone replacement therapy)and the control group(n=76,conventional treatment only)via random casting.The improvement observed in the following items were compared between the groups:Kupperman menopausal index(KMI),emotional state[The Positive and Negative Affect Scale(PANAS)],sleep quality[Self-Rating Scale of Sleep(SRSS)],treatment effectiveness,and treatment safety.RESULTS The modified KMI and SRSS scores of the observation group were lower than those of the control group after three rounds of treatment.The improvement in the PANAS score observed in the observation group was greater than that observed in the control group(P<0.05).The total treatment effectivity rate in the observation group was higher than that in the control group(86.84%vs 96.05%,χ2=4.121,P=0.042).The incidence rate of adverse reactions in the two groups was comparable(6.58%vs 9.21%,χ2=0.361,P=0.547).CONCLUSION Hormone replacement therapy effectively improved the clinical symptoms,actively channeled negative emotions,and improved the quality of sleep in menopausal patients,indicating its effectiveness and safety.
文摘Marked alterations in the normal female hormonal milieu in the perimenopausal period significantly affect women’s health,leading to decreased well-being,psychological distress,and impaired quality of life.Common menopausal symp-toms include hot flashes,sleep and mood changes,fatigue,weight gain,and urogenital disturbances.Clinicians often neglect mood swings and disrupted sleep,although those can significantly limit the productivity of women and impair their cognitive function and mental health.Evidence-based management should include a personalized,holistic approach to alleviate symptoms and careful consideration of the risks vs benefits of hormone replacement therapy(HRT),with due consideration of personal preferences.A research paper in the recent issue of the World Journal of Psychiatry by Liu et al investigated the role of HRT in altering mood changes and impaired sleep quality in menopausal women,which helps us to understand the benefits of this treatment approach.
文摘Available evidence points to a possible role of the renin-angiotensin system(RAS)in the pathophysiology of mood disorders and suicide.We carried out a critical analysis of literature data regarding this role,with a focus on the proposed association between RAS dysfunction and suicidal behavior.Epidemiological,genetic,and biochemical findings are described,and the pathophysiological hypothesis aiming at explaining the possible relationship between RAS and suicide are discussed.Available findings do support the involvement of the RAS in the neurobiology of suicide,although the exact mechanisms underlying this involvement are still unknown.
文摘BACKGROUND Nowadays there is an increasing use of transcranial magnetic stimulation(TMS)both in neurological and psychiatric fields.After Food and Drug Administration approval of TMS for the therapy of treatment-resistant depression,TMS has been widely used in the context of mood disorders(MD).However,growing reports regarding the possibility of developing hypomanic/manic switch(HMS)have generated concern regarding its use in MDs.AIM To investigate the actual risk of developing HMS due to TMS in the treatment of MD.METHODS We led our research on PubMed,Scopus and Web of Science on March 22,2020,in accordance to the PRISMA guidelines for systematic review.Only double blind/single blind studies,written in English and focused on the TMS treatment of MD,were included.A meta-analysis of repetitive TMS protocol studies including HMS was conducted using RevMan 5.4 software.The assessment of Risk of Bias was done using Cochrane risk of bias tool.This protocol was registered on PROSPERO with the CRD42020175811 code.RESULTS Twenty-five studies were included in our meta-analysis:Twenty-one double blind randomized controlled trials(RCT)and four single blind-RCT(no.of subjects involved in active stimulation=576;no.of subjects involved in sham protocol=487).The most frequently treated pathology was major depressive episode/major depressive disorder,followed by resistant depression,bipolar depression and other MD.The majority of the studies used a repetitive TMS protocol,and the left dorsolateral prefrontal cortex was the main target area.Side effects were reported in eight studies and HMS(described as greater energy,insomnia,irritability,anxiety,suicidal attempt)in four studies.When comparing active TMS vs sham treatment,the risk of developing HMS was not significantly different between conditions.CONCLUSION Applying the most usual protocols and the appropriate precautionary measures,TMS seems not to be related to HMS development.
文摘The aim of this study was to investigate changes in the Autonomic Nervous System (ANS) and moods before and after participation in a Mindfulness Art Therapy Short version (MATS). The study design was non-randomized controlled trial in intervention study. Participants were 10 Japanese patients with advanced cancer. They received the MATS in one session, which consisted of mindfulness practices and making arts. Their Autonomic Nervous System (sympathetic nervous, parasympathetic nervous) physiologically and mood (Tense Arousal: TA, Energetic Arousal: EA) psychologically were measured before and after the MATS. The results showed that the level of parasympathetic nervous system decreased and that the sympathetic nervous system increased in small effect size. The TA decreased in a large effect size and EA increased in a middle effect size. These results suggested that the MATS might activate physiologically, alleviate tension and increase energy psychologically.
基金Project of Science and Technology Department of Hubei Province in 2023:to Investigate the Therapeutic Mechanism of Qingre Lishi Huayu Herbs on Pelvic Inflammatory Disease Based on NOTCH Signaling Pathway(No.2023AFD167)。
文摘OBJECTIVE:To systematically evaluate the efficacy and safety of acupuncture(AM)in the treatment of pregnancyrelated symptoms such as acute vomiting during pregnancy.METHODS:We comprehensively searched the available literature up to November 2021,including Pub Med,Embase,Cochrane Library,Chinese Biomedical Literature Database,and China National Knowledge Infrastructure Database,for randomized controlled trials(RCTs)on AM for the treatment of severe vomiting,insomnia,pharyngeal and pelvic pain,mood abnormalities,and dyspepsia during pregnancy.RESULTS:Sixteen RCTs with a cumulative sample size of 1178 cases were included.Of these,964 patients were included in the Meta-analysis.The Meta-analysis results showed that AM was more efficient than Western medicine in treating discomfort during pregnancy[odds ratio(OR)=1.19,95%confidence interval(CI)(1.11,1.28),P<0.01].AM was better than the control group in improving the visual analog scale scores[standard mean difference(SMD)=0.62,95%CI(0.53,0.71),P<0.01].AM was superior to the control group in improving Numerical Rating Scale(NRS)symptom scores[OR=7.31,95%CI(3.36,15.94),P<0.01].There was no significant difference in adverse effects between the AM and sham-AM groups and the analgesic drug group[OR=0.70,95%CI(0.39,1.28),P=0.25],but the treatment and control groups had mild adverse effects with a low incidence.CONCLUSIONS:AM is more effective than other treatments or pharmacotherapy alone in the treatment of pregnancy-related symptoms,and is relatively safe.However,the quality of the included trials was rather poor,and high-quality studies are required to confirm our findings.
文摘Noise is one of the environmental factors with mental and physical effects.The workload is also the multiple mental and physical demands of the task.Therefore,his study investigated the relationship between noise exposure and mood states at different levels of workload.The study recruited 50 workers from the manufacturing sector(blue-collar workers)as the exposed group and 50 workers from the office sector(white-collar workers)as the control group.Their occupational noise exposure was measured by dosimetry.The Stress-Arousal Checklist(SACL)and the NASA Task Load Index(NASA-TLX)were used to measure mood and workload,respectively.The equivalent noise exposure level of the exposed group at high and very high workload levels was 85 and 87 dBA,respectively.The mean mood score of the exposed group was 76 at very high workload.The correlation coefficient between noise exposure level and mood state based on workload levels ranged from 0.3 at medium workload to 0.57 at very high workload.Noise exposure at high workload levels can increase its adverse effects,so controlling and optimizing the multiple demands of the task in the workplace can be used as a privative measure to reduce the adverse effects of noise.
文摘Few studies have examined the impacts of color stimuli on perioperative mood and quality of recovery;thus, this randomized controlled trial aimed to assess impacts of vividly colored accessories on mood and quality of recovery after breast surgery. This single-center, single-blind randomized controlled trial included 36 participants (all aged ≥ 20 years) who were randomized into intervention (n = 19) and control groups (n = 17). The intervention group received vividly colored accessories. The primary and secondary study outcomes were patient mood, evaluated using a two-dimensional mood scale, and postoperative recovery, evaluated using Quality of Recovery-15, which were assessed on postoperative day 3. There were no statistical intergroup differences in the scores of the Two-Dimensional Mood Scale (11.2 [intervention group] vs. 10.4 [control group], P = 0.75) and Quality of Recovery-15 (126.8 [intervention group] vs. 129.3 [control group], P = 0.73). Thus, the use of vividly colored accessories by patients undergoing breast surgery was not found to affect patients’ mood and quality of recovery.
