Monochromatic x-ray imaging is an essential method for plasma diagnostics related to density information.Large-field high-resolution monochromatic imaging of a He-like iron(Fe XXV)Kαcharacteristic line(6.701 keV)for ...Monochromatic x-ray imaging is an essential method for plasma diagnostics related to density information.Large-field high-resolution monochromatic imaging of a He-like iron(Fe XXV)Kαcharacteristic line(6.701 keV)for laser plasma diagnostics was achieved using a developed toroidal crystal x-ray imager.A high-index crystal orientation Ge(531)wafer with a Bragg angle of 75.37°and the toroidal substrate were selected to obtain sufficient diffraction efficiency and compensate for astigmatism under oblique incidence.A precise offline assembly method of the toroidal crystal imager based on energy substitution was proposed,and a spatial resolution of 3-7μm was obtained by toroidal crystal imaging of a 600 line-pairs/inch Au grid within an object field of view larger than 1.0 mm.The toroidal crystal x-ray imager has been successfully tested via side-on backlight imaging experiments of the sinusoidal modulation target and a 1000 line-pairs/inch Au grid with a linewidth of 5μm using an online alignment method based on dual positioning balls to indicate the target and backlighter.This paper describes the optical design,adjustment method,and experimental results of a toroidal crystal system in a laboratory and laser facility.展开更多
In this study,a toroidal quartz(2023)crystal is designed for monochromatic X-ray imaging at 72.3◦.The designed crystal produces excellent images of a laser-produced plasma emitting He-like Ti X-rays at 4.75 keV.Based ...In this study,a toroidal quartz(2023)crystal is designed for monochromatic X-ray imaging at 72.3◦.The designed crystal produces excellent images of a laser-produced plasma emitting He-like Ti X-rays at 4.75 keV.Based on the simulations,the imaging resolutions of the spherical and toroidal crystals in the sagittal direction are found to be 15 and 5μm,respectively.Moreover,the simulation results show that a higher resolution image of the source can be obtained by using a toroidal crystal.An X-ray backlight imaging experiment is conducted using 4.75 keV He-like Ti X-rays,a 3×3 metal grid,an imaging plate and a toroidal quartz crystal with a lattice constant of 2d=0.2749 nm.The meridional and sagittal radii of the toroidalα-quartz crystal are 295.6 and 268.5 mm,respectively.A highly resolved image of the microgrid,with a spatial resolution of 10μm,is obtained in the experiment.By using similar toroidal crystal designs,the application of a spatially resolved spectrometer with high-resolution X-ray imaging ability is capable of providing imaging data with the same magnification ratio in the sagittal and meridional planes.展开更多
The measurement of X-ray continuous emission from laser-driven plasma was achieved through multiple monochromatic imaging utilizing a multilayer mirror array.This methodology was exemplified by the development of an e...The measurement of X-ray continuous emission from laser-driven plasma was achieved through multiple monochromatic imaging utilizing a multilayer mirror array.This methodology was exemplified by the development of an eight-channel X-ray imaging system,capable of operating in the energy range of several ke V with a spatial resolution of approximately3 μm.By integrating this system with a streak camera,the temperature and trajectory of imploding capsules were successfully measured at the kJ-class Shenguang III prototype laser facility.This approach provides a synchronous diagnostic method for the spatial,temporal and spectral analysis of laser-driven plasma,characterized by its high efficiency and resolution.展开更多
Curved crystal imaging is an important means of plasma diagnosis.Due to the short wavelengths of high-energy X rays and the fixed lattice constant of the spherical crystal,it is difficult to apply the spherical crysta...Curved crystal imaging is an important means of plasma diagnosis.Due to the short wavelengths of high-energy X rays and the fixed lattice constant of the spherical crystal,it is difficult to apply the spherical crystal in high-energy X-ray imaging.In this study,we have developed a high-energy,high-resolution X-ray imager based on a toroidal crystal that can effectively correct astigmatism.We prepared a Ge<511>toroidal crystal for backlighting Mo Kα1 characteristic lines(∼17.48 keV)and verified its high-resolution imaging ability in high-energy X-ray region,achieving a spatial resolution of 5–10μm in a field of view larger than 1.0 mm.展开更多
Multicolor imaging has been widely applied across various biological and medical applications,especially essential for probing diverse biological structures.However,existing multicolor imaging methods often sacrifice ...Multicolor imaging has been widely applied across various biological and medical applications,especially essential for probing diverse biological structures.However,existing multicolor imaging methods often sacrifice either simultaneity or speed,posing a challenge for simultaneous imaging of over three fluorophores.Here,we proposed off-axis spectral encoding multicolor microscopy(OSEM)with a single camera that simultaneously captures encoded multicolor signals and reconstructs monochromatic images by decoding.Based on the natural intensity modulation difference of a single illumination spot across off-axis detection positions,we adjusted the multicolor excitation beams with distinct off-axis offsets from the same detection position to achieve spectral encoding.The method achieved multicolor simultaneous imaging in a single camera without extra sacrifice of frame rate.We evaluated OSEM's imaging performance by imaging multicolor synthetic samples and fluorescent microbeads.We also demonstrated that OSEM reduced imaging time by 5.8 times and achieved 99%accuracy in classifying and counting multicolor fluorescent bacteria,outperforming sequential imaging.We obtained four-color fluorescent optical-sectioning images of a mouse brain slice at a speed of 2.85 mm^(2)∕s,demonstrating its effectiveness for high-throughput multicolor imaging of large tissue samples.These results indicate that OSEM offers a reliable and efficient tool for multicolor fluorescent imaging of large biological tissues.展开更多
基金National Natural Science Foundation of China(No.11805212)National Key Research and Development Program of China(No.2019YFE03080200)。
文摘Monochromatic x-ray imaging is an essential method for plasma diagnostics related to density information.Large-field high-resolution monochromatic imaging of a He-like iron(Fe XXV)Kαcharacteristic line(6.701 keV)for laser plasma diagnostics was achieved using a developed toroidal crystal x-ray imager.A high-index crystal orientation Ge(531)wafer with a Bragg angle of 75.37°and the toroidal substrate were selected to obtain sufficient diffraction efficiency and compensate for astigmatism under oblique incidence.A precise offline assembly method of the toroidal crystal imager based on energy substitution was proposed,and a spatial resolution of 3-7μm was obtained by toroidal crystal imaging of a 600 line-pairs/inch Au grid within an object field of view larger than 1.0 mm.The toroidal crystal x-ray imager has been successfully tested via side-on backlight imaging experiments of the sinusoidal modulation target and a 1000 line-pairs/inch Au grid with a linewidth of 5μm using an online alignment method based on dual positioning balls to indicate the target and backlighter.This paper describes the optical design,adjustment method,and experimental results of a toroidal crystal system in a laboratory and laser facility.
基金supported by the National Natural Science Foundation of China(Nos.61604028,11775203,and 12075219)the Chongqing Study Abroad Innovation Fund Project(No.cx2018023)+1 种基金the Plasma Physics Key Laboratory Fund Project(No.6142A04180207)the Innovation and Development Fund of China Academy of Engineering Physics(No.CX20210019)。
文摘In this study,a toroidal quartz(2023)crystal is designed for monochromatic X-ray imaging at 72.3◦.The designed crystal produces excellent images of a laser-produced plasma emitting He-like Ti X-rays at 4.75 keV.Based on the simulations,the imaging resolutions of the spherical and toroidal crystals in the sagittal direction are found to be 15 and 5μm,respectively.Moreover,the simulation results show that a higher resolution image of the source can be obtained by using a toroidal crystal.An X-ray backlight imaging experiment is conducted using 4.75 keV He-like Ti X-rays,a 3×3 metal grid,an imaging plate and a toroidal quartz crystal with a lattice constant of 2d=0.2749 nm.The meridional and sagittal radii of the toroidalα-quartz crystal are 295.6 and 268.5 mm,respectively.A highly resolved image of the microgrid,with a spatial resolution of 10μm,is obtained in the experiment.By using similar toroidal crystal designs,the application of a spatially resolved spectrometer with high-resolution X-ray imaging ability is capable of providing imaging data with the same magnification ratio in the sagittal and meridional planes.
基金supported by the National Key Research and Development Program(Grant No.2019YFE03080200)the National Natural Science Foundation of China(Grant No.12204353)。
文摘The measurement of X-ray continuous emission from laser-driven plasma was achieved through multiple monochromatic imaging utilizing a multilayer mirror array.This methodology was exemplified by the development of an eight-channel X-ray imaging system,capable of operating in the energy range of several ke V with a spatial resolution of approximately3 μm.By integrating this system with a streak camera,the temperature and trajectory of imploding capsules were successfully measured at the kJ-class Shenguang III prototype laser facility.This approach provides a synchronous diagnostic method for the spatial,temporal and spectral analysis of laser-driven plasma,characterized by its high efficiency and resolution.
基金supported by the National Key Research and Development Program of China(No.2019YFE03080200)the National Natural Science Foundation of China(Nos.11875202 and 11875048).
文摘Curved crystal imaging is an important means of plasma diagnosis.Due to the short wavelengths of high-energy X rays and the fixed lattice constant of the spherical crystal,it is difficult to apply the spherical crystal in high-energy X-ray imaging.In this study,we have developed a high-energy,high-resolution X-ray imager based on a toroidal crystal that can effectively correct astigmatism.We prepared a Ge<511>toroidal crystal for backlighting Mo Kα1 characteristic lines(∼17.48 keV)and verified its high-resolution imaging ability in high-energy X-ray region,achieving a spatial resolution of 5–10μm in a field of view larger than 1.0 mm.
基金National Natural Science Foundation of China(62325502,81827901)。
文摘Multicolor imaging has been widely applied across various biological and medical applications,especially essential for probing diverse biological structures.However,existing multicolor imaging methods often sacrifice either simultaneity or speed,posing a challenge for simultaneous imaging of over three fluorophores.Here,we proposed off-axis spectral encoding multicolor microscopy(OSEM)with a single camera that simultaneously captures encoded multicolor signals and reconstructs monochromatic images by decoding.Based on the natural intensity modulation difference of a single illumination spot across off-axis detection positions,we adjusted the multicolor excitation beams with distinct off-axis offsets from the same detection position to achieve spectral encoding.The method achieved multicolor simultaneous imaging in a single camera without extra sacrifice of frame rate.We evaluated OSEM's imaging performance by imaging multicolor synthetic samples and fluorescent microbeads.We also demonstrated that OSEM reduced imaging time by 5.8 times and achieved 99%accuracy in classifying and counting multicolor fluorescent bacteria,outperforming sequential imaging.We obtained four-color fluorescent optical-sectioning images of a mouse brain slice at a speed of 2.85 mm^(2)∕s,demonstrating its effectiveness for high-throughput multicolor imaging of large tissue samples.These results indicate that OSEM offers a reliable and efficient tool for multicolor fluorescent imaging of large biological tissues.
